Denali Therapeutics Inc.
DNLI- Exchange
- Nasdaq
- Industry
- Biological Products, (No Diagnostic Substances)
- SEC CIK
- 0001714899
In the last 90 days, Denali Therapeutics Inc. insiders filed 0 open-market purchases and 4 sales; 294 institutions reported holding it in 13F filings for Q2 2026, worth $4.00B in total; no superinvestor holds it.
13F holders, Q3 2025
Institutional positions in Denali Therapeutics Inc. as of Sep 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 240
- +13 vs. Q2 2025
- Shares held
- 135.5M
- +2.28M (+1.7%) vs. Q2 2025
- Total value
- $1.97B
- +$103.6M (+5.6%) vs. Q2 2025
- New holders
- 35
- 91 more added
- Sold out
- 22
- 67 more reduced
4 institutions that held it in Q2 2025 haven't filed for Q3 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q2 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting DNLI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 294 | $4.00B |
| Q1 2026 | 269 | $2.82B |
| Q4 2025 | 250 | $2.50B |
| Q3 2025 | 240 | $1.97B |
| Q2 2025 | 231 | $1.93B |
| Q1 2025 | 222 | $1.85B |
| Q4 2024 | 224 | $2.61B |
| Q3 2024 | 217 | $3.69B |
| Q2 2024 | 203 | $2.88B |
| Q1 2024 | 211 | $2.51B |
| Q4 2023 | 209 | $2.47B |
| Q3 2023 | 195 | $2.24B |
| Q2 2023 | 203 | $3.18B |
| Q1 2023 | 202 | $2.49B |
| Q4 2022 | 199 | $2.94B |
| Q3 2022 | 200 | $2.84B |
| Q2 2022 | 188 | $2.73B |
| Q1 2022 | 190 | $2.79B |
| Q4 2021 | 213 | $3.80B |
| Q3 2021 | 214 | $4.28B |
| Q2 2021 | 210 | $6.32B |
| Q1 2021 | 218 | $4.60B |
Institutions, Q3 2025
Shares, value and share of portfolio for each institution holding Denali Therapeutics Inc.; share changes are against Q2 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| BlackRock, Inc. | 12,289,626 | $178.4M | 0.00% | +236,281+2.0% | Added |
| Vanguard Group Inc | 11,992,918 | $174.1M | 0.00% | +182,183+1.5% | Added |
| Baillie Gifford & Co | 11,591,585 | $168.3M | 0.12% | −363,738−3.0% | Reduced |
| FMR LLC | 6,340,316 | $92.1M | 0.00% | −1,198,152−15.9% | Reduced |
| T. Rowe Price Investment Management, Inc. | 5,638,567 | $81.9M | 0.05% | +2,391,633+73.7% | Added |
| UBS Asset Management Americas Inc | 5,465,037 | $79.4M | 0.02% | −797,240−12.7% | Reduced |
| State Street Corp | 5,464,261 | $79.3M | 0.00% | +946,267+20.9% | Added |
| Temasek Holdings (Private) Ltd | 5,355,832 | $77.8M | 0.27% | 00.0% | Unchanged |
| Capital Research Global Investors | 4,760,858 | $69.1M | 0.01% | +10,279+0.2% | Added |
| Price T Rowe Associates Inc | 4,568,368 | $66.3M | 0.01% | −2,013,927−30.6% | Reduced |
| Baker Bros. Advisors LP | 3,731,695 | $54.2M | 0.39% | 00.0% | Unchanged |
| Alliancebernstein L.P. | 3,520,414 | $51.1M | 0.02% | +383,274+12.2% | Added |
| Geode Capital Management, LLC | 3,466,057 | $50.3M | 0.00% | +293,752+9.3% | Added |
| Crestline Management, LP | 3,410,732 | $49.5M | 85.26% | −450,000−11.7% | Reduced |
| Holocene Advisors, LP | 3,135,712 | $45.5M | 0.10% | +2,732,540+677.8% | Added |
| Point72 Asset Management, L.P. | 2,519,535 | $36.6M | 0.08% | +305,588+13.8% | Added |
| Dimensional Fund Advisors LP | 2,357,214 | $34.2M | 0.01% | −55,714−2.3% | Reduced |
| Goldman Sachs Group Inc | 2,163,705 | $31.4M | 0.00% | +298,381+16.0% | Added |
| UBS Group AG | 2,012,353 | $29.2M | 0.01% | +1,061,589+111.7% | Added |
| StemPoint Capital LP | 1,734,659 | $25.2M | 5.08% | +1,026,744+145.0% | Added |
| Morgan Stanley | 1,689,492 | $24.5M | 0.00% | +377,476+28.8% | Added |
| Fisher Asset Management, LLC | 1,631,496 | $23.7M | 0.01% | +115,505+7.6% | Added |
| Millennium Management LLC | 1,307,171 | $19.0M | 0.01% | +406,670+45.2% | Added |
| Principal Financial Group Inc | 1,271,190 | $18.5M | 0.01% | +198,207+18.5% | Added |
| Northern Trust Corp | 1,234,179 | $17.9M | 0.00% | +32,470+2.7% | Added |
| Charles Schwab Investment Management Inc | 1,151,384 | $16.7M | 0.00% | +95,365+9.0% | Added |
| Standard Life Aberdeen plc | 1,113,586 | $16.2M | 0.03% | +210,835+23.4% | Added |
| Foresite Capital Management VI LLC | 1,000,000 | $14.5M | 5.61% | +1,000,000 | New |
| Bank of America Corp | 961,138 | $14.0M | 0.00% | +310,916+47.8% | Added |
| Voloridge Investment Management, LLC | 936,230 | $13.6M | 0.05% | +165,703+21.5% | Added |
| Casdin Capital, LLC | 890,000 | $12.9M | 1.08% | 00.0% | Unchanged |
| Candriam Luxembourg S.C.A. | 833,582 | $12.1M | 0.06% | −10,667−1.3% | Reduced |
| Siren, L.L.C. | 821,513 | $11.9M | 0.47% | 00.0% | Unchanged |
| Bank of New York Mellon Corp | 800,747 | $11.6M | 0.00% | +9,991+1.3% | Added |
| Marshall Wace, LLP | 787,029 | $11.4M | 0.01% | −618,221−44.0% | Reduced |
| Masters Capital Management LLC | 750,000 | $10.9M | 1.75% | +150,000+25.0% | Added |
| Citadel Advisors LLC | 688,224 | $9.99M | 0.01% | −560,729−44.9% | Reduced |
| Cercano Management LLC | 625,000 | $9.07M | 0.35% | 00.0% | Unchanged |
| Ensign Peak Advisors, Inc | 534,071 | $7.75M | 0.01% | +60,376+12.7% | Added |
| Segall Bryant & Hamill, LLC | 512,958 | $7.45M | 0.10% | +12,399+2.5% | Added |
| Pictet Asset Management Holding SA | 499,162 | $7.25M | 0.01% | +84,050+20.2% | Added |
| Yiheng Capital Management, L.P. | 469,981 | $6.82M | 2.26% | 00.0% | Unchanged |
| Barclays PLC | 437,001 | $6.35M | 0.00% | +11,020+2.6% | Added |
| Trexquant Investment LP | 430,566 | $6.25M | 0.06% | +321,324+294.1% | Added |
| Palo Alto Investors LP | 408,006 | $5.92M | 1.10% | +168,197+70.1% | Added |
| TD Asset Management Inc | 394,600 | $5.73M | 0.00% | −101,690−20.5% | Reduced |
| Royal Bank of Canada | 372,176 | $5.40M | 0.00% | −17,979−4.6% | Reduced |
| Clarius Group, LLC | 359,745 | $5.22M | 0.31% | −9,250−2.5% | Reduced |
| American Century Companies Inc | 357,341 | $5.19M | 0.00% | +39,148+12.3% | Added |
| Hudson Bay Capital Management LP | 305,000 | $4.43M | 0.03% | +15,000+5.2% | Added |
| Pier Capital, LLC | 301,171 | $4.37M | 0.68% | −13,625−4.3% | Reduced |
| AXA Investment Managers S.A. | 294,732 | $4.28M | 0.01% | +294,732 | New |
| Marex Group plc | 291,000 | $4.23M | 0.05% | +29,000+11.1% | Added |
| Nuveen, LLC | 284,777 | $4.13M | 0.00% | −310,440−52.2% | Reduced |
| Swiss National Bank | 267,500 | $3.88M | 0.00% | +16,600+6.6% | Added |
| Two Sigma Investments, LP | 266,292 | $3.87M | 0.01% | +246,992+1,279.8% | Added |
| BNP Paribas Arbitrage, SA | 264,061 | $3.83M | 0.00% | +244,979+1,283.8% | Added |
| Lynx1 Capital Management LP | 261,687 | $3.80M | 0.77% | +261,687 | New |
| Boxer Capital Management, LLC | 250,000 | $3.63M | 1.16% | +250,000 | New |
| Invesco Ltd. | 249,467 | $3.62M | 0.00% | +29,672+13.5% | Added |
| Cubist Systematic Strategies, LLC | 230,968 | $3.35M | 0.05% | −165,618−41.8% | Reduced |
| Qube Research & Technologies Ltd | 227,990 | $3.31M | 0.00% | +227,990 | New |
| Schonfeld Strategic Advisors LLC | 226,203 | $3.28M | 0.02% | +226,203 | New |
| Jane Street Group, LLC | 224,903 | $3.27M | 0.00% | +139,571+163.6% | Added |
| Campbell & CO Investment Adviser LLC | 216,774 | $3.15M | 0.24% | +74,066+51.9% | Added |
| Schroder Investment Management Group | 209,595 | $3.04M | 0.00% | −176,944−45.8% | Reduced |
| Deutsche Bank AG | 207,594 | $3.01M | 0.00% | +71,625+52.7% | Added |
| Manufacturers Life Insurance Company, The | 205,845 | $2.99M | 0.00% | −109,257−34.7% | Reduced |
| Edmond de Rothschild Holding S.A. | 205,680 | $2.99M | 0.05% | 00.0% | Unchanged |
| Rhumbline Advisers | 201,565 | $2.93M | 0.00% | −10,938−5.1% | Reduced |
| SCS Capital Management LLC | 197,998 | $2.87M | 0.03% | 00.0% | Unchanged |
| Rafferty Asset Management, LLC | 182,886 | $2.66M | 0.01% | +60,624+49.6% | Added |
| JPMorgan Chase & Co | 175,021 | $2.54M | 0.00% | −16,592−8.7% | Reduced |
| Teachers Retirement System of the State of Kentucky | 171,553 | $2.49M | 0.02% | 00.0% | Unchanged |
| DAFNA Capital Management LLC | 168,500 | $2.45M | 0.60% | 00.0% | Unchanged |
| Jump Financial, LLC | 166,399 | $2.42M | 0.03% | +166,399 | New |
| Legal & General Group Plc | 143,952 | $2.09M | 0.00% | +12,197+9.3% | Added |
| State of New Jersey Common Pension Fund D | 139,663 | $2.03M | 0.01% | +1,783+1.3% | Added |
| Groupama Asset Managment | 135,758 | $1.97M | 0.03% | −39,773−22.7% | Reduced |
| Mirae Asset Global ETFs Holdings Ltd. | 129,887 | $1.89M | 0.00% | −4,816−3.6% | Reduced |
| California State Teachers Retirement System | 129,526 | $1.88M | 0.00% | +10,199+8.5% | Added |
| Edgestream Partners, L.P. | 123,819 | $1.80M | 0.05% | −219,104−63.9% | Reduced |
| Woodline Partners LP | 113,517 | $1.65M | 0.01% | 00.0% | Unchanged |
| Wells Fargo & Company | 104,179 | $1.51M | 0.00% | +14,540+16.2% | Added |
| Algert Global LLC | 101,260 | $1.47M | 0.02% | +15,420+18.0% | Added |
| Rhenman & Partners Asset Management AB | 100,000 | $1.45M | 0.16% | 00.0% | Unchanged |
| Ameriprise Financial Inc | 99,561 | $1.45M | 0.00% | −2,472−2.4% | Reduced |
| Integrated Wealth Concepts LLC | 91,074 | $1.32M | 0.01% | −4,972−5.2% | Reduced |
| Two Sigma Advisers, LP | 90,000 | $1.31M | 0.00% | +62,400+226.1% | Added |
| Squarepoint Ops LLC | 80,518 | $1.17M | 0.00% | +80,518 | New |
| State of Wisconsin Investment Board | 80,126 | $1.16M | 0.00% | +499+0.6% | Added |
| MetLife Investment Management | 79,075 | $1.15M | 0.01% | 00.0% | Unchanged |
| Savvy Advisors, Inc. | 77,093 | $1.12M | 0.05% | −20,700−21.2% | Reduced |
| Quest Partners LLC | 74,422 | $1.08M | 0.07% | +51,458+224.1% | Added |
| Alps Advisors Inc | 70,230 | $1.02M | 0.01% | −8,126−10.4% | Reduced |
| Engineers Gate Manager LP | 69,216 | $1.01M | 0.01% | −46,885−40.4% | Reduced |
| Pier 88 Investment Partners LLC | 67,440 | $979.2K | 0.18% | +10,290+18.0% | Added |
| XTX Topco Ltd | 65,345 | $948.8K | 0.05% | +65,345 | New |
| TT International Asset Management LTD | 65,000 | $943.8K | 0.18% | 00.0% | Unchanged |
| Franklin Resources Inc | 64,634 | $938.5K | 0.00% | +109+0.2% | Added |