Ionis Pharmaceuticals Inc
IONS- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000874015
In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 4 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.
13F holders, Q2 2025
Institutional positions in Ionis Pharmaceuticals Inc as of Jun 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 363
- +21 vs. Q1 2025
- Shares held
- 168.9M
- +2.14M (+1.3%) vs. Q1 2025
- Total value
- $6.67B
- +$1.64B (+32.6%) vs. Q1 2025
- New holders
- 80
- 121 more added
- Sold out
- 59
- 109 more reduced
2 institutions that held it in Q1 2025 haven't filed for Q2 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q1 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 515 | $14.3B |
| Q1 2026 | 497 | $13.0B |
| Q4 2025 | 494 | $13.5B |
| Q3 2025 | 437 | $11.0B |
| Q2 2025 | 363 | $6.67B |
| Q1 2025 | 344 | $5.03B |
| Q4 2024 | 356 | $5.61B |
| Q3 2024 | 354 | $6.31B |
| Q2 2024 | 357 | $6.83B |
| Q1 2024 | 361 | $6.17B |
| Q4 2023 | 365 | $7.21B |
| Q3 2023 | 312 | $6.35B |
| Q2 2023 | 305 | $5.60B |
| Q1 2023 | 315 | $4.69B |
| Q4 2022 | 339 | $4.93B |
| Q3 2022 | 350 | $5.59B |
| Q2 2022 | 351 | $4.61B |
| Q1 2022 | 333 | $4.63B |
| Q4 2021 | 341 | $3.75B |
| Q3 2021 | 326 | $4.08B |
| Q2 2021 | 338 | $4.96B |
| Q1 2021 | 365 | $5.55B |
Institutions, Q2 2025
Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q1 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Ci Investments Inc. | 2,416 | $95.0K | 0.00% | −126−5.0% | Reduced |
| STRS Ohio | 3,714 | $146.7K | 0.00% | +3,714 | New |
| GF Fund Management Co. Ltd. | 4,042 | $159.7K | 0.00% | 00.0% | Unchanged |
| US Bancorp | 4,285 | $169.3K | 0.00% | +1,128+35.7% | Added |
| KBC Group NV | 4,699 | $186.0K | 0.00% | −1,816−27.9% | Reduced |
| Wexford Capital LP | 4,749 | $187.6K | 0.05% | +4,749 | New |
| Moisand Fitzgerald Tamayo, LLC | 5,000 | $197.6K | 0.02% | 00.0% | Unchanged |
| Empowered Funds, LLC | 5,067 | $200.2K | 0.00% | +5,067 | New |
| Pinnacle Wealth Planning Services, Inc. | 5,284 | $208.8K | 0.03% | +5,284 | New |
| Advisor Group Holdings, Inc. | 5,296 | $208.8K | 0.00% | +2,923+123.2% | Added |
| HighTower Advisors, LLC | 5,357 | $211.7K | 0.00% | +5,357 | New |
| Mitsubishi UFJ Kokusai Asset Management Co., Ltd. | 5,398 | $213.3K | 0.00% | −737−12.0% | Reduced |
| Callan Family Office, LLC | 5,400 | $213.4K | 0.01% | +5,400 | New |
| Castle Rock Wealth Management, LLC | 5,122 | $215.2K | 0.05% | +5,122 | New |
| Franklin Resources Inc | 5,556 | $219.5K | 0.00% | +5,556 | New |
| Savant Capital, LLC | 5,570 | $220.1K | 0.00% | +5,570 | New |
| Brinker Capital Investments, LLC | 5,600 | $221.3K | 0.00% | +5,600 | New |
| Cambridge Investment Research Advisors, Inc. | 5,682 | $224.0K | 0.00% | −1,122−16.5% | Reduced |
| Wedmont Private Capital | 5,282 | $226.2K | 0.01% | +5,282 | New |
| Frank, Rimerman Advisors LLC | 5,763 | $227.7K | 0.02% | +5,763 | New |
| ProShare Advisors LLC | 5,943 | $234.8K | 0.00% | −1,228−17.1% | Reduced |
| Advisors Asset Management, Inc. | 5,999 | $237.0K | 0.00% | −49−0.8% | Reduced |
| Mirae Asset Global Investments Co., Ltd. | 6,148 | $242.9K | 0.00% | +829+15.6% | Added |
| Teza Capital Management LLC | 6,604 | $260.9K | 0.19% | −3,640−35.5% | Reduced |
| Meeder Advisory Services, Inc. | 6,644 | $262.5K | 0.01% | +6,644 | New |
| Everence Capital Management Inc | 6,770 | $267.0K | 0.02% | 00.0% | Unchanged |
| Jacobs Levy Equity Management, Inc | 6,813 | $269.2K | 0.00% | +6,813 | New |
| Clearstead Advisors, LLC | 7,000 | $276.6K | 0.00% | 00.0% | Unchanged |
| Silvercrest Asset Management Group LLC | 7,068 | $279.3K | 0.00% | +166+2.4% | Added |
| Mirae Asset Global ETFs Holdings Ltd. | 7,071 | $281.4K | 0.00% | −1,135−13.8% | Reduced |
| Jain Global LLC | 7,195 | $284.3K | 0.00% | −1,400−16.3% | Reduced |
| Jones Financial Companies LLLP | 7,196 | $286.4K | 0.00% | −6,539−47.6% | Reduced |
| Fifth Third Bancorp | 7,598 | $300.2K | 0.00% | −2,391−23.9% | Reduced |
| Commerce Bank | 7,607 | $300.6K | 0.00% | +332+4.6% | Added |
| M&T Bank Corp | 7,651 | $303.0K | 0.00% | +7,651 | New |
| Principal Financial Group Inc | 7,951 | $314.1K | 0.00% | −2,496−23.9% | Reduced |
| Point72 (DIFC) Ltd | 8,087 | $319.5K | 0.03% | −33,260−80.4% | Reduced |
| Atria Investments LLC | 8,186 | $323.4K | 0.00% | +8,186 | New |
| International Assets Investment Management, LLC | 8,207 | $324.3K | 0.03% | 00.0% | Unchanged |
| Maryland State Retirement & Pension System | 8,284 | $327.3K | 0.01% | 00.0% | Unchanged |
| Aigen Investment Management, LP | 8,298 | $327.9K | 0.04% | +8,298 | New |
| Utah Retirement Systems | 8,400 | $331.9K | 0.00% | 00.0% | Unchanged |
| Fiduciary Trust Co | 8,551 | $337.9K | 0.00% | +813+10.5% | Added |
| Wealth Enhancement Advisory Services, LLC | 7,915 | $340.3K | 0.00% | +7,915 | New |
| Prudential Financial Inc | 9,254 | $340.9K | 0.00% | +2,991+47.8% | Added |
| Exchange Traded Concepts, LLC | 8,802 | $347.8K | 0.00% | +5,558+171.3% | Added |
| Man Group plc | 8,969 | $354.4K | 0.00% | −1,064−10.6% | Reduced |
| Jump Financial, LLC | 9,018 | $356.3K | 0.00% | −72,303−88.9% | Reduced |
| MetLife Investment Management | 9,161 | $362.0K | 0.00% | +17+0.2% | Added |
| Sectoral Asset Management Inc | 9,205 | $363.7K | 0.24% | −235−2.5% | Reduced |
| Russell Investments Group, Ltd. | 9,265 | $366.1K | 0.00% | +3,512+61.0% | Added |
| Fred Alger Management, LLC | 9,464 | $373.9K | 0.00% | +9,464 | New |
| Semanteon Capital Management, LP | 9,536 | $376.8K | 0.57% | +1,993+26.4% | Added |
| Perbak Capital Partners LLP | 9,538 | $376.8K | 0.09% | +9,538 | New |
| Westfield Capital Management Co LP | 9,561 | $377.8K | 0.00% | +9,561 | New |
| Cypress Capital, LLC | 10,000 | $395.1K | 0.11% | 00.0% | Unchanged |
| Colony Group, LLC | 10,056 | $397.3K | 0.00% | +224+2.3% | Added |
| Harbor Advisors LLC | 10,500 | $414.9K | 0.07% | 00.0% | Unchanged |
| Suvretta Capital Management, LLC | 10,800 | $426.7K | 0.02% | 00.0% | Unchanged |
| Fox Run Management, L.L.C. | 10,988 | $434.1K | 0.07% | +10,988 | New |
| Plancorp, LLC | 11,208 | $442.8K | 0.02% | +80+0.7% | Added |
| The PNC Financial Services Group, Inc. | 11,411 | $450.8K | 0.00% | +424+3.9% | Added |
| Amalgamated Bank | 11,526 | $455.0K | 0.00% | +953+9.0% | Added |
| Wiley Bros.-Aintree Capital, LLC | 11,758 | $464.6K | 0.00% | +754+6.9% | Added |
| Horizon Kinetics Asset Management LLC | 11,952 | $472.2K | 0.01% | −524−4.2% | Reduced |
| Vident Advisory, LLC | 12,000 | $474.1K | 0.01% | +12,000 | New |
| JustInvest LLC | 12,072 | $477.0K | 0.01% | +1,759+17.1% | Added |
| Brown Advisory Inc | 12,191 | $481.7K | 0.00% | +165+1.4% | Added |
| Northwestern Mutual Wealth Management Co | 12,244 | $483.8K | 0.00% | −114−0.9% | Reduced |
| DnB Asset Management AS | 12,271 | $484.8K | 0.00% | +12,271 | New |
| Virtus Investment Advisers, Inc. | 12,476 | $492.9K | 0.17% | +2,775+28.6% | Added |
| Paloma Partners Management Co | 12,557 | $496.1K | 0.11% | +12,557 | New |
| Annis Gardner Whiting Capital Advisors, LLC | 12,801 | $505.8K | 0.18% | +2,065+19.2% | Added |
| Westmount Partners, LLC | 12,961 | $512.1K | 0.14% | 00.0% | Unchanged |
| Marshall Wace, LLP | 13,100 | $517.6K | 0.00% | +3,998+43.9% | Added |
| Davy Global Fund Management Ltd | 13,263 | $524.0K | 0.05% | +5,204+64.6% | Added |
| Envestnet Asset Management Inc | 13,544 | $535.1K | 0.00% | −1,495−9.9% | Reduced |
| Commonwealth Equity Services, LLC | 13,942 | $551.0K | 0.00% | −2,456−15.0% | Reduced |
| Gotham Asset Management, LLC | 14,279 | $564.2K | 0.00% | +14,279 | New |
| Vestmark Advisory Solutions, Inc. | 14,341 | $566.6K | 0.01% | +14,341 | New |
| Corton Capital Inc. | 14,424 | $569.9K | 0.66% | +14,424 | New |
| Significant Wealth Partners LLC | 15,504 | $612.6K | 0.30% | +1,899+14.0% | Added |
| Public Employees Retirement Association of Colorado | 15,589 | $616.0K | 0.00% | 00.0% | Unchanged |
| E Fund Management Co., Ltd. | 16,160 | $638.5K | 0.03% | −311−1.9% | Reduced |
| Bayesian Capital Management, LP | 16,600 | $655.9K | 0.10% | +8,100+95.3% | Added |
| North Star Asset Management Inc | 16,610 | $656.3K | 0.03% | +3,000+22.0% | Added |
| SummitTX Capital, L.P. | 17,149 | $677.6K | 0.03% | −17,954−51.1% | Reduced |
| Fieldview Capital Management, LLC | 17,306 | $683.8K | 0.10% | +17,306 | New |
| Quantinno Capital Management LP | 17,542 | $693.1K | 0.00% | +9,027+106.0% | Added |
| Assenagon Asset Management S.A. | 17,654 | $697.5K | 0.00% | +17,654 | New |
| Bleakley Financial Group, LLC | 18,129 | $716.3K | 0.02% | −4,155−18.6% | Reduced |
| Victory Capital Management Inc | 18,516 | $731.6K | 0.00% | −125−0.7% | Reduced |
| Nicollet Investment Management, Inc. | 20,747 | $820.0K | 0.27% | −704−3.3% | Reduced |
| Graham Capital Management, L.P. | 20,935 | $827.1K | 0.03% | +20,935 | New |
| Jefferies Financial Group Inc. | 22,381 | $884.3K | 0.01% | −460−2.0% | Reduced |
| Oxford Asset Management LLP | 22,405 | $885.2K | 0.29% | +22,405 | New |
| Xponance, Inc. | 22,754 | $899.0K | 0.01% | +2,435+12.0% | Added |
| Teachers Retirement System of the State of Kentucky | 24,083 | $952.0K | 0.01% | 00.0% | Unchanged |
| LPL Financial LLC | 24,872 | $982.7K | 0.00% | +906+3.8% | Added |
| Alpine Global Management, LLC | 25,437 | $1.01M | 0.23% | −2,660−9.5% | Reduced |