Denali Therapeutics Inc.
DNLI- Exchange
- Nasdaq
- Industry
- Biological Products, (No Diagnostic Substances)
- SEC CIK
- 0001714899
In the last 90 days, Denali Therapeutics Inc. insiders filed 0 open-market purchases and 4 sales; 294 institutions reported holding it in 13F filings for Q2 2026, worth $4.00B in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in Denali Therapeutics Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 250
- +17 vs. Q3 2025
- Shares held
- 151.1M
- +16.2M (+12.0%) vs. Q3 2025
- Total value
- $2.50B
- +$536.1M (+27.4%) vs. Q3 2025
- New holders
- 51
- 86 more added
- Sold out
- 34
- 71 more reduced
7 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting DNLI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 294 | $4.00B |
| Q1 2026 | 269 | $2.82B |
| Q4 2025 | 250 | $2.50B |
| Q3 2025 | 240 | $1.97B |
| Q2 2025 | 231 | $1.93B |
| Q1 2025 | 222 | $1.85B |
| Q4 2024 | 224 | $2.61B |
| Q3 2024 | 217 | $3.69B |
| Q2 2024 | 203 | $2.88B |
| Q1 2024 | 211 | $2.51B |
| Q4 2023 | 209 | $2.47B |
| Q3 2023 | 195 | $2.24B |
| Q2 2023 | 203 | $3.18B |
| Q1 2023 | 202 | $2.49B |
| Q4 2022 | 199 | $2.94B |
| Q3 2022 | 200 | $2.84B |
| Q2 2022 | 188 | $2.73B |
| Q1 2022 | 190 | $2.79B |
| Q4 2021 | 213 | $3.80B |
| Q3 2021 | 214 | $4.28B |
| Q2 2021 | 210 | $6.32B |
| Q1 2021 | 218 | $4.60B |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Denali Therapeutics Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| 1492 Capital Management LLC | 67,487 | $1.11M | 0.43% | +67,487 | New |
| Capricorn Fund Managers Ltd | 62,197 | $1.03M | 0.25% | +62,197 | New |
| Creative Planning | 60,766 | $1.00M | 0.00% | +5,932+10.8% | Added |
| Franklin Resources Inc | 60,270 | $995.1K | 0.00% | −4,364−6.8% | Reduced |
| Janus Henderson Group PLC | 60,028 | $991.4K | 0.00% | 00.0% | Unchanged |
| Wellington Management Group LLP | 54,543 | $900.5K | 0.00% | −4,691−7.9% | Reduced |
| Tudor Investment Corp Et Al | 53,683 | $886.3K | 0.00% | −2,685−4.8% | Reduced |
| Intech Investment Management LLC | 52,632 | $869.0K | 0.01% | +5,835+12.5% | Added |
| ADAR1 Capital Management, LLC | 52,116 | $860.4K | 0.06% | +600+1.2% | Added |
| Clough Capital Partners L P | 51,830 | $855.7K | 0.08% | +51,830 | New |
| Pathstone Holdings, LLC | 51,424 | $849.0K | 0.00% | +5,594+12.2% | Added |
| Ironwood Investment Management LLC | 50,933 | $840.9K | 0.35% | −1,853−3.5% | Reduced |
| Dana Investment Advisors, Inc. | 50,582 | $835.1K | 0.02% | −134−0.3% | Reduced |
| Knights of Columbus Asset Advisors LLC | 49,007 | $809.1K | 0.05% | −1,183−2.4% | Reduced |
| Man Group plc | 48,994 | $808.9K | 0.00% | +48,994 | New |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 47,459 | $783.5K | 0.00% | 00.0% | Unchanged |
| State of New Jersey Common Pension Fund D | 47,410 | $782.7K | 0.00% | −92,253−66.1% | Reduced |
| Employees Retirement System of Texas | 47,177 | $779.0K | 0.01% | +3,408+7.8% | Added |
| MAI Capital Management | 46,526 | $768.1K | 0.00% | 00.0% | Unchanged |
| Headlands Technologies LLC | 46,383 | $765.8K | 0.06% | +46,383 | New |
| Handelsbanken Fonder AB | 43,800 | $723.0K | 0.00% | +5,500+14.4% | Added |
| Jane Street Group, LLC | 42,922 | $708.6K | 0.00% | −181,981−80.9% | Reduced |
| Quest Partners LLC | 42,909 | $708.4K | 0.04% | −31,513−42.3% | Reduced |
| Jump Financial, LLC | 40,608 | $670.4K | 0.01% | −125,791−75.6% | Reduced |
| Savvy Advisors, Inc. | 39,030 | $644.4K | 0.02% | −38,063−49.4% | Reduced |
| Capstone Investment Advisors, LLC | 38,812 | $640.8K | 0.01% | +38,812 | New |
| Envestnet Asset Management Inc | 38,669 | $638.4K | 0.00% | +6,254+19.3% | Added |
| Arizona State Retirement System | 38,645 | $638.0K | 0.00% | −2,168−5.3% | Reduced |
| New York State Common Retirement Fund | 38,478 | $635.3K | 0.00% | 00.0% | Unchanged |
| AQR Capital Management LLC | 38,438 | $634.6K | 0.00% | +14,299+59.2% | Added |
| Police & Firemen's Retirement System of New Jersey | 36,607 | $604.4K | 0.01% | −56−0.2% | Reduced |
| Susquehanna International Group, LLP | 34,768 | $574.0K | 0.00% | −6,218−15.2% | Reduced |
| State Board of Administration of Florida Retirement System | 34,168 | $564.1K | 0.00% | 00.0% | Unchanged |
| Thrivent Financial for Lutherans | 32,555 | $538.0K | 0.00% | −3,064−8.6% | Reduced |
| PSP Research LLC | 31,762 | $524.4K | 0.46% | +31,762 | New |
| Citigroup Inc | 30,945 | $510.9K | 0.00% | +16,009+107.2% | Added |
| ProShare Advisors LLC | 30,682 | $506.6K | 0.00% | +2,827+10.1% | Added |
| KLP Kapitalforvaltning AS | 29,900 | $493.6K | 0.00% | 00.0% | Unchanged |
| Erste Asset Management GmbH | 26,900 | $446.0K | 0.00% | 00.0% | Unchanged |
| Polen Capital Management LLC | 26,900 | $444.1K | 0.00% | +26,900 | New |
| Quantinno Capital Management LP | 26,313 | $434.4K | 0.00% | +1,606+6.5% | Added |
| Raymond James Financial Inc | 25,592 | $422.5K | 0.00% | +266+1.1% | Added |
| China Universal Asset Management Co., Ltd. | 23,898 | $394.6K | 0.03% | −1,731−6.8% | Reduced |
| Voya Investment Management LLC | 23,805 | $393.0K | 0.00% | 00.0% | Unchanged |
| TT International Asset Management LTD | 27,000 | $353.0K | 0.07% | −38,000−58.5% | Reduced |
| Teacher Retirement System of Texas | 20,540 | $339.1K | 0.00% | −13,287−39.3% | Reduced |
| Bayforest Capital Ltd | 20,433 | $337.3K | 0.25% | +20,433 | New |
| Martingale Asset Management L P | 18,535 | $306.0K | 0.01% | +18,535 | New |
| Graham Capital Management, L.P. | 18,121 | $299.2K | 0.01% | −21,198−53.9% | Reduced |
| SBI Okasan Asset Management Co.Ltd. | 18,000 | $298.4K | 0.02% | +18,000 | New |
| Breakwater Capital Group | 16,366 | $270.2K | 0.04% | +500+3.2% | Added |
| BNP Paribas Arbitrage, SA | 15,497 | $255.9K | 0.00% | −248,564−94.1% | Reduced |
| Victory Capital Management Inc | 15,064 | $248.7K | 0.00% | 00.0% | Unchanged |
| Virtus Investment Advisers, Inc. | 14,795 | $244.3K | 0.07% | +7,171+94.1% | Added |
| Russell Investments Group, Ltd. | 13,467 | $222.3K | 0.00% | −332−2.4% | Reduced |
| Great West Life Assurance Co | 13,434 | $222.0K | 0.00% | 00.0% | Unchanged |
| Tower Research Capital LLC (TRC) | 12,941 | $213.7K | 0.01% | +5,565+75.4% | Added |
| Winton Group Ltd | 12,700 | $209.7K | 0.01% | +12,700 | New |
| Walleye Capital LLC | 12,652 | $208.9K | 0.00% | +12,652 | New |
| Perbak Capital Partners LLP | 12,611 | $208.2K | 0.06% | +12,611 | New |
| Guggenheim Capital LLC | 12,468 | $205.8K | 0.00% | −37,057−74.8% | Reduced |
| Public Employees Retirement Association of Colorado | 12,238 | $202.0K | 0.00% | 00.0% | Unchanged |
| HighTower Advisors, LLC | 11,757 | $194.1K | 0.00% | −9,565−44.9% | Reduced |
| JustInvest LLC | 11,736 | $193.8K | 0.00% | −790−6.3% | Reduced |
| Royal Bank of Canada | 11,335 | $187.0K | 0.00% | −360,841−97.0% | Reduced |
| Empowered Funds, LLC | 11,325 | $187.0K | 0.00% | +288+2.6% | Added |
| Intrust Bank NA | 11,164 | $184.3K | 0.02% | +589+5.6% | Added |
| Ameritas Investment Partners, Inc. | 11,065 | $182.7K | 0.01% | 00.0% | Unchanged |
| Renaissance Technologies LLC | 10,700 | $176.7K | 0.00% | −49,100−82.1% | Reduced |
| LPL Financial LLC | 10,504 | $173.4K | 0.00% | −144−1.4% | Reduced |
| Xponance, Inc. | 10,497 | $173.3K | 0.00% | +97+0.9% | Added |
| The PNC Financial Services Group, Inc. | 8,481 | $140.0K | 0.00% | +191+2.3% | Added |
| Sterling Capital Management LLC | 7,238 | $119.5K | 0.00% | −1,416−16.4% | Reduced |
| Bellevue Group AG | 7,138 | $117.8K | 0.00% | +7,138 | New |
| Mirae Asset Global Investments Co., Ltd. | 7,127 | $117.7K | 0.00% | +1,474+26.1% | Added |
| Quarry LP | 7,000 | $115.6K | 0.02% | +2,625+60.0% | Added |
| NBC Securities, Inc. | 6,536 | $107.9K | 0.01% | +6,004+1,128.6% | Added |
| KBC Group NV | 6,268 | $103.0K | 0.00% | +1,773+39.4% | Added |
| Persistent Asset Partners Ltd | 5,670 | $93.6K | 0.05% | +5,670 | New |
| Assetmark, Inc | 5,187 | $85.6K | 0.00% | +1,250+31.8% | Added |
| Eurizon Capital SGR S.p.A. | 5,045 | $82.7K | 0.00% | +5,045 | New |
| Amalgamated Bank | 4,161 | $69.0K | 0.00% | −144−3.3% | Reduced |
| Aster Capital Management (DIFC) Ltd | 3,451 | $57.0K | 0.02% | +3,451 | New |
| Pinnacle Wealth Planning Services, Inc. | 2,957 | $48.8K | 0.01% | +2,957 | New |
| GF Fund Management Co. Ltd. | 2,881 | $47.6K | 0.00% | −265−8.4% | Reduced |
| State of Wyoming | 2,686 | $44.3K | 0.00% | +532+24.7% | Added |
| CWM, LLC | 2,606 | $43.0K | 0.00% | +209+8.7% | Added |
| Bartlett & Co. Wealth Management LLC | 1,500 | $24.8K | 0.00% | 00.0% | Unchanged |
| Versant Capital Management, Inc | 1,476 | $24.4K | 0.00% | 00.0% | Unchanged |
| Nisa Investment Advisors, LLC | 1,449 | $23.9K | 0.00% | −34−2.3% | Reduced |
| Smartleaf Asset Management LLC | 1,313 | $21.5K | 0.00% | +359+37.6% | Added |
| Comerica Bank | 1,284 | $21.2K | 0.00% | 00.0% | Unchanged |
| Rockefeller Capital Management L.P. | 1,265 | $20.9K | 0.00% | +182+16.8% | Added |
| SBI Securities Co., Ltd. | 1,222 | $20.2K | 0.00% | +1,200+5,454.5% | Added |
| Advisor Group Holdings, Inc. | 1,074 | $17.7K | 0.00% | −314−22.6% | Reduced |
| Mitsubishi UFJ Kokusai Asset Management Co., Ltd. | 1,001 | $16.3K | 0.00% | 00.0% | Unchanged |
| GAMMA Investing LLC | 962 | $15.9K | 0.00% | +233+32.0% | Added |
| US Bancorp | 834 | $13.8K | 0.00% | +138+19.8% | Added |
| Quadrant Capital Group LLC | 758 | $12.5K | 0.00% | −24−3.1% | Reduced |
| Nemes Rush Group LLC | 700 | $11.6K | 0.00% | 00.0% | Unchanged |