Ionis Pharmaceuticals Inc
IONS- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000874015
In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 4 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.
13F holders, Q4 2021
Institutional positions in Ionis Pharmaceuticals Inc as of Dec 31, 2021. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 341
- +20 vs. Q3 2021
- Shares held
- 123.2M
- +1.71M (+1.4%) vs. Q3 2021
- Total value
- $3.75B
- −$326.3M (−8.0%) vs. Q3 2021
- New holders
- 59
- 106 more added
- Sold out
- 39
- 119 more reduced
5 institutions that held it in Q3 2021 haven't filed for Q4 2021 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2021: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 515 | $14.3B |
| Q1 2026 | 497 | $13.0B |
| Q4 2025 | 494 | $13.5B |
| Q3 2025 | 437 | $11.0B |
| Q2 2025 | 363 | $6.67B |
| Q1 2025 | 344 | $5.03B |
| Q4 2024 | 356 | $5.61B |
| Q3 2024 | 354 | $6.31B |
| Q2 2024 | 357 | $6.83B |
| Q1 2024 | 361 | $6.17B |
| Q4 2023 | 365 | $7.21B |
| Q3 2023 | 312 | $6.35B |
| Q2 2023 | 305 | $5.60B |
| Q1 2023 | 315 | $4.69B |
| Q4 2022 | 339 | $4.93B |
| Q3 2022 | 350 | $5.59B |
| Q2 2022 | 351 | $4.61B |
| Q1 2022 | 333 | $4.63B |
| Q4 2021 | 341 | $3.75B |
| Q3 2021 | 326 | $4.08B |
| Q2 2021 | 338 | $4.96B |
| Q1 2021 | 365 | $5.55B |
Institutions, Q4 2021
Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q3 2021.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Eaton Vance Management | 27,692 | $843.0K | 0.00% | +818+3.0% | Added |
| First Foundation Advisors | 27,972 | $851.0K | 0.03% | −7,774−21.7% | Reduced |
| Capital Fund Management S.A. | 28,108 | $855.3K | 0.02% | +28,108 | New |
| Ensign Peak Advisors, Inc | 28,330 | $862.0K | 0.00% | +28,330 | New |
| Commonwealth Equity Services, LLC | 28,766 | $875.0K | 0.00% | −9,352−24.5% | Reduced |
| Koss-Olinger Consulting, LLC | 29,161 | $887.0K | 0.14% | +17,729+155.1% | Added |
| Amalgamated Bank | 29,324 | $892.0K | 0.01% | +3,923+15.4% | Added |
| Truist Financial Corp | 30,937 | $941.0K | 0.00% | −40−0.1% | Reduced |
| Principal Financial Group Inc | 31,755 | $966.0K | 0.00% | −10,930−25.6% | Reduced |
| Employees Retirement System of Texas | 32,409 | $986.0K | 0.01% | 00.0% | Unchanged |
| Macquarie Group Ltd | 32,549 | $991.0K | 0.00% | +121+0.4% | Added |
| Trexquant Investment LP | 33,903 | $1.03M | 0.06% | +20,606+155.0% | Added |
| Healthcare of Ontario Pension Plan Trust Fund | 34,069 | $1.04M | 0.00% | +34,069 | New |
| Arizona State Retirement System | 34,190 | $1.04M | 0.01% | −367−1.1% | Reduced |
| Engineers Gate Manager LP | 34,380 | $1.05M | 0.05% | +17,708+106.2% | Added |
| Group One Trading, L.P. | 36,268 | $1.10M | 0.02% | +4,735+15.0% | Added |
| Janney Montgomery Scott LLC | 36,424 | $1.11M | 0.00% | +2,271+6.6% | Added |
| Algert Global LLC | 38,430 | $1.17M | 0.15% | +14,956+63.7% | Added |
| Capital Counsel LLC | 40,580 | $1.24M | 0.05% | 00.0% | Unchanged |
| Bard Financial Services, Inc. | 41,520 | $1.26M | 0.10% | +31,795+326.9% | Added |
| NJ State Employees Deferred Compensation Plan | 42,000 | $1.28M | 0.16% | 00.0% | Unchanged |
| Jefferies Group LLC | 44,000 | $1.34M | 0.02% | −137−0.3% | Reduced |
| Assenagon Asset Management S.A. | 48,401 | $1.47M | 0.01% | +42,379+703.7% | Added |
| Pura Vida Investments, LLC | 48,544 | $1.48M | 0.15% | +48,544 | New |
| Raymond James Financial Services Advisors, Inc. | 48,981 | $1.49M | 0.00% | +2,825+6.1% | Added |
| Alpha DNA Investment Management LLC | 50,614 | $1.54M | 0.98% | +50,614 | New |
| Treasurer of the State of North Carolina | 50,846 | $1.55M | 0.01% | +330+0.7% | Added |
| Erste Asset Management GmbH | 51,300 | $1.57M | 0.03% | 00.0% | Unchanged |
| Jane Street Group, LLC | 52,550 | $1.60M | 0.00% | −11,926−18.5% | Reduced |
| AlphaCrest Capital Management LLC | 52,907 | $1.61M | 0.06% | +823+1.6% | Added |
| Point72 Asset Management, L.P. | 53,981 | $1.64M | 0.01% | −165,319−75.4% | Reduced |
| Canada Pension Plan Investment Board | 57,924 | $1.76M | 0.00% | +57,924 | New |
| Squarepoint Ops LLC | 61,340 | $1.87M | 0.01% | −108,525−63.9% | Reduced |
| Voya Investment Management LLC | 65,508 | $1.99M | 0.00% | +22,808+53.4% | Added |
| PDT Partners, LLC | 67,697 | $2.06M | 0.16% | +67,697 | New |
| National Bank of Canada | 70,000 | $2.13M | 0.01% | +70,000 | New |
| Guggenheim Capital LLC | 72,978 | $2.22M | 0.01% | +10,341+16.5% | Added |
| Rhenman & Partners Asset Management AB | 75,000 | $2.29M | 0.15% | 00.0% | Unchanged |
| PFS Investments Inc. | 76,179 | $2.32M | 0.04% | −663−0.9% | Reduced |
| Parkman Healthcare Partners LLC | 80,238 | $2.44M | 0.55% | −56,142−41.2% | Reduced |
| Allianz Asset Management GmbH | 81,830 | $2.49M | 0.00% | +62,120+315.2% | Added |
| Davenport & Co LLC | 84,663 | $2.58M | 0.02% | −37,640−30.8% | Reduced |
| Public Employees Retirement System of Ohio | 84,661 | $2.58M | 0.01% | −2,783−3.2% | Reduced |
| Gateway Investment Advisers LLC | 85,103 | $2.59M | 0.02% | +46,971+123.2% | Added |
| AXA S.A. | 87,900 | $2.67M | 0.01% | +30,700+53.7% | Added |
| LPL Financial LLC | 88,666 | $2.70M | 0.00% | +5,051+6.0% | Added |
| Envestnet Asset Management Inc | 91,292 | $2.78M | 0.00% | −11,130−10.9% | Reduced |
| State of New Jersey Common Pension Fund D | 95,234 | $2.90M | 0.01% | +8,018+9.2% | Added |
| Allspring Global Investments Holdings, LLC | 98,574 | $3.00M | 0.00% | +98,574 | New |
| Alliancebernstein L.P. | 103,214 | $3.14M | 0.00% | +34,763+50.8% | Added |
| Wolverine Trading, LLC | 108,529 | $3.31M | 0.04% | +1,651+1.5% | Added |
| DekaBank Deutsche Girozentrale | 109,476 | $3.35M | 0.01% | +1,900+1.8% | Added |
| Connor, Clark & Lunn Investment Management Ltd. | 112,525 | $3.42M | 0.02% | +76,989+216.7% | Added |
| Private Advisor Group, LLC | 115,742 | $3.52M | 0.03% | +71,637+162.4% | Added |
| Jump Financial, LLC | 120,500 | $3.67M | 0.23% | +120,500 | New |
| Invesco Ltd. | 132,242 | $4.02M | 0.00% | −9,113−6.4% | Reduced |
| Peregrine Capital Management LLC | 139,721 | $4.25M | 0.09% | +3,934+2.9% | Added |
| Rhumbline Advisers | 139,749 | $4.25M | 0.01% | +1,386+1.0% | Added |
| BLB&B Advisors, LLC | 150,935 | $4.59M | 0.30% | −5,265−3.4% | Reduced |
| New York State Common Retirement Fund | 153,800 | $4.68M | 0.00% | −87,359−36.2% | Reduced |
| Sonora Investment Management Group, LLC | 156,790 | $4.77M | 0.55% | +156,790 | New |
| Legal & General Group Plc | 158,344 | $4.82M | 0.00% | −9,077−5.4% | Reduced |
| D. E. Shaw & Co., Inc. | 160,659 | $4.89M | 0.01% | +34,553+27.4% | Added |
| Alps Advisors Inc | 163,424 | $4.97M | 0.06% | +163,424 | New |
| Tocqueville Asset Management L.P. | 170,405 | $5.18M | 0.07% | +1,875+1.1% | Added |
| State Board of Administration of Florida Retirement System | 173,260 | $5.27M | 0.01% | +11,322+7.0% | Added |
| Tekla Capital Management LLC | 175,680 | $5.35M | 0.17% | −146,841−45.5% | Reduced |
| Majedie Asset Management Ltd | 175,508 | $5.35M | 0.41% | 00.0% | Unchanged |
| Credit Suisse AG | 176,767 | $5.38M | 0.00% | −5,895−3.2% | Reduced |
| Tudor Investment Corp Et Al | 178,386 | $5.43M | 0.10% | −23,227−11.5% | Reduced |
| Pictet Asset Management SA | 183,087 | $5.57M | 0.01% | +47,391+34.9% | Added |
| UBS Asset Management Americas Inc | 183,752 | $5.59M | 0.00% | +3,087+1.7% | Added |
| California State Teachers Retirement System | 184,004 | $5.60M | 0.01% | −41,987−18.6% | Reduced |
| Citigroup Inc | 186,047 | $5.66M | 0.01% | +64,983+53.7% | Added |
| Rafferty Asset Management, LLC | 189,639 | $5.77M | 0.03% | +92,902+96.0% | Added |
| Balyasny Asset Management LLC | 193,120 | $5.88M | 0.03% | +51,105+36.0% | Added |
| UBS Group AG | 193,589 | $5.89M | 0.00% | +60,777+45.8% | Added |
| Russell Investments Group, Ltd. | 194,145 | $5.91M | 0.01% | −37,720−16.3% | Reduced |
| MUFG Securities EMEA plc | 200,000 | $6.09M | 0.13% | +200,000 | New |
| Susquehanna International Group, LLP | 204,255 | $6.21M | 0.01% | +30,089+17.3% | Added |
| Sector Gamma AS | 209,537 | $6.38M | 1.50% | −54,333−20.6% | Reduced |
| Morningstar Investment Services LLC | 219,432 | $6.68M | 0.07% | +5,291+2.5% | Added |
| Parametric Portfolio Associates LLC | 225,106 | $6.85M | 0.00% | −6,400−2.8% | Reduced |
| Renaissance Technologies LLC | 230,814 | $7.02M | 0.01% | +133,100+136.2% | Added |
| Bank of Montreal | 229,407 | $7.17M | 0.00% | −20,297−8.1% | Reduced |
| Raymond James & Associates | 257,985 | $7.85M | 0.01% | −43,464−14.4% | Reduced |
| Voloridge Investment Management, LLC | 266,845 | $8.12M | 0.04% | +266,845 | New |
| Swiss National Bank | 279,300 | $8.50M | 0.01% | −600−0.2% | Reduced |
| Sicart Associates LLC | 282,531 | $8.63M | 2.25% | −8,723−3.0% | Reduced |
| California Public Employees Retirement System | 284,424 | $8.65M | 0.01% | −3,704−1.3% | Reduced |
| Cubist Systematic Strategies, LLC | 297,182 | $9.04M | 0.09% | +210,428+242.6% | Added |
| Natixis | 300,797 | $9.15M | 0.03% | +300,797 | New |
| Dowling & Yahnke LLC | 302,421 | $9.20M | 0.44% | −1000.0% | Reduced |
| Hudson Bay Capital Management LP | 305,000 | $9.28M | 0.10% | +40,000+15.1% | Added |
| BNP Paribas Arbitrage, SA | 306,253 | $9.32M | 0.02% | +280,521+1,090.2% | Added |
| Baillie Gifford & Co | 315,820 | $9.61M | 0.01% | +13,817+4.6% | Added |
| Sio Capital Management, LLC | 322,566 | $9.82M | 2.99% | +322,566 | New |
| Barclays PLC | 329,938 | $10.0M | 0.01% | −353−0.1% | Reduced |
| Nuveen Asset Management, LLC | 351,476 | $10.7M | 0.00% | −277,000−44.1% | Reduced |
| International Biotechnology Trust PLC | 355,088 | $10.8M | 2.41% | +310,307+692.9% | Added |