Ionis Pharmaceuticals Inc
IONS- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000874015
In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 4 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.
13F holders, Q3 2025
Institutional positions in Ionis Pharmaceuticals Inc as of Sep 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 437
- +78 vs. Q2 2025
- Shares held
- 168.2M
- −221.1K (−0.1%) vs. Q2 2025
- Total value
- $11.0B
- +$4.36B (+65.5%) vs. Q2 2025
- New holders
- 115
- 136 more added
- Sold out
- 37
- 116 more reduced
4 institutions that held it in Q2 2025 haven't filed for Q3 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q2 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 515 | $14.3B |
| Q1 2026 | 497 | $13.0B |
| Q4 2025 | 494 | $13.5B |
| Q3 2025 | 437 | $11.0B |
| Q2 2025 | 363 | $6.67B |
| Q1 2025 | 344 | $5.03B |
| Q4 2024 | 356 | $5.61B |
| Q3 2024 | 354 | $6.31B |
| Q2 2024 | 357 | $6.83B |
| Q1 2024 | 361 | $6.17B |
| Q4 2023 | 365 | $7.21B |
| Q3 2023 | 312 | $6.35B |
| Q2 2023 | 305 | $5.60B |
| Q1 2023 | 315 | $4.69B |
| Q4 2022 | 339 | $4.93B |
| Q3 2022 | 350 | $5.59B |
| Q2 2022 | 351 | $4.61B |
| Q1 2022 | 333 | $4.63B |
| Q4 2021 | 341 | $3.75B |
| Q3 2021 | 326 | $4.08B |
| Q2 2021 | 338 | $4.96B |
| Q1 2021 | 365 | $5.55B |
Institutions, Q3 2025
Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q2 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Root Financial Partners, LLC | 1,340 | $87.7K | 0.01% | +1,340 | New |
| GAMMA Investing LLC | 1,341 | $87.7K | 0.00% | +411+44.2% | Added |
| Danske Bank A/S | 1,400 | $91.6K | 0.00% | 00.0% | Unchanged |
| Ci Investments Inc. | 1,453 | $95.0K | 0.00% | −963−39.9% | Reduced |
| Versant Capital Management, Inc | 1,465 | $95.8K | 0.01% | 00.0% | Unchanged |
| Twin Lakes Capital Management, LLC | 1,500 | $98.1K | 0.05% | 00.0% | Unchanged |
| Abich Financial Wealth Management LLC | 1,708 | $111.7K | 0.04% | +1,708 | New |
| Harvest Fund Management Co., Ltd | 1,746 | $114.0K | 0.00% | −83−4.5% | Reduced |
| Parallel Advisors, LLC | 1,877 | $122.8K | 0.00% | +5+0.3% | Added |
| Signaturefd, LLC | 2,003 | $131.0K | 0.00% | −27−1.3% | Reduced |
| Ancora Advisors, LLC | 2,137 | $139.8K | 0.00% | +137+6.9% | Added |
| Comerica Bank | 2,187 | $143.1K | 0.00% | +570+35.3% | Added |
| Rockefeller Capital Management L.P. | 2,203 | $144.1K | 0.00% | +2,203 | New |
| CWM, LLC | 2,488 | $163.0K | 0.00% | +170+7.3% | Added |
| Tower Research Capital LLC (TRC) | 3,045 | $199.2K | 0.01% | +1,464+92.6% | Added |
| Point72 Europe (London) LLP | 3,051 | $199.6K | 0.01% | +3,051 | New |
| Voleon Capital Management LP | 3,060 | $200.2K | 0.00% | +3,060 | New |
| Westfield Capital Management Co LP | 3,093 | $202.3K | 0.00% | −6,468−67.6% | Reduced |
| Raab & Moskowitz Asset Management LLC | 3,115 | $203.8K | 0.05% | +3,115 | New |
| Anb Bank | 3,231 | $211.4K | 0.09% | +3,231 | New |
| Victrix Investment Advisors | 3,400 | $222.4K | 0.12% | +3,400 | New |
| GF Fund Management Co. Ltd. | 3,429 | $224.3K | 0.00% | −613−15.2% | Reduced |
| EntryPoint Capital, LLC | 3,458 | $226.2K | 0.09% | +3,458 | New |
| Massar Capital Management, LP | 3,462 | $226.5K | 0.08% | +3,462 | New |
| Bank of Nova Scotia | 3,509 | $229.6K | 0.00% | +3,509 | New |
| Mitchell & Pahl Private Wealth, LLC | 3,572 | $233.7K | 0.10% | +3,572 | New |
| PharVision Advisers, LLC | 3,587 | $234.7K | 0.13% | +3,587 | New |
| Mackenzie Financial Corp | 3,588 | $234.7K | 0.00% | +3,588 | New |
| Resources Investment Advisors, LLC. | 3,588 | $234.7K | 0.00% | +3,588 | New |
| Berkshire Asset Management LLC | 3,614 | $236.4K | 0.01% | +3,614 | New |
| Sanctuary Advisors, LLC | 3,637 | $237.9K | 0.00% | +3,637 | New |
| Nwam LLC | 3,238 | $238.2K | 0.01% | +3,238 | New |
| STRS Ohio | 3,716 | $243.1K | 0.00% | +2+0.1% | Added |
| Mercer Global Advisors Inc | 3,747 | $245.1K | 0.00% | +3,747 | New |
| Regions Financial Corp | 3,800 | $248.6K | 0.00% | +3,800 | New |
| Prime Capital Investment Advisors, LLC | 3,934 | $257.4K | 0.00% | +3,934 | New |
| Pitcairn Co | 4,075 | $266.6K | 0.02% | +4,075 | New |
| Checchi Capital Advisers, LLC | 4,233 | $276.9K | 0.02% | +4,233 | New |
| Perbak Capital Partners LLP | 4,426 | $289.5K | 0.05% | −5,112−53.6% | Reduced |
| Coldstream Capital Management Inc | 4,479 | $293.0K | 0.00% | +4,479 | New |
| Brevan Howard Capital Management LP | 4,516 | $295.4K | 0.00% | −28,216−86.2% | Reduced |
| Prospera Financial Services Inc | 4,581 | $299.7K | 0.01% | +4,581 | New |
| CIBC Asset Management Inc | 4,608 | $301.5K | 0.00% | +4,608 | New |
| KBC Group NV | 4,699 | $307.0K | 0.00% | 00.0% | Unchanged |
| US Bancorp | 4,704 | $307.7K | 0.00% | +419+9.8% | Added |
| Credit Agricole S A | 4,710 | $308.1K | 0.00% | +4,710 | New |
| Requisite Capital Management, LLC | 4,734 | $309.7K | 0.05% | +4,734 | New |
| Principal Financial Group Inc | 4,785 | $313.0K | 0.00% | −3,166−39.8% | Reduced |
| Group One Trading, L.P. | 4,796 | $313.8K | 0.01% | +4,796 | New |
| Farallon Capital Management, L.L.C. | 4,800 | $314.0K | 0.00% | +4,800 | New |
| Truist Financial Corp | 4,812 | $314.8K | 0.00% | +4,812 | New |
| GWM Advisors LLC | 4,822 | $315.5K | 0.00% | +4,626+2,360.2% | Added |
| Kestra Advisory Services, LLC | 4,972 | $325.3K | 0.00% | +4,972 | New |
| Moisand Fitzgerald Tamayo, LLC | 5,000 | $327.1K | 0.04% | 00.0% | Unchanged |
| International Assets Investment Management, LLC | 8,207 | $327.8K | 0.03% | 00.0% | Unchanged |
| Pinnacle Wealth Planning Services, Inc. | 5,113 | $334.5K | 0.04% | −171−3.2% | Reduced |
| SG Americas Securities, LLC | 5,150 | $337.0K | 0.00% | +5,150 | New |
| O'Shaughnessy Asset Management, LLC | 5,297 | $346.5K | 0.00% | +5,297 | New |
| Mitsubishi UFJ Kokusai Asset Management Co., Ltd. | 5,407 | $353.7K | 0.00% | +9+0.2% | Added |
| Edgestream Partners, L.P. | 5,450 | $356.5K | 0.01% | +5,450 | New |
| Advisors Asset Management, Inc. | 5,454 | $356.8K | 0.01% | −545−9.1% | Reduced |
| HighTower Advisors, LLC | 5,458 | $357.1K | 0.00% | +101+1.9% | Added |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | 5,463 | $357.4K | 0.52% | +5,463 | New |
| Wedmont Private Capital | 5,363 | $369.7K | 0.01% | +81+1.5% | Added |
| ProShare Advisors LLC | 5,678 | $371.5K | 0.00% | −265−4.5% | Reduced |
| Frank, Rimerman Advisors LLC | 5,765 | $377.1K | 0.02% | +20.0% | Added |
| M&T Bank Corp | 6,010 | $392.7K | 0.00% | −1,641−21.4% | Reduced |
| PEAK6 LLC | 6,112 | $399.8K | 0.01% | +6,112 | New |
| Mirae Asset Global Investments Co., Ltd. | 6,162 | $403.1K | 0.00% | +14+0.2% | Added |
| Summit Trail Advisors, LLC | 6,205 | $405.9K | 0.01% | +6,205 | New |
| Fisher Asset Management, LLC | 6,210 | $406.3K | 0.00% | +6,210 | New |
| Mirae Asset Global ETFs Holdings Ltd. | 6,431 | $412.5K | 0.00% | −640−9.1% | Reduced |
| Fiduciary Trust Co | 6,377 | $417.2K | 0.00% | −2,174−25.4% | Reduced |
| CI Private Wealth, LLC | 6,590 | $431.1K | 0.00% | −231,250−97.2% | Reduced |
| Franklin Resources Inc | 6,593 | $431.3K | 0.00% | +1,037+18.7% | Added |
| Jones Financial Companies LLLP | 6,834 | $438.0K | 0.00% | −362−5.0% | Reduced |
| AQR Capital Management LLC | 6,815 | $438.7K | 0.00% | +6,815 | New |
| Marex Group plc | 6,722 | $439.8K | 0.01% | −76,639−91.9% | Reduced |
| Meeder Advisory Services, Inc. | 6,770 | $442.9K | 0.02% | +126+1.9% | Added |
| Everence Capital Management Inc | 6,770 | $443.0K | 0.03% | 00.0% | Unchanged |
| Swiss Life Asset Management Ltd | 6,827 | $446.6K | 0.00% | +6,827 | New |
| Cetera Investment Advisers | 6,873 | $449.7K | 0.00% | +6,873 | New |
| Atria Investments LLC | 7,030 | $459.9K | 0.01% | −1,156−14.1% | Reduced |
| Silvercrest Asset Management Group LLC | 7,118 | $465.7K | 0.00% | +50+0.7% | Added |
| Savant Capital, LLC | 7,237 | $473.4K | 0.00% | +1,667+29.9% | Added |
| Commerce Bank | 7,607 | $497.6K | 0.00% | 00.0% | Unchanged |
| Inceptionr LLC | 7,621 | $498.6K | 0.12% | +7,621 | New |
| Stratos Wealth Partners, LTD. | 7,764 | $507.9K | 0.01% | +7,764 | New |
| Wealth Enhancement Advisory Services, LLC | 7,439 | $512.8K | 0.00% | −476−6.0% | Reduced |
| Fifth Third Bancorp | 7,944 | $519.7K | 0.00% | +346+4.6% | Added |
| Empire Financial Management Company, LLC | 8,000 | $523.4K | 0.12% | +8,000 | New |
| Maryland State Retirement & Pension System | 8,284 | $541.9K | 0.01% | 00.0% | Unchanged |
| Utah Retirement Systems | 8,300 | $543.0K | 0.01% | −100−1.2% | Reduced |
| Sectoral Asset Management Inc | 9,205 | $602.2K | 0.37% | 00.0% | Unchanged |
| DnB Asset Management AS | 9,308 | $608.9K | 0.00% | −2,963−24.1% | Reduced |
| Prudential Financial Inc | 9,344 | $611.3K | 0.00% | +90+1.0% | Added |
| MetLife Investment Management | 9,428 | $616.8K | 0.00% | +267+2.9% | Added |
| Advisor Group Holdings, Inc. | 10,167 | $618.0K | 0.00% | +4,871+92.0% | Added |
| Brinker Capital Investments, LLC | 9,962 | $651.7K | 0.01% | +4,362+77.9% | Added |
| Thrivent Financial for Lutherans | 9,962 | $652.0K | 0.00% | +9,962 | New |