Denali Therapeutics Inc.
DNLI- Exchange
- Nasdaq
- Industry
- Biological Products, (No Diagnostic Substances)
- SEC CIK
- 0001714899
In the last 90 days, Denali Therapeutics Inc. insiders filed 0 open-market purchases and 4 sales; 294 institutions reported holding it in 13F filings for Q2 2026, worth $4.00B in total; no superinvestor holds it.
13F holders, Q2 2025
Institutional positions in Denali Therapeutics Inc. as of Jun 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 231
- +10 vs. Q1 2025
- Shares held
- 137.6M
- +1.67M (+1.2%) vs. Q1 2025
- Total value
- $1.93B
- +$76.1M (+4.1%) vs. Q1 2025
- New holders
- 46
- 84 more added
- Sold out
- 36
- 64 more reduced
1 institution that held it in Q1 2025 haven't filed for Q2 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q1 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting DNLI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 294 | $4.00B |
| Q1 2026 | 269 | $2.82B |
| Q4 2025 | 250 | $2.50B |
| Q3 2025 | 240 | $1.97B |
| Q2 2025 | 231 | $1.93B |
| Q1 2025 | 222 | $1.85B |
| Q4 2024 | 224 | $2.61B |
| Q3 2024 | 217 | $3.69B |
| Q2 2024 | 203 | $2.88B |
| Q1 2024 | 211 | $2.51B |
| Q4 2023 | 209 | $2.47B |
| Q3 2023 | 195 | $2.24B |
| Q2 2023 | 203 | $3.18B |
| Q1 2023 | 202 | $2.49B |
| Q4 2022 | 199 | $2.94B |
| Q3 2022 | 200 | $2.84B |
| Q2 2022 | 188 | $2.73B |
| Q1 2022 | 190 | $2.79B |
| Q4 2021 | 213 | $3.80B |
| Q3 2021 | 214 | $4.28B |
| Q2 2021 | 210 | $6.32B |
| Q1 2021 | 218 | $4.60B |
Institutions, Q2 2025
Shares, value and share of portfolio for each institution holding Denali Therapeutics Inc.; share changes are against Q1 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| BlackRock, Inc. | 12,053,345 | $168.6M | 0.00% | −1,781,611−12.9% | Reduced |
| Baillie Gifford & Co | 11,955,323 | $167.3M | 0.12% | −134,717−1.1% | Reduced |
| Vanguard Group Inc | 11,810,735 | $165.2M | 0.00% | +10,978+0.1% | Added |
| FMR LLC | 7,538,468 | $105.5M | 0.01% | +125,114+1.7% | Added |
| Price T Rowe Associates Inc | 6,582,295 | $92.1M | 0.01% | +2,215,061+50.7% | Added |
| UBS Asset Management Americas Inc | 6,262,277 | $87.6M | 0.02% | −504,639−7.5% | Reduced |
| Wellington Management Group LLP | 5,664,733 | $79.2M | 0.01% | −5,744,865−50.4% | Reduced |
| Temasek Holdings (Private) Ltd | 5,355,832 | $74.9M | 0.29% | 00.0% | Unchanged |
| Capital Research Global Investors | 4,750,579 | $66.5M | 0.01% | −14,558−0.3% | Reduced |
| State Street Corp | 4,517,994 | $63.2M | 0.00% | +57,237+1.3% | Added |
| Norges Bank | 3,947,387 | $55.2M | 0.01% | +899,781+29.5% | Added |
| Crestline Management, LP | 3,860,732 | $54.0M | 86.33% | −300,000−7.2% | Reduced |
| Baker Bros. Advisors LP | 3,731,695 | $52.2M | 0.51% | 00.0% | Unchanged |
| T. Rowe Price Investment Management, Inc. | 3,246,934 | $45.4M | 0.03% | +3,246,934 | New |
| Geode Capital Management, LLC | 3,172,305 | $44.4M | 0.00% | +135,129+4.4% | Added |
| Alliancebernstein L.P. | 3,137,140 | $43.9M | 0.01% | −17,247−0.5% | Reduced |
| Dimensional Fund Advisors LP | 2,412,928 | $33.8M | 0.01% | +312,072+14.9% | Added |
| Point72 Asset Management, L.P. | 2,213,947 | $31.0M | 0.07% | +2,213,947 | New |
| Goldman Sachs Group Inc | 1,865,324 | $26.1M | 0.00% | +193,246+11.6% | Added |
| Fisher Asset Management, LLC | 1,515,991 | $21.2M | 0.01% | +151,032+11.1% | Added |
| Marshall Wace, LLP | 1,405,250 | $19.7M | 0.02% | −783,172−35.8% | Reduced |
| Morgan Stanley | 1,312,016 | $18.4M | 0.00% | +58,413+4.7% | Added |
| Citadel Advisors LLC | 1,248,953 | $17.5M | 0.02% | +79,270+6.8% | Added |
| Northern Trust Corp | 1,201,709 | $16.8M | 0.00% | +69,536+6.1% | Added |
| Principal Financial Group Inc | 1,072,983 | $15.0M | 0.01% | −8,595−0.8% | Reduced |
| Charles Schwab Investment Management Inc | 1,056,019 | $14.8M | 0.00% | +46,123+4.6% | Added |
| UBS Group AG | 950,764 | $13.3M | 0.00% | +162,335+20.6% | Added |
| Standard Life Aberdeen plc | 902,751 | $12.6M | 0.02% | +142,936+18.8% | Added |
| Millennium Management LLC | 900,501 | $12.6M | 0.01% | −592,567−39.7% | Reduced |
| Casdin Capital, LLC | 890,000 | $12.5M | 1.13% | −100,000−10.1% | Reduced |
| Candriam Luxembourg S.C.A. | 844,249 | $11.8M | 0.07% | −13,913−1.6% | Reduced |
| Siren, L.L.C. | 821,513 | $11.5M | 0.59% | 00.0% | Unchanged |
| Bank of New York Mellon Corp | 790,756 | $11.1M | 0.00% | −313,136−28.4% | Reduced |
| Voloridge Investment Management, LLC | 770,527 | $10.8M | 0.04% | +468,554+155.2% | Added |
| StemPoint Capital LP | 707,915 | $9.90M | 3.19% | +40,837+6.1% | Added |
| Bank of America Corp | 650,222 | $9.10M | 0.00% | +202,465+45.2% | Added |
| Cercano Management LLC | 625,000 | $8.74M | 0.25% | 00.0% | Unchanged |
| Masters Capital Management LLC | 600,000 | $8.39M | 1.62% | +600,000 | New |
| Nuveen, LLC | 595,217 | $8.33M | 0.00% | +272,272+84.3% | Added |
| Segall Bryant & Hamill, LLC | 500,559 | $7.00M | 0.10% | +219,420+78.0% | Added |
| TD Asset Management Inc | 496,290 | $6.94M | 0.01% | +187,710+60.8% | Added |
| Ensign Peak Advisors, Inc | 473,695 | $6.63M | 0.01% | −114,090−19.4% | Reduced |
| Yiheng Capital Management, L.P. | 469,981 | $6.58M | 2.38% | 00.0% | Unchanged |
| Barclays PLC | 425,981 | $5.96M | 0.00% | +185,333+77.0% | Added |
| Pictet Asset Management Holding SA | 415,112 | $5.85M | 0.01% | +71,153+20.7% | Added |
| Holocene Advisors, LP | 403,172 | $5.64M | 0.01% | +403,172 | New |
| Camber Capital Management LP | 400,000 | $5.60M | 0.78% | −850,000−68.0% | Reduced |
| Cubist Systematic Strategies, LLC | 396,586 | $5.55M | 0.06% | +396,586 | New |
| Royal Bank of Canada | 390,155 | $5.46M | 0.00% | +375,719+2,602.7% | Added |
| Schroder Investment Management Group | 386,539 | $5.41M | 0.00% | +94,744+32.5% | Added |
| Clarius Group, LLC | 368,995 | $5.16M | 0.30% | 00.0% | Unchanged |
| Edgestream Partners, L.P. | 342,923 | $4.80M | 0.13% | +342,923 | New |
| American Century Companies Inc | 318,193 | $4.45M | 0.00% | −31,227−8.9% | Reduced |
| Manufacturers Life Insurance Company, The | 315,102 | $4.41M | 0.00% | +56,970+22.1% | Added |
| Pier Capital, LLC | 314,796 | $4.40M | 0.67% | −20,708−6.2% | Reduced |
| AXA S.A. | 293,853 | $4.11M | 0.01% | +472+0.2% | Added |
| Hudson Bay Capital Management LP | 290,000 | $4.06M | 0.03% | +40,000+16.0% | Added |
| Marex Group plc | 262,000 | $3.67M | 0.07% | +262,000 | New |
| Swiss National Bank | 250,900 | $3.51M | 0.00% | 00.0% | Unchanged |
| Palo Alto Investors LP | 239,809 | $3.35M | 0.71% | +239,809 | New |
| Invesco Ltd. | 219,795 | $3.07M | 0.00% | +30,368+16.0% | Added |
| Rhumbline Advisers | 212,503 | $2.97M | 0.00% | +22,247+11.7% | Added |
| Twinbeech Capital LP | 210,370 | $2.94M | 0.07% | +138,348+192.1% | Added |
| Edmond de Rothschild Holding S.A. | 205,680 | $2.88M | 0.05% | 00.0% | Unchanged |
| SCS Capital Management LLC | 197,998 | $2.77M | 0.03% | 00.0% | Unchanged |
| Renaissance Technologies LLC | 195,700 | $2.74M | 0.00% | +22,600+13.1% | Added |
| JPMorgan Chase & Co | 191,613 | $2.68M | 0.00% | +3,210+1.7% | Added |
| Soleus Capital Management, L.P. | 182,110 | $2.55M | 0.18% | +47,110+34.9% | Added |
| Groupama Asset Managment | 175,531 | $2.47M | 0.04% | +31,043+21.5% | Added |
| Teachers Retirement System of the State of Kentucky | 171,553 | $2.40M | 0.02% | −11,839−6.5% | Reduced |
| DAFNA Capital Management LLC | 168,500 | $2.36M | 0.65% | +40,600+31.7% | Added |
| Susquehanna International Group, LLP | 161,136 | $2.25M | 0.00% | −6,061−3.6% | Reduced |
| Campbell & CO Investment Adviser LLC | 142,708 | $2.00M | 0.13% | +74,523+109.3% | Added |
| State of New Jersey Common Pension Fund D | 137,880 | $1.93M | 0.01% | +44,290+47.3% | Added |
| Deutsche Bank AG | 135,969 | $1.90M | 0.00% | −20,283−13.0% | Reduced |
| Mirae Asset Global ETFs Holdings Ltd. | 134,703 | $1.89M | 0.00% | +46,196+52.2% | Added |
| Legal & General Group Plc | 131,755 | $1.84M | 0.00% | −20,207−13.3% | Reduced |
| Rafferty Asset Management, LLC | 122,262 | $1.71M | 0.01% | −6,873−5.3% | Reduced |
| California State Teachers Retirement System | 119,327 | $1.67M | 0.00% | +1,792+1.5% | Added |
| Engineers Gate Manager LP | 116,101 | $1.62M | 0.02% | +98,903+575.1% | Added |
| Woodline Partners LP | 113,517 | $1.59M | 0.01% | 00.0% | Unchanged |
| Trexquant Investment LP | 109,242 | $1.53M | 0.02% | −3,982−3.5% | Reduced |
| Ameriprise Financial Inc | 102,033 | $1.43M | 0.00% | +102,033 | New |
| Rhenman & Partners Asset Management AB | 100,000 | $1.40M | 0.18% | 00.0% | Unchanged |
| Savvy Advisors, Inc. | 97,793 | $1.37M | 0.09% | +97,793 | New |
| Integrated Wealth Concepts LLC | 96,046 | $1.34M | 0.01% | +96,046 | New |
| Polar Asset Management Partners Inc. | 91,600 | $1.28M | 0.03% | +70,648+337.2% | Added |
| Wells Fargo & Company | 89,639 | $1.25M | 0.00% | +12,357+16.0% | Added |
| Algert Global LLC | 85,840 | $1.20M | 0.03% | +85,840 | New |
| Jane Street Group, LLC | 85,332 | $1.19M | 0.00% | −128,341−60.1% | Reduced |
| State of Wisconsin Investment Board | 79,627 | $1.11M | 0.00% | −264−0.3% | Reduced |
| MetLife Investment Management | 79,075 | $1.11M | 0.01% | +4,310+5.8% | Added |
| Alps Advisors Inc | 78,356 | $1.10M | 0.01% | −33,019−29.6% | Reduced |
| Citigroup Inc | 76,315 | $1.07M | 0.00% | −117,689−60.7% | Reduced |
| Intech Investment Management LLC | 71,866 | $1.01M | 0.01% | −5,724−7.4% | Reduced |
| Man Group plc | 70,028 | $979.7K | 0.00% | −99,357−58.7% | Reduced |
| Thrivent Financial for Lutherans | 67,917 | $950.0K | 0.00% | 00.0% | Unchanged |
| TT International Asset Management LTD | 65,000 | $909.4K | 0.18% | +65,000 | New |
| Graham Capital Management, L.P. | 64,799 | $906.5K | 0.03% | +21,794+50.7% | Added |
| Franklin Resources Inc | 64,525 | $902.7K | 0.00% | −18,723−22.5% | Reduced |