Ionis Pharmaceuticals Inc
IONS- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000874015
In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 4 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.
13F holders, Q4 2022
Institutional positions in Ionis Pharmaceuticals Inc as of Dec 31, 2022. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 339
- −4 vs. Q3 2022
- Shares held
- 130.6M
- +4.77M (+3.8%) vs. Q3 2022
- Total value
- $4.93B
- −$630.7M (−11.3%) vs. Q3 2022
- New holders
- 50
- 115 more added
- Sold out
- 54
- 107 more reduced
7 institutions that held it in Q3 2022 haven't filed for Q4 2022 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2022: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 515 | $14.3B |
| Q1 2026 | 497 | $13.0B |
| Q4 2025 | 494 | $13.5B |
| Q3 2025 | 437 | $11.0B |
| Q2 2025 | 363 | $6.67B |
| Q1 2025 | 344 | $5.03B |
| Q4 2024 | 356 | $5.61B |
| Q3 2024 | 354 | $6.31B |
| Q2 2024 | 357 | $6.83B |
| Q1 2024 | 361 | $6.17B |
| Q4 2023 | 365 | $7.21B |
| Q3 2023 | 312 | $6.35B |
| Q2 2023 | 305 | $5.60B |
| Q1 2023 | 315 | $4.69B |
| Q4 2022 | 339 | $4.93B |
| Q3 2022 | 350 | $5.59B |
| Q2 2022 | 351 | $4.61B |
| Q1 2022 | 333 | $4.63B |
| Q4 2021 | 341 | $3.75B |
| Q3 2021 | 326 | $4.08B |
| Q2 2021 | 338 | $4.96B |
| Q1 2021 | 365 | $5.55B |
Institutions, Q4 2022
Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q3 2022.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Janney Montgomery Scott LLC | 33,058 | $1.25M | 0.00% | +643+2.0% | Added |
| Magnetar Financial LLC | 34,597 | $1.31M | 0.02% | +34,597 | New |
| Envestnet Asset Management Inc | 35,429 | $1.34M | 0.00% | −3,835−9.8% | Reduced |
| Arizona State Retirement System | 36,047 | $1.36M | 0.01% | +1,367+3.9% | Added |
| Tudor Investment Corp Et Al | 36,365 | $1.37M | 0.03% | +15,256+72.3% | Added |
| Principal Financial Group Inc | 38,322 | $1.45M | 0.00% | −21,947−36.4% | Reduced |
| Teacher Retirement System of Texas | 38,378 | $1.45M | 0.01% | −3,466−8.3% | Reduced |
| Capital Counsel LLC | 40,230 | $1.52M | 0.10% | 00.0% | Unchanged |
| Highland Capital Management, LLC | 40,310 | $1.52M | 0.11% | +1,437+3.7% | Added |
| NJ State Employees Deferred Compensation Plan | 42,000 | $1.59M | 0.26% | 00.0% | Unchanged |
| SEI Investments Co | 45,941 | $1.74M | 0.00% | +26,812+140.2% | Added |
| Trexquant Investment LP | 46,945 | $1.77M | 0.05% | −8,619−15.5% | Reduced |
| Rhenman & Partners Asset Management AB | 50,000 | $1.89M | 0.20% | 00.0% | Unchanged |
| Intech Investment Management LLC | 50,510 | $1.91M | 0.01% | −6,630−11.6% | Reduced |
| Erste Asset Management GmbH | 51,300 | $1.92M | 0.04% | 00.0% | Unchanged |
| Gateway Investment Advisers LLC | 51,174 | $1.93M | 0.02% | +975+1.9% | Added |
| Duality Advisers, LP | 53,524 | $2.02M | 0.23% | +47,732+824.1% | Added |
| Janus Henderson Group PLC | 53,722 | $2.03M | 0.00% | +30,582+132.2% | Added |
| Bard Financial Services, Inc. | 53,925 | $2.04M | 0.17% | −33,970−38.6% | Reduced |
| Ensign Peak Advisors, Inc | 54,891 | $2.07M | 0.00% | +22,576+69.9% | Added |
| Susquehanna International Group, LLP | 57,872 | $2.19M | 0.00% | +17,002+41.6% | Added |
| Alliancebernstein L.P. | 58,504 | $2.21M | 0.00% | +402+0.7% | Added |
| National Bank of Canada | 60,895 | $2.30M | 0.01% | +9,175+17.7% | Added |
| Treasurer of the State of North Carolina | 61,302 | $2.31M | 0.01% | +780+1.3% | Added |
| Guggenheim Capital LLC | 62,159 | $2.35M | 0.02% | +7,190+13.1% | Added |
| Healthcare of Ontario Pension Plan Trust Fund | 63,000 | $2.38M | 0.01% | −29,700−32.0% | Reduced |
| Deutsche Bank AG | 66,625 | $2.52M | 0.00% | +1,199+1.8% | Added |
| Gotham Asset Management, LLC | 69,896 | $2.64M | 0.07% | +46,656+200.8% | Added |
| Voya Investment Management LLC | 70,277 | $2.65M | 0.00% | +20.0% | Added |
| PFS Investments Inc. | 72,125 | $2.72M | 0.05% | −3,077−4.1% | Reduced |
| Canada Pension Plan Investment Board | 72,900 | $2.75M | 0.00% | +72,900 | New |
| Algert Global LLC | 73,547 | $2.78M | 0.15% | +12,610+20.7% | Added |
| LPL Financial LLC | 74,099 | $2.80M | 0.00% | −641−0.9% | Reduced |
| Public Employees Retirement System of Ohio | 76,345 | $2.88M | 0.01% | +222+0.3% | Added |
| State of New Jersey Common Pension Fund D | 80,433 | $3.04M | 0.01% | 00.0% | Unchanged |
| Davenport & Co LLC | 80,617 | $3.04M | 0.03% | −4,246−5.0% | Reduced |
| Manufacturers Life Insurance Company, The | 82,523 | $3.08M | 0.00% | −6,573−7.4% | Reduced |
| Tekla Capital Management LLC | 87,840 | $3.32M | 0.13% | 00.0% | Unchanged |
| Susquehanna Fundamental Investments, LLC | 93,435 | $3.53M | 0.06% | −60,201−39.2% | Reduced |
| Public Sector Pension Investment Board | 98,000 | $3.70M | 0.03% | +98,000 | New |
| Alberta Investment Management Corp | 101,426 | $3.83M | 0.03% | +101,426 | New |
| Allianz Asset Management GmbH | 102,487 | $3.87M | 0.01% | +73,607+254.9% | Added |
| Eventide Asset Management, LLC | 110,000 | $4.15M | 0.08% | 00.0% | Unchanged |
| Millennium Management LLC | 115,506 | $4.36M | 0.00% | +96,577+510.2% | Added |
| M28 Capital Management LP | 126,300 | $4.77M | 4.55% | +126,300 | New |
| Legal & General Group Plc | 127,088 | $4.80M | 0.00% | −1,365−1.1% | Reduced |
| Cubist Systematic Strategies, LLC | 128,070 | $4.84M | 0.04% | +57,662+81.9% | Added |
| State of Wisconsin Investment Board | 128,227 | $4.84M | 0.02% | −1,627−1.3% | Reduced |
| Citigroup Inc | 129,129 | $4.88M | 0.01% | −47,863−27.0% | Reduced |
| Peregrine Capital Management LLC | 131,711 | $4.97M | 0.16% | +8,315+6.7% | Added |
| Kennedy Capital Management, Inc. | 139,181 | $5.26M | 0.15% | −5,614−3.9% | Reduced |
| New York State Common Retirement Fund | 140,500 | $5.31M | 0.01% | −2,400−1.7% | Reduced |
| Parkman Healthcare Partners LLC | 141,115 | $5.33M | 1.42% | −100,830−41.7% | Reduced |
| Sector Gamma AS | 141,373 | $5.34M | 1.22% | −22,850−13.9% | Reduced |
| Privium Fund Management B.V. | 148,807 | $5.56M | 2.11% | 00.0% | Unchanged |
| BLB&B Advisors, LLC | 148,960 | $5.63M | 0.44% | −110−0.1% | Reduced |
| DekaBank Deutsche Girozentrale | 153,000 | $5.70M | 0.02% | +28,224+22.6% | Added |
| State Board of Administration of Florida Retirement System | 155,145 | $5.86M | 0.01% | −8,110−5.0% | Reduced |
| Sonora Investment Management Group, LLC | 156,115 | $5.90M | 0.54% | −908−0.6% | Reduced |
| Natixis | 159,678 | $6.03M | 0.04% | +25,597+19.1% | Added |
| UBS Group AG | 161,471 | $6.10M | 0.00% | +100,161+163.4% | Added |
| Tocqueville Asset Management L.P. | 161,569 | $6.10M | 0.12% | −825−0.5% | Reduced |
| Rhumbline Advisers | 165,163 | $6.24M | 0.01% | +9,449+6.1% | Added |
| California State Teachers Retirement System | 167,875 | $6.34M | 0.01% | +1,950+1.2% | Added |
| UBS Asset Management Americas Inc | 175,796 | $6.64M | 0.00% | −103,828−37.1% | Reduced |
| Squarepoint Ops LLC | 181,007 | $6.84M | 0.05% | +88,953+96.6% | Added |
| Credit Suisse AG | 184,302 | $6.96M | 0.01% | +29,604+19.1% | Added |
| Russell Investments Group, Ltd. | 190,298 | $7.19M | 0.01% | +97,978+106.1% | Added |
| Fred Alger Management, LLC | 190,353 | $7.19M | 0.04% | +47,831+33.6% | Added |
| BNP Paribas Arbitrage, SA | 191,947 | $7.25M | 0.02% | +59,207+44.6% | Added |
| Jefferies Financial Group Inc. | 197,009 | $7.44M | 0.13% | +197,009 | New |
| Tang Capital Management LLC | 200,000 | $7.55M | 1.10% | 00.0% | Unchanged |
| Two Sigma Investments, LP | 201,267 | $7.60M | 0.02% | −91,727−31.3% | Reduced |
| Rafferty Asset Management, LLC | 218,979 | $8.27M | 0.07% | +67,005+44.1% | Added |
| Hudson Bay Capital Management LP | 225,000 | $8.50M | 0.10% | +25,200+12.6% | Added |
| Raymond James & Associates | 225,470 | $8.52M | 0.01% | −12,698−5.3% | Reduced |
| Man Group plc | 230,525 | $8.71M | 0.03% | +52,928+29.8% | Added |
| Connor, Clark & Lunn Investment Management Ltd. | 230,577 | $8.71M | 0.05% | +1,516+0.7% | Added |
| Eversept Partners, LP | 240,975 | $9.10M | 0.87% | +39,142+19.4% | Added |
| Bank of Montreal | 221,978 | $9.21M | 0.01% | −101,551−31.4% | Reduced |
| Sicart Associates LLC | 246,258 | $9.30M | 3.28% | −7,718−3.0% | Reduced |
| Schonfeld Strategic Advisors LLC | 265,798 | $10.0M | 0.08% | +58,126+28.0% | Added |
| Redmile Group, LLC | 266,187 | $10.1M | 0.41% | −141,472−34.7% | Reduced |
| Stifel Financial Corp | 269,744 | $10.2M | 0.02% | −30,269−10.1% | Reduced |
| D. E. Shaw & Co., Inc. | 299,231 | $11.3M | 0.02% | +89,786+42.9% | Added |
| CI Private Wealth, LLC | 302,677 | $11.4M | 0.04% | +302,677 | New |
| ExodusPoint Capital Management, LP | 304,390 | $11.5M | 0.18% | +297,973+4,643.5% | Added |
| Swiss National Bank | 308,400 | $11.6M | 0.01% | +5,800+1.9% | Added |
| Altrinsic Global Advisors LLC | 319,174 | $12.1M | 0.51% | +157,928+97.9% | Added |
| Invesco Ltd. | 322,447 | $12.2M | 0.00% | +27,248+9.2% | Added |
| Nuveen Asset Management, LLC | 323,178 | $12.2M | 0.00% | −16,106−4.7% | Reduced |
| California Public Employees Retirement System | 329,837 | $12.5M | 0.01% | +6,251+1.9% | Added |
| Qube Research & Technologies Ltd | 330,724 | $12.5M | 0.08% | +319,027+2,727.4% | Added |
| Baillie Gifford & Co | 333,788 | $12.6M | 0.01% | +8,946+2.8% | Added |
| Nikko Asset Management Americas, Inc. | 336,732 | $12.7M | 0.18% | −100,444−23.0% | Reduced |
| Sumitomo Mitsui Trust Holdings, Inc. | 336,732 | $12.7M | 0.01% | −100,444−23.0% | Reduced |
| Pictet Asset Management SA | 373,586 | $14.1M | 0.02% | +96,609+34.9% | Added |
| Citadel Advisors LLC | 395,546 | $14.9M | 0.02% | −22,686−5.4% | Reduced |
| Nomura Holdings Inc | 400,057 | $15.1M | 0.15% | +12,149+3.1% | Added |
| Assenagon Asset Management S.A. | 441,802 | $16.7M | 0.07% | −10,958−2.4% | Reduced |