Ionis Pharmaceuticals Inc
IONS- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000874015
In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 4 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.
13F holders, Q1 2025
Institutional positions in Ionis Pharmaceuticals Inc as of Mar 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 344
- −6 vs. Q4 2024
- Shares held
- 166.7M
- +6.69M (+4.2%) vs. Q4 2024
- Total value
- $5.03B
- −$564.9M (−10.1%) vs. Q4 2024
- New holders
- 54
- 102 more added
- Sold out
- 60
- 123 more reduced
6 institutions that held it in Q4 2024 haven't filed for Q1 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2024: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 515 | $14.3B |
| Q1 2026 | 497 | $13.0B |
| Q4 2025 | 494 | $13.5B |
| Q3 2025 | 437 | $11.0B |
| Q2 2025 | 363 | $6.67B |
| Q1 2025 | 344 | $5.03B |
| Q4 2024 | 356 | $5.61B |
| Q3 2024 | 354 | $6.31B |
| Q2 2024 | 357 | $6.83B |
| Q1 2024 | 361 | $6.17B |
| Q4 2023 | 365 | $7.21B |
| Q3 2023 | 312 | $6.35B |
| Q2 2023 | 305 | $5.60B |
| Q1 2023 | 315 | $4.69B |
| Q4 2022 | 339 | $4.93B |
| Q3 2022 | 350 | $5.59B |
| Q2 2022 | 351 | $4.61B |
| Q1 2022 | 333 | $4.63B |
| Q4 2021 | 341 | $3.75B |
| Q3 2021 | 326 | $4.08B |
| Q2 2021 | 338 | $4.96B |
| Q1 2021 | 365 | $5.55B |
Institutions, Q1 2025
Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q4 2024.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Ci Investments Inc. | 2,542 | $77.0K | 0.00% | −1,548−37.8% | Reduced |
| Corebridge Financial, Inc. | 2,657 | $80.2K | 0.00% | −102−3.7% | Reduced |
| Quarry LP | 3,000 | $90.5K | 0.02% | −3,000−50.0% | Reduced |
| US Bancorp | 3,157 | $95.2K | 0.00% | −1,063−25.2% | Reduced |
| Exchange Traded Concepts, LLC | 3,244 | $97.9K | 0.00% | +3,066+1,722.5% | Added |
| Amundi | 3,873 | $110.5K | 0.00% | −7,501−65.9% | Reduced |
| GF Fund Management Co. Ltd. | 4,042 | $121.9K | 0.00% | +727+21.9% | Added |
| Moisand Fitzgerald Tamayo, LLC | 5,000 | $150.8K | 0.02% | +5,000 | New |
| Mirae Asset Global Investments Co., Ltd. | 5,319 | $165.7K | 0.00% | +57+1.1% | Added |
| Russell Investments Group, Ltd. | 5,753 | $173.6K | 0.00% | −56,447−90.8% | Reduced |
| Advisors Asset Management, Inc. | 6,048 | $182.5K | 0.00% | −22−0.4% | Reduced |
| Mitsubishi UFJ Kokusai Asset Management Co., Ltd. | 6,135 | $185.1K | 0.00% | +481+8.5% | Added |
| KBC Group NV | 6,515 | $197.0K | 0.00% | +31+0.5% | Added |
| Tanaka Capital Management Inc | 6,714 | $203.0K | 0.48% | −178−2.6% | Reduced |
| Everence Capital Management Inc | 6,770 | $204.0K | 0.01% | 00.0% | Unchanged |
| Cambridge Investment Research Advisors, Inc. | 6,804 | $205.0K | 0.00% | −961−12.4% | Reduced |
| Silvercrest Asset Management Group LLC | 6,902 | $208.2K | 0.00% | +285+4.3% | Added |
| Prudential Financial Inc | 6,263 | $209.5K | 0.00% | +6,263 | New |
| Clearstead Advisors, LLC | 7,000 | $211.2K | 0.00% | −185−2.6% | Reduced |
| ProShare Advisors LLC | 7,171 | $216.3K | 0.00% | −309−4.1% | Reduced |
| Commerce Bank | 7,275 | $219.5K | 0.00% | −6,309−46.4% | Reduced |
| Semanteon Capital Management, LP | 7,543 | $227.6K | 0.12% | +7,543 | New |
| Fiduciary Trust Co | 7,738 | $233.5K | 0.00% | +7,738 | New |
| Davy Global Fund Management Ltd | 8,059 | $243.1K | 0.03% | +8,059 | New |
| International Assets Investment Management, LLC | 8,207 | $247.6K | 0.02% | 00.0% | Unchanged |
| Maryland State Retirement & Pension System | 8,284 | $249.9K | 0.01% | 00.0% | Unchanged |
| Utah Retirement Systems | 8,400 | $253.4K | 0.00% | 00.0% | Unchanged |
| Mirae Asset Global ETFs Holdings Ltd. | 8,206 | $255.6K | 0.00% | −1,244−13.2% | Reduced |
| Bayesian Capital Management, LP | 8,500 | $256.4K | 0.04% | +8,500 | New |
| Quantinno Capital Management LP | 8,515 | $256.9K | 0.00% | +8,515 | New |
| Jain Global LLC | 8,595 | $259.3K | 0.01% | +8,595 | New |
| Marshall Wace, LLP | 9,102 | $274.6K | 0.00% | −803,204−98.9% | Reduced |
| MetLife Investment Management | 9,144 | $275.9K | 0.00% | −16−0.2% | Reduced |
| Walleye Trading LLC | 9,361 | $282.4K | 0.01% | −559−5.6% | Reduced |
| Sectoral Asset Management Inc | 9,440 | $284.8K | 0.22% | +2,240+31.1% | Added |
| Virtus Investment Advisers, Inc. | 9,701 | $292.7K | 0.08% | +9,701 | New |
| Colony Group, LLC | 9,832 | $296.6K | 0.00% | +1,777+22.1% | Added |
| Tower Research Capital LLC (TRC) | 9,873 | $298.5K | 0.01% | −4,284−30.3% | Reduced |
| Fifth Third Bancorp | 9,989 | $301.4K | 0.00% | +458+4.8% | Added |
| Cypress Capital, LLC | 10,000 | $301.7K | 0.09% | 00.0% | Unchanged |
| Man Group plc | 10,033 | $302.7K | 0.00% | +1,718+20.7% | Added |
| Teza Capital Management LLC | 10,244 | $309.1K | 0.14% | +1,719+20.2% | Added |
| JustInvest LLC | 10,313 | $311.1K | 0.00% | −1,958−16.0% | Reduced |
| Capula Management Ltd | 10,382 | $313.2K | 0.00% | +10,382 | New |
| Principal Financial Group Inc | 10,447 | $315.2K | 0.00% | −3,169−23.3% | Reduced |
| Harbor Advisors LLC | 10,500 | $316.8K | 0.06% | 00.0% | Unchanged |
| Amalgamated Bank | 10,573 | $319.0K | 0.00% | +281+2.7% | Added |
| Annis Gardner Whiting Capital Advisors, LLC | 10,736 | $323.9K | 0.14% | 00.0% | Unchanged |
| Suvretta Capital Management, LLC | 10,800 | $325.8K | 0.01% | 00.0% | Unchanged |
| The PNC Financial Services Group, Inc. | 10,987 | $331.5K | 0.00% | −7−0.1% | Reduced |
| Plancorp, LLC | 11,128 | $335.7K | 0.01% | 00.0% | Unchanged |
| Wiley Bros.-Aintree Capital, LLC | 11,004 | $342.8K | 0.00% | +687+6.7% | Added |
| Twin Tree Management, LP | 11,385 | $343.5K | 0.01% | −77,515−87.2% | Reduced |
| FORA Capital, LLC | 11,570 | $349.1K | 0.04% | +11,570 | New |
| SIH Partners, LLLP | 11,999 | $362.0K | 0.03% | +11,999 | New |
| Brown Advisory Inc | 12,026 | $362.8K | 0.00% | −704−5.5% | Reduced |
| Intech Investment Management LLC | 12,207 | $368.3K | 0.00% | +12,207 | New |
| Northwestern Mutual Wealth Management Co | 12,358 | $372.8K | 0.00% | +1,031+9.1% | Added |
| XTX Topco Ltd | 12,404 | $374.2K | 0.02% | −12,958−51.1% | Reduced |
| Horizon Kinetics Asset Management LLC | 12,476 | $376.4K | 0.00% | 00.0% | Unchanged |
| Point72 Hong Kong Ltd | 12,862 | $388.0K | 0.03% | +12,862 | New |
| Westmount Partners, LLC | 12,961 | $391.0K | 0.12% | −501−3.7% | Reduced |
| Significant Wealth Partners LLC | 13,605 | $410.5K | 0.21% | +2,700+24.8% | Added |
| North Star Asset Management Inc | 13,610 | $410.6K | 0.02% | −30−0.2% | Reduced |
| Jones Financial Companies LLLP | 13,735 | $427.8K | 0.00% | +4,397+47.1% | Added |
| Envestnet Asset Management Inc | 15,039 | $453.7K | 0.00% | −37,649−71.5% | Reduced |
| Public Employees Retirement Association of Colorado | 15,589 | $470.0K | 0.00% | 00.0% | Unchanged |
| Twinbeech Capital LP | 15,938 | $480.8K | 0.01% | +15,938 | New |
| Commonwealth Equity Services, LLC | 16,398 | $495.0K | 0.00% | −5,428−24.9% | Reduced |
| E Fund Management Co., Ltd. | 16,471 | $496.9K | 0.02% | −397−2.4% | Reduced |
| Virginia Retirement Systems Et Al | 16,522 | $498.5K | 0.00% | +16,522 | New |
| NBT Bank N A | 17,050 | $514.4K | 0.04% | 00.0% | Unchanged |
| Victory Capital Management Inc | 18,641 | $562.4K | 0.00% | +637+3.5% | Added |
| SG Americas Securities, LLC | 20,050 | $605.0K | 0.00% | −3,877−16.2% | Reduced |
| Xponance, Inc. | 20,319 | $613.0K | 0.01% | +980+5.1% | Added |
| Bridgefront Capital, LLC | 20,528 | $619.3K | 0.18% | −1,274−5.8% | Reduced |
| Nicollet Investment Management, Inc. | 21,451 | $647.0K | 0.23% | +1,665+8.4% | Added |
| Toroso Investments, LLC | 21,833 | $658.7K | 0.01% | +4,426+25.4% | Added |
| Daiwa Securities Group Inc. | 22,141 | $667.0K | 0.00% | +21,600+3,992.6% | Added |
| Bleakley Financial Group, LLC | 22,284 | $672.3K | 0.02% | +5,342+31.5% | Added |
| Jefferies Financial Group Inc. | 22,841 | $689.1K | 0.01% | +460+2.1% | Added |
| Brevan Howard Capital Management LP | 22,973 | $693.1K | 0.02% | +1,607+7.5% | Added |
| Castle Hook Partners LP | 23,940 | $722.3K | 0.02% | 00.0% | Unchanged |
| LPL Financial LLC | 23,966 | $723.1K | 0.00% | −16,410−40.6% | Reduced |
| Teachers Retirement System of the State of Kentucky | 24,083 | $727.0K | 0.01% | 00.0% | Unchanged |
| BlueCrest Capital Management Ltd | 24,800 | $748.2K | 0.12% | −1,400−5.3% | Reduced |
| NEOS Investment Management LLC | 25,141 | $758.5K | 0.01% | −31,703−55.8% | Reduced |
| Tema ETFs LLC | 25,141 | $758.5K | 0.23% | −31,703−55.8% | Reduced |
| HRT Financial LP | 25,824 | $779.0K | 0.00% | +25,824 | New |
| ExodusPoint Capital Management, LP | 26,261 | $792.0K | 0.01% | +26,261 | New |
| KLP Kapitalforvaltning AS | 27,400 | $826.7K | 0.00% | −1,800−6.2% | Reduced |
| Alpine Global Management, LLC | 28,097 | $847.7K | 0.22% | +28,097 | New |
| Axq Capital, LP | 30,104 | $908.2K | 0.36% | +30,104 | New |
| Liontrust Investment Partners LLP | 30,390 | $916.9K | 0.01% | −11,231−27.0% | Reduced |
| China Universal Asset Management Co., Ltd. | 31,886 | $962.0K | 0.09% | −1,594−4.8% | Reduced |
| Mariner, LLC | 33,483 | $1.01M | 0.00% | +5,822+21.0% | Added |
| Pathstone Holdings, LLC | 34,372 | $1.03M | 0.00% | +8,314+31.9% | Added |
| Private Advisor Group, LLC | 34,531 | $1.04M | 0.01% | −6,142−15.1% | Reduced |
| Profund Advisors LLC | 34,887 | $1.05M | 0.05% | −8,672−19.9% | Reduced |
| Allostery Investments LP | 35,000 | $1.06M | 1.52% | −30,000−46.2% | Reduced |