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Denali Therapeutics Inc.

DNLI
Exchange
Nasdaq
Industry
Biological Products, (No Diagnostic Substances)
SEC CIK
0001714899

In the last 90 days, Denali Therapeutics Inc. insiders filed 0 open-market purchases and 4 sales; 294 institutions reported holding it in 13F filings for Q2 2026, worth $4.00B in total; no superinvestor holds it.

13F holders, Q3 2023

Institutional positions in Denali Therapeutics Inc. as of Sep 30, 2023. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
195
−6 vs. Q2 2023
Shares held
108.6M
+2.04M (+1.9%) vs. Q2 2023
Total value
$2.24B
−$898.3M (−28.6%) vs. Q2 2023
New holders
29
77 more added
Sold out
35
57 more reduced

2 institutions that held it in Q2 2023 haven't filed for Q3 2023 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.

Compare with Q2 2023: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting DNLI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ3 2023: 195 institutions
Q1 2021: 218 institutionsQ2 2021: 210 institutionsQ3 2021: 214 institutionsQ4 2021: 213 institutionsQ1 2022: 190 institutionsQ2 2022: 188 institutionsQ3 2022: 200 institutionsQ4 2022: 199 institutionsQ1 2023: 202 institutionsQ2 2023: 203 institutionsQ3 2023: 195 institutionsQ4 2023: 209 institutionsQ1 2024: 211 institutionsQ2 2024: 203 institutionsQ3 2024: 217 institutionsQ4 2024: 224 institutionsQ1 2025: 222 institutionsQ2 2025: 231 institutionsQ3 2025: 240 institutionsQ4 2025: 250 institutionsQ1 2026: 269 institutionsQ2 2026: 294 institutions
Value heldQ3 2023: $2.24B
Q1 2021: $4.60BQ2 2021: $6.32BQ3 2021: $4.28BQ4 2021: $3.80BQ1 2022: $2.79BQ2 2022: $2.73BQ3 2022: $2.84BQ4 2022: $2.94BQ1 2023: $2.49BQ2 2023: $3.18BQ3 2023: $2.24BQ4 2023: $2.47BQ1 2024: $2.51BQ2 2024: $2.88BQ3 2024: $3.69BQ4 2024: $2.61BQ1 2025: $1.85BQ2 2025: $1.93BQ3 2025: $1.97BQ4 2025: $2.50BQ1 2026: $2.82BQ2 2026: $4.00B
Institutions holding DNLI and their total value by quarter
QuarterHoldersValue
Q2 2026294$4.00B
Q1 2026269$2.82B
Q4 2025250$2.50B
Q3 2025240$1.97B
Q2 2025231$1.93B
Q1 2025222$1.85B
Q4 2024224$2.61B
Q3 2024217$3.69B
Q2 2024203$2.88B
Q1 2024211$2.51B
Q4 2023209$2.47B
Q3 2023195$2.24B
Q2 2023203$3.18B
Q1 2023202$2.49B
Q4 2022199$2.94B
Q3 2022200$2.84B
Q2 2022188$2.73B
Q1 2022190$2.79B
Q4 2021213$3.80B
Q3 2021214$4.28B
Q2 2021210$6.32B
Q1 2021218$4.60B

Institutions, Q3 2023

Shares, value and share of portfolio for each institution holding Denali Therapeutics Inc.; share changes are against Q2 2023.

Institutions holding DNLI in Q3 2023
InstitutionSharesValue% of portfolioChange in sharesAction
Baillie Gifford & Co14,681,027$302.9M0.28%−162,743−1.1%Reduced
BlackRock Inc.10,885,296$224.6M0.01%+779,021+7.7%Added
Vanguard Group Inc10,597,781$218.6M0.01%+354,798+3.5%Added
Wellington Management Group LLP7,288,960$150.4M0.03%+250,784+3.6%Added
Temasek Holdings (Private) Ltd6,895,992$142.3M0.85%00.0%Unchanged
Crestline Management, LP5,960,732$123.0M14.69%−150,000−2.5%Reduced
State Street Corp4,275,328$88.2M0.00%−193,163−4.3%Reduced
Price T Rowe Associates Inc2,891,950$59.7M0.01%−553,362−16.1%Reduced
Capital Research Global Investors2,880,323$59.4M0.02%+42,671+1.5%Added
Flagship Pioneering Inc.2,619,968$54.0M3.92%00.0%Unchanged
Geode Capital Management, LLC2,531,835$52.2M0.01%+213,538+9.2%Added
Baker Bros. Advisors LP2,292,003$47.3M0.27%+836,681+57.5%Added
Bank of New York Mellon Corp1,963,688$40.5M0.01%−26,019−1.3%Reduced
Credit Suisse AG1,567,309$32.3M0.03%−5,739−0.4%Reduced
Federated Hermes, Inc.1,351,900$27.9M0.07%+288,400+27.1%Added
Casdin Capital, LLC1,300,000$26.8M2.99%00.0%Unchanged
Gilder Gagnon Howe & Co LLC1,246,199$25.7M0.39%−333,746−21.1%Reduced
Yiheng Capital Management, L.P.1,150,684$23.7M2.14%00.0%Unchanged
Northern Trust Corp1,116,742$23.0M0.00%+27,044+2.5%Added
FMR LLC1,058,497$21.8M0.00%−21,360−2.0%Reduced
Polar Capital Holdings Plc1,007,086$20.8M0.15%00.0%Unchanged
Morgan Stanley981,569$20.2M0.00%−95,317−8.9%Reduced
Charles Schwab Investment Management Inc981,059$20.2M0.01%+113,428+13.1%Added
Dimensional Fund Advisors LP973,234$20.1M0.01%+218,433+28.9%Added
Woodline Partners LP851,489$17.6M0.21%+739,277+658.8%Added
Norges Bank803,892$16.6M0.00%+223,558+38.5%Added
Artal Group S.A.802,899$16.6M0.72%00.0%Unchanged
ARCH Venture Management, LLC693,749$14.3M9.30%00.0%Unchanged
Principal Financial Group Inc680,078$14.0M0.01%−6,414−0.9%Reduced
T. Rowe Price Investment Management, Inc.647,013$13.3M0.01%00.0%Unchanged
UBS Asset Management Americas Inc643,300$13.3M0.01%+76,159+13.4%Added
Cercano Management LLC625,000$12.9M0.46%00.0%Unchanged
Eventide Asset Management, LLC621,850$12.8M0.23%+308,443+98.4%Added
Deerfield Management Company, L.P. (Series C)594,989$12.3M0.27%00.0%Unchanged
Pictet Asset Management Holding SA589,499$12.2M0.02%+589,499New
American Century Companies Inc474,336$9.79M0.01%+427+0.1%Added
Renaissance Technologies LLC467,851$9.65M0.02%+510.0%Added
Man Group plc–$8.74M0.03%––
Goldman Sachs Group Inc407,393$8.40M0.00%−237,521−36.8%Reduced
Artisan Partners Limited Partnership406,622$8.39M0.01%−10,161−2.4%Reduced
Clarius Group, LLC378,262$7.80M0.74%−50.0%Reduced
Nuveen Asset Management, LLC363,665$7.50M0.00%−1,791−0.5%Reduced
Candriam Luxembourg S.C.A.357,878$7.38M0.06%00.0%Unchanged
AXA S.A.354,529$7.31M0.03%−3,853−1.1%Reduced
Ensign Peak Advisors, Inc348,497$7.19M0.02%+200,000+134.7%Added
Skandinaviska Enskilda Banken AB (publ)348,203$7.18M0.05%00.0%Unchanged
Wasatch Advisors Inc321,467$6.63M0.04%−510,830−61.4%Reduced
Bank of America Corp295,794$6.10M0.00%+25,549+9.5%Added
Mitsubishi UFJ Trust & Banking Corp290,960$6.00M0.02%+1,380+0.5%Added
Eagle Asset Management Inc289,133$5.96M0.04%−5,658−1.9%Reduced
Voya Investment Management LLC264,616$5.46M0.01%+1,109+0.4%Added
Sectoral Asset Management Inc254,941$5.26M1.02%+9,650+3.9%Added
Swiss National Bank240,800$4.97M0.00%+2,700+1.1%Added
Rafferty Asset Management, LLC229,313$4.73M0.03%−19,213−7.7%Reduced
Teachers Retirement System of the State of Kentucky218,194$4.50M0.05%−1,254−0.6%Reduced
California Public Employees Retirement System176,131$3.63M0.00%00.0%Unchanged
Rhumbline Advisers169,124$3.49M0.00%+7,142+4.4%Added
JPMorgan Chase & Co167,964$3.47M0.00%+9,972+6.3%Added
Barclays PLC166,507$3.44M0.00%+8,045+5.1%Added
BNP Paribas Arbitrage, SA162,826$3.36M0.01%+55,344+51.5%Added
Prudential Financial Inc153,828$3.17M0.00%+29,506+23.7%Added
International Biotechnology Trust PLC154,000$3.17M1.07%−34,000−18.1%Reduced
TCW Group Inc141,924$2.93M0.04%+51,953+57.7%Added
Citigroup Inc138,309$2.85M0.00%+30,282+28.0%Added
Alliancebernstein L.P.136,760$2.82M0.00%−41,960−23.5%Reduced
Wells Fargo & Company135,926$2.80M0.00%−26,628−16.4%Reduced
TD Asset Management Inc135,000$2.79M0.00%+50,578+59.9%Added
New York State Common Retirement Fund129,853$2.68M0.00%+3,954+3.1%Added
Pier Capital, LLC125,080$2.58M0.42%−2,048−1.6%Reduced
California State Teachers Retirement System122,904$2.54M0.00%−12,611−9.3%Reduced
Millennium Management LLC118,351$2.44M0.00%−359,835−75.3%Reduced
Deutsche Bank AG116,498$2.40M0.00%−28,379−19.6%Reduced
Russell Investments Group, Ltd.114,058$2.35M0.00%+7,244+6.8%Added
Manufacturers Life Insurance Company, The113,398$2.34M0.00%−5,551−4.7%Reduced
Squarepoint Ops LLC110,069$2.27M0.01%+110,069New
UBS Group AG109,696$2.26M0.00%−22,244−16.9%Reduced
State of New Jersey Common Pension Fund D107,089$2.21M0.01%+28,836+36.8%Added
Legal & General Group Plc105,825$2.18M0.00%+933+0.9%Added
Alps Advisors Inc101,400$2.09M0.02%+780+0.8%Added
Edmond de Rothschild Holding S.A.99,880$2.06M0.04%00.0%Unchanged
State of Wisconsin Investment Board97,856$2.02M0.01%−733−0.7%Reduced
Susquehanna International Group, LLP93,803$1.94M0.00%−23,789−20.2%Reduced
Invesco Ltd.88,353$1.82M0.00%−4,568−4.9%Reduced
Susquehanna Fundamental Investments, LLC81,308$1.68M0.11%−9,941−10.9%Reduced
Northwest & Ethical Investments L.P.74,768$1.54M0.05%00.0%Unchanged
Mirae Asset Global Investments Co., Ltd.69,674$1.44M0.00%−40.0%Reduced
AIA Group Ltd68,447$1.41M0.07%+12,203+21.7%Added
DekaBank Deutsche Girozentrale64,210$1.35M0.00%+4,410+7.4%Added
MetLife Investment Management62,264$1.28M0.01%00.0%Unchanged
Citadel Advisors LLC61,905$1.28M0.00%+5,802+10.3%Added
Franklin Resources Inc59,351$1.22M0.00%+59,351New
American International Group, Inc.58,962$1.22M0.01%+2,096+3.7%Added
UBS Oconnor LLC58,952$1.22M0.02%+10,000+20.4%Added
Guggenheim Capital LLC57,370$1.18M0.01%+3,584+6.7%Added
HighTower Advisors, LLC54,332$1.13M0.00%−185−0.3%Reduced
Janus Henderson Group PLC52,767$1.09M0.00%+130.0%Added
Harbor Capital Advisors, Inc.52,279$1.08M0.23%+14,155+37.1%Added
Pier 88 Investment Partners LLC50,700$1.05M0.26%+3,020+6.3%Added
Bamco Inc50,500$1.04M0.00%00.0%Unchanged
Los Angeles Capital Management LLC46,002$949.0K0.00%+1,046+2.3%Added