Ionis Pharmaceuticals Inc
IONS- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000874015
In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 4 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.
13F holders, Q1 2026
Institutional positions in Ionis Pharmaceuticals Inc as of Mar 31, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 497
- +8 vs. Q4 2025
- Shares held
- 172.6M
- +19.1M (+12.5%) vs. Q4 2025
- Total value
- $13.0B
- +$828.1M (+6.8%) vs. Q4 2025
- New holders
- 73
- 179 more added
- Sold out
- 65
- 158 more reduced
5 institutions that held it in Q4 2025 haven't filed for Q1 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 515 | $14.3B |
| Q1 2026 | 497 | $13.0B |
| Q4 2025 | 494 | $13.5B |
| Q3 2025 | 437 | $11.0B |
| Q2 2025 | 363 | $6.67B |
| Q1 2025 | 344 | $5.03B |
| Q4 2024 | 356 | $5.61B |
| Q3 2024 | 354 | $6.31B |
| Q2 2024 | 357 | $6.83B |
| Q1 2024 | 361 | $6.17B |
| Q4 2023 | 365 | $7.21B |
| Q3 2023 | 312 | $6.35B |
| Q2 2023 | 305 | $5.60B |
| Q1 2023 | 315 | $4.69B |
| Q4 2022 | 339 | $4.93B |
| Q3 2022 | 350 | $5.59B |
| Q2 2022 | 351 | $4.61B |
| Q1 2022 | 333 | $4.63B |
| Q4 2021 | 341 | $3.75B |
| Q3 2021 | 326 | $4.08B |
| Q2 2021 | 338 | $4.96B |
| Q1 2021 | 365 | $5.55B |
Institutions, Q1 2026
Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q4 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| AdvisorNet Financial, Inc | 573 | $43.0K | 0.00% | −40−6.5% | Reduced |
| Archer Investment Corp | 600 | $45.1K | 0.01% | 00.0% | Unchanged |
| Advisory Services Network, LLC | 604 | $45.4K | 0.00% | +604 | New |
| Quadrant Capital Group LLC | 616 | $46.3K | 0.00% | 00.0% | Unchanged |
| Root Financial Partners, LLC | 681 | $51.1K | 0.00% | −658−49.1% | Reduced |
| Huntington National Bank | 681 | $51.1K | 0.00% | −14−2.0% | Reduced |
| Los Angeles Capital Management LLC | 700 | $52.6K | 0.00% | 00.0% | Unchanged |
| MAI Capital Management | 940 | $70.6K | 0.00% | +40+4.4% | Added |
| IFP Advisors, Inc | 950 | $71.3K | 0.00% | −64−6.3% | Reduced |
| Sunbelt Securities, Inc. | 1,014 | $76.1K | 0.00% | 00.0% | Unchanged |
| Stephens Inc | 26,761 | $91.4K | 0.00% | +26,761 | New |
| International Assets Investment Management, LLC | 1,221 | $91.7K | 0.01% | +4+0.3% | Added |
| Smartleaf Asset Management LLC | 1,416 | $102.7K | 0.00% | +28+2.0% | Added |
| Sterling Capital Management LLC | 1,425 | $107.0K | 0.00% | −288−16.8% | Reduced |
| Versant Capital Management, Inc | 1,555 | $116.8K | 0.01% | +59+3.9% | Added |
| GAMMA Investing LLC | 1,766 | $132.6K | 0.01% | +33+1.9% | Added |
| EverSource Wealth Advisors, LLC | 1,794 | $134.7K | 0.00% | +657+57.8% | Added |
| Advisors Asset Management, Inc. | 1,878 | $141.0K | 0.00% | −957−33.8% | Reduced |
| Parallel Advisors, LLC | 1,883 | $141.4K | 0.00% | +1+0.1% | Added |
| Farther Finance Advisors, LLC | 1,883 | $141.5K | 0.00% | +684+57.0% | Added |
| Group One Trading, L.P. | 1,892 | $142.1K | 0.00% | −1,886−49.9% | Reduced |
| Signaturefd, LLC | 2,078 | $156.0K | 0.00% | +37+1.8% | Added |
| Ancora Advisors, LLC | 2,391 | $179.5K | 0.00% | +49+2.1% | Added |
| Fideuram Asset Management (Ireland) dac | 2,213 | $181.6K | 0.02% | +2,213 | New |
| New York Life Investment Management LLC | 2,688 | $201.8K | 0.00% | +2,688 | New |
| Mitsubishi UFJ Kokusai Asset Management Co., Ltd. | 2,693 | $202.2K | 0.00% | −57−2.1% | Reduced |
| Montis Financial, LLC | 2,700 | $202.7K | 0.04% | 00.0% | Unchanged |
| Integrated Wealth Concepts LLC | 2,724 | $204.5K | 0.00% | +2,724 | New |
| AlphaCore Capital LLC | 2,762 | $207.4K | 0.00% | +2,762 | New |
| Blueshift Asset Management, LLC | 2,777 | $208.5K | 0.06% | −7,666−73.4% | Reduced |
| National Asset Management, Inc. | 2,945 | $213.6K | 0.01% | −30−1.0% | Reduced |
| Cambria Investment Management, L.P. | 2,885 | $216.6K | 0.01% | −799−21.7% | Reduced |
| Norden Group LLC | 2,889 | $216.9K | 0.02% | −46−1.6% | Reduced |
| HB Wealth Management, LLC | 2,926 | $219.7K | 0.00% | +4+0.1% | Added |
| EntryPoint Capital, LLC | 2,963 | $222.5K | 0.07% | +2,963 | New |
| Argent Trust Co | 3,018 | $226.6K | 0.01% | 00.0% | Unchanged |
| Larson Financial Group LLC | 3,031 | $227.6K | 0.01% | +691+29.5% | Added |
| Venturi Wealth Management, LLC | 3,061 | $229.9K | 0.01% | 00.0% | Unchanged |
| QRG Capital Management, Inc. | 3,094 | $232.3K | 0.00% | +3,094 | New |
| Campbell & CO Investment Adviser LLC | 3,101 | $232.9K | 0.01% | +317+11.4% | Added |
| Raab & Moskowitz Asset Management LLC | 3,115 | $233.9K | 0.05% | 00.0% | Unchanged |
| Gsa Capital Partners LLP | 3,172 | $238.0K | 0.01% | +3,172 | New |
| MML Investors Services, LLC | 3,173 | $238.3K | 0.00% | −91−2.8% | Reduced |
| Crossmark Global Holdings, Inc. | 3,199 | $240.2K | 0.00% | +97+3.1% | Added |
| Nwam LLC | 3,238 | $243.1K | 0.01% | 00.0% | Unchanged |
| Mitchell & Pahl Private Wealth, LLC | 3,261 | $244.9K | 0.10% | −118−3.5% | Reduced |
| Eurizon Capital SGR S.p.A. | 3,514 | $256.1K | 0.00% | +200+6.0% | Added |
| Perigon Wealth Management, LLC | 3,430 | $257.6K | 0.00% | +3,430 | New |
| Everhart Financial Group, Inc. | 3,470 | $260.6K | 0.02% | +5+0.1% | Added |
| Westfield Capital Management Co LP | 3,502 | $263.0K | 0.00% | +345+10.9% | Added |
| Marex Group plc | 3,610 | $271.1K | 0.00% | +86+2.4% | Added |
| Berkshire Asset Management LLC | 3,637 | $273.1K | 0.01% | +7+0.2% | Added |
| GF Fund Management Co. Ltd. | 3,637 | $273.1K | 0.00% | +454+14.3% | Added |
| Steward Partners Investment Advisory, LLC | 3,639 | $273.3K | 0.00% | +2,570+240.4% | Added |
| CWM, LLC | 3,717 | $279.1K | 0.00% | −1,332−26.4% | Reduced |
| Anb Bank | 3,769 | $283.0K | 0.11% | +576+18.0% | Added |
| Mackenzie Financial Corp | 3,795 | $285.0K | 0.00% | −96−2.5% | Reduced |
| HighTower Advisors, LLC | 3,797 | $285.1K | 0.00% | −1,325−25.9% | Reduced |
| Axq Capital, LP | 3,846 | $288.8K | 0.04% | +3,846 | New |
| Sanctuary Advisors, LLC | 3,918 | $294.2K | 0.00% | −584−13.0% | Reduced |
| Congress Asset Management Co | 3,946 | $296.3K | 0.00% | +3,946 | New |
| Prime Capital Investment Advisors, LLC | 3,971 | $298.2K | 0.00% | −10−0.3% | Reduced |
| Optas, LLC | 4,034 | $302.9K | 0.05% | +4,034 | New |
| Intrust Bank NA | 4,056 | $304.6K | 0.02% | +4,056 | New |
| Wealth Enhancement Advisory Services, LLC | 4,125 | $308.5K | 0.00% | −4,131−50.0% | Reduced |
| Inspire Advisors, LLC | 4,120 | $309.4K | 0.03% | −731−15.1% | Reduced |
| Mirae Asset Global ETFs Holdings Ltd. | 4,273 | $309.9K | 0.00% | −61−1.4% | Reduced |
| Rockefeller Capital Management L.P. | 4,155 | $312.0K | 0.00% | +1,429+52.4% | Added |
| Pinnacle Wealth Planning Services, Inc. | 4,213 | $316.4K | 0.03% | +349+9.0% | Added |
| Prospera Financial Services Inc | 4,341 | $325.9K | 0.01% | −418−8.8% | Reduced |
| R Squared Ltd | 4,359 | $327.3K | 0.18% | +4,359 | New |
| Kestra Advisory Services, LLC | 4,372 | $328.3K | 0.00% | −79−1.8% | Reduced |
| Credit Agricole S A | 4,410 | $331.1K | 0.00% | 00.0% | Unchanged |
| Checchi Capital Advisers, LLC | 4,429 | $332.6K | 0.02% | +157+3.7% | Added |
| Tower Research Capital LLC (TRC) | 4,466 | $335.4K | 0.01% | +1,203+36.9% | Added |
| Vise Technologies, Inc. | 4,305 | $340.6K | 0.01% | 00.0% | Unchanged |
| North Dakota State Investment Board | 4,623 | $347.1K | 0.02% | −857−15.6% | Reduced |
| GWM Advisors LLC | 4,786 | $359.4K | 0.00% | −152−3.1% | Reduced |
| Farallon Capital Management, L.L.C. | 4,800 | $360.4K | 0.00% | 00.0% | Unchanged |
| Lighthouse Investment Partners, LLC | 4,970 | $373.2K | 0.01% | −8,112−62.0% | Reduced |
| Captrust Financial Advisors | 5,000 | $375.4K | 0.00% | −293−5.5% | Reduced |
| Moisand Fitzgerald Tamayo, LLC | 5,000 | $375.4K | 0.04% | 00.0% | Unchanged |
| CIBC Asset Management Inc | 5,017 | $376.7K | 0.00% | 00.0% | Unchanged |
| US Bancorp | 5,047 | $379.0K | 0.00% | −94−1.8% | Reduced |
| Atria Investments LLC | 5,227 | $392.5K | 0.00% | −428−7.6% | Reduced |
| Vontobel Holding Ltd. | 5,240 | $393.5K | 0.00% | 00.0% | Unchanged |
| Virtu Financial LLC | 5,342 | $401.0K | 0.02% | +5,342 | New |
| Granite Investment Partners, LLC | 5,345 | $401.4K | 0.02% | +539+11.2% | Added |
| Resources Investment Advisors, LLC. | 5,390 | $404.7K | 0.00% | +384+7.7% | Added |
| Mesirow Financial Investment Management, Inc. | 5,460 | $410.0K | 0.01% | +5,460 | New |
| Cynosure Management, LLC | 5,614 | $421.6K | 0.05% | +5,614 | New |
| Coldstream Capital Management Inc | 5,653 | $424.5K | 0.01% | −966−14.6% | Reduced |
| Robeco Institutional Asset Management B.V. | 5,660 | $425.0K | 0.00% | +5,660 | New |
| Tema ETFs LLC | 5,673 | $426.0K | 0.03% | −2,884−33.7% | Reduced |
| Frank, Rimerman Advisors LLC | 5,781 | $434.1K | 0.03% | 00.0% | Unchanged |
| Cypress Capital, LLC | 6,000 | $450.5K | 0.13% | −4,000−40.0% | Reduced |
| Regions Financial Corp | 6,122 | $459.7K | 0.00% | +33+0.5% | Added |
| Everence Capital Management Inc | 6,232 | $468.0K | 0.03% | −538−7.9% | Reduced |
| Mercer Global Advisors Inc | 6,296 | $472.8K | 0.00% | +742+13.4% | Added |
| J. Safra Sarasin Holding AG | 6,431 | $482.9K | 0.01% | −10,973−63.0% | Reduced |