Denali Therapeutics Inc.
DNLI- Exchange
- Nasdaq
- Industry
- Biological Products, (No Diagnostic Substances)
- SEC CIK
- 0001714899
In the last 90 days, Denali Therapeutics Inc. insiders filed 0 open-market purchases and 4 sales; 294 institutions reported holding it in 13F filings for Q2 2026, worth $4.00B in total; no superinvestor holds it.
13F holders, Q3 2025
Institutional positions in Denali Therapeutics Inc. as of Sep 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 240
- +13 vs. Q2 2025
- Shares held
- 135.5M
- +2.28M (+1.7%) vs. Q2 2025
- Total value
- $1.97B
- +$103.6M (+5.6%) vs. Q2 2025
- New holders
- 35
- 91 more added
- Sold out
- 22
- 67 more reduced
4 institutions that held it in Q2 2025 haven't filed for Q3 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q2 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting DNLI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 294 | $4.00B |
| Q1 2026 | 269 | $2.82B |
| Q4 2025 | 250 | $2.50B |
| Q3 2025 | 240 | $1.97B |
| Q2 2025 | 231 | $1.93B |
| Q1 2025 | 222 | $1.85B |
| Q4 2024 | 224 | $2.61B |
| Q3 2024 | 217 | $3.69B |
| Q2 2024 | 203 | $2.88B |
| Q1 2024 | 211 | $2.51B |
| Q4 2023 | 209 | $2.47B |
| Q3 2023 | 195 | $2.24B |
| Q2 2023 | 203 | $3.18B |
| Q1 2023 | 202 | $2.49B |
| Q4 2022 | 199 | $2.94B |
| Q3 2022 | 200 | $2.84B |
| Q2 2022 | 188 | $2.73B |
| Q1 2022 | 190 | $2.79B |
| Q4 2021 | 213 | $3.80B |
| Q3 2021 | 214 | $4.28B |
| Q2 2021 | 210 | $6.32B |
| Q1 2021 | 218 | $4.60B |
Institutions, Q3 2025
Shares, value and share of portfolio for each institution holding Denali Therapeutics Inc.; share changes are against Q2 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Simplex Trading, LLC | 41 | $0 | 0.00% | −2,461−98.4% | Reduced |
| Avion Wealth | 40 | $0 | 0.00% | 00.0% | Unchanged |
| Hemington Wealth Management | 34 | $0 | 0.00% | 00.0% | Unchanged |
| Cloud Capital Management, LLC | 2 | $0 | 0.00% | +2 | New |
| Bay Harbor Wealth Management, LLC | 1 | $14 | 0.00% | 00.0% | Unchanged |
| Global Retirement Partners, LLC | 1 | $15 | 0.00% | −2−66.7% | Reduced |
| Truvestments Capital LLC | 1 | $18 | 0.00% | 00.0% | Unchanged |
| HFM Investment Advisors, LLC | 2 | $29 | 0.00% | −1−33.3% | Reduced |
| Rialto Wealth Management, LLC | 2 | $30 | 0.00% | 00.0% | Unchanged |
| SJS Investment Consulting Inc. | 4 | $59 | 0.00% | 00.0% | Unchanged |
| Private Wealth Asset Management, LLC | 8 | $116 | 0.00% | 00.0% | Unchanged |
| IFP Advisors, Inc | 9 | $131 | 0.00% | +9 | Added |
| Fortitude Family Office, LLC | 9 | $131 | 0.00% | −32−78.0% | Reduced |
| SBI Securities Co., Ltd. | 22 | $319 | 0.00% | +17+340.0% | Added |
| Sunbelt Securities, Inc. | 22 | $319 | 0.00% | +22 | New |
| Advisory Services Network, LLC | 39 | $566 | 0.00% | +39 | New |
| Ronald Blue Trust, Inc. | 40 | $581 | 0.00% | 00.0% | Unchanged |
| Point72 (DIFC) Ltd | 43 | $622 | 0.00% | +43 | New |
| National Bank of Canada | 50 | $726 | 0.00% | −122−70.9% | Reduced |
| Guerra Advisors Inc | 50 | $726 | 0.00% | +50 | New |
| True Wealth Design, LLC | 56 | $814 | 0.00% | 00.0% | Unchanged |
| Bell Investment Advisors, Inc | 59 | $857 | 0.00% | −64−52.0% | Reduced |
| Root Financial Partners, LLC | 70 | $1.02K | 0.00% | +70 | New |
| TD Private Client Wealth LLC | 71 | $1.03K | 0.00% | +71 | New |
| Rise Advisors, LLC | 74 | $1.07K | 0.00% | 00.0% | Unchanged |
| UMA Financial Services, Inc. | 76 | $1.10K | 0.00% | −64−45.7% | Reduced |
| Allworth Financial LP | 99 | $1.44K | 0.00% | −176−64.0% | Reduced |
| Harbour Investments, Inc. | 100 | $1.45K | 0.00% | 00.0% | Unchanged |
| Your Advocates Ltd., LLP | 100 | $1.45K | 0.00% | 00.0% | Unchanged |
| Halbert Hargrove Global Advisors, LLC | 104 | $1.51K | 0.00% | +104 | New |
| Farther Finance Advisors, LLC | 127 | $1.84K | 0.00% | +20+18.7% | Added |
| Massmutual Trust Co FSB | 143 | $2.08K | 0.00% | +20+16.3% | Added |
| EverSource Wealth Advisors, LLC | 166 | $2.41K | 0.00% | +51+44.3% | Added |
| Parkside Financial Bank & Trust | 189 | $2.75K | 0.00% | +39+26.0% | Added |
| Meeder Asset Management Inc | 206 | $2.99K | 0.00% | +206 | New |
| Rothschild Investment LLC | 225 | $3.27K | 0.00% | −100−30.8% | Reduced |
| Signaturefd, LLC | 230 | $3.34K | 0.00% | −99−30.1% | Reduced |
| City State Bank | 250 | $3.63K | 0.00% | 00.0% | Unchanged |
| Private Wealth Management Group, LLC | 296 | $4.30K | 0.00% | 00.0% | Unchanged |
| Huntington National Bank | 308 | $4.47K | 0.00% | +38+14.1% | Added |
| GWM Advisors LLC | 400 | $5.81K | 0.00% | 00.0% | Unchanged |
| Parallel Advisors, LLC | 434 | $6.30K | 0.00% | −111−20.4% | Reduced |
| Daiwa Securities Group Inc. | 475 | $7.00K | 0.00% | 00.0% | Unchanged |
| Groupe la Francaise | 620 | $7.67K | 0.00% | +620 | New |
| NBC Securities, Inc. | 532 | $7.72K | 0.00% | 00.0% | Unchanged |
| Covestor Ltd | 579 | $8.00K | 0.00% | −1−0.2% | Reduced |
| US Bancorp | 696 | $10.1K | 0.00% | +255+57.8% | Added |
| Nemes Rush Group LLC | 700 | $10.2K | 0.00% | 00.0% | Unchanged |
| GAMMA Investing LLC | 729 | $10.6K | 0.00% | −20−2.7% | Reduced |
| Quadrant Capital Group LLC | 782 | $11.4K | 0.00% | +782 | New |
| Optiver Holding B.V. | 896 | $13.0K | 0.00% | +3+0.3% | Added |
| Smartleaf Asset Management LLC | 954 | $13.9K | 0.00% | +500+110.1% | Added |
| Mitsubishi UFJ Kokusai Asset Management Co., Ltd. | 1,001 | $14.5K | 0.00% | 00.0% | Unchanged |
| Rockefeller Capital Management L.P. | 1,083 | $15.7K | 0.00% | +1,083 | New |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 1,271 | $18.0K | 0.00% | +132+11.6% | Added |
| Comerica Bank | 1,284 | $18.6K | 0.00% | 00.0% | Unchanged |
| Advisor Group Holdings, Inc. | 1,388 | $20.9K | 0.00% | −207−13.0% | Reduced |
| Versant Capital Management, Inc | 1,476 | $21.4K | 0.00% | +190+14.8% | Added |
| Nisa Investment Advisors, LLC | 1,483 | $21.5K | 0.00% | +266+21.9% | Added |
| Bartlett & Co. Wealth Management LLC | 1,500 | $21.8K | 0.00% | 00.0% | Unchanged |
| Shell Asset Management Co | 1,492 | $22.0K | 0.00% | −2,517−62.8% | Reduced |
| Caitong International Asset Management Co., Ltd | 1,528 | $22.2K | 0.02% | +1,328+664.0% | Added |
| Johnson Financial Group, Inc. | 1,975 | $28.7K | 0.00% | +1,975 | New |
| State of Wyoming | 2,154 | $31.3K | 0.00% | +55+2.6% | Added |
| CWM, LLC | 2,397 | $35.0K | 0.00% | +122+5.4% | Added |
| GF Fund Management Co. Ltd. | 3,146 | $45.7K | 0.00% | −539−14.6% | Reduced |
| Assetmark, Inc | 3,937 | $57.2K | 0.00% | +317+8.8% | Added |
| Amalgamated Bank | 4,305 | $63.0K | 0.00% | 00.0% | Unchanged |
| Quarry LP | 4,375 | $63.5K | 0.02% | +4,375 | New |
| KBC Group NV | 4,495 | $65.0K | 0.00% | 00.0% | Unchanged |
| Mirae Asset Global Investments Co., Ltd. | 5,653 | $82.1K | 0.00% | +41+0.7% | Added |
| Caption Management, LLC | 7,366 | $107.0K | 0.01% | +7,366 | New |
| Tower Research Capital LLC (TRC) | 7,376 | $107.1K | 0.00% | −6,293−46.0% | Reduced |
| Virtus Investment Advisers, Inc. | 7,624 | $110.7K | 0.03% | +1,324+21.0% | Added |
| The PNC Financial Services Group, Inc. | 8,290 | $120.4K | 0.00% | +54+0.7% | Added |
| Sterling Capital Management LLC | 8,654 | $125.7K | 0.00% | +5,268+155.6% | Added |
| Xponance, Inc. | 10,400 | $151.0K | 0.00% | +48+0.5% | Added |
| Intrust Bank NA | 10,575 | $153.5K | 0.01% | +10,575 | New |
| LPL Financial LLC | 10,648 | $154.6K | 0.00% | +10,648 | New |
| Empowered Funds, LLC | 11,037 | $160.3K | 0.00% | −3,783−25.5% | Reduced |
| Ameritas Investment Partners, Inc. | 11,065 | $160.7K | 0.00% | −2,457−18.2% | Reduced |
| Aigen Investment Management, LP | 12,075 | $175.3K | 0.03% | +1,413+13.3% | Added |
| Public Employees Retirement Association of Colorado | 12,238 | $178.0K | 0.00% | 00.0% | Unchanged |
| MONECO Advisors, LLC | 12,478 | $181.2K | 0.02% | +2,000+19.1% | Added |
| JustInvest LLC | 12,526 | $181.9K | 0.00% | −2,803−18.3% | Reduced |
| Great West Life Assurance Co | 13,434 | $195.0K | 0.00% | 00.0% | Unchanged |
| Russell Investments Group, Ltd. | 13,799 | $200.4K | 0.00% | +11,241+439.4% | Added |
| HSBC Holdings PLC | 14,004 | $200.8K | 0.00% | +3,956+39.4% | Added |
| CIBC Bancorp USA Inc. | 14,118 | $205.0K | 0.00% | +14,118 | New |
| Citigroup Inc | 14,936 | $216.9K | 0.00% | −61,379−80.4% | Reduced |
| Victory Capital Management Inc | 15,064 | $218.7K | 0.00% | −30,552−67.0% | Reduced |
| Breakwater Capital Group | 15,866 | $230.4K | 0.03% | −1,230−7.2% | Reduced |
| Prudential Financial Inc | 16,938 | $245.9K | 0.00% | +60+0.4% | Added |
| Jain Global LLC | 17,414 | $252.9K | 0.00% | +2,928+20.2% | Added |
| Verition Fund Management LLC | 17,629 | $256.0K | 0.00% | −33,180−65.3% | Reduced |
| HighTower Advisors, LLC | 21,322 | $309.6K | 0.00% | −1,211−5.4% | Reduced |
| Oxford Asset Management LLP | 22,231 | $322.8K | 0.11% | +22,231 | New |
| Voya Investment Management LLC | 23,805 | $345.6K | 0.00% | −12,103−33.7% | Reduced |
| EntryPoint Capital, LLC | 24,058 | $349.3K | 0.14% | +24,058 | New |
| AQR Capital Management LLC | 24,139 | $350.5K | 0.00% | +2,922+13.8% | Added |