Protagonist Therapeutics, Inc
PTGX- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001377121
In the last 90 days, Protagonist Therapeutics, Inc insiders filed 0 open-market purchases and 3 sales; 346 institutions reported holding it in 13F filings for Q2 2026, worth $9.30B in total; Duquesne Family Office is the only superinvestor holding it.
13F holders, Q1 2026
Institutional positions in Protagonist Therapeutics, Inc as of Mar 31, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 322
- +10 vs. Q4 2025
- Shares held
- 78.9M
- +13.3M (+20.3%) vs. Q4 2025
- Total value
- $8.31B
- +$2.61B (+45.7%) vs. Q4 2025
- New holders
- 60
- 111 more added
- Sold out
- 50
- 104 more reduced
7 institutions that held it in Q4 2025 haven't filed for Q1 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting PTGX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 346 | $9.30B |
| Q1 2026 | 322 | $8.31B |
| Q4 2025 | 319 | $6.18B |
| Q3 2025 | 275 | $4.70B |
| Q2 2025 | 274 | $3.92B |
| Q1 2025 | 275 | $3.15B |
| Q4 2024 | 241 | $2.44B |
| Q3 2024 | 240 | $2.78B |
| Q2 2024 | 188 | $2.05B |
| Q1 2024 | 185 | $1.73B |
| Q4 2023 | 157 | $1.32B |
| Q3 2023 | 144 | $945.9M |
| Q2 2023 | 167 | $1.57B |
| Q1 2023 | 138 | $1.22B |
| Q4 2022 | 137 | $533.3M |
| Q3 2022 | 133 | $398.9M |
| Q2 2022 | 131 | $422.1M |
| Q1 2022 | 140 | $1.19B |
| Q4 2021 | 149 | $1.68B |
| Q3 2021 | 132 | $820.8M |
| Q2 2021 | 139 | $2.16B |
| Q1 2021 | 127 | $1.15B |
Institutions, Q1 2026
Shares, value and share of portfolio for each institution holding Protagonist Therapeutics, Inc; share changes are against Q4 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Keybank National Association | 4,286 | $451.7K | 0.00% | +4,286 | New |
| Abel Hall, LLC | 4,258 | $448.8K | 0.10% | +4,258 | New |
| Amundi | 4,113 | $433.5K | 0.00% | +4,113 | New |
| Abacus Wealth Partners, LLC | 4,094 | $431.5K | 0.04% | +331+8.8% | Added |
| King Wealth | 4,000 | $422.0K | 0.05% | 00.0% | Unchanged |
| Seven Fleet Capital Management LP | 4,000 | $421.6K | 0.13% | −4,000−50.0% | Reduced |
| The PNC Financial Services Group, Inc. | 3,998 | $421.4K | 0.00% | +1,039+35.1% | Added |
| US Bancorp | 3,914 | $412.5K | 0.00% | −481−10.9% | Reduced |
| M&T Bank Corp | 3,858 | $406.8K | 0.00% | +105+2.8% | Added |
| Nisa Investment Advisors, LLC | 3,802 | $400.7K | 0.00% | +22+0.6% | Added |
| Vestcor Inc | 3,765 | $397.0K | 0.01% | 00.0% | Unchanged |
| Hudson Bay Capital Management LP | 3,760 | $396.3K | 0.00% | −105,855−96.6% | Reduced |
| Velan Capital Investment Management LP | 3,700 | $390.0K | 0.24% | 00.0% | Unchanged |
| Jane Street Group, LLC | 3,607 | $380.2K | 0.00% | −30,700−89.5% | Reduced |
| Wealth Enhancement Advisory Services, LLC | 3,657 | $379.5K | 0.00% | +103+2.9% | Added |
| Crossmark Global Holdings, Inc. | 3,489 | $367.7K | 0.01% | −471−11.9% | Reduced |
| Mirae Asset Global Investments Co., Ltd. | 3,328 | $350.8K | 0.00% | +290+9.5% | Added |
| Gabelli Funds LLC | 3,229 | $340.3K | 0.00% | +3,229 | New |
| Burney Co | 3,179 | $335.1K | 0.01% | −501−13.6% | Reduced |
| Pinnacle Wealth Planning Services, Inc. | 3,132 | $330.1K | 0.03% | +268+9.4% | Added |
| Swiss Life Asset Management Ltd | 3,104 | $327.2K | 0.00% | +673+27.7% | Added |
| PSP Research LLC | 3,000 | $316.2K | 0.22% | −3,121−51.0% | Reduced |
| CIBC Bancorp USA Inc. | 2,968 | $312.8K | 0.00% | +2,968 | New |
| Headlands Technologies LLC | 2,957 | $311.7K | 0.04% | −14,122−82.7% | Reduced |
| GAMMA Investing LLC | 2,901 | $305.8K | 0.01% | +229+8.6% | Added |
| AE Wealth Management LLC | 2,888 | $304.4K | 0.00% | +2,888 | New |
| Virtus Investment Advisers, Inc. | 2,860 | $301.4K | 0.08% | +70+2.5% | Added |
| Evergreen Capital Management LLC | 2,820 | $297.2K | 0.01% | +8+0.3% | Added |
| Norden Group LLC | 2,810 | $296.2K | 0.03% | +2,810 | New |
| LPL Financial LLC | 2,793 | $294.4K | 0.00% | −472−14.5% | Reduced |
| Mariner, LLC | 2,775 | $292.4K | 0.00% | −4,845−63.6% | Reduced |
| Sumitomo Mitsui Trust Holdings, Inc. | 2,760 | $290.9K | 0.00% | +200+7.8% | Added |
| Jones Financial Companies LLLP | 2,923 | $289.3K | 0.00% | +2,877+6,254.3% | Added |
| New Age Alpha Advisors, LLC | 2,706 | $285.2K | 0.01% | −78−2.8% | Reduced |
| CIBC Asset Management Inc | 2,667 | $281.1K | 0.00% | 00.0% | Unchanged |
| Eventide Asset Management, LLC | 2,795 | $279.2K | 0.00% | +2,795 | New |
| NBC Securities, Inc. | 2,547 | $268.5K | 0.02% | −430−14.4% | Reduced |
| Vise Technologies, Inc. | 2,996 | $261.7K | 0.01% | 00.0% | Unchanged |
| O'Shaughnessy Asset Management, LLC | 2,440 | $257.2K | 0.00% | −1,929−44.2% | Reduced |
| GTS Securities LLC | 2,416 | $254.6K | 0.01% | +2,416 | New |
| Empowered Funds, LLC | 2,321 | $244.6K | 0.00% | +2,321 | New |
| DnB Asset Management AS | 2,244 | $236.5K | 0.00% | +2,244 | New |
| RSM US Wealth Management LLC | 2,234 | $235.5K | 0.00% | +2,234 | New |
| TFB Advisors LLC | 2,191 | $230.9K | 0.12% | +2,191 | New |
| Concurrent Investment Advisors, LLC | 2,060 | $217.1K | 0.00% | +2,060 | New |
| Prelude Capital Management, LLC | 2,012 | $212.1K | 0.02% | +2,012 | New |
| Axiom Investment Management LLC | 2,000 | $210.8K | 0.16% | +2,000 | New |
| Shelton Capital Management | 1,908 | $201.1K | 0.00% | +1,908 | New |
| HSBC Holdings PLC | 1,907 | $201.0K | 0.00% | +1,907 | New |
| Captrust Financial Advisors | 1,902 | $200.5K | 0.00% | −830−30.4% | Reduced |
| Oppenheimer & Co Inc | 1,900 | $200.3K | 0.00% | +1,900 | New |
| Royal Bank of Canada | 1,599 | $169.0K | 0.00% | −1,584−49.8% | Reduced |
| KBC Group NV | 1,574 | $166.0K | 0.00% | 00.0% | Unchanged |
| Quadrant Capital Group LLC | 1,429 | $150.6K | 0.00% | −38−2.6% | Reduced |
| GF Fund Management Co. Ltd. | 1,404 | $148.0K | 0.00% | +177+14.4% | Added |
| Advisor Group Holdings, Inc. | 1,197 | $126.2K | 0.00% | −3,004−71.5% | Reduced |
| Truvestments Capital LLC | 1,161 | $122.4K | 0.02% | 00.0% | Unchanged |
| Federated Hermes, Inc. | 1,001 | $105.5K | 0.00% | +1,001 | New |
| Canton Hathaway, LLC | 1,000 | $105.4K | 0.02% | 00.0% | Unchanged |
| EverSource Wealth Advisors, LLC | 911 | $96.0K | 0.00% | +352+63.0% | Added |
| Covestor Ltd | 875 | $92.0K | 0.06% | −562−39.1% | Reduced |
| Hantz Financial Services, Inc. | 857 | $90.0K | 0.00% | −94−9.9% | Reduced |
| Smartleaf Asset Management LLC | 890 | $88.9K | 0.00% | −837−48.5% | Reduced |
| Larson Financial Group LLC | 819 | $86.3K | 0.00% | +648+378.9% | Added |
| CWM, LLC | 737 | $77.7K | 0.00% | +181+32.6% | Added |
| CFG Wealth Management Services, Inc. | 611 | $64.4K | 0.06% | +9+1.5% | Added |
| Salomon & Ludwin, LLC | 595 | $61.7K | 0.01% | +159+36.5% | Added |
| Kemnay Advisory Services Inc. | 521 | $54.9K | 0.01% | +340+187.8% | Added |
| Sterling Capital Management LLC | 377 | $39.7K | 0.00% | −1−0.3% | Reduced |
| Umb Bank N A | 353 | $37.2K | 0.00% | +20+6.0% | Added |
| Toronto Dominion Bank | 349 | $36.8K | 0.00% | +349 | New |
| Ameritas Advisory Services, LLC | 334 | $35.2K | 0.00% | +334 | New |
| Farther Finance Advisors, LLC | 333 | $34.5K | 0.00% | +36+12.1% | Added |
| Allworth Financial LP | 313 | $33.0K | 0.00% | +58+22.7% | Added |
| Signaturefd, LLC | 288 | $30.4K | 0.00% | +125+76.7% | Added |
| Keating Financial Advisory Services, Inc. | 224 | $23.6K | 0.00% | +222+11,100.0% | Added |
| Clearstead Advisors, LLC | 200 | $21.1K | 0.00% | −22−9.9% | Reduced |
| Twin Peaks Wealth Advisors, LLC | 173 | $18.2K | 0.00% | +173 | New |
| E Fund Management (Hong Kong) Co., Ltd. | 156 | $16.4K | 0.01% | +156 | New |
| Sound Income Strategies, LLC | 156 | $16.2K | 0.00% | −128−45.1% | Reduced |
| Massmutual Trust Co FSB | 125 | $13.2K | 0.00% | +6+5.0% | Added |
| Parallel Advisors, LLC | 123 | $13.0K | 0.00% | +14+12.8% | Added |
| Cedar Mountain Advisors, LLC | 113 | $11.9K | 0.00% | +113 | New |
| Rothschild Investment LLC | 107 | $11.3K | 0.00% | +21+24.4% | Added |
| WPG Advisers, LLC | 97 | $10.2K | 0.01% | +1+1.0% | Added |
| Bare Financial Services, Inc | 95 | $10.0K | 0.00% | −15−13.6% | Reduced |
| Bell Investment Advisors, Inc | 81 | $8.54K | 0.00% | 00.0% | Unchanged |
| Brown Brothers Harriman & Co | 81 | $8.54K | 0.00% | 00.0% | Unchanged |
| Parkside Financial Bank & Trust | 76 | $8.01K | 0.00% | −8−9.5% | Reduced |
| Annis Gardner Whiting Capital Advisors, LLC | 76 | $8.01K | 0.00% | 00.0% | Unchanged |
| SBI Securities Co., Ltd. | 70 | $7.38K | 0.00% | 00.0% | Unchanged |
| Raffa Wealth Management, LLC | 60 | $6.32K | 0.00% | 00.0% | Unchanged |
| Sankala Group LLC | 60 | $6.07K | 0.00% | 00.0% | Unchanged |
| Hollencrest Capital Management | 45 | $4.74K | 0.00% | +45 | New |
| MCF Advisors LLC | 40 | $4.22K | 0.00% | +40 | New |
| Huntington National Bank | 35 | $3.69K | 0.00% | 00.0% | Unchanged |
| Farmers & Merchants Investments Inc | 35 | $3.69K | 0.00% | 00.0% | Unchanged |
| Wolff Wiese Magana LLC | 35 | $3.69K | 0.00% | 00.0% | Unchanged |
| Torren Management, LLC | 30 | $3.16K | 0.00% | −9−23.1% | Reduced |
| Marquette Asset Management, LLC | 28 | $2.95K | 0.00% | 00.0% | Unchanged |