Ionis Pharmaceuticals Inc
IONS- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000874015
In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 4 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.
13F holders, Q2 2026
Institutional positions in Ionis Pharmaceuticals Inc as of Jun 30, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 515
- +21 vs. Q1 2026
- Shares held
- 179.7M
- +7.19M (+4.2%) vs. Q1 2026
- Total value
- $14.3B
- +$1.30B (+10.0%) vs. Q1 2026
- New holders
- 67
- 199 more added
- Sold out
- 46
- 162 more reduced
3 institutions that held it in Q1 2026 haven't filed for Q2 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q1 2026: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 515 | $14.3B |
| Q1 2026 | 497 | $13.0B |
| Q4 2025 | 494 | $13.5B |
| Q3 2025 | 437 | $11.0B |
| Q2 2025 | 363 | $6.67B |
| Q1 2025 | 344 | $5.03B |
| Q4 2024 | 356 | $5.61B |
| Q3 2024 | 354 | $6.31B |
| Q2 2024 | 357 | $6.83B |
| Q1 2024 | 361 | $6.17B |
| Q4 2023 | 365 | $7.21B |
| Q3 2023 | 312 | $6.35B |
| Q2 2023 | 305 | $5.60B |
| Q1 2023 | 315 | $4.69B |
| Q4 2022 | 339 | $4.93B |
| Q3 2022 | 350 | $5.59B |
| Q2 2022 | 351 | $4.61B |
| Q1 2022 | 333 | $4.63B |
| Q4 2021 | 341 | $3.75B |
| Q3 2021 | 326 | $4.08B |
| Q2 2021 | 338 | $4.96B |
| Q1 2021 | 365 | $5.55B |
Institutions, Q2 2026
Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q1 2026.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Great West Life Assurance Co | 24,515 | $1.94M | 0.00% | +2,380+10.8% | Added |
| Brinker Capital Investments, LLC | 24,870 | $1.97M | 0.02% | −36,474−59.5% | Reduced |
| BI Asset Management Fondsmaeglerselskab A/S | 25,727 | $2.04M | 0.02% | +25,727 | New |
| Bank of Montreal | 25,782 | $2.04M | 0.00% | −803−3.0% | Reduced |
| Jupiter Asset Management Ltd | 25,949 | $2.06M | 0.01% | +25,949 | New |
| Intech Investment Management LLC | 26,041 | $2.06M | 0.02% | −12,474−32.4% | Reduced |
| Xponance, Inc. | 26,687 | $2.12M | 0.01% | +303+1.1% | Added |
| LPL Financial LLC | 27,868 | $2.21M | 0.00% | −4,064−12.7% | Reduced |
| BLB&B Advisors, LLC | 28,570 | $2.27M | 0.08% | −6,600−18.8% | Reduced |
| Kornitzer Capital Management Inc | 29,105 | $2.31M | 0.05% | 00.0% | Unchanged |
| Calamos Advisors LLC | 29,358 | $2.33M | 0.01% | +9,577+48.4% | Added |
| PEAK6 LLC | 29,460 | $2.34M | 0.06% | −4,959−14.4% | Reduced |
| LMR Partners LLP | 30,800 | $2.44M | 0.02% | +15,800+105.3% | Added |
| Mutual of America Capital Management LLC | 31,299 | $2.48M | 0.02% | +3,173+11.3% | Added |
| Trexquant Investment LP | 31,538 | $2.50M | 0.02% | −182,107−85.2% | Reduced |
| Blair William & Co | 31,606 | $2.51M | 0.01% | −2,251−6.6% | Reduced |
| Ethic Inc. | 31,679 | $2.51M | 0.03% | +31,679 | New |
| Jain Global LLC | 32,931 | $2.61M | 0.03% | +6,646+25.3% | Added |
| Canada Pension Plan Investment Board | 33,300 | $2.64M | 0.00% | +19,200+136.2% | Added |
| Pathstone Holdings, LLC | 34,004 | $2.70M | 0.01% | +1,169+3.6% | Added |
| Prudential Financial Inc | 35,338 | $2.80M | 0.00% | +70+0.2% | Added |
| Raiffeisen Bank International AG | 35,000 | $2.82M | 0.03% | −1,000−2.8% | Reduced |
| ExodusPoint Capital Management, LP | 35,645 | $2.83M | 0.03% | −191,439−84.3% | Reduced |
| DeepCurrents Investment Group LLC | 36,212 | $2.87M | 0.10% | +8,790+32.1% | Added |
| Entropy Technologies, LP | 36,815 | $2.92M | 0.12% | +9,608+35.3% | Added |
| KLP Kapitalforvaltning AS | 37,000 | $2.93M | 0.01% | +3,100+9.1% | Added |
| Grandfield & Dodd, LLC | 37,077 | $2.94M | 0.15% | −249−0.7% | Reduced |
| DCF Advisers, LLC | 37,500 | $2.97M | 0.78% | −18,500−33.0% | Reduced |
| Rafferty Asset Management, LLC | 37,648 | $2.99M | 0.01% | −22,660−37.6% | Reduced |
| STRS Ohio | 38,166 | $3.03M | 0.01% | +9,384+32.6% | Added |
| Vanguard Investments Australia, Ltd. | 38,557 | $3.06M | 0.01% | 00.0% | Unchanged |
| Exchange Traded Concepts, LLC | 38,627 | $3.06M | 0.02% | +4,686+13.8% | Added |
| Jefferies Financial Group Inc. | 38,665 | $3.07M | 0.03% | −20,400−34.5% | Reduced |
| J. Goldman & Co LP | 40,366 | $3.20M | 0.11% | −194,894−82.8% | Reduced |
| Assenagon Asset Management S.A. | 40,927 | $3.25M | 0.00% | +7,254+21.5% | Added |
| Guggenheim Capital LLC | 41,405 | $3.28M | 0.02% | −2,645−6.0% | Reduced |
| Aquatic Capital Management LLC | 42,581 | $3.38M | 0.12% | −104,798−71.1% | Reduced |
| Arizona State Retirement System | 43,302 | $3.43M | 0.02% | +1,036+2.5% | Added |
| Natixis Advisors, L.P. | 44,728 | $3.55M | 0.00% | +21,007+88.6% | Added |
| Public Employees Retirement System of Ohio | 46,862 | $3.72M | 0.01% | +832+1.8% | Added |
| Nikko Asset Management Americas, Inc. | 47,656 | $3.78M | 0.05% | −34,040−41.7% | Reduced |
| Sumitomo Mitsui Trust Holdings, Inc. | 47,836 | $3.79M | 0.00% | −34,040−41.6% | Reduced |
| Jones Financial Companies LLLP | 47,442 | $3.85M | 0.00% | +20,719+77.5% | Added |
| Worldquant Millennium Advisors LLC | 48,976 | $3.88M | 0.01% | +21,052+75.4% | Added |
| Toroso Investments, LLC | 49,178 | $3.90M | 0.01% | +14,746+42.8% | Added |
| Capital Counsel LLC | 49,580 | $3.93M | 0.15% | 00.0% | Unchanged |
| Campbell & CO Investment Adviser LLC | 49,632 | $3.94M | 0.21% | +46,531+1,500.5% | Added |
| Creative Planning | 50,554 | $4.01M | 0.00% | −1,674−3.2% | Reduced |
| State of New Jersey Common Pension Fund D | 50,743 | $4.02M | 0.01% | −1,845−3.5% | Reduced |
| KBC Group NV | 51,127 | $4.05M | 0.01% | +20,914+69.2% | Added |
| Nicola Wealth Management Ltd. | 52,000 | $4.12M | 0.47% | 00.0% | Unchanged |
| Fideuram - Intesa Sanpaolo Private Banking S.P.A. | 53,795 | $4.27M | 0.13% | −474−0.9% | Reduced |
| One Capital Management, LLC | 58,939 | $4.43M | 0.12% | 00.0% | Unchanged |
| Edgestream Partners, L.P. | 56,715 | $4.50M | 0.13% | −11,654−17.0% | Reduced |
| Sovran Advisors, LLC | 84,984 | $4.70M | 0.35% | +84,984 | New |
| Rhenman & Partners Asset Management AB | 59,900 | $4.75M | 0.45% | −33,000−35.5% | Reduced |
| Schroder Investment Management Group | 58,865 | $4.75M | 0.00% | +58,865 | New |
| XTX Topco Ltd | 60,776 | $4.82M | 0.06% | −19,743−24.5% | Reduced |
| Stanley-Laman Group, Ltd. | 60,842 | $4.82M | 0.49% | +21,536+54.8% | Added |
| Panagora Asset Management Inc | 61,125 | $4.85M | 0.01% | +3,679+6.4% | Added |
| Thrivent Financial for Lutherans | 62,743 | $4.97M | 0.01% | +52,781+529.8% | Added |
| Van Eck Associates Corp | 63,396 | $5.03M | 0.00% | +28,891+83.7% | Added |
| Quantinno Capital Management LP | 64,914 | $5.15M | 0.01% | +9,412+17.0% | Added |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 65,077 | $5.16M | 0.01% | +4,838+8.0% | Added |
| Vanguard Global Advisers, LLC | 65,858 | $5.22M | 0.00% | −6,053−8.4% | Reduced |
| Victory Capital Management Inc | 65,967 | $5.23M | 0.00% | −42,777−39.3% | Reduced |
| Voya Investment Management LLC | 66,303 | $5.26M | 0.00% | −2,833−4.1% | Reduced |
| Great Lakes Advisors, LLC | 66,924 | $5.31M | 0.04% | −52,002−43.7% | Reduced |
| Y-Intercept (Hong Kong) Ltd | 67,374 | $5.34M | 0.11% | +67,374 | New |
| Ameriprise Financial Inc | 67,705 | $5.37M | 0.00% | −592,439−89.7% | Reduced |
| Jupiter Topco LLC | 68,191 | $5.41M | 0.00% | +68,191 | New |
| Bank of Nova Scotia | 68,548 | $5.44M | 0.01% | +68,548 | New |
| Treasurer of the State of North Carolina | 70,021 | $5.55M | 0.01% | +2,320+3.4% | Added |
| Hillsdale Investment Management Inc. | 70,900 | $5.62M | 0.13% | 00.0% | Unchanged |
| Future Fund LLC | 71,362 | $5.66M | 1.62% | +12,630+21.5% | Added |
| Erste Asset Management GmbH | 71,800 | $5.79M | 0.05% | 00.0% | Unchanged |
| SG Americas Securities, LLC | 74,589 | $5.91M | 0.00% | +11,294+17.8% | Added |
| Police & Firemen's Retirement System of New Jersey | 75,061 | $5.95M | 0.04% | +7,738+11.5% | Added |
| China Universal Asset Management Co., Ltd. | 76,302 | $6.05M | 0.36% | −1,013−1.3% | Reduced |
| Fred Alger Management, LLC | 78,932 | $6.26M | 0.02% | +50,480+177.4% | Added |
| Russell Investments Group, Ltd. | 81,319 | $6.45M | 0.01% | +18,400+29.2% | Added |
| Dimensional Fund Advisors LP | 84,748 | $6.72M | 0.00% | −182,467−68.3% | Reduced |
| DekaBank Deutsche Girozentrale | 93,807 | $6.78M | 0.01% | 00.0% | Unchanged |
| Citigroup Inc | 86,746 | $6.88M | 0.00% | −59,795−40.8% | Reduced |
| Exome Asset Management LLC | 88,177 | $6.99M | 4.31% | −21,887−19.9% | Reduced |
| CenterBook Partners LP | 89,280 | $7.08M | 0.35% | −61,632−40.8% | Reduced |
| Public Employees Retirement Association of Colorado | 90,589 | $7.18M | 0.02% | +75,000+481.1% | Added |
| State of Wisconsin Investment Board | 94,492 | $7.49M | 0.02% | −1,999−2.1% | Reduced |
| Swedbank AB | 95,666 | $7.59M | 0.01% | +63,413+196.6% | Added |
| Polygon Management Ltd. | 97,173 | $7.70M | 1.25% | +55,409+132.7% | Added |
| Envestnet Asset Management Inc | 98,124 | $7.78M | 0.00% | +4,742+5.1% | Added |
| Kennedy Capital Management, Inc. | 106,342 | $8.43M | 0.15% | −5,488−4.9% | Reduced |
| Squarepoint Ops LLC | 109,379 | $8.67M | 0.02% | −585,897−84.3% | Reduced |
| Edmond de Rothschild Holding S.A. | 113,320 | $8.99M | 0.12% | −23,870−17.4% | Reduced |
| SEB Asset Management AB | 114,334 | $9.07M | 0.03% | 00.0% | Unchanged |
| Norges Bank | 114,359 | $9.07M | 0.00% | +114,359 | New |
| Braidwell LP | 116,762 | $9.26M | 0.34% | −14,100−10.8% | Reduced |
| Manufacturers Life Insurance Company, The | 120,678 | $9.57M | 0.01% | −28,860−19.3% | Reduced |
| Gotham Asset Management, LLC | 121,252 | $9.61M | 0.02% | +22,284+22.5% | Added |
| EFG International AG | 122,804 | $9.74M | 0.18% | +28,824+30.7% | Added |