Ionis Pharmaceuticals Inc
IONS- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000874015
In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 4 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.
13F holders, Q4 2024
Institutional positions in Ionis Pharmaceuticals Inc as of Dec 31, 2024. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 356
- +9 vs. Q3 2024
- Shares held
- 160.5M
- +3.10M (+2.0%) vs. Q3 2024
- Total value
- $5.61B
- −$692.3M (−11.0%) vs. Q3 2024
- New holders
- 58
- 119 more added
- Sold out
- 49
- 121 more reduced
7 institutions that held it in Q3 2024 haven't filed for Q4 2024 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2024: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 515 | $14.3B |
| Q1 2026 | 497 | $13.0B |
| Q4 2025 | 494 | $13.5B |
| Q3 2025 | 437 | $11.0B |
| Q2 2025 | 363 | $6.67B |
| Q1 2025 | 344 | $5.03B |
| Q4 2024 | 356 | $5.61B |
| Q3 2024 | 354 | $6.31B |
| Q2 2024 | 357 | $6.83B |
| Q1 2024 | 361 | $6.17B |
| Q4 2023 | 365 | $7.21B |
| Q3 2023 | 312 | $6.35B |
| Q2 2023 | 305 | $5.60B |
| Q1 2023 | 315 | $4.69B |
| Q4 2022 | 339 | $4.93B |
| Q3 2022 | 350 | $5.59B |
| Q2 2022 | 351 | $4.61B |
| Q1 2022 | 333 | $4.63B |
| Q4 2021 | 341 | $3.75B |
| Q3 2021 | 326 | $4.08B |
| Q2 2021 | 338 | $4.96B |
| Q1 2021 | 365 | $5.55B |
Institutions, Q4 2024
Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q3 2024.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| PDT Partners, LLC | 28,994 | $1.01M | 0.09% | +15,594+116.4% | Added |
| KLP Kapitalforvaltning AS | 29,200 | $1.02M | 0.00% | +29,200 | New |
| China Universal Asset Management Co., Ltd. | 33,480 | $1.17M | 0.11% | +5,359+19.1% | Added |
| Guggenheim Capital LLC | 35,373 | $1.24M | 0.01% | −1,786−4.8% | Reduced |
| Grandfield & Dodd, LLC | 35,887 | $1.25M | 0.08% | +1,074+3.1% | Added |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 36,322 | $1.27M | 0.00% | +5,400+17.5% | Added |
| Capital Counsel LLC | 37,080 | $1.30M | 0.06% | 00.0% | Unchanged |
| Great West Life Assurance Co | 39,214 | $1.37M | 0.00% | −621−1.6% | Reduced |
| Jump Financial, LLC | 39,737 | $1.39M | 0.03% | +39,737 | New |
| Blair William & Co | 39,882 | $1.39M | 0.00% | −6,769−14.5% | Reduced |
| LPL Financial LLC | 40,376 | $1.41M | 0.00% | −2,244−5.3% | Reduced |
| Private Advisor Group, LLC | 40,673 | $1.42M | 0.01% | −3,114−7.1% | Reduced |
| Arizona State Retirement System | 41,147 | $1.44M | 0.01% | +3,320+8.8% | Added |
| Liontrust Investment Partners LLP | 41,621 | $1.46M | 0.02% | −18,023−30.2% | Reduced |
| NJ State Employees Deferred Compensation Plan | 42,000 | $1.47M | 0.18% | 00.0% | Unchanged |
| Profund Advisors LLC | 43,559 | $1.52M | 0.06% | +5,963+15.9% | Added |
| Handelsbanken Fonder AB | 43,811 | $1.53M | 0.01% | +800+1.9% | Added |
| Qsemble Capital Management, LP | 46,573 | $1.63M | 0.22% | +46,573 | New |
| Creative Planning | 46,803 | $1.64M | 0.00% | +18,421+64.9% | Added |
| Fieldview Capital Management, LLC | 51,282 | $1.79M | 0.28% | +51,282 | New |
| Alliancebernstein L.P. | 52,136 | $1.82M | 0.00% | −260.0% | Reduced |
| Envestnet Asset Management Inc | 52,688 | $1.84M | 0.00% | −6,126−10.4% | Reduced |
| Erste Asset Management GmbH | 51,300 | $1.84M | 0.02% | 00.0% | Unchanged |
| Ensign Peak Advisors, Inc | 53,320 | $1.86M | 0.00% | −16,560−23.7% | Reduced |
| Public Employees Retirement System of Ohio | 53,748 | $1.88M | 0.01% | −3,077−5.4% | Reduced |
| Police & Firemen's Retirement System of New Jersey | 56,695 | $1.98M | 0.02% | +56,695 | New |
| NEOS Investment Management LLC | 56,844 | $1.99M | 0.05% | −2,400−4.1% | Reduced |
| Tema ETFs LLC | 56,844 | $1.99M | 0.83% | +56,844 | New |
| Skandinaviska Enskilda Banken AB (publ) | 59,626 | $2.08M | 0.01% | 00.0% | Unchanged |
| UBS Oconnor LLC | 60,580 | $2.12M | 0.05% | +23,623+63.9% | Added |
| Exome Asset Management LLC | 61,367 | $2.15M | 1.61% | +61,367 | New |
| Van Eck Associates Corp | 61,619 | $2.15M | 0.00% | +2,613+4.4% | Added |
| Russell Investments Group, Ltd. | 62,200 | $2.17M | 0.00% | −66,269−51.6% | Reduced |
| Davenport & Co LLC | 62,740 | $2.19M | 0.01% | −12,858−17.0% | Reduced |
| State of New Jersey Common Pension Fund D | 63,206 | $2.21M | 0.01% | +11,431+22.1% | Added |
| Sphera Funds Management Ltd. | 63,821 | $2.23M | 0.41% | 00.0% | Unchanged |
| Janus Henderson Group PLC | 63,877 | $2.23M | 0.00% | +4,900+8.3% | Added |
| Allostery Investments LP | 65,000 | $2.27M | 4.46% | +65,000 | New |
| Teacher Retirement System of Texas | 65,792 | $2.30M | 0.01% | +9,093+16.0% | Added |
| Treasurer of the State of North Carolina | 68,803 | $2.40M | 0.01% | +440+0.6% | Added |
| SEI Investments Co | 70,091 | $2.45M | 0.00% | −119,746−63.1% | Reduced |
| Granite Investment Partners, LLC | 73,866 | $2.58M | 0.11% | −11,927−13.9% | Reduced |
| DCF Advisers, LLC | 82,882 | $2.90M | 1.46% | +43,382+109.8% | Added |
| HSBC Holdings PLC | 83,055 | $2.93M | 0.00% | +83,055 | New |
| New York State Common Retirement Fund | 84,261 | $2.95M | 0.00% | −114,498−57.6% | Reduced |
| Trexquant Investment LP | 84,913 | $2.97M | 0.03% | −45,945−35.1% | Reduced |
| Twin Tree Management, LP | 88,900 | $3.11M | 0.08% | +76,472+615.3% | Added |
| Deutsche Bank AG | 91,901 | $3.21M | 0.00% | +17,027+22.7% | Added |
| Voya Investment Management LLC | 92,531 | $3.23M | 0.00% | −3,290−3.4% | Reduced |
| Dimensional Fund Advisors LP | 94,157 | $3.29M | 0.00% | −175−0.2% | Reduced |
| DekaBank Deutsche Girozentrale | 93,807 | $3.32M | 0.01% | 00.0% | Unchanged |
| Neuberger Berman Group LLC | 96,631 | $3.38M | 0.00% | +31,757+49.0% | Added |
| Ghisallo Capital Management LLC | 100,000 | $3.50M | 0.20% | −300,000−75.0% | Reduced |
| Schroder Investment Management Group | 100,659 | $3.52M | 0.00% | +44,437+79.0% | Added |
| State of Wisconsin Investment Board | 101,231 | $3.54M | 0.01% | +15,065+17.5% | Added |
| Raymond James Financial Inc | 105,619 | $3.69M | 0.00% | +105,619 | New |
| Woodline Partners LP | 107,610 | $3.76M | 0.03% | +107,610 | New |
| Swedbank AB | 124,237 | $4.34M | 0.01% | −5,136−4.0% | Reduced |
| Nicola Wealth Management Ltd. | 87,000 | $4.37M | 0.41% | 00.0% | Unchanged |
| Connor, Clark & Lunn Investment Management Ltd. | 125,389 | $4.38M | 0.02% | +107,648+606.8% | Added |
| California State Teachers Retirement System | 133,902 | $4.68M | 0.01% | +7,722+6.1% | Added |
| Assenagon Asset Management S.A. | 141,917 | $4.96M | 0.01% | +128,619+967.2% | Added |
| Sonora Investment Management Group, LLC | 148,776 | $5.20M | 0.40% | −4,399−2.9% | Reduced |
| Alyeska Investment Group, L.P. | 150,000 | $5.24M | 0.02% | −18,951−11.2% | Reduced |
| Tang Capital Management LLC | 150,000 | $5.24M | 0.35% | 00.0% | Unchanged |
| BLB&B Advisors, LLC | 152,050 | $5.32M | 0.27% | −200−0.1% | Reduced |
| State Board of Administration of Florida Retirement System | 152,315 | $5.32M | 0.01% | +1,260+0.8% | Added |
| Nikko Asset Management Americas, Inc. | 156,657 | $5.47M | 0.06% | −39,457−20.1% | Reduced |
| Sumitomo Mitsui Trust Holdings, Inc. | 156,657 | $5.48M | 0.00% | −39,457−20.1% | Reduced |
| Sovran Advisors, LLC | 171,812 | $5.62M | 0.80% | +171,812 | New |
| Jane Street Group, LLC | 164,634 | $5.76M | 0.01% | −11,926−6.8% | Reduced |
| Squarepoint Ops LLC | 166,468 | $5.82M | 0.01% | +39,127+30.7% | Added |
| Legal & General Group Plc | 168,080 | $5.88M | 0.00% | +10,793+6.9% | Added |
| Citigroup Inc | 169,155 | $5.91M | 0.01% | +98,860+140.6% | Added |
| Driehaus Capital Management LLC | 180,002 | $6.29M | 0.05% | −49,967−21.7% | Reduced |
| Sicart Associates LLC | 185,821 | $6.50M | 2.32% | −5,702−3.0% | Reduced |
| GW&K Investment Management, LLC | 187,220 | $6.54M | 0.06% | +187,220 | New |
| Rhumbline Advisers | 191,893 | $6.71M | 0.01% | −5,049−2.6% | Reduced |
| California Public Employees Retirement System | 192,130 | $6.72M | 0.00% | −19,626−9.3% | Reduced |
| Verition Fund Management LLC | 200,184 | $7.00M | 0.04% | +200,184 | New |
| Renaissance Technologies LLC | 205,514 | $7.18M | 0.01% | +15,000+7.9% | Added |
| Stifel Financial Corp | 211,493 | $7.39M | 0.01% | +28,988+15.9% | Added |
| Rhenman & Partners Asset Management AB | 212,500 | $7.43M | 0.76% | +17,500+9.0% | Added |
| Susquehanna Fundamental Investments, LLC | 213,015 | $7.45M | 0.12% | +213,015 | New |
| Eversept Partners, LP | 214,952 | $7.51M | 0.78% | −256,403−54.4% | Reduced |
| Orion Investment Co | 216,000 | $7.55M | 3.03% | −2,525−1.2% | Reduced |
| Kennedy Capital Management, Inc. | 223,278 | $7.81M | 0.17% | +61,202+37.8% | Added |
| Aquatic Capital Management LLC | 230,016 | $8.04M | 0.22% | +230,016 | New |
| Sector Gamma AS | 235,842 | $8.25M | 2.83% | +25,000+11.9% | Added |
| Rafferty Asset Management, LLC | 237,337 | $8.30M | 0.03% | +38,578+19.4% | Added |
| CI Private Wealth, LLC | 239,163 | $8.36M | 0.01% | +2,087+0.9% | Added |
| Siren, L.L.C. | 250,000 | $8.74M | 0.39% | 00.0% | Unchanged |
| Artisan Partners Limited Partnership | 252,635 | $8.83M | 0.01% | −1,987,820−88.7% | Reduced |
| BNP Paribas Arbitrage, SA | 254,521 | $8.90M | 0.01% | +79,193+45.2% | Added |
| Privium Fund Management B.V. | 266,794 | $9.33M | 2.11% | +16,050+6.4% | Added |
| Adage Capital Partners GP, L.L.C. | 275,000 | $9.61M | 0.02% | −225,000−45.0% | Reduced |
| Swiss National Bank | 279,200 | $9.76M | 0.01% | +22,600+8.8% | Added |
| Jacobs Levy Equity Management, Inc | 281,813 | $9.85M | 0.03% | −368,966−56.7% | Reduced |
| Manufacturers Life Insurance Company, The | 286,279 | $10.0M | 0.01% | −22,668−7.3% | Reduced |
| Nuveen Asset Management, LLC | 290,954 | $10.2M | 0.00% | −13,825−4.5% | Reduced |