Denali Therapeutics Inc.
DNLI- Exchange
- Nasdaq
- Industry
- Biological Products, (No Diagnostic Substances)
- SEC CIK
- 0001714899
In the last 90 days, Denali Therapeutics Inc. insiders filed 0 open-market purchases and 4 sales; 294 institutions reported holding it in 13F filings for Q2 2026, worth $4.00B in total; no superinvestor holds it.
13F holders, Q1 2025
Institutional positions in Denali Therapeutics Inc. as of Mar 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 222
- +1 vs. Q4 2024
- Shares held
- 135.9M
- +8.35M (+6.5%) vs. Q4 2024
- Total value
- $1.85B
- −$751.0M (−28.9%) vs. Q4 2024
- New holders
- 36
- 74 more added
- Sold out
- 35
- 80 more reduced
3 institutions that held it in Q4 2024 haven't filed for Q1 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2024: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting DNLI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 294 | $4.00B |
| Q1 2026 | 269 | $2.82B |
| Q4 2025 | 250 | $2.50B |
| Q3 2025 | 240 | $1.97B |
| Q2 2025 | 231 | $1.93B |
| Q1 2025 | 222 | $1.85B |
| Q4 2024 | 224 | $2.61B |
| Q3 2024 | 217 | $3.69B |
| Q2 2024 | 203 | $2.88B |
| Q1 2024 | 211 | $2.51B |
| Q4 2023 | 209 | $2.47B |
| Q3 2023 | 195 | $2.24B |
| Q2 2023 | 203 | $3.18B |
| Q1 2023 | 202 | $2.49B |
| Q4 2022 | 199 | $2.94B |
| Q3 2022 | 200 | $2.84B |
| Q2 2022 | 188 | $2.73B |
| Q1 2022 | 190 | $2.79B |
| Q4 2021 | 213 | $3.80B |
| Q3 2021 | 214 | $4.28B |
| Q2 2021 | 210 | $6.32B |
| Q1 2021 | 218 | $4.60B |
Institutions, Q1 2025
Shares, value and share of portfolio for each institution holding Denali Therapeutics Inc.; share changes are against Q4 2024.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| BlackRock, Inc. | 13,834,956 | $188.1M | 0.00% | −85,289−0.6% | Reduced |
| Baillie Gifford & Co | 12,090,040 | $164.4M | 0.14% | −223,891−1.8% | Reduced |
| Vanguard Group Inc | 11,799,757 | $160.4M | 0.00% | −221,473−1.8% | Reduced |
| Wellington Management Group LLP | 11,409,598 | $155.1M | 0.03% | +1,561,647+15.9% | Added |
| FMR LLC | 7,413,354 | $100.8M | 0.01% | −606,392−7.6% | Reduced |
| UBS Asset Management Americas Inc | 6,766,916 | $92.0M | 0.02% | +3,184,042+88.9% | Added |
| Temasek Holdings (Private) Ltd | 5,355,832 | $72.8M | 0.29% | 00.0% | Unchanged |
| Capital Research Global Investors | 4,765,137 | $64.8M | 0.01% | −712,074−13.0% | Reduced |
| State Street Corp | 4,460,757 | $60.6M | 0.00% | −84,216−1.9% | Reduced |
| Price T Rowe Associates Inc | 4,367,234 | $59.4M | 0.01% | +1,308,619+42.8% | Added |
| Crestline Management, LP | 4,160,732 | $56.6M | 89.45% | −150,000−3.5% | Reduced |
| Baker Bros. Advisors LP | 3,731,695 | $50.7M | 0.56% | 00.0% | Unchanged |
| Alliancebernstein L.P. | 3,154,387 | $42.9M | 0.02% | −161,255−4.9% | Reduced |
| Norges Bank | 3,047,606 | $41.4M | 0.01% | +1,981,998+186.0% | Added |
| Geode Capital Management, LLC | 3,037,176 | $41.3M | 0.00% | +101,893+3.5% | Added |
| Marshall Wace, LLP | 2,188,422 | $29.8M | 0.04% | +399,685+22.3% | Added |
| Dimensional Fund Advisors LP | 2,100,856 | $28.6M | 0.01% | +245,820+13.3% | Added |
| Goldman Sachs Group Inc | 1,672,078 | $22.7M | 0.00% | +614,555+58.1% | Added |
| Millennium Management LLC | 1,493,068 | $20.3M | 0.02% | +1,088,844+269.4% | Added |
| Fisher Asset Management, LLC | 1,364,959 | $18.6M | 0.01% | +572,460+72.2% | Added |
| Morgan Stanley | 1,253,603 | $17.0M | 0.00% | +24,463+2.0% | Added |
| Camber Capital Management LP | 1,250,000 | $17.0M | 1.06% | −1,000,000−44.4% | Reduced |
| Citadel Advisors LLC | 1,169,683 | $15.9M | 0.02% | +339,772+40.9% | Added |
| Northern Trust Corp | 1,132,173 | $15.4M | 0.00% | −69,345−5.8% | Reduced |
| Bank of New York Mellon Corp | 1,103,892 | $15.0M | 0.00% | −139,095−11.2% | Reduced |
| Principal Financial Group Inc | 1,081,578 | $14.7M | 0.01% | −49,385−4.4% | Reduced |
| Charles Schwab Investment Management Inc | 1,009,896 | $13.7M | 0.00% | −18,566−1.8% | Reduced |
| Casdin Capital, LLC | 990,000 | $13.5M | 1.10% | 00.0% | Unchanged |
| Candriam Luxembourg S.C.A. | 858,162 | $11.7M | 0.07% | +25,185+3.0% | Added |
| Siren, L.L.C. | 821,513 | $11.2M | 0.63% | −12,515−1.5% | Reduced |
| UBS Group AG | 788,429 | $10.7M | 0.00% | −64,432−7.6% | Reduced |
| Standard Life Aberdeen plc | 759,815 | $10.3M | 0.02% | +357,533+88.9% | Added |
| Squarepoint Ops LLC | 687,151 | $9.34M | 0.02% | +638,532+1,313.3% | Added |
| StemPoint Capital LP | 667,078 | $9.07M | 2.90% | +82,750+14.2% | Added |
| Cercano Management LLC | 625,000 | $8.50M | 0.25% | 00.0% | Unchanged |
| Artisan Partners Limited Partnership | 612,438 | $8.33M | 0.01% | −442,085−41.9% | Reduced |
| Ensign Peak Advisors, Inc | 587,785 | $7.99M | 0.02% | +241,481+69.7% | Added |
| Yiheng Capital Management, L.P. | 469,981 | $6.39M | 2.25% | −230,117−32.9% | Reduced |
| Bank of America Corp | 447,757 | $6.09M | 0.00% | +177,424+65.6% | Added |
| Pictet Asset Management Holding SA | 343,959 | $5.06M | 0.01% | +324,603+1,677.0% | Added |
| Clarius Group, LLC | 368,995 | $5.02M | 0.32% | −41,000−10.0% | Reduced |
| American Century Companies Inc | 349,420 | $4.75M | 0.00% | −131,109−27.3% | Reduced |
| Pier Capital, LLC | 335,504 | $4.56M | 0.76% | +3,185+1.0% | Added |
| Nuveen, LLC | 322,945 | $4.39M | 0.00% | +322,945 | New |
| Schroder Investment Management Group | 291,795 | $4.31M | 0.00% | +43,995+17.8% | Added |
| TD Asset Management Inc | 308,580 | $4.20M | 0.00% | +42,828+16.1% | Added |
| Voloridge Investment Management, LLC | 301,973 | $4.11M | 0.02% | +301,973 | New |
| AXA S.A. | 293,381 | $3.99M | 0.01% | −374−0.1% | Reduced |
| Qube Research & Technologies Ltd | 288,221 | $3.92M | 0.01% | −23,286−7.5% | Reduced |
| Segall Bryant & Hamill, LLC | 281,139 | $3.82M | 0.06% | −7,936−2.7% | Reduced |
| Manufacturers Life Insurance Company, The | 258,132 | $3.51M | 0.00% | +49,611+23.8% | Added |
| Swiss National Bank | 250,900 | $3.41M | 0.00% | −2,600−1.0% | Reduced |
| Boxer Capital Management, LLC | 250,000 | $3.40M | 1.02% | +250,000 | New |
| Hudson Bay Capital Management LP | 250,000 | $3.40M | 0.02% | +157,500+170.3% | Added |
| Barclays PLC | 240,648 | $3.27M | 0.00% | −37,419−13.5% | Reduced |
| Jane Street Group, LLC | 213,673 | $2.90M | 0.01% | −15,492−6.8% | Reduced |
| Edmond de Rothschild Holding S.A. | 205,680 | $2.80M | 0.05% | 00.0% | Unchanged |
| SCS Capital Management LLC | 197,998 | $2.69M | 0.03% | +197,998 | New |
| Citigroup Inc | 194,004 | $2.64M | 0.00% | +27,298+16.4% | Added |
| Rhumbline Advisers | 190,256 | $2.59M | 0.00% | −134−0.1% | Reduced |
| Invesco Ltd. | 189,427 | $2.58M | 0.00% | +67,949+55.9% | Added |
| JPMorgan Chase & Co | 188,403 | $2.56M | 0.00% | −34,580−15.5% | Reduced |
| Teachers Retirement System of the State of Kentucky | 183,392 | $2.49M | 0.02% | −23,732−11.5% | Reduced |
| Renaissance Technologies LLC | 173,100 | $2.35M | 0.00% | +173,100 | New |
| Man Group plc | 169,385 | $2.30M | 0.01% | +146,950+655.0% | Added |
| Susquehanna International Group, LLP | 167,197 | $2.27M | 0.00% | +95,957+134.7% | Added |
| Groupama Asset Managment | 144,488 | $2.14M | 0.04% | +34,281+31.1% | Added |
| Deutsche Bank AG | 156,252 | $2.13M | 0.00% | −121,601−43.8% | Reduced |
| Legal & General Group Plc | 151,962 | $2.07M | 0.00% | +2,449+1.6% | Added |
| Soleus Capital Management, L.P. | 135,000 | $1.84M | 0.14% | +135,000 | New |
| Rafferty Asset Management, LLC | 129,135 | $1.76M | 0.01% | −12,175−8.6% | Reduced |
| DAFNA Capital Management LLC | 127,900 | $1.74M | 0.49% | +127,900 | New |
| California State Teachers Retirement System | 117,535 | $1.60M | 0.00% | −2,639−2.2% | Reduced |
| Woodline Partners LP | 113,517 | $1.54M | 0.01% | +13,517+13.5% | Added |
| Trexquant Investment LP | 113,224 | $1.54M | 0.02% | +52,568+86.7% | Added |
| Alps Advisors Inc | 111,375 | $1.51M | 0.01% | −5,002−4.3% | Reduced |
| Two Sigma Investments, LP | 102,403 | $1.39M | 0.00% | −77,481−43.1% | Reduced |
| Rhenman & Partners Asset Management AB | 100,000 | $1.36M | 0.16% | +100,000 | New |
| State of New Jersey Common Pension Fund D | 93,590 | $1.27M | 0.01% | +7,347+8.5% | Added |
| Mirae Asset Global ETFs Holdings Ltd. | 88,507 | $1.21M | 0.00% | +3,432+4.0% | Added |
| Franklin Resources Inc | 83,248 | $1.13M | 0.00% | +8,386+11.2% | Added |
| Dark Forest Capital Management LP | 80,820 | $1.10M | 0.05% | +67,932+527.1% | Added |
| State of Wisconsin Investment Board | 79,891 | $1.09M | 0.00% | −13,203−14.2% | Reduced |
| D. E. Shaw & Co., Inc. | 78,218 | $1.06M | 0.00% | +78,218 | New |
| Intech Investment Management LLC | 77,590 | $1.05M | 0.01% | +30,189+63.7% | Added |
| Wells Fargo & Company | 77,282 | $1.05M | 0.00% | −11,651−13.1% | Reduced |
| MetLife Investment Management | 74,765 | $1.02M | 0.01% | −1,285−1.7% | Reduced |
| Tudor Investment Corp Et Al | 72,597 | $987.0K | 0.01% | +72,597 | New |
| Twinbeech Capital LP | 72,022 | $979.1K | 0.02% | −182,564−71.7% | Reduced |
| New York State Common Retirement Fund | 70,240 | $954.9K | 0.00% | −74,484−51.5% | Reduced |
| DekaBank Deutsche Girozentrale | 64,210 | $935.0K | 0.00% | +4,410+7.4% | Added |
| Campbell & CO Investment Adviser LLC | 68,185 | $927.0K | 0.07% | +30,500+80.9% | Added |
| Thrivent Financial for Lutherans | 67,917 | $924.0K | 0.00% | −25,055−26.9% | Reduced |
| Janus Henderson Group PLC | 60,028 | $887.5K | 0.00% | 00.0% | Unchanged |
| Corebridge Financial, Inc. | 60,898 | $827.9K | 0.00% | −902−1.5% | Reduced |
| HSBC Holdings PLC | 58,003 | $778.5K | 0.00% | +24,613+73.7% | Added |
| Guggenheim Capital LLC | 56,012 | $761.5K | 0.01% | +7,881+16.4% | Added |
| Y-Intercept (Hong Kong) Ltd | 54,813 | $745.2K | 0.05% | +18,807+52.2% | Added |
| Voya Investment Management LLC | 51,011 | $693.5K | 0.00% | −3,802−6.9% | Reduced |
| Ironwood Investment Management LLC | 49,305 | $670.3K | 0.37% | +12,759+34.9% | Added |