Ionis Pharmaceuticals Inc
IONS- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000874015
In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 4 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.
13F holders, Q2 2026
Institutional positions in Ionis Pharmaceuticals Inc as of Jun 30, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 515
- +21 vs. Q1 2026
- Shares held
- 179.7M
- +7.19M (+4.2%) vs. Q1 2026
- Total value
- $14.3B
- +$1.30B (+10.0%) vs. Q1 2026
- New holders
- 67
- 199 more added
- Sold out
- 46
- 162 more reduced
3 institutions that held it in Q1 2026 haven't filed for Q2 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q1 2026: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 515 | $14.3B |
| Q1 2026 | 497 | $13.0B |
| Q4 2025 | 494 | $13.5B |
| Q3 2025 | 437 | $11.0B |
| Q2 2025 | 363 | $6.67B |
| Q1 2025 | 344 | $5.03B |
| Q4 2024 | 356 | $5.61B |
| Q3 2024 | 354 | $6.31B |
| Q2 2024 | 357 | $6.83B |
| Q1 2024 | 361 | $6.17B |
| Q4 2023 | 365 | $7.21B |
| Q3 2023 | 312 | $6.35B |
| Q2 2023 | 305 | $5.60B |
| Q1 2023 | 315 | $4.69B |
| Q4 2022 | 339 | $4.93B |
| Q3 2022 | 350 | $5.59B |
| Q2 2022 | 351 | $4.61B |
| Q1 2022 | 333 | $4.63B |
| Q4 2021 | 341 | $3.75B |
| Q3 2021 | 326 | $4.08B |
| Q2 2021 | 338 | $4.96B |
| Q1 2021 | 365 | $5.55B |
Institutions, Q2 2026
Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q1 2026.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| MCF Advisors LLC | 6,136 | $486.5K | 0.02% | +6,086+12,172.0% | Added |
| Cypress Capital, LLC | 6,000 | $475.7K | 0.13% | 00.0% | Unchanged |
| Cerity Partners LLC | 5,989 | $474.9K | 0.00% | −1,607−21.2% | Reduced |
| Frank, Rimerman Advisors LLC | 5,807 | $460.4K | 0.03% | +26+0.4% | Added |
| Regions Financial Corp | 5,604 | $444.3K | 0.00% | −518−8.5% | Reduced |
| Robeco Institutional Asset Management B.V. | 5,578 | $442.3K | 0.00% | −82−1.4% | Reduced |
| E Fund Management Co., Ltd. | 5,569 | $441.6K | 0.01% | −41,119−88.1% | Reduced |
| Tema ETFs LLC | 5,525 | $438.1K | 0.01% | −148−2.6% | Reduced |
| ProShare Advisors LLC | 5,417 | $429.5K | 0.00% | −1,973−26.7% | Reduced |
| VARCOV Co. | 5,390 | $427.4K | 0.16% | +5,390 | New |
| Coldstream Capital Management Inc | 5,352 | $424.4K | 0.01% | −301−5.3% | Reduced |
| Resources Investment Advisors, LLC. | 5,345 | $423.8K | 0.00% | −45−0.8% | Reduced |
| R Squared Ltd | 5,313 | $421.3K | 0.22% | +954+21.9% | Added |
| Captrust Financial Advisors | 5,030 | $398.8K | 0.00% | +30+0.6% | Added |
| Granite Investment Partners, LLC | 5,026 | $398.5K | 0.02% | −319−6.0% | Reduced |
| CIBC Asset Management Inc | 5,017 | $397.8K | 0.00% | 00.0% | Unchanged |
| Moisand Fitzgerald Tamayo, LLC | 5,000 | $396.4K | 0.04% | 00.0% | Unchanged |
| AlphaCore Capital LLC | 4,986 | $395.3K | 0.01% | +2,224+80.5% | Added |
| Vontobel Holding Ltd. | 4,957 | $393.0K | 0.00% | −283−5.4% | Reduced |
| Wedmont Private Capital | 6,723 | $391.6K | 0.01% | +159+2.4% | Added |
| GWM Advisors LLC | 4,822 | $382.3K | 0.00% | +36+0.8% | Added |
| Quantbot Technologies LP | 4,812 | $381.5K | 0.02% | +4,812 | New |
| Azzad Asset Management Inc | 4,784 | $379.3K | 0.03% | +4,784 | New |
| North Dakota State Investment Board | 4,703 | $372.9K | 0.02% | +80+1.7% | Added |
| Atria Investments LLC | 4,690 | $371.9K | 0.00% | −537−10.3% | Reduced |
| Gateway Investment Advisers LLC | 4,630 | $367.1K | 0.00% | +4,630 | New |
| Mirae Asset Global ETFs Holdings Ltd. | 4,373 | $352.9K | 0.00% | +100+2.3% | Added |
| Blueshift Asset Management, LLC | 4,433 | $351.5K | 0.08% | +1,656+59.6% | Added |
| Credit Agricole S A | 4,410 | $349.7K | 0.00% | 00.0% | Unchanged |
| Yorktown Management & Research Co Inc | 4,400 | $348.9K | 0.21% | +4,400 | New |
| Kestra Advisory Services, LLC | 4,384 | $347.6K | 0.00% | +12+0.3% | Added |
| Intrust Bank NA | 4,339 | $344.0K | 0.03% | +283+7.0% | Added |
| Checchi Capital Advisers, LLC | 4,308 | $341.6K | 0.02% | −121−2.7% | Reduced |
| Westfield Capital Management Co LP | 4,233 | $335.6K | 0.00% | +731+20.9% | Added |
| Prospera Financial Services Inc | 4,194 | $332.5K | 0.00% | −147−3.4% | Reduced |
| HighTower Advisors, LLC | 4,084 | $323.8K | 0.00% | +287+7.6% | Added |
| Wealth Enhancement Advisory Services, LLC | 5,394 | $314.2K | 0.00% | +1,269+30.8% | Added |
| Prime Capital Investment Advisors, LLC | 3,938 | $312.2K | 0.00% | −33−0.8% | Reduced |
| Sanctuary Advisors, LLC | 3,938 | $312.2K | 0.00% | +20+0.5% | Added |
| Susquehanna Portfolio Strategies, LLC | 3,935 | $312.0K | 0.00% | −92,025−95.9% | Reduced |
| Qsemble Capital Management, LP | 3,887 | $308.2K | 0.04% | −21,871−84.9% | Reduced |
| Susquehanna International Group, LLP | 3,839 | $304.4K | 0.00% | −8,520−68.9% | Reduced |
| Rockefeller Capital Management L.P. | 3,832 | $303.8K | 0.00% | −323−7.8% | Reduced |
| Pinnacle Wealth Planning Services, Inc. | 3,780 | $299.7K | 0.03% | −433−10.3% | Reduced |
| Bridgefront Capital, LLC | 3,778 | $299.6K | 0.08% | +3,778 | New |
| Anb Bank | 3,733 | $296.0K | 0.11% | −36−1.0% | Reduced |
| Eurizon Capital SGR S.p.A. | 3,639 | $293.9K | 0.00% | +125+3.6% | Added |
| Park Avenue Securities LLC | 3,677 | $292.0K | 0.00% | +3,677 | New |
| Berkshire Asset Management LLC | 3,630 | $287.8K | 0.01% | −7−0.2% | Reduced |
| Crossmark Global Holdings, Inc. | 3,615 | $286.6K | 0.00% | +416+13.0% | Added |
| MML Investors Services, LLC | 3,600 | $285.4K | 0.00% | +427+13.5% | Added |
| Sequoia Financial Advisors, LLC | 3,567 | $282.8K | 0.00% | +3,567 | New |
| Everhart Financial Group, Inc. | 3,503 | $277.8K | 0.02% | +33+1.0% | Added |
| GF Fund Management Co. Ltd. | 3,497 | $277.3K | 0.00% | −140−3.8% | Reduced |
| Perigon Wealth Management, LLC | 3,477 | $275.7K | 0.00% | +47+1.4% | Added |
| New York Life Investment Management LLC | 3,458 | $274.2K | 0.00% | +770+28.6% | Added |
| Victrix Investment Advisors | 3,400 | $269.6K | 0.11% | +3,400 | New |
| Mitchell & Pahl Private Wealth, LLC | 3,261 | $258.6K | 0.09% | 00.0% | Unchanged |
| Nwam LLC | 3,238 | $256.7K | 0.01% | 00.0% | Unchanged |
| Raab & Moskowitz Asset Management LLC | 3,115 | $247.0K | 0.05% | 00.0% | Unchanged |
| QRG Capital Management, Inc. | 3,079 | $244.1K | 0.00% | −15−0.5% | Reduced |
| M&G Plc | 3,090 | $244.1K | 0.00% | −11,333−78.6% | Reduced |
| Venturi Wealth Management, LLC | 3,061 | $242.7K | 0.01% | 00.0% | Unchanged |
| HB Wealth Management, LLC | 3,025 | $239.9K | 0.00% | +99+3.4% | Added |
| Argent Trust Co | 3,018 | $239.3K | 0.01% | 00.0% | Unchanged |
| Larson Financial Group LLC | 3,000 | $237.9K | 0.01% | −31−1.0% | Reduced |
| National Asset Management, Inc. | 2,897 | $233.8K | 0.01% | −48−1.6% | Reduced |
| AlphaGrep UK Ltd | 2,946 | $233.6K | 0.07% | +2,946 | New |
| Integrated Wealth Concepts LLC | 2,926 | $232.0K | 0.00% | +202+7.4% | Added |
| University of Texas/Texas Am Investment Managment Co | 2,923 | $231.8K | 0.03% | +2,923 | New |
| Cambria Investment Management, L.P. | 2,885 | $228.8K | 0.01% | 00.0% | Unchanged |
| Voleon Capital Management LP | 2,862 | $226.9K | 0.00% | −20,185−87.6% | Reduced |
| Montis Financial, LLC | 2,700 | $214.1K | 0.04% | 00.0% | Unchanged |
| Norden Group LLC | 2,685 | $212.9K | 0.02% | −204−7.1% | Reduced |
| IFG Advisory, LLC | 2,678 | $212.3K | 0.01% | +2,678 | New |
| Kerntke Otto McGlone Wealth Management Group | 2,654 | $210.4K | 0.13% | +2,654 | New |
| Mitsubishi UFJ Kokusai Asset Management Co., Ltd. | 2,618 | $207.6K | 0.00% | −75−2.8% | Reduced |
| Mesirow Financial Investment Management, Inc. | 2,530 | $200.6K | 0.00% | −2,930−53.7% | Reduced |
| Steward Partners Investment Advisory, LLC | 2,355 | $186.7K | 0.00% | −1,284−35.3% | Reduced |
| Global Retirement Partners, LLC | 2,282 | $180.9K | 0.00% | +2,282 | New |
| Ancora Advisors, LLC | 2,215 | $175.6K | 0.00% | −176−7.4% | Reduced |
| GAMMA Investing LLC | 2,168 | $171.9K | 0.01% | +402+22.8% | Added |
| State of Wyoming | 2,024 | $160.5K | 0.02% | +2,024 | New |
| Signaturefd, LLC | 1,880 | $149.1K | 0.00% | −198−9.5% | Reduced |
| Caption Management, LLC | 1,759 | $139.5K | 0.00% | −13,832−88.7% | Reduced |
| Parallel Advisors, LLC | 1,684 | $133.5K | 0.00% | −199−10.6% | Reduced |
| Versant Capital Management, Inc | 1,460 | $115.8K | 0.01% | −95−6.1% | Reduced |
| Smartleaf Asset Management LLC | 1,416 | $114.3K | 0.00% | 00.0% | Unchanged |
| Harbor Investment Advisory, LLC | 1,407 | $111.6K | 0.01% | +1,407 | New |
| Sterling Capital Management LLC | 1,289 | $102.2K | 0.00% | −136−9.5% | Reduced |
| Graticule Asia Macro Advisors LLC | 1,264 | $100.2K | 0.01% | +1,264 | New |
| International Assets Investment Management, LLC | 1,232 | $97.6K | 0.01% | +11+0.9% | Added |
| Farther Finance Advisors, LLC | 1,111 | $88.2K | 0.00% | −772−41.0% | Reduced |
| IMA Wealth, Inc. | 1,037 | $82.2K | 0.01% | +1,009+3,603.6% | Added |
| SRS Capital Advisors, Inc. | 1,004 | $79.6K | 0.00% | +1,004 | New |
| IFP Advisors, Inc | 952 | $75.5K | 0.00% | +2+0.2% | Added |
| AdvisorNet Financial, Inc | 904 | $71.7K | 0.00% | +331+57.8% | Added |
| Tripletail Wealth Management, LLC | 850 | $69.5K | 0.08% | +850 | New |
| EverSource Wealth Advisors, LLC | 858 | $68.0K | 0.00% | −936−52.2% | Reduced |
| Huntington National Bank | 734 | $58.2K | 0.00% | +53+7.8% | Added |