Ionis Pharmaceuticals Inc
IONS- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000874015
In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 4 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.
13F holders, Q4 2025
Institutional positions in Ionis Pharmaceuticals Inc as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 494
- +68 vs. Q3 2025
- Shares held
- 170.2M
- +2.78M (+1.7%) vs. Q3 2025
- Total value
- $13.5B
- +$2.50B (+22.8%) vs. Q3 2025
- New holders
- 112
- 167 more added
- Sold out
- 44
- 142 more reduced
11 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 515 | $14.3B |
| Q1 2026 | 497 | $13.0B |
| Q4 2025 | 494 | $13.5B |
| Q3 2025 | 437 | $11.0B |
| Q2 2025 | 363 | $6.67B |
| Q1 2025 | 344 | $5.03B |
| Q4 2024 | 356 | $5.61B |
| Q3 2024 | 354 | $6.31B |
| Q2 2024 | 357 | $6.83B |
| Q1 2024 | 361 | $6.17B |
| Q4 2023 | 365 | $7.21B |
| Q3 2023 | 312 | $6.35B |
| Q2 2023 | 305 | $5.60B |
| Q1 2023 | 315 | $4.69B |
| Q4 2022 | 339 | $4.93B |
| Q3 2022 | 350 | $5.59B |
| Q2 2022 | 351 | $4.61B |
| Q1 2022 | 333 | $4.63B |
| Q4 2021 | 341 | $3.75B |
| Q3 2021 | 326 | $4.08B |
| Q2 2021 | 338 | $4.96B |
| Q1 2021 | 365 | $5.55B |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | 25,017 | $1.98M | 0.29% | +19,554+357.9% | Added |
| Profund Advisors LLC | 26,673 | $2.11M | 0.06% | +741+2.9% | Added |
| HSBC Holdings PLC | 26,941 | $2.14M | 0.00% | −18,515−40.7% | Reduced |
| Swedbank AB | 27,253 | $2.16M | 0.00% | +27,253 | New |
| Qsemble Capital Management, LP | 27,579 | $2.18M | 0.18% | +27,579 | New |
| Standard Life Aberdeen plc | 28,926 | $2.29M | 0.00% | −58,998−67.1% | Reduced |
| Kornitzer Capital Management Inc | 29,105 | $2.30M | 0.05% | +29,105 | New |
| Assenagon Asset Management S.A. | 29,316 | $2.32M | 0.00% | −282,981−90.6% | Reduced |
| Jane Street Group, LLC | 30,471 | $2.41M | 0.00% | −334,599−91.7% | Reduced |
| Wolverine Asset Management LLC | 30,515 | $2.41M | 0.03% | +30,515 | New |
| PEAK6 LLC | 30,642 | $2.42M | 0.07% | +24,530+401.3% | Added |
| LPL Financial LLC | 31,069 | $2.46M | 0.00% | +6,606+27.0% | Added |
| Mutual of America Capital Management LLC | 31,459 | $2.49M | 0.03% | +31,459 | New |
| Twin Tree Management, LP | 32,476 | $2.57M | 0.26% | +3,901+13.7% | Added |
| Prelude Capital Management, LLC | 32,481 | $2.57M | 0.19% | −4,812−12.9% | Reduced |
| Susquehanna International Group, LLP | 32,504 | $2.57M | 0.00% | −388,446−92.3% | Reduced |
| Lisanti Capital Growth, LLC | 32,789 | $2.59M | 0.61% | −59,335−64.4% | Reduced |
| Calamos Advisors LLC | 33,189 | $2.63M | 0.01% | +7,326+28.3% | Added |
| SG Americas Securities, LLC | 33,409 | $2.64M | 0.00% | +28,259+548.7% | Added |
| KLP Kapitalforvaltning AS | 33,500 | $2.65M | 0.01% | +2,000+6.3% | Added |
| Blair William & Co | 33,788 | $2.67M | 0.01% | −583−1.7% | Reduced |
| Pathstone Holdings, LLC | 34,304 | $2.71M | 0.01% | +702+2.1% | Added |
| Acadian Asset Management LLC | 34,691 | $2.74M | 0.00% | −75,753−68.6% | Reduced |
| Raiffeisen Bank International AG | 35,000 | $2.76M | 0.04% | −15,000−30.0% | Reduced |
| Bamco Inc | 36,000 | $2.85M | 0.01% | +11,000+44.0% | Added |
| Bank of Montreal | 36,362 | $2.88M | 0.00% | −711,040−95.1% | Reduced |
| Stanley-Laman Group, Ltd. | 36,512 | $2.89M | 0.37% | +738+2.1% | Added |
| Guggenheim Capital LLC | 37,709 | $2.98M | 0.02% | +2,352+6.7% | Added |
| Grandfield & Dodd, LLC | 37,821 | $2.99M | 0.17% | +146+0.4% | Added |
| West Michigan Advisors, LLC | 38,413 | $3.04M | 0.70% | +38,413 | New |
| Fred Alger Management, LLC | 38,423 | $3.04M | 0.01% | −3,978−9.4% | Reduced |
| China Universal Asset Management Co., Ltd. | 42,394 | $3.35M | 0.26% | +14,455+51.7% | Added |
| Arizona State Retirement System | 42,421 | $3.36M | 0.02% | −2,310−5.2% | Reduced |
| Gotham Asset Management, LLC | 43,212 | $3.42M | 0.01% | +11,060+34.4% | Added |
| Russell Investments Group, Ltd. | 43,912 | $3.47M | 0.00% | −33,381−43.2% | Reduced |
| Future Fund LLC | 45,851 | $3.63M | 1.28% | +9,695+26.8% | Added |
| One Capital Management, LLC | 46,121 | $3.65M | 0.11% | +9,695+26.6% | Added |
| Lazard Asset Management LLC | 46,402 | $3.67M | 0.01% | −17,389−27.3% | Reduced |
| Van Eck Associates Corp | 47,102 | $3.73M | 0.00% | −64,717−57.9% | Reduced |
| Quantinno Capital Management LP | 47,378 | $3.75M | 0.01% | +11,263+31.2% | Added |
| Atika Capital Management LLC | 47,488 | $3.76M | 0.52% | +25,988+120.9% | Added |
| Public Employees Retirement System of Ohio | 47,598 | $3.77M | 0.01% | −947−2.0% | Reduced |
| Mariner, LLC | 47,740 | $3.78M | 0.00% | +23,513+97.1% | Added |
| Handelsbanken Fonder AB | 47,911 | $3.79M | 0.01% | −4,000−7.7% | Reduced |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 48,921 | $3.87M | 0.01% | +3,701+8.2% | Added |
| Capital Counsel LLC | 49,605 | $3.92M | 0.15% | 00.0% | Unchanged |
| Jefferies Financial Group Inc. | 50,395 | $3.99M | 0.03% | +40,226+395.6% | Added |
| Alpine Global Management, LLC | 53,600 | $4.24M | 0.94% | −2,300−4.1% | Reduced |
| Ensign Peak Advisors, Inc | 53,664 | $4.25M | 0.01% | +26,069+94.5% | Added |
| EAM Investors, LLC | 53,914 | $4.27M | 0.48% | −1,063−1.9% | Reduced |
| DekaBank Deutsche Girozentrale | 93,807 | $4.30M | 0.01% | 00.0% | Unchanged |
| PDT Partners, LLC | 54,365 | $4.30M | 0.28% | 00.0% | Unchanged |
| Creative Planning | 54,774 | $4.33M | 0.00% | +3,300+6.4% | Added |
| State of New Jersey Common Pension Fund D | 54,783 | $4.33M | 0.02% | −5,034−8.4% | Reduced |
| BLB&B Advisors, LLC | 61,520 | $4.87M | 0.20% | −57,080−48.1% | Reduced |
| BI Asset Management Fondsmaeglerselskab A/S | 62,073 | $4.91M | 0.04% | +62,073 | New |
| Treasurer of the State of North Carolina | 66,262 | $5.24M | 0.02% | −3,600−5.2% | Reduced |
| Police & Firemen's Retirement System of New Jersey | 66,849 | $5.29M | 0.04% | −2,475−3.6% | Reduced |
| J. Goldman & Co LP | 67,639 | $5.35M | 0.21% | −28,559−29.7% | Reduced |
| Bridgewater Associates, LP | 67,706 | $5.36M | 0.02% | +24,128+55.4% | Added |
| Janus Henderson Group PLC | 68,191 | $5.40M | 0.00% | +4,314+6.8% | Added |
| Hillsdale Investment Management Inc. | 70,900 | $5.61M | 0.15% | 00.0% | Unchanged |
| Erste Asset Management GmbH | 71,800 | $5.74M | 0.05% | 00.0% | Unchanged |
| Voya Investment Management LLC | 73,760 | $5.84M | 0.01% | −37,829−33.9% | Reduced |
| Rafferty Asset Management, LLC | 73,983 | $5.85M | 0.02% | −51,790−41.2% | Reduced |
| EFG International AG | 75,276 | $5.96M | 0.12% | +75,276 | New |
| Boothbay Fund Management, LLC | 75,562 | $5.98M | 0.16% | −87,900−53.8% | Reduced |
| Victory Capital Management Inc | 80,729 | $6.39M | 0.00% | +62,518+343.3% | Added |
| ExodusPoint Capital Management, LP | 83,875 | $6.64M | 0.07% | −68,250−44.9% | Reduced |
| Nicola Wealth Management Ltd. | 87,000 | $6.88M | 0.63% | 00.0% | Unchanged |
| Citigroup Inc | 89,340 | $7.07M | 0.00% | −66,513−42.7% | Reduced |
| Envestnet Asset Management Inc | 89,919 | $7.11M | 0.00% | +62,410+226.9% | Added |
| HealthInvest Partners AB | 92,377 | $7.31M | 2.33% | +92,377 | New |
| Millennium Management LLC | 93,262 | $7.38M | 0.01% | −686,308−88.0% | Reduced |
| Nikko Asset Management Americas, Inc. | 93,571 | $7.40M | 0.09% | −21,021−18.3% | Reduced |
| Sumitomo Mitsui Trust Holdings, Inc. | 93,751 | $7.42M | 0.00% | −21,021−18.3% | Reduced |
| State of Wisconsin Investment Board | 94,761 | $7.50M | 0.02% | −2,076−2.1% | Reduced |
| Susquehanna Portfolio Strategies, LLC | 95,960 | $7.59M | 0.12% | 00.0% | Unchanged |
| Simplex Trading, LLC | 96,647 | $7.65M | 0.22% | −3,559−3.6% | Reduced |
| DCF Advisers, LLC | 103,000 | $8.15M | 2.69% | −5,413−5.0% | Reduced |
| Neuberger Berman Group LLC | 108,044 | $8.55M | 0.01% | −6,699−5.8% | Reduced |
| Kennedy Capital Management, Inc. | 109,291 | $8.65M | 0.18% | −13,475−11.0% | Reduced |
| Healthcare of Ontario Pension Plan Trust Fund | 110,000 | $8.70M | 0.01% | −6,000−5.2% | Reduced |
| Skandinaviska Enskilda Banken AB (publ) | 115,293 | $9.12M | 0.04% | −40,497−26.0% | Reduced |
| SEI Investments Co | 115,917 | $9.17M | 0.01% | −3,111−2.6% | Reduced |
| Exome Asset Management LLC | 116,515 | $9.22M | 4.55% | −14,501−11.1% | Reduced |
| Balyasny Asset Management LLC | 120,577 | $9.54M | 0.02% | −639,534−84.1% | Reduced |
| Fideuram - Intesa Sanpaolo Private Banking S.P.A. | 121,628 | $9.62M | 0.35% | +121,628 | New |
| Edmond de Rothschild Holding S.A. | 122,190 | $9.67M | 0.14% | −34,500−22.0% | Reduced |
| Algert Global LLC | 127,205 | $10.1M | 0.16% | −125,076−49.6% | Reduced |
| Trexquant Investment LP | 132,241 | $10.5M | 0.09% | −82,880−38.5% | Reduced |
| Aquatic Capital Management LLC | 132,826 | $10.5M | 0.30% | −26,219−16.5% | Reduced |
| State Board of Administration of Florida Retirement System | 135,878 | $10.7M | 0.02% | −7,656−5.3% | Reduced |
| Adage Capital Partners GP, L.L.C. | 140,000 | $11.1M | 0.02% | −1,175,000−89.4% | Reduced |
| Fisher Asset Management, LLC | 141,615 | $11.2M | 0.00% | +135,405+2,180.4% | Added |
| California State Teachers Retirement System | 144,173 | $11.4M | 0.01% | −939−0.6% | Reduced |
| Artia Global Partners LP | 144,376 | $11.4M | 1.84% | +84,200+139.9% | Added |
| ADAR1 Capital Management, LLC | 147,130 | $11.6M | 0.87% | +13,312+9.9% | Added |
| Great Lakes Advisors, LLC | 149,180 | $11.8M | 0.10% | −37,770−20.2% | Reduced |
| Deutsche Bank AG | 149,443 | $11.8M | 0.00% | +60,640+68.3% | Added |