Ionis Pharmaceuticals Inc
IONS- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000874015
In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 4 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.
13F holders, Q1 2026
Institutional positions in Ionis Pharmaceuticals Inc as of Mar 31, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 497
- +8 vs. Q4 2025
- Shares held
- 172.6M
- +19.1M (+12.5%) vs. Q4 2025
- Total value
- $13.0B
- +$828.1M (+6.8%) vs. Q4 2025
- New holders
- 73
- 179 more added
- Sold out
- 65
- 158 more reduced
5 institutions that held it in Q4 2025 haven't filed for Q1 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 515 | $14.3B |
| Q1 2026 | 497 | $13.0B |
| Q4 2025 | 494 | $13.5B |
| Q3 2025 | 437 | $11.0B |
| Q2 2025 | 363 | $6.67B |
| Q1 2025 | 344 | $5.03B |
| Q4 2024 | 356 | $5.61B |
| Q3 2024 | 354 | $6.31B |
| Q2 2024 | 357 | $6.83B |
| Q1 2024 | 361 | $6.17B |
| Q4 2023 | 365 | $7.21B |
| Q3 2023 | 312 | $6.35B |
| Q2 2023 | 305 | $5.60B |
| Q1 2023 | 315 | $4.69B |
| Q4 2022 | 339 | $4.93B |
| Q3 2022 | 350 | $5.59B |
| Q2 2022 | 351 | $4.61B |
| Q1 2022 | 333 | $4.63B |
| Q4 2021 | 341 | $3.75B |
| Q3 2021 | 326 | $4.08B |
| Q2 2021 | 338 | $4.96B |
| Q1 2021 | 365 | $5.55B |
Institutions, Q1 2026
Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q4 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| LPL Financial LLC | 31,932 | $2.40M | 0.00% | +863+2.8% | Added |
| Swedbank AB | 32,253 | $2.42M | 0.00% | +5,000+18.3% | Added |
| Pathstone Holdings, LLC | 32,835 | $2.47M | 0.01% | −1,469−4.3% | Reduced |
| Toroso Investments, LLC | 34,432 | $2.51M | 0.01% | +16,524+92.3% | Added |
| Assenagon Asset Management S.A. | 33,673 | $2.53M | 0.00% | +4,357+14.9% | Added |
| Blair William & Co | 33,857 | $2.54M | 0.01% | +69+0.2% | Added |
| KLP Kapitalforvaltning AS | 33,900 | $2.55M | 0.01% | +400+1.2% | Added |
| Exchange Traded Concepts, LLC | 33,941 | $2.55M | 0.02% | +12,847+60.9% | Added |
| PEAK6 LLC | 34,419 | $2.58M | 0.07% | +3,777+12.3% | Added |
| Van Eck Associates Corp | 34,505 | $2.59M | 0.00% | −12,597−26.7% | Reduced |
| Raiffeisen Bank International AG | 36,000 | $2.61M | 0.04% | +1,000+2.9% | Added |
| BLB&B Advisors, LLC | 35,170 | $2.64M | 0.11% | −26,350−42.8% | Reduced |
| Prudential Financial Inc | 35,268 | $2.65M | 0.00% | +11,260+46.9% | Added |
| Grandfield & Dodd, LLC | 37,326 | $2.80M | 0.16% | −495−1.3% | Reduced |
| Intech Investment Management LLC | 38,515 | $2.89M | 0.03% | +28,913+301.1% | Added |
| Vanguard Investments Australia, Ltd. | 38,557 | $2.90M | 0.01% | +38,557 | New |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | 38,988 | $2.93M | 4.26% | +13,971+55.8% | Added |
| Stanley-Laman Group, Ltd. | 39,306 | $2.95M | 0.36% | +2,794+7.7% | Added |
| Polygon Management Ltd. | 41,764 | $3.14M | 0.62% | +41,764 | New |
| Arizona State Retirement System | 42,266 | $3.17M | 0.02% | −155−0.4% | Reduced |
| Qube Research & Technologies Ltd | 42,856 | $3.22M | 0.00% | +42,856 | New |
| Guggenheim Capital LLC | 44,050 | $3.31M | 0.03% | +6,341+16.8% | Added |
| West Michigan Advisors, LLC | 44,614 | $3.35M | 0.74% | +6,201+16.1% | Added |
| Bamco Inc | 45,000 | $3.38M | 0.01% | +9,000+25.0% | Added |
| Ensign Peak Advisors, Inc | 46,004 | $3.45M | 0.01% | −7,660−14.3% | Reduced |
| Public Employees Retirement System of Ohio | 46,030 | $3.46M | 0.01% | −1,568−3.3% | Reduced |
| E Fund Management Co., Ltd. | 46,688 | $3.51M | 0.10% | +46,688 | New |
| Tudor Investment Corp Et Al | 48,244 | $3.62M | 0.02% | +44,583+1,217.8% | Added |
| Capital Counsel LLC | 49,580 | $3.72M | 0.16% | −25−0.1% | Reduced |
| Adage Capital Partners GP, L.L.C. | 50,000 | $3.75M | 0.01% | −90,000−64.3% | Reduced |
| Nicola Wealth Management Ltd. | 52,000 | $3.90M | 0.47% | −35,000−40.2% | Reduced |
| Creative Planning | 52,228 | $3.92M | 0.00% | −2,546−4.6% | Reduced |
| State of New Jersey Common Pension Fund D | 52,588 | $3.95M | 0.02% | −2,195−4.0% | Reduced |
| Carmignac Gestion | 53,000 | $3.98M | 0.06% | +53,000 | New |
| Fideuram - Intesa Sanpaolo Private Banking S.P.A. | 54,269 | $4.08M | 0.14% | −67,359−55.4% | Reduced |
| Quantinno Capital Management LP | 55,502 | $4.17M | 0.01% | +8,124+17.1% | Added |
| DCF Advisers, LLC | 56,000 | $4.21M | 1.59% | −47,000−45.6% | Reduced |
| Panagora Asset Management Inc | 57,446 | $4.31M | 0.02% | +57,446 | New |
| Future Fund LLC | 58,732 | $4.41M | 1.55% | +12,881+28.1% | Added |
| One Capital Management, LLC | 58,939 | $4.43M | 0.12% | +12,818+27.8% | Added |
| Jefferies Financial Group Inc. | 59,065 | $4.44M | 0.05% | +8,670+17.2% | Added |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 60,239 | $4.52M | 0.01% | +11,318+23.1% | Added |
| Rafferty Asset Management, LLC | 60,308 | $4.53M | 0.02% | −13,675−18.5% | Reduced |
| Polymer Capital Management (HK) LTD | 61,200 | $4.60M | 0.64% | +61,200 | New |
| Brinker Capital Investments, LLC | 61,344 | $4.61M | 0.04% | +37,770+160.2% | Added |
| Russell Investments Group, Ltd. | 62,919 | $4.72M | 0.01% | +19,007+43.3% | Added |
| SG Americas Securities, LLC | 63,295 | $4.75M | 0.01% | +29,886+89.5% | Added |
| Walleye Capital LLC | 65,949 | $4.95M | 0.03% | +65,624+20,192.0% | Added |
| Police & Firemen's Retirement System of New Jersey | 67,323 | $5.06M | 0.04% | +474+0.7% | Added |
| Treasurer of the State of North Carolina | 67,701 | $5.08M | 0.02% | +1,439+2.2% | Added |
| Janus Henderson Group PLC | 68,191 | $5.12M | 0.00% | 00.0% | Unchanged |
| Edgestream Partners, L.P. | 68,369 | $5.13M | 0.17% | +68,369 | New |
| Voya Investment Management LLC | 69,136 | $5.19M | 0.01% | −4,624−6.3% | Reduced |
| Erste Asset Management GmbH | 71,800 | $5.21M | 0.05% | 00.0% | Unchanged |
| Hillsdale Investment Management Inc. | 70,900 | $5.32M | 0.14% | 00.0% | Unchanged |
| Vanguard Global Advisers, LLC | 71,911 | $5.40M | 0.00% | +71,911 | New |
| Lisanti Capital Growth, LLC | 75,699 | $5.68M | 1.43% | +42,910+130.9% | Added |
| Boothbay Fund Management, LLC | 76,571 | $5.75M | 0.14% | +1,009+1.3% | Added |
| China Universal Asset Management Co., Ltd. | 77,315 | $5.81M | 0.44% | +34,921+82.4% | Added |
| CSS LLC | 79,093 | $5.94M | 0.33% | +79,093 | New |
| XTX Topco Ltd | 80,519 | $6.05M | 0.11% | +63,602+376.0% | Added |
| Nikko Asset Management Americas, Inc. | 81,696 | $6.13M | 0.09% | −11,875−12.7% | Reduced |
| Sumitomo Mitsui Trust Holdings, Inc. | 81,876 | $6.15M | 0.00% | −11,875−12.7% | Reduced |
| DekaBank Deutsche Girozentrale | 93,807 | $6.92M | 0.01% | 00.0% | Unchanged |
| Rhenman & Partners Asset Management AB | 92,900 | $6.98M | 0.86% | −65,600−41.4% | Reduced |
| Envestnet Asset Management Inc | 93,382 | $7.01M | 0.00% | +3,463+3.9% | Added |
| EFG International AG | 93,980 | $7.06M | 0.15% | +18,704+24.8% | Added |
| Marshall Wace, LLP | 95,954 | $7.21M | 0.01% | −160,979−62.7% | Reduced |
| Susquehanna Portfolio Strategies, LLC | 95,960 | $7.21M | 0.11% | 00.0% | Unchanged |
| State of Wisconsin Investment Board | 96,491 | $7.25M | 0.02% | +1,730+1.8% | Added |
| Gotham Asset Management, LLC | 98,968 | $7.43M | 0.02% | +55,756+129.0% | Added |
| Empowered Funds, LLC | 103,141 | $7.74M | 0.05% | +103,141 | New |
| Winton Group Ltd | 106,532 | $8.00M | 0.28% | +106,532 | New |
| Victory Capital Management Inc | 108,744 | $8.17M | 0.01% | +28,015+34.7% | Added |
| Exome Asset Management LLC | 110,064 | $8.26M | 4.86% | −6,451−5.5% | Reduced |
| Kennedy Capital Management, Inc. | 111,830 | $8.40M | 0.18% | +2,539+2.3% | Added |
| Standard Life Aberdeen plc | 113,843 | $8.55M | 0.01% | +84,917+293.6% | Added |
| Nomura Holdings Inc | 114,080 | $8.57M | 0.07% | −734,735−86.6% | Reduced |
| SEB Asset Management AB | 114,334 | $8.59M | 0.04% | +114,334 | New |
| Algert Global LLC | 116,563 | $8.75M | 0.13% | −10,642−8.4% | Reduced |
| Great Lakes Advisors, LLC | 118,926 | $8.93M | 0.07% | −30,254−20.3% | Reduced |
| Integral Health Asset Management, LLC | 125,000 | $9.39M | 0.50% | +125,000 | New |
| HealthInvest Partners AB | 27,873 | $9.40M | 3.03% | −64,504−69.8% | Reduced |
| Ikarian Capital, LLC | 127,038 | $9.54M | 1.36% | −75,000−37.1% | Reduced |
| Braidwell LP | 130,862 | $9.83M | 0.33% | +130,862 | New |
| Engineers Gate Manager LP | 133,827 | $10.0M | 0.13% | +111,636+503.1% | Added |
| State Board of Administration of Florida Retirement System | 135,878 | $10.2M | 0.02% | 00.0% | Unchanged |
| Edmond de Rothschild Holding S.A. | 137,190 | $10.3M | 0.15% | +15,000+12.3% | Added |
| Vanguard Asset Management, Ltd | 137,507 | $10.3M | 0.01% | +137,507 | New |
| Fisher Asset Management, LLC | 141,544 | $10.6M | 0.00% | −71−0.1% | Reduced |
| Capital Fund Management S.A. | 142,201 | $10.7M | 0.10% | +142,201 | New |
| Artia Global Partners LP | 144,376 | $10.8M | 2.44% | 00.0% | Unchanged |
| Citigroup Inc | 146,541 | $11.0M | 0.01% | +57,201+64.0% | Added |
| Aquatic Capital Management LLC | 147,379 | $11.1M | 0.32% | +14,553+11.0% | Added |
| Manufacturers Life Insurance Company, The | 149,538 | $11.2M | 0.01% | −3,703−2.4% | Reduced |
| CenterBook Partners LP | 150,912 | $11.3M | 0.61% | −3,037−2.0% | Reduced |
| SEI Investments Co | 157,222 | $11.8M | 0.01% | +41,305+35.6% | Added |
| Sicart Associates LLC | 159,412 | $12.0M | 3.07% | −4,145−2.5% | Reduced |
| Deutsche Bank AG | 159,891 | $12.0M | 0.00% | +10,448+7.0% | Added |
| ADAR1 Capital Management, LLC | 160,338 | $12.0M | 0.72% | +13,208+9.0% | Added |