Denali Therapeutics Inc.
DNLI- Exchange
- Nasdaq
- Industry
- Biological Products, (No Diagnostic Substances)
- SEC CIK
- 0001714899
In the last 90 days, Denali Therapeutics Inc. insiders filed 0 open-market purchases and 4 sales; 294 institutions reported holding it in 13F filings for Q2 2026, worth $4.00B in total; no superinvestor holds it.
13F holders, Q1 2026
Institutional positions in Denali Therapeutics Inc. as of Mar 31, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 269
- +25 vs. Q4 2025
- Shares held
- 147.4M
- +14.8M (+11.2%) vs. Q4 2025
- Total value
- $2.82B
- +$631.6M (+28.8%) vs. Q4 2025
- New holders
- 55
- 104 more added
- Sold out
- 30
- 58 more reduced
6 institutions that held it in Q4 2025 haven't filed for Q1 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting DNLI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 294 | $4.00B |
| Q1 2026 | 269 | $2.82B |
| Q4 2025 | 250 | $2.50B |
| Q3 2025 | 240 | $1.97B |
| Q2 2025 | 231 | $1.93B |
| Q1 2025 | 222 | $1.85B |
| Q4 2024 | 224 | $2.61B |
| Q3 2024 | 217 | $3.69B |
| Q2 2024 | 203 | $2.88B |
| Q1 2024 | 211 | $2.51B |
| Q4 2023 | 209 | $2.47B |
| Q3 2023 | 195 | $2.24B |
| Q2 2023 | 203 | $3.18B |
| Q1 2023 | 202 | $2.49B |
| Q4 2022 | 199 | $2.94B |
| Q3 2022 | 200 | $2.84B |
| Q2 2022 | 188 | $2.73B |
| Q1 2022 | 190 | $2.79B |
| Q4 2021 | 213 | $3.80B |
| Q3 2021 | 214 | $4.28B |
| Q2 2021 | 210 | $6.32B |
| Q1 2021 | 218 | $4.60B |
Institutions, Q1 2026
Shares, value and share of portfolio for each institution holding Denali Therapeutics Inc.; share changes are against Q4 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Winton Group Ltd | 71,179 | $1.37M | 0.05% | +58,479+460.5% | Added |
| Profund Advisors LLC | 68,227 | $1.31M | 0.05% | −3,407−4.8% | Reduced |
| 1492 Capital Management LLC | 67,417 | $1.29M | 0.49% | −70−0.1% | Reduced |
| Polen Capital Management LLC | 65,301 | $1.25M | 0.01% | +38,401+142.8% | Added |
| Pier 88 Investment Partners LLC | 64,800 | $1.24M | 0.32% | −3,400−5.0% | Reduced |
| DekaBank Deutsche Girozentrale | 59,800 | $1.15M | 0.00% | 00.0% | Unchanged |
| Janus Henderson Group PLC | 60,028 | $1.15M | 0.00% | 00.0% | Unchanged |
| Vanguard Global Advisers, LLC | 58,779 | $1.13M | 0.00% | +58,779 | New |
| Knights of Columbus Asset Advisors LLC | 56,329 | $1.08M | 0.06% | +7,322+14.9% | Added |
| Pathstone Holdings, LLC | 56,325 | $1.08M | 0.00% | +4,901+9.5% | Added |
| Wellington Management Group LLP | 53,363 | $1.02M | 0.00% | −1,180−2.2% | Reduced |
| SEI Investments Co | 52,235 | $1.00M | 0.00% | +52,235 | New |
| Barclays PLC | 52,084 | $1.00M | 0.00% | −355,275−87.2% | Reduced |
| Ironwood Investment Management LLC | 52,062 | $999.6K | 0.42% | +1,129+2.2% | Added |
| Dana Investment Advisors, Inc. | 51,922 | $996.9K | 0.03% | +1,340+2.6% | Added |
| Envestnet Asset Management Inc | 50,900 | $977.3K | 0.00% | +12,231+31.6% | Added |
| Susquehanna International Group, LLP | 50,475 | $969.1K | 0.00% | +15,707+45.2% | Added |
| Franklin Resources Inc | 48,732 | $935.7K | 0.00% | −11,538−19.1% | Reduced |
| State of New Jersey Common Pension Fund D | 47,471 | $911.4K | 0.00% | +61+0.1% | Added |
| Employees Retirement System of Texas | 47,177 | $906.0K | 0.01% | 00.0% | Unchanged |
| SG Americas Securities, LLC | 46,642 | $896.0K | 0.00% | −102,950−68.8% | Reduced |
| MAI Capital Management | 46,590 | $894.5K | 0.01% | +64+0.1% | Added |
| Handelsbanken Fonder AB | 43,800 | $841.0K | 0.00% | 00.0% | Unchanged |
| Virtu Financial LLC | 43,362 | $833.0K | 0.03% | +43,362 | New |
| China Universal Asset Management Co., Ltd. | 40,643 | $780.3K | 0.06% | +16,745+70.1% | Added |
| BNP Paribas Arbitrage, SA | 39,893 | $765.9K | 0.00% | +24,396+157.4% | Added |
| Citigroup Inc | 39,278 | $754.1K | 0.00% | +8,333+26.9% | Added |
| Intech Investment Management LLC | 38,931 | $747.5K | 0.01% | −13,701−26.0% | Reduced |
| Police & Firemen's Retirement System of New Jersey | 38,545 | $740.1K | 0.01% | +1,938+5.3% | Added |
| Arizona State Retirement System | 38,153 | $732.5K | 0.00% | −492−1.3% | Reduced |
| Vanguard Investments Australia, Ltd. | 37,410 | $718.3K | 0.00% | +37,410 | New |
| Nomura Asset Management Co Ltd | 36,732 | $705.3K | 0.00% | +36,732 | New |
| Seven Fleet Capital Management LP | 35,286 | $677.5K | 0.21% | +35,286 | New |
| Jefferies Financial Group Inc. | 34,425 | $661.0K | 0.01% | +34,425 | New |
| Raymond James Financial Inc | 34,383 | $660.2K | 0.00% | +8,791+34.4% | Added |
| State Board of Administration of Florida Retirement System | 34,168 | $656.0K | 0.00% | 00.0% | Unchanged |
| Thrivent Financial for Lutherans | 32,555 | $626.0K | 0.00% | 00.0% | Unchanged |
| Jane Street Group, LLC | 32,147 | $617.2K | 0.00% | −10,775−25.1% | Reduced |
| KLP Kapitalforvaltning AS | 30,900 | $593.3K | 0.00% | +1,000+3.3% | Added |
| Prudential Financial Inc | 30,570 | $586.9K | 0.00% | +30,570 | New |
| Quantinno Capital Management LP | 30,170 | $579.3K | 0.00% | +3,857+14.7% | Added |
| SBI Okasan Asset Management Co.Ltd. | 29,500 | $533.4K | 0.02% | +11,500+63.9% | Added |
| ProShare Advisors LLC | 27,737 | $532.5K | 0.00% | −2,945−9.6% | Reduced |
| Rockefeller Capital Management L.P. | 25,935 | $498.0K | 0.00% | +24,670+1,950.2% | Added |
| Erste Asset Management GmbH | 26,900 | $486.4K | 0.00% | 00.0% | Unchanged |
| Voya Investment Management LLC | 23,672 | $454.5K | 0.00% | −133−0.6% | Reduced |
| Twinbeech Capital LP | 23,000 | $441.6K | 0.05% | +23,000 | New |
| Tower Research Capital LLC (TRC) | 20,978 | $402.8K | 0.01% | +8,037+62.1% | Added |
| E Fund Management Co., Ltd. | 18,942 | $363.7K | 0.01% | +18,942 | New |
| Amundi | 18,604 | $357.2K | 0.00% | +18,604 | New |
| Martingale Asset Management L P | 18,535 | $355.9K | 0.01% | 00.0% | Unchanged |
| Mariner, LLC | 18,131 | $348.1K | 0.00% | +18,131 | New |
| Teacher Retirement System of Texas | 17,882 | $343.3K | 0.00% | −2,658−12.9% | Reduced |
| Bellevue Group AG | 17,766 | $341.1K | 0.01% | +10,628+148.9% | Added |
| Advisor Group Holdings, Inc. | 16,413 | $315.1K | 0.00% | +15,339+1,428.2% | Added |
| Victory Capital Management Inc | 16,194 | $310.9K | 0.00% | +1,130+7.5% | Added |
| Engineers Gate Manager LP | 16,110 | $309.3K | 0.00% | +16,110 | New |
| Caitong International Asset Management Co., Ltd | 15,861 | $304.5K | 0.06% | +15,861 | New |
| Empowered Funds, LLC | 15,787 | $303.1K | 0.00% | +4,462+39.4% | Added |
| Breakwater Capital Group | 15,586 | $299.3K | 0.04% | −780−4.8% | Reduced |
| Virtus Investment Advisers, Inc. | 15,166 | $291.2K | 0.08% | +371+2.5% | Added |
| Contravisory Investment Management, Inc. | 14,451 | $277.5K | 0.06% | +14,451 | New |
| Intrust Bank NA | 14,339 | $275.3K | 0.02% | +3,175+28.4% | Added |
| Russell Investments Group, Ltd. | 14,058 | $269.9K | 0.00% | +591+4.4% | Added |
| Guggenheim Capital LLC | 13,825 | $265.4K | 0.00% | +1,357+10.9% | Added |
| Great West Life Assurance Co | 13,434 | $259.0K | 0.00% | 00.0% | Unchanged |
| Xponance, Inc. | 13,240 | $254.2K | 0.00% | +2,743+26.1% | Added |
| Perbak Capital Partners LLP | 13,175 | $253.0K | 0.06% | +564+4.5% | Added |
| Capstone Investment Advisors, LLC | 12,963 | $248.9K | 0.00% | −25,849−66.6% | Reduced |
| Cerity Partners LLC | 12,658 | $243.0K | 0.00% | +12,658 | New |
| Simplex Trading, LLC | 12,315 | $236.4K | 0.01% | +12,315 | New |
| LPL Financial LLC | 12,274 | $235.7K | 0.00% | +1,770+16.9% | Added |
| Public Employees Retirement Association of Colorado | 12,238 | $235.0K | 0.00% | 00.0% | Unchanged |
| Atria Investments LLC | 12,112 | $232.6K | 0.00% | +12,112 | New |
| HighTower Advisors, LLC | 11,971 | $229.8K | 0.00% | +214+1.8% | Added |
| Ameritas Investment Partners, Inc. | 11,654 | $223.8K | 0.01% | +589+5.3% | Added |
| JustInvest LLC | 11,622 | $223.1K | 0.00% | −114−1.0% | Reduced |
| National Asset Management, Inc. | 12,213 | $220.8K | 0.01% | +12,213 | New |
| Pinnacle Wealth Planning Services, Inc. | 11,406 | $219.0K | 0.02% | +8,449+285.7% | Added |
| Cetera Investment Advisers | 11,059 | $212.3K | 0.00% | +11,059 | New |
| DnB Asset Management AS | 10,959 | $210.4K | 0.00% | +10,959 | New |
| Gilbert & Cook, Inc. | 10,871 | $208.7K | 0.03% | +10,871 | New |
| Headlands Technologies LLC | 10,557 | $202.7K | 0.02% | −35,826−77.2% | Reduced |
| The PNC Financial Services Group, Inc. | 9,220 | $177.0K | 0.00% | +739+8.7% | Added |
| Mirae Asset Global Investments Co., Ltd. | 8,272 | $158.8K | 0.00% | +1,145+16.1% | Added |
| NBC Securities, Inc. | 7,617 | $146.2K | 0.01% | +1,081+16.5% | Added |
| Royal Bank of Canada | 7,535 | $145.0K | 0.00% | −3,800−33.5% | Reduced |
| Assetmark, Inc | 5,199 | $99.8K | 0.00% | +12+0.2% | Added |
| KBC Group NV | 4,943 | $95.0K | 0.00% | −1,325−21.1% | Reduced |
| Eurizon Capital SGR S.p.A. | 5,045 | $91.7K | 0.00% | 00.0% | Unchanged |
| CWM, LLC | 4,651 | $89.3K | 0.00% | +2,045+78.5% | Added |
| Sterling Capital Management LLC | 4,493 | $86.3K | 0.00% | −2,745−37.9% | Reduced |
| GF Fund Management Co. Ltd. | 3,294 | $63.2K | 0.00% | +413+14.3% | Added |
| Fifth Third Bancorp | 2,847 | $54.7K | 0.00% | +2,847 | New |
| Nisa Investment Advisors, LLC | 2,424 | $46.5K | 0.00% | +975+67.3% | Added |
| Versant Capital Management, Inc | 1,476 | $28.3K | 0.00% | 00.0% | Unchanged |
| Bartlett & Co. Wealth Management LLC | 1,500 | $28.0K | 0.00% | 00.0% | Unchanged |
| GAMMA Investing LLC | 1,428 | $27.4K | 0.00% | +466+48.4% | Added |
| Kemnay Advisory Services Inc. | 1,134 | $21.8K | 0.00% | +1,134 | New |
| Smartleaf Asset Management LLC | 1,107 | $20.0K | 0.00% | −206−15.7% | Reduced |