Denali Therapeutics Inc.
DNLI- Exchange
- Nasdaq
- Industry
- Biological Products, (No Diagnostic Substances)
- SEC CIK
- 0001714899
In the last 90 days, Denali Therapeutics Inc. insiders filed 0 open-market purchases and 4 sales; 294 institutions reported holding it in 13F filings for Q2 2026, worth $4.00B in total; no superinvestor holds it.
13F holders, Q1 2026
Institutional positions in Denali Therapeutics Inc. as of Mar 31, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 269
- +25 vs. Q4 2025
- Shares held
- 147.4M
- +14.8M (+11.2%) vs. Q4 2025
- Total value
- $2.82B
- +$631.6M (+28.8%) vs. Q4 2025
- New holders
- 55
- 104 more added
- Sold out
- 30
- 58 more reduced
6 institutions that held it in Q4 2025 haven't filed for Q1 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting DNLI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 294 | $4.00B |
| Q1 2026 | 269 | $2.82B |
| Q4 2025 | 250 | $2.50B |
| Q3 2025 | 240 | $1.97B |
| Q2 2025 | 231 | $1.93B |
| Q1 2025 | 222 | $1.85B |
| Q4 2024 | 224 | $2.61B |
| Q3 2024 | 217 | $3.69B |
| Q2 2024 | 203 | $2.88B |
| Q1 2024 | 211 | $2.51B |
| Q4 2023 | 209 | $2.47B |
| Q3 2023 | 195 | $2.24B |
| Q2 2023 | 203 | $3.18B |
| Q1 2023 | 202 | $2.49B |
| Q4 2022 | 199 | $2.94B |
| Q3 2022 | 200 | $2.84B |
| Q2 2022 | 188 | $2.73B |
| Q1 2022 | 190 | $2.79B |
| Q4 2021 | 213 | $3.80B |
| Q3 2021 | 214 | $4.28B |
| Q2 2021 | 210 | $6.32B |
| Q1 2021 | 218 | $4.60B |
Institutions, Q1 2026
Shares, value and share of portfolio for each institution holding Denali Therapeutics Inc.; share changes are against Q4 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| BlackRock, Inc. | 13,034,434 | $250.3M | 0.00% | +319,233+2.5% | Added |
| Baillie Gifford & Co | 12,066,479 | $231.7M | 0.24% | −244,410−2.0% | Reduced |
| T. Rowe Price Investment Management, Inc. | 8,519,192 | $163.6M | 0.11% | +1,265,060+17.4% | Added |
| Temasek Holdings (Private) Ltd | 7,012,974 | $134.6M | 0.45% | 00.0% | Unchanged |
| State Street Corp | 6,272,001 | $120.4M | 0.00% | +8,630+0.1% | Added |
| Vanguard Capital Management LLC | 6,147,957 | $118.0M | 0.00% | +6,147,957 | New |
| Vanguard Portfolio Management LLC | 6,120,160 | $117.5M | 0.01% | +6,120,160 | New |
| FMR LLC | 4,575,374 | $87.8M | 0.00% | −1,521,837−25.0% | Reduced |
| UBS Asset Management Americas Inc | 4,432,314 | $85.1M | 0.02% | −551,412−11.1% | Reduced |
| Goldman Sachs Group Inc | 4,407,255 | $84.6M | 0.01% | +571,452+14.9% | Added |
| Baker Bros. Advisors LP | 3,731,695 | $71.6M | 0.41% | 00.0% | Unchanged |
| Geode Capital Management, LLC | 3,727,114 | $71.6M | 0.00% | +268,983+7.8% | Added |
| Holocene Advisors, LP | 3,195,429 | $61.4M | 0.15% | +42,695+1.4% | Added |
| Dimensional Fund Advisors LP | 2,692,175 | $51.7M | 0.01% | +317,872+13.4% | Added |
| UBS Group AG | 2,571,344 | $49.4M | 0.01% | +166,640+6.9% | Added |
| Pictet Asset Management Holding SA | 2,558,865 | $48.4M | 0.05% | +1,229,757+92.5% | Added |
| Capital Research Global Investors | 2,514,588 | $48.3M | 0.01% | −1,214,656−32.6% | Reduced |
| Alliancebernstein L.P. | 2,893,618 | $47.8M | 0.02% | −664,317−18.7% | Reduced |
| Price T Rowe Associates Inc | 2,464,146 | $47.3M | 0.01% | −1,451,805−37.1% | Reduced |
| Fisher Asset Management, LLC | 2,436,895 | $46.8M | 0.02% | −152,508−5.9% | Reduced |
| Crestline Management, LP | 2,210,732 | $42.4M | 91.74% | −600,000−21.3% | Reduced |
| Alyeska Investment Group, L.P. | 1,941,123 | $37.3M | 0.11% | +1,082,015+125.9% | Added |
| Lynx1 Capital Management LP | 1,880,303 | $36.1M | 5.71% | +141,553+8.1% | Added |
| ADAR1 Capital Management, LLC | 1,871,455 | $35.9M | 2.16% | +1,819,339+3,490.9% | Added |
| Standard Life Aberdeen plc | 1,854,446 | $35.6M | 0.06% | −178,521−8.8% | Reduced |
| Casdin Capital, LLC | 1,840,000 | $35.3M | 2.68% | 00.0% | Unchanged |
| Vestal Point Capital, LP | 1,773,326 | $34.0M | 0.95% | +1,308,326+281.4% | Added |
| Principal Financial Group Inc | 1,478,486 | $28.4M | 0.02% | −45,637−3.0% | Reduced |
| Siren, L.L.C. | 1,396,513 | $26.8M | 0.74% | 00.0% | Unchanged |
| Defilade Capital Management, L.P. | 1,359,969 | $26.1M | 3.67% | +703,256+107.1% | Added |
| Northern Trust Corp | 1,310,656 | $25.2M | 0.00% | +110,912+9.2% | Added |
| Millennium Management LLC | 1,257,950 | $24.2M | 0.02% | +888,183+240.2% | Added |
| Foresite Capital Management VI LLC | 1,209,971 | $23.2M | 5.05% | +209,971+21.0% | Added |
| Charles Schwab Investment Management Inc | 1,207,399 | $23.2M | 0.00% | +6,924+0.6% | Added |
| Bank of America Corp | 1,134,183 | $21.8M | 0.00% | +202,039+21.7% | Added |
| Morgan Stanley | 1,104,757 | $21.2M | 0.00% | −115,097−9.4% | Reduced |
| Candriam Luxembourg S.C.A. | 1,099,845 | $21.1M | 0.11% | −66,534−5.7% | Reduced |
| Artisan Partners Limited Partnership | 1,099,719 | $21.1M | 0.03% | +1,099,719 | New |
| Marshall Wace, LLP | 991,268 | $19.0M | 0.02% | +227,376+29.8% | Added |
| Vanguard Fiduciary Trust Co | 949,695 | $18.2M | 0.00% | +949,695 | New |
| American Century Companies Inc | 935,692 | $18.0M | 0.01% | +556,641+146.9% | Added |
| Bank of New York Mellon Corp | 768,039 | $14.7M | 0.00% | +5,952+0.8% | Added |
| Clearstead Advisors, LLC | 737,990 | $14.2M | 0.13% | +737,990 | New |
| Cercano Management LLC | 625,000 | $12.0M | 0.52% | 00.0% | Unchanged |
| Masters Capital Management LLC | 600,000 | $11.5M | 1.70% | −400,000−40.0% | Reduced |
| Ensign Peak Advisors, Inc | 515,721 | $9.90M | 0.02% | 00.0% | Unchanged |
| Segall Bryant & Hamill, LLC | 510,543 | $9.80M | 0.14% | −26,457−4.9% | Reduced |
| StemPoint Capital LP | 426,561 | $8.19M | 1.57% | +7,503+1.8% | Added |
| Woodline Partners LP | 364,082 | $6.99M | 0.03% | +250,000+219.1% | Added |
| Hudson Bay Capital Management LP | 346,360 | $6.65M | 0.04% | −103,640−23.0% | Reduced |
| DAFNA Capital Management LLC | 318,500 | $6.12M | 1.39% | 00.0% | Unchanged |
| Invesco Ltd. | 310,196 | $5.96M | 0.00% | +18,260+6.3% | Added |
| JPMorgan Chase & Co | 323,989 | $5.86M | 0.00% | +152,041+88.4% | Added |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 296,503 | $5.69M | 0.01% | −2,289−0.8% | Reduced |
| Braidwell LP | 296,324 | $5.69M | 0.19% | +296,324 | New |
| Nuveen, LLC | 295,586 | $5.68M | 0.00% | +20,078+7.3% | Added |
| Marex Group plc | 287,000 | $5.51M | 0.06% | −10.0% | Reduced |
| Swiss National Bank | 273,800 | $5.26M | 0.00% | 00.0% | Unchanged |
| Schroder Investment Management Group | 285,820 | $5.17M | 0.00% | −165,165−36.6% | Reduced |
| TD Asset Management Inc | 255,766 | $4.91M | 0.00% | −83,644−24.6% | Reduced |
| Privium Fund Management B.V. | 254,857 | $4.89M | 1.02% | +254,857 | New |
| Palo Alto Investors LP | 234,582 | $4.50M | 0.69% | −406,657−63.4% | Reduced |
| Great Lakes Advisors, LLC | 227,110 | $4.36M | 0.04% | +227,110 | New |
| Edmond de Rothschild Holding S.A. | 225,680 | $4.33M | 0.06% | 00.0% | Unchanged |
| Groupama Asset Managment | 207,130 | $3.98M | 0.06% | +55,539+36.6% | Added |
| Burkehill Global Management, LP | 200,000 | $3.84M | 0.19% | 00.0% | Unchanged |
| Rhenman & Partners Asset Management AB | 199,000 | $3.82M | 0.47% | +99,000+99.0% | Added |
| SCS Capital Management LLC | 197,998 | $3.80M | 0.04% | 00.0% | Unchanged |
| Balyasny Asset Management LLC | 195,108 | $3.75M | 0.01% | +195,108 | New |
| Rhumbline Advisers | 184,248 | $3.54M | 0.00% | +1,248+0.7% | Added |
| Citadel Advisors LLC | 181,417 | $3.48M | 0.00% | −597,731−76.7% | Reduced |
| Teachers Retirement System of the State of Kentucky | 166,181 | $3.19M | 0.02% | +12,400+8.1% | Added |
| Sector Gamma AS | 162,710 | $3.12M | 0.74% | +162,710 | New |
| California State Teachers Retirement System | 162,576 | $3.12M | 0.00% | +33,167+25.6% | Added |
| Susquehanna Portfolio Strategies, LLC | 157,896 | $3.03M | 0.05% | −9,817−5.9% | Reduced |
| Rafferty Asset Management, LLC | 150,687 | $2.89M | 0.01% | −40,880−21.3% | Reduced |
| Man Group plc | 139,045 | $2.67M | 0.01% | +90,051+183.8% | Added |
| Alps Advisors Inc | 129,105 | $2.48M | 0.01% | +8,387+6.9% | Added |
| New York State Common Retirement Fund | 128,119 | $2.46M | 0.00% | +89,641+233.0% | Added |
| Manufacturers Life Insurance Company, The | 125,442 | $2.41M | 0.00% | −58,796−31.9% | Reduced |
| Vanguard Asset Management, Ltd | 125,243 | $2.40M | 0.00% | +125,243 | New |
| Deutsche Bank AG | 120,368 | $2.31M | 0.00% | +15,282+14.5% | Added |
| Nomura Asset Management International Inc. | 114,524 | $2.20M | 0.00% | +7,031+6.5% | Added |
| B. Metzler seel. Sohn & Co. AG | 112,300 | $2.16M | 0.02% | 00.0% | Unchanged |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 111,694 | $2.14M | 0.00% | +64,235+135.3% | Added |
| Legal & General Group Plc | 110,250 | $2.12M | 0.00% | −20,973−16.0% | Reduced |
| D.A. Davidson & Co. | 110,235 | $2.12M | 0.01% | +3,302+3.1% | Added |
| Wells Fargo & Company | 107,657 | $2.07M | 0.00% | −86,024−44.4% | Reduced |
| AQR Capital Management LLC | 102,579 | $1.97M | 0.00% | +64,141+166.9% | Added |
| Ghisallo Capital Management LLC | 100,000 | $1.92M | 0.05% | 00.0% | Unchanged |
| Integrated Wealth Concepts LLC | 99,554 | $1.91M | 0.02% | +4,972+5.3% | Added |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 99,503 | $1.91M | 0.00% | +28,673+40.5% | Added |
| Lumbard & Kellner, LLC | 94,782 | $1.82M | 0.63% | +94,782 | New |
| Mirae Asset Global ETFs Holdings Ltd. | 95,193 | $1.82M | 0.00% | −33,607−26.1% | Reduced |
| Ameriprise Financial Inc | 89,534 | $1.72M | 0.00% | −90,687−50.3% | Reduced |
| State of Wisconsin Investment Board | 82,357 | $1.58M | 0.00% | +8,776+11.9% | Added |
| XTX Topco Ltd | 78,567 | $1.51M | 0.03% | +78,567 | New |
| Y-Intercept (Hong Kong) Ltd | 78,007 | $1.50M | 0.03% | −15,580−16.6% | Reduced |
| MetLife Investment Management | 77,558 | $1.49M | 0.01% | +2,394+3.2% | Added |
| Creative Planning | 74,069 | $1.42M | 0.00% | +13,303+21.9% | Added |