Denali Therapeutics Inc.
DNLI- Exchange
- Nasdaq
- Industry
- Biological Products, (No Diagnostic Substances)
- SEC CIK
- 0001714899
In the last 90 days, Denali Therapeutics Inc. insiders filed 0 open-market purchases and 4 sales; 294 institutions reported holding it in 13F filings for Q2 2026, worth $4.46B in total; no superinvestor holds it.
13F holders, Q2 2026
Institutional positions in Denali Therapeutics Inc. as of Jun 30, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 294
- +28 vs. Q1 2026
- Shares held
- 156.2M
- +8.46M (+5.7%) vs. Q1 2026
- Total value
- $4.46B
- +$1.63B (+57.7%) vs. Q1 2026
- New holders
- 56
- 120 more added
- Sold out
- 28
- 68 more reduced
3 institutions that held it in Q1 2026 haven't filed for Q2 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q1 2026: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting DNLI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 294 | $4.46B |
| Q1 2026 | 269 | $2.83B |
| Q4 2025 | 250 | $2.52B |
| Q3 2025 | 240 | $1.97B |
| Q2 2025 | 231 | $1.93B |
| Q1 2025 | 222 | $1.85B |
| Q4 2024 | 224 | $2.61B |
| Q3 2024 | 217 | $3.70B |
| Q2 2024 | 203 | $2.89B |
| Q1 2024 | 211 | $2.55B |
| Q4 2023 | 209 | $2.50B |
| Q3 2023 | 195 | $2.24B |
| Q2 2023 | 203 | $3.18B |
| Q1 2023 | 202 | $2.51B |
| Q4 2022 | 199 | $2.94B |
| Q3 2022 | 200 | $2.84B |
| Q2 2022 | 188 | $2.74B |
| Q1 2022 | 190 | $2.81B |
| Q4 2021 | 213 | $3.81B |
| Q3 2021 | 214 | $4.28B |
| Q2 2021 | 210 | $6.33B |
| Q1 2021 | 218 | $4.60B |
Institutions, Q2 2026
Shares, value and share of portfolio for each institution holding Denali Therapeutics Inc.; share changes are against Q1 2026.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Banque Cantonale Vaudoise | 17,926 | $461.0M | 0.06% | +17,926 | New |
| T. Rowe Price Investment Management, Inc. | 16,178,963 | $416.1M | 0.27% | +7,659,771+89.9% | Added |
| BlackRock, Inc. | 14,026,413 | $360.8M | 0.01% | +991,979+7.6% | Added |
| Baillie Gifford & Co | 11,960,230 | $307.6M | 0.28% | −106,249−0.9% | Reduced |
| State Street Corp | 7,049,304 | $181.3M | 0.01% | +777,303+12.4% | Added |
| Temasek Holdings (Private) Ltd | 7,012,974 | $180.4M | 0.49% | 00.0% | Unchanged |
| Vanguard Portfolio Management LLC | 6,477,057 | $166.6M | 0.01% | +356,897+5.8% | Added |
| Vanguard Capital Management LLC | 6,275,729 | $161.4M | 0.00% | +127,772+2.1% | Added |
| FMR LLC | 4,535,836 | $116.7M | 0.01% | −39,538−0.9% | Reduced |
| Goldman Sachs Group Inc | 4,155,895 | $106.9M | 0.01% | −251,360−5.7% | Reduced |
| Geode Capital Management, LLC | 3,973,342 | $102.2M | 0.01% | +246,228+6.6% | Added |
| Holocene Advisors, LP | 3,905,225 | $100.4M | 0.23% | +709,796+22.2% | Added |
| Baker Bros. Advisors LP | 3,734,336 | $96.0M | 0.48% | +2,641+0.1% | Added |
| UBS Asset Management Americas Inc | 3,161,972 | $81.3M | 0.01% | −1,270,342−28.7% | Reduced |
| Price T Rowe Associates Inc | 3,136,149 | $80.7M | 0.01% | +672,003+27.3% | Added |
| UBS Group AG | 3,120,592 | $80.3M | 0.01% | +549,248+21.4% | Added |
| Dimensional Fund Advisors LP | 2,860,604 | $73.6M | 0.01% | +168,429+6.3% | Added |
| Norges Bank | 2,824,746 | $72.7M | 0.01% | +2,824,746 | New |
| Pictet Asset Management Holding SA | 2,791,206 | $71.9M | 0.07% | +232,341+9.1% | Added |
| Capital Research Global Investors | 2,565,817 | $66.0M | 0.01% | +51,229+2.0% | Added |
| Fisher Asset Management, LLC | 2,414,162 | $62.1M | 0.02% | −22,733−0.9% | Reduced |
| Alliancebernstein L.P. | 2,984,807 | $57.3M | 0.02% | +91,189+3.2% | Added |
| Nomura Asset Management International Inc. | 2,208,263 | $56.8M | 0.09% | +2,093,739+1,828.2% | Added |
| Casdin Capital, LLC | 2,045,000 | $52.6M | 2.63% | +205,000+11.1% | Added |
| Crestline Management, LP | 1,910,732 | $49.1M | 91.90% | −300,000−13.6% | Reduced |
| Principal Financial Group Inc | 1,420,083 | $36.5M | 0.02% | −58,403−4.0% | Reduced |
| Foresite Capital Management VI LLC | 1,396,771 | $35.9M | 5.59% | +186,800+15.4% | Added |
| Siren, L.L.C. | 1,396,513 | $35.9M | 0.73% | 00.0% | Unchanged |
| Northern Trust Corp | 1,389,765 | $35.7M | 0.00% | +79,109+6.0% | Added |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 1,355,514 | $34.9M | 0.03% | +1,059,011+357.2% | Added |
| Standard Life Aberdeen plc | 1,345,481 | $34.6M | 0.05% | −508,965−27.4% | Reduced |
| Charles Schwab Investment Management Inc | 1,244,955 | $32.0M | 0.00% | +37,556+3.1% | Added |
| Bank of America Corp | 1,230,957 | $31.7M | 0.00% | +96,774+8.5% | Added |
| Artisan Partners Limited Partnership | 1,224,497 | $31.5M | 0.05% | +124,778+11.3% | Added |
| Candriam Luxembourg S.C.A. | 1,189,886 | $30.6M | 0.14% | +90,041+8.2% | Added |
| Millennium Management LLC | 1,125,748 | $29.0M | 0.02% | −132,202−10.5% | Reduced |
| ADAR1 Capital Management, LLC | 1,029,080 | $26.5M | 1.24% | −842,375−45.0% | Reduced |
| Vanguard Fiduciary Trust Co | 991,904 | $25.5M | 0.01% | +42,209+4.4% | Added |
| Morgan Stanley | 961,050 | $24.7M | 0.00% | −143,707−13.0% | Reduced |
| Bank of New York Mellon Corp | 800,283 | $20.6M | 0.00% | +32,244+4.2% | Added |
| DAFNA Capital Management LLC | 739,014 | $19.0M | 3.62% | +420,514+132.0% | Added |
| American Century Companies Inc | 712,526 | $18.3M | 0.01% | −223,166−23.9% | Reduced |
| Cercano Management LLC | 625,000 | $16.1M | 2.14% | 00.0% | Unchanged |
| Nuveen, LLC | 608,967 | $15.7M | 0.00% | +313,381+106.0% | Added |
| Ensign Peak Advisors, Inc | 582,669 | $15.0M | 0.02% | +66,948+13.0% | Added |
| Marshall Wace, LLP | 549,830 | $14.1M | 0.01% | −441,438−44.5% | Reduced |
| Segall Bryant & Hamill, LLC | 519,483 | $13.4M | 0.16% | +8,940+1.8% | Added |
| Citigroup Inc | 487,278 | $12.5M | 0.01% | +448,000+1,140.6% | Added |
| Defilade Capital Management, L.P. | 391,866 | $10.1M | 1.35% | −968,103−71.2% | Reduced |
| AQR Capital Management LLC | 388,469 | $9.99M | 0.00% | +285,890+278.7% | Added |
| Woodline Partners LP | 364,082 | $9.36M | 0.03% | 00.0% | Unchanged |
| Invesco Ltd. | 343,898 | $8.85M | 0.00% | +33,702+10.9% | Added |
| ExodusPoint Capital Management, LP | 336,567 | $8.66M | 0.08% | +336,567 | New |
| Marex Group plc | 295,631 | $7.60M | 0.06% | +8,631+3.0% | Added |
| JPMorgan Chase & Co | 287,019 | $7.59M | 0.00% | −36,970−11.4% | Reduced |
| Swiss National Bank | 270,500 | $6.96M | 0.00% | −3,300−1.2% | Reduced |
| TD Asset Management Inc | 231,644 | $5.96M | 0.01% | −24,122−9.4% | Reduced |
| Groupama Asset Managment | 229,939 | $5.91M | 0.07% | +22,809+11.0% | Added |
| Privium Fund Management B.V. | 229,857 | $5.91M | 1.09% | −25,000−9.8% | Reduced |
| XTX Topco Ltd | 226,953 | $5.84M | 0.08% | +148,386+188.9% | Added |
| Alyeska Investment Group, L.P. | 219,334 | $5.64M | 0.01% | −1,721,789−88.7% | Reduced |
| Susquehanna Portfolio Strategies, LLC | 211,474 | $5.44M | 0.09% | +53,578+33.9% | Added |
| Masters Capital Management LLC | 200,000 | $5.14M | 0.72% | −400,000−66.7% | Reduced |
| Burkehill Global Management, LP | 200,000 | $5.14M | 0.19% | 00.0% | Unchanged |
| SCS Capital Management LLC | 197,998 | $5.09M | 0.05% | 00.0% | Unchanged |
| Rhumbline Advisers | 194,787 | $5.01M | 0.00% | +10,539+5.7% | Added |
| Wells Fargo & Company | 189,865 | $4.88M | 0.00% | +82,208+76.4% | Added |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 179,195 | $4.61M | 0.01% | +79,692+80.1% | Added |
| Rhenman & Partners Asset Management AB | 179,000 | $4.60M | 0.43% | −20,000−10.1% | Reduced |
| New York State Common Retirement Fund | 171,712 | $4.42M | 0.01% | +43,593+34.0% | Added |
| Teachers Retirement System of the State of Kentucky | 166,181 | $4.27M | 0.03% | 00.0% | Unchanged |
| Edmond de Rothschild Holding S.A. | 165,080 | $4.25M | 0.06% | −60,600−26.9% | Reduced |
| Alps Advisors Inc | 160,378 | $4.12M | 0.02% | +31,273+24.2% | Added |
| E. Ohman J:or Asset Management AB | 160,000 | $4.12M | 0.10% | +160,000 | New |
| California State Teachers Retirement System | 152,086 | $3.91M | 0.00% | −10,490−6.5% | Reduced |
| Deutsche Bank AG | 149,804 | $3.85M | 0.00% | +29,436+24.5% | Added |
| Great Lakes Advisors, LLC | 145,045 | $3.73M | 0.03% | −82,065−36.1% | Reduced |
| Vanguard Asset Management, Ltd | 141,153 | $3.63M | 0.00% | +15,910+12.7% | Added |
| Man Group plc | 139,065 | $3.58M | 0.01% | +200.0% | Added |
| Hudson Bay Capital Management LP | 130,000 | $3.34M | 0.02% | −216,360−62.5% | Reduced |
| Odyssean, LLC | 125,062 | $3.22M | 0.52% | +125,062 | New |
| Susquehanna International Group, LLP | 123,258 | $3.17M | 0.00% | +72,783+144.2% | Added |
| Manufacturers Life Insurance Company, The | 117,348 | $3.02M | 0.00% | −8,094−6.5% | Reduced |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 115,775 | $2.98M | 0.01% | +4,081+3.7% | Added |
| B. Metzler seel. Sohn & Co. AG | 112,300 | $2.89M | 0.02% | 00.0% | Unchanged |
| Legal & General Group Plc | 111,953 | $2.88M | 0.00% | +1,703+1.5% | Added |
| Integrated Wealth Concepts LLC | 102,241 | $2.63M | 0.02% | +2,687+2.7% | Added |
| PFM Health Sciences, LP | 100,966 | $2.60M | 0.23% | +100,966 | New |
| Ghisallo Capital Management LLC | 100,000 | $2.57M | 0.05% | 00.0% | Unchanged |
| Integral Health Asset Management, LLC | 100,000 | $2.57M | 0.11% | +100,000 | New |
| Lumbard & Kellner, LLC | 98,282 | $2.53M | 0.77% | +3,500+3.7% | Added |
| Rafferty Asset Management, LLC | 96,342 | $2.48M | 0.01% | −54,345−36.1% | Reduced |
| D.A. Davidson & Co. | 87,741 | $2.26M | 0.01% | −22,494−20.4% | Reduced |
| Russell Investments Group, Ltd. | 86,032 | $2.21M | 0.00% | +71,974+512.0% | Added |
| MetLife Investment Management | 85,621 | $2.20M | 0.01% | +8,063+10.4% | Added |
| Barclays PLC | 84,892 | $2.18M | 0.00% | +32,808+63.0% | Added |
| State of Wisconsin Investment Board | 84,652 | $2.18M | 0.00% | +2,295+2.8% | Added |
| Creative Planning | 84,644 | $2.18M | 0.00% | +10,575+14.3% | Added |
| Ameriprise Financial Inc | 82,650 | $2.13M | 0.00% | −6,884−7.7% | Reduced |
| Mirae Asset Global ETFs Holdings Ltd. | 78,937 | $2.03M | 0.00% | −16,256−17.1% | Reduced |