Protagonist Therapeutics, Inc
PTGX- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001377121
In the last 90 days, Protagonist Therapeutics, Inc insiders filed 0 open-market purchases and 3 sales; 346 institutions reported holding it in 13F filings for Q2 2026, worth $9.30B in total; Duquesne Family Office is the only superinvestor holding it.
13F holders, Q2 2025
Institutional positions in Protagonist Therapeutics, Inc as of Jun 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 274
- +3 vs. Q1 2025
- Shares held
- 71.0M
- +5.66M (+8.7%) vs. Q1 2025
- Total value
- $3.92B
- +$774.8M (+24.6%) vs. Q1 2025
- New holders
- 52
- 120 more added
- Sold out
- 49
- 76 more reduced
4 institutions that held it in Q1 2025 haven't filed for Q2 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q1 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting PTGX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 346 | $9.30B |
| Q1 2026 | 322 | $8.31B |
| Q4 2025 | 319 | $6.18B |
| Q3 2025 | 275 | $4.70B |
| Q2 2025 | 274 | $3.92B |
| Q1 2025 | 275 | $3.15B |
| Q4 2024 | 241 | $2.44B |
| Q3 2024 | 240 | $2.78B |
| Q2 2024 | 188 | $2.05B |
| Q1 2024 | 185 | $1.73B |
| Q4 2023 | 157 | $1.32B |
| Q3 2023 | 144 | $945.9M |
| Q2 2023 | 167 | $1.57B |
| Q1 2023 | 138 | $1.22B |
| Q4 2022 | 137 | $533.3M |
| Q3 2022 | 133 | $398.9M |
| Q2 2022 | 131 | $422.1M |
| Q1 2022 | 140 | $1.19B |
| Q4 2021 | 149 | $1.68B |
| Q3 2021 | 132 | $820.8M |
| Q2 2021 | 139 | $2.16B |
| Q1 2021 | 127 | $1.15B |
Institutions, Q2 2025
Shares, value and share of portfolio for each institution holding Protagonist Therapeutics, Inc; share changes are against Q1 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Cornerstone Investment Partners, LLC | 4,980 | $275.2K | 0.01% | +3+0.1% | Added |
| Graham Capital Management, L.P. | 4,979 | $275.2K | 0.01% | +4,979 | New |
| LPL Financial LLC | 4,818 | $266.3K | 0.00% | −70−1.4% | Reduced |
| Advisors Asset Management, Inc. | 4,724 | $261.1K | 0.00% | +3+0.1% | Added |
| Bridgefront Capital, LLC | 4,545 | $251.2K | 0.07% | +4,545 | New |
| Xponance, Inc. | 4,506 | $249.0K | 0.00% | +42+0.9% | Added |
| HSBC Holdings PLC | 4,340 | $242.1K | 0.00% | −4,118−48.7% | Reduced |
| Crossmark Global Holdings, Inc. | 4,065 | $224.7K | 0.00% | +4,065 | New |
| State of Wyoming | 3,985 | $220.3K | 0.03% | +2,528+173.5% | Added |
| Nisa Investment Advisors, LLC | 3,903 | $215.7K | 0.00% | +1,071+37.8% | Added |
| Velan Capital Investment Management LP | 3,700 | $204.5K | 0.20% | +3,700 | New |
| Wexford Capital LP | 3,315 | $183.2K | 0.05% | +3,315 | New |
| NBC Securities, Inc. | 2,565 | $141.0K | 0.01% | +2,565 | New |
| The PNC Financial Services Group, Inc. | 2,414 | $133.4K | 0.00% | +422+21.2% | Added |
| Mirae Asset Global Investments Co., Ltd. | 2,394 | $132.3K | 0.00% | +340+16.6% | Added |
| SG Americas Securities, LLC | 1,924 | $106.0K | 0.00% | +1,924 | New |
| Covestor Ltd | 1,745 | $97.0K | 0.06% | −342−16.4% | Reduced |
| Virtus Investment Advisers, Inc. | 1,670 | $92.3K | 0.03% | −2,395−58.9% | Reduced |
| KBC Group NV | 1,574 | $87.0K | 0.00% | −519−24.8% | Reduced |
| GF Fund Management Co. Ltd. | 1,526 | $84.3K | 0.00% | 00.0% | Unchanged |
| Smartleaf Asset Management LLC | 1,257 | $70.0K | 0.01% | +46+3.8% | Added |
| Advisor Group Holdings, Inc. | 1,185 | $65.5K | 0.00% | +525+79.5% | Added |
| GAMMA Investing LLC | 1,077 | $59.5K | 0.00% | −126−10.5% | Reduced |
| Truvestments Capital LLC | 650 | $35.9K | 0.01% | +369+131.3% | Added |
| CWM, LLC | 609 | $34.0K | 0.00% | +407+201.5% | Added |
| Bessemer Group Inc | 504 | $28.0K | 0.00% | +318+171.0% | Added |
| FNY Investment Advisers, LLC | 500 | $27.0K | 0.01% | +500 | New |
| Skopos Labs, Inc. | 487 | $26.9K | 0.00% | −913−65.2% | Reduced |
| Global Retirement Partners, LLC | 316 | $17.5K | 0.00% | +316 | New |
| Assetmark, Inc | 290 | $16.0K | 0.00% | −5−1.7% | Reduced |
| EverSource Wealth Advisors, LLC | 226 | $12.5K | 0.00% | +137+153.9% | Added |
| Rise Advisors, LLC | 224 | $12.4K | 0.00% | 00.0% | Unchanged |
| Daiwa Securities Group Inc. | 215 | $12.0K | 0.00% | 00.0% | Unchanged |
| Fifth Third Bancorp | 211 | $11.7K | 0.00% | −71−25.2% | Reduced |
| Umb Bank N A | 199 | $11.0K | 0.00% | +41+25.9% | Added |
| Twin Peaks Wealth Advisors, LLC | 171 | $9.32K | 0.00% | +171 | New |
| Signaturefd, LLC | 149 | $8.23K | 0.00% | +55+58.5% | Added |
| Hantz Financial Services, Inc. | 143 | $8.00K | 0.00% | +141+7,050.0% | Added |
| Sterling Capital Management LLC | 143 | $7.90K | 0.00% | +80+127.0% | Added |
| Russell Investments Group, Ltd. | 129 | $7.13K | 0.00% | −3,229−96.2% | Reduced |
| Massmutual Trust Co FSB | 119 | $6.58K | 0.00% | +74+164.4% | Added |
| Allworth Financial LP | 117 | $6.47K | 0.00% | +87+290.0% | Added |
| Clearstead Advisors, LLC | 110 | $6.08K | 0.00% | 00.0% | Unchanged |
| Rothschild Investment LLC | 110 | $6.08K | 0.00% | +15+15.8% | Added |
| Danske Bank A/S | 100 | $5.53K | 0.00% | 00.0% | Unchanged |
| Parallel Advisors, LLC | 97 | $5.36K | 0.00% | +70+259.3% | Added |
| Farther Finance Advisors, LLC | 93 | $5.14K | 0.00% | −296−76.1% | Reduced |
| MAI Capital Management | 86 | $4.75K | 0.00% | +86 | New |
| Bell Investment Advisors, Inc | 81 | $4.48K | 0.00% | +50+161.3% | Added |
| Brown Brothers Harriman & Co | 81 | $4.48K | 0.00% | +81 | New |
| WPG Advisers, LLC | 78 | $4.31K | 0.00% | +70+875.0% | Added |
| Annis Gardner Whiting Capital Advisors, LLC | 76 | $4.20K | 0.00% | +76 | New |
| Riggs Asset Managment Co. Inc. | 71 | $3.92K | 0.00% | +71 | New |
| Raffa Wealth Management, LLC | 60 | $3.32K | 0.00% | +60 | New |
| IFP Advisors, Inc | 0 | $3.10K | 0.00% | 0 | New |
| Kestra Investment Management, LLC | 54 | $2.80K | 0.00% | +27+100.0% | Added |
| Geneos Wealth Management Inc. | 47 | $2.60K | 0.00% | +35+291.7% | Added |
| Parkside Financial Bank & Trust | 45 | $2.49K | 0.00% | +11+32.4% | Added |
| Caitong International Asset Management Co., Ltd | 41 | $2.27K | 0.00% | −2,747−98.5% | Reduced |
| Huntington National Bank | 39 | $2.15K | 0.00% | +39 | New |
| Principal Securities, Inc. | 36 | $1.99K | 0.00% | +24+200.0% | Added |
| Wolff Wiese Magana LLC | 35 | $1.94K | 0.00% | 00.0% | Unchanged |
| Farmers & Merchants Investments Inc | 35 | $1.93K | 0.00% | 00.0% | Unchanged |
| Versant Capital Management, Inc | 29 | $1.60K | 0.00% | +29 | New |
| Larson Financial Group LLC | 26 | $1.44K | 0.00% | −100−79.4% | Reduced |
| Bare Financial Services, Inc | 23 | $1.27K | 0.00% | +23 | New |
| Whipplewood Advisors, LLC | 22 | $1.22K | 0.00% | +22 | New |
| Atlantic Trust, LLC | 21 | $1.16K | 0.00% | +21 | New |
| Jones Financial Companies LLLP | 20 | $1.11K | 0.00% | +20 | New |
| Picton Mahoney Asset Management | 25 | $1.00K | 0.00% | 00.0% | Unchanged |
| UMA Financial Services, Inc. | 9 | $498 | 0.00% | +9 | New |
| Abound Wealth Management | 4 | $222 | 0.00% | 00.0% | Unchanged |
| Kilter Group LLC | 4 | $222 | 0.00% | +4 | New |
| DecisionPoint Financial, LLC | 4 | $201 | 0.00% | +4 | New |
| Colony Group, LLC | 0 | $0 | 0.00% | −435,097−100.0% | Sold out |
| Jane Street Group, LLC | 0 | $0 | 0.00% | −193,300−100.0% | Sold out |
| Soleus Capital Management, L.P. | 0 | $0 | 0.00% | −169,000−100.0% | Sold out |
| Jacobs Levy Equity Management, Inc | 0 | $0 | 0.00% | −128,654−100.0% | Sold out |
| Nan Fung Group Holdings Ltd | 0 | $0 | 0.00% | −121,400−100.0% | Sold out |
| Empowered Funds, LLC | 0 | $0 | 0.00% | −102,532−100.0% | Sold out |
| Lazard Asset Management LLC | 0 | $0 | 0.00% | −96,420−100.0% | Sold out |
| Aquilo Capital Management, LLC | 0 | $0 | 0.00% | −81,692−100.0% | Sold out |
| HRT Financial LP | 0 | $0 | 0.00% | −69,242−100.0% | Sold out |
| BCJ Capital Management, LLC | 0 | $0 | 0.00% | −58,413−100.0% | Sold out |
| Jump Financial, LLC | 0 | $0 | 0.00% | −56,780−100.0% | Sold out |
| D. E. Shaw & Co., Inc. | 0 | $0 | 0.00% | −47,361−100.0% | Sold out |
| Tudor Investment Corp Et Al | 0 | $0 | 0.00% | −42,583−100.0% | Sold out |
| Corebridge Financial, Inc. | 0 | $0 | 0.00% | −31,020−100.0% | Sold out |
| Hennion & Walsh Asset Management, Inc. | 0 | $0 | 0.00% | −26,066−100.0% | Sold out |
| Quadrature Capital Ltd | 0 | $0 | 0.00% | −26,061−100.0% | Sold out |
| Jain Global LLC | 0 | $0 | 0.00% | −24,867−100.0% | Sold out |
| Y-Intercept (Hong Kong) Ltd | 0 | $0 | 0.00% | −20,169−100.0% | Sold out |
| Verition Fund Management LLC | 0 | $0 | 0.00% | −19,847−100.0% | Sold out |
| Coppell Advisory Solutions LLC | 0 | $0 | 0.00% | −20,765−100.0% | Sold out |
| Campbell & CO Investment Adviser LLC | 0 | $0 | 0.00% | −19,015−100.0% | Sold out |
| Jennison Associates LLC | 0 | $0 | 0.00% | −18,317−100.0% | Sold out |
| Scientech Research LLC | 0 | $0 | 0.00% | −18,271−100.0% | Sold out |
| Engineers Gate Manager LP | 0 | $0 | 0.00% | −15,327−100.0% | Sold out |
| Springhill Fund Asset Management (HK) Co Ltd | 0 | $0 | 0.00% | −12,859−100.0% | Sold out |
| Gsa Capital Partners LLP | 0 | $0 | 0.00% | −11,963−100.0% | Sold out |