Denali Therapeutics Inc.
DNLI- Exchange
- Nasdaq
- Industry
- Biological Products, (No Diagnostic Substances)
- SEC CIK
- 0001714899
In the last 90 days, Denali Therapeutics Inc. insiders filed 0 open-market purchases and 4 sales; 294 institutions reported holding it in 13F filings for Q2 2026, worth $4.00B in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in Denali Therapeutics Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 250
- +17 vs. Q3 2025
- Shares held
- 151.1M
- +16.2M (+12.0%) vs. Q3 2025
- Total value
- $2.50B
- +$536.1M (+27.4%) vs. Q3 2025
- New holders
- 51
- 86 more added
- Sold out
- 34
- 71 more reduced
7 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting DNLI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 294 | $4.00B |
| Q1 2026 | 269 | $2.82B |
| Q4 2025 | 250 | $2.50B |
| Q3 2025 | 240 | $1.97B |
| Q2 2025 | 231 | $1.93B |
| Q1 2025 | 222 | $1.85B |
| Q4 2024 | 224 | $2.61B |
| Q3 2024 | 217 | $3.69B |
| Q2 2024 | 203 | $2.88B |
| Q1 2024 | 211 | $2.51B |
| Q4 2023 | 209 | $2.47B |
| Q3 2023 | 195 | $2.24B |
| Q2 2023 | 203 | $3.18B |
| Q1 2023 | 202 | $2.49B |
| Q4 2022 | 199 | $2.94B |
| Q3 2022 | 200 | $2.84B |
| Q2 2022 | 188 | $2.73B |
| Q1 2022 | 190 | $2.79B |
| Q4 2021 | 213 | $3.80B |
| Q3 2021 | 214 | $4.28B |
| Q2 2021 | 210 | $6.32B |
| Q1 2021 | 218 | $4.60B |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Denali Therapeutics Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Vanguard Group Inc | 13,057,890 | $215.6M | 0.00% | +1,064,972+8.9% | Added |
| BlackRock, Inc. | 12,715,201 | $209.9M | 0.00% | +425,575+3.5% | Added |
| Baillie Gifford & Co | 12,310,889 | $203.3M | 0.17% | +719,304+6.2% | Added |
| T. Rowe Price Investment Management, Inc. | 7,254,132 | $119.8M | 0.08% | +1,615,565+28.7% | Added |
| Temasek Holdings (Private) Ltd | 7,012,974 | $115.8M | 0.37% | +1,657,142+30.9% | Added |
| State Street Corp | 6,263,371 | $103.4M | 0.00% | +799,110+14.6% | Added |
| FMR LLC | 6,097,211 | $100.7M | 0.01% | −243,105−3.8% | Reduced |
| Norges Bank | 5,119,622 | $84.5M | 0.01% | +5,119,622 | New |
| UBS Asset Management Americas Inc | 4,983,726 | $82.3M | 0.02% | −481,311−8.8% | Reduced |
| Price T Rowe Associates Inc | 3,915,951 | $64.7M | 0.01% | −652,417−14.3% | Reduced |
| Goldman Sachs Group Inc | 3,835,803 | $63.3M | 0.01% | +1,672,098+77.3% | Added |
| Baker Bros. Advisors LP | 3,731,695 | $61.6M | 0.36% | 00.0% | Unchanged |
| Capital Research Global Investors | 3,729,244 | $61.6M | 0.01% | −1,031,614−21.7% | Reduced |
| Alliancebernstein L.P. | 3,557,935 | $58.7M | 0.02% | +37,521+1.1% | Added |
| Geode Capital Management, LLC | 3,458,131 | $57.1M | 0.00% | −7,926−0.2% | Reduced |
| Holocene Advisors, LP | 3,152,734 | $52.1M | 0.11% | +17,022+0.5% | Added |
| Crestline Management, LP | 2,810,732 | $46.4M | 87.02% | −600,000−17.6% | Reduced |
| Fisher Asset Management, LLC | 2,589,403 | $42.8M | 0.01% | +957,907+58.7% | Added |
| UBS Group AG | 2,404,704 | $39.7M | 0.01% | +392,351+19.5% | Added |
| Dimensional Fund Advisors LP | 2,374,303 | $39.2M | 0.01% | +17,089+0.7% | Added |
| Standard Life Aberdeen plc | 2,032,967 | $33.6M | 0.05% | +919,381+82.6% | Added |
| Casdin Capital, LLC | 1,840,000 | $30.4M | 1.89% | +950,000+106.7% | Added |
| Lynx1 Capital Management LP | 1,738,750 | $28.7M | 5.81% | +1,477,063+564.4% | Added |
| Point72 Asset Management, L.P. | 1,700,000 | $28.1M | 0.04% | −819,535−32.5% | Reduced |
| Principal Financial Group Inc | 1,524,123 | $25.2M | 0.01% | +252,933+19.9% | Added |
| Siren, L.L.C. | 1,396,513 | $23.1M | 0.69% | +575,000+70.0% | Added |
| Pictet Asset Management Holding SA | 1,329,108 | $22.0M | 0.02% | +829,946+166.3% | Added |
| Morgan Stanley | 1,219,854 | $20.1M | 0.00% | −469,638−27.8% | Reduced |
| Charles Schwab Investment Management Inc | 1,200,475 | $19.8M | 0.00% | +49,091+4.3% | Added |
| Northern Trust Corp | 1,199,744 | $19.8M | 0.00% | −34,435−2.8% | Reduced |
| Candriam Luxembourg S.C.A. | 1,166,379 | $19.3M | 0.10% | +332,797+39.9% | Added |
| ExodusPoint Capital Management, LP | 1,023,253 | $16.9M | 0.19% | +1,023,253 | New |
| Foresite Capital Management VI LLC | 1,000,000 | $16.5M | 4.99% | 00.0% | Unchanged |
| Masters Capital Management LLC | 1,000,000 | $16.5M | 2.28% | +250,000+33.3% | Added |
| Bank of America Corp | 932,144 | $15.4M | 0.00% | −28,994−3.0% | Reduced |
| Alyeska Investment Group, L.P. | 859,108 | $14.2M | 0.04% | +859,108 | New |
| Citadel Advisors LLC | 779,148 | $12.9M | 0.01% | +90,924+13.2% | Added |
| Marshall Wace, LLP | 763,892 | $12.6M | 0.01% | −23,137−2.9% | Reduced |
| Bank of New York Mellon Corp | 762,087 | $12.6M | 0.00% | −38,660−4.8% | Reduced |
| Defilade Capital Management, L.P. | 656,713 | $10.8M | 1.47% | +656,713 | New |
| Palo Alto Investors LP | 641,239 | $10.6M | 1.47% | +233,233+57.2% | Added |
| Cercano Management LLC | 625,000 | $10.3M | 0.39% | 00.0% | Unchanged |
| Voloridge Investment Management, LLC | 591,461 | $9.77M | 0.03% | −344,769−36.8% | Reduced |
| Qube Research & Technologies Ltd | 590,314 | $9.75M | 0.01% | +362,324+158.9% | Added |
| Segall Bryant & Hamill, LLC | 537,000 | $8.87M | 0.12% | +24,042+4.7% | Added |
| Ensign Peak Advisors, Inc | 515,721 | $8.51M | 0.02% | −18,350−3.4% | Reduced |
| Vestal Point Capital, LP | 465,000 | $7.68M | 0.28% | +465,000 | New |
| Hudson Bay Capital Management LP | 450,000 | $7.43M | 0.04% | +145,000+47.5% | Added |
| Schroder Investment Management Group | 450,985 | $7.40M | 0.01% | +241,390+115.2% | Added |
| Two Sigma Investments, LP | 430,177 | $7.10M | 0.01% | +163,885+61.5% | Added |
| StemPoint Capital LP | 419,058 | $6.92M | 1.19% | −1,315,601−75.8% | Reduced |
| Barclays PLC | 407,359 | $6.73M | 0.00% | −29,642−6.8% | Reduced |
| American Century Companies Inc | 379,051 | $6.26M | 0.00% | +21,710+6.1% | Added |
| Millennium Management LLC | 369,767 | $6.10M | 0.00% | −937,404−71.7% | Reduced |
| Clarius Group, LLC | 368,995 | $6.09M | 0.35% | +9,250+2.6% | Added |
| TD Asset Management Inc | 339,410 | $5.60M | 0.00% | −55,190−14.0% | Reduced |
| DAFNA Capital Management LLC | 318,500 | $5.26M | 1.22% | +150,000+89.0% | Added |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 298,792 | $4.93M | 0.01% | +297,521+23,408.4% | Added |
| Invesco Ltd. | 291,936 | $4.82M | 0.00% | +42,469+17.0% | Added |
| Marex Group plc | 287,001 | $4.74M | 0.05% | −3,999−1.4% | Reduced |
| Nuveen, LLC | 275,508 | $4.55M | 0.00% | −9,269−3.3% | Reduced |
| Swiss National Bank | 273,800 | $4.52M | 0.00% | +6,300+2.4% | Added |
| Edmond de Rothschild Holding S.A. | 225,680 | $3.73M | 0.05% | +20,000+9.7% | Added |
| Trexquant Investment LP | 209,609 | $3.46M | 0.03% | −220,957−51.3% | Reduced |
| Burkehill Global Management, LP | 200,000 | $3.30M | 0.22% | +200,000 | New |
| SCS Capital Management LLC | 197,998 | $3.27M | 0.03% | 00.0% | Unchanged |
| Wells Fargo & Company | 193,681 | $3.20M | 0.00% | +89,502+85.9% | Added |
| Rafferty Asset Management, LLC | 191,567 | $3.16M | 0.01% | +8,681+4.7% | Added |
| Manufacturers Life Insurance Company, The | 184,238 | $3.03M | 0.00% | −21,607−10.5% | Reduced |
| Rhumbline Advisers | 183,000 | $3.02M | 0.00% | −18,565−9.2% | Reduced |
| Ameriprise Financial Inc | 180,221 | $2.98M | 0.00% | +80,660+81.0% | Added |
| JPMorgan Chase & Co | 171,948 | $2.84M | 0.00% | −3,073−1.8% | Reduced |
| Susquehanna Portfolio Strategies, LLC | 167,713 | $2.77M | 0.04% | +167,713 | New |
| Two Sigma Advisers, LP | 154,800 | $2.56M | 0.00% | +64,800+72.0% | Added |
| Teachers Retirement System of the State of Kentucky | 153,781 | $2.54M | 0.02% | −17,772−10.4% | Reduced |
| Groupama Asset Managment | 151,591 | $2.50M | 0.04% | +15,833+11.7% | Added |
| SG Americas Securities, LLC | 149,592 | $2.47M | 0.00% | +111,391+291.6% | Added |
| Legal & General Group Plc | 131,223 | $2.17M | 0.00% | −12,729−8.8% | Reduced |
| California State Teachers Retirement System | 129,409 | $2.14M | 0.00% | −117−0.1% | Reduced |
| Mirae Asset Global ETFs Holdings Ltd. | 128,800 | $2.13M | 0.00% | −1,087−0.8% | Reduced |
| Algert Global LLC | 127,030 | $2.10M | 0.03% | +25,770+25.4% | Added |
| Alps Advisors Inc | 120,718 | $1.99M | 0.01% | +50,488+71.9% | Added |
| Woodline Partners LP | 114,082 | $1.88M | 0.01% | +565+0.5% | Added |
| B. Metzler seel. Sohn & Co. AG | 112,300 | $1.84M | 0.02% | +112,300 | New |
| Nomura Asset Management International Inc. | 107,493 | $1.77M | 0.00% | +107,493 | New |
| D.A. Davidson & Co. | 106,933 | $1.77M | 0.01% | +106,933 | New |
| Deutsche Bank AG | 105,086 | $1.73M | 0.00% | −102,508−49.4% | Reduced |
| Rhenman & Partners Asset Management AB | 100,000 | $1.65M | 0.15% | 00.0% | Unchanged |
| Ghisallo Capital Management LLC | 100,000 | $1.65M | 0.07% | +100,000 | New |
| Integrated Wealth Concepts LLC | 94,582 | $1.56M | 0.02% | +3,508+3.9% | Added |
| Y-Intercept (Hong Kong) Ltd | 93,587 | $1.55M | 0.03% | +93,587 | New |
| Monashee Investment Management LLC | 91,620 | $1.51M | 0.85% | +91,620 | New |
| DekaBank Deutsche Girozentrale | 59,800 | $1.35M | 0.00% | 00.0% | Unchanged |
| HRT Financial LP | 78,352 | $1.29M | 0.00% | +78,352 | New |
| MetLife Investment Management | 75,164 | $1.24M | 0.01% | −3,911−4.9% | Reduced |
| State of Wisconsin Investment Board | 73,581 | $1.21M | 0.00% | −6,545−8.2% | Reduced |
| Profund Advisors LLC | 71,634 | $1.18M | 0.04% | +31,478+78.4% | Added |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 70,830 | $1.17M | 0.00% | +44,607+170.1% | Added |
| Ishara Investments LP | 70,000 | $1.16M | 1.35% | +70,000 | New |
| Pier 88 Investment Partners LLC | 68,200 | $1.13M | 0.25% | +760+1.1% | Added |