Denali Therapeutics Inc.
DNLI- Exchange
- Nasdaq
- Industry
- Biological Products, (No Diagnostic Substances)
- SEC CIK
- 0001714899
In the last 90 days, Denali Therapeutics Inc. insiders filed 0 open-market purchases and 4 sales; 294 institutions reported holding it in 13F filings for Q2 2026, worth $4.00B in total; no superinvestor holds it.
13F holders, Q2 2025
Institutional positions in Denali Therapeutics Inc. as of Jun 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 231
- +10 vs. Q1 2025
- Shares held
- 137.6M
- +1.67M (+1.2%) vs. Q1 2025
- Total value
- $1.93B
- +$76.1M (+4.1%) vs. Q1 2025
- New holders
- 46
- 84 more added
- Sold out
- 36
- 64 more reduced
1 institution that held it in Q1 2025 haven't filed for Q2 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q1 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting DNLI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 294 | $4.00B |
| Q1 2026 | 269 | $2.82B |
| Q4 2025 | 250 | $2.50B |
| Q3 2025 | 240 | $1.97B |
| Q2 2025 | 231 | $1.93B |
| Q1 2025 | 222 | $1.85B |
| Q4 2024 | 224 | $2.61B |
| Q3 2024 | 217 | $3.69B |
| Q2 2024 | 203 | $2.88B |
| Q1 2024 | 211 | $2.51B |
| Q4 2023 | 209 | $2.47B |
| Q3 2023 | 195 | $2.24B |
| Q2 2023 | 203 | $3.18B |
| Q1 2023 | 202 | $2.49B |
| Q4 2022 | 199 | $2.94B |
| Q3 2022 | 200 | $2.84B |
| Q2 2022 | 188 | $2.73B |
| Q1 2022 | 190 | $2.79B |
| Q4 2021 | 213 | $3.80B |
| Q3 2021 | 214 | $4.28B |
| Q2 2021 | 210 | $6.32B |
| Q1 2021 | 218 | $4.60B |
Institutions, Q2 2025
Shares, value and share of portfolio for each institution holding Denali Therapeutics Inc.; share changes are against Q1 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| DekaBank Deutsche Girozentrale | 59,800 | $841.0K | 0.00% | −4,410−6.9% | Reduced |
| Janus Henderson Group PLC | 60,028 | $839.5K | 0.00% | 00.0% | Unchanged |
| Creative Planning | 57,678 | $806.9K | 0.00% | +27,114+88.7% | Added |
| Pier 88 Investment Partners LLC | 57,150 | $799.5K | 0.15% | +12,240+27.3% | Added |
| Tudor Investment Corp Et Al | 55,448 | $775.7K | 0.01% | −17,149−23.6% | Reduced |
| Ironwood Investment Management LLC | 53,212 | $744.4K | 0.36% | +3,907+7.9% | Added |
| Guggenheim Capital LLC | 51,860 | $725.5K | 0.01% | −4,152−7.4% | Reduced |
| Verition Fund Management LLC | 50,809 | $710.8K | 0.00% | +37,080+270.1% | Added |
| MAI Capital Management | 46,526 | $650.9K | 0.00% | 00.0% | Unchanged |
| Victory Capital Management Inc | 45,616 | $638.2K | 0.00% | +3,989+9.6% | Added |
| Pathstone Holdings, LLC | 45,040 | $630.1K | 0.00% | +6,735+17.6% | Added |
| Employees Retirement System of Texas | 43,769 | $612.0K | 0.00% | 00.0% | Unchanged |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 43,587 | $609.8K | 0.00% | +3,830+9.6% | Added |
| Skandinaviska Enskilda Banken AB (publ) | 43,245 | $605.0K | 0.00% | 00.0% | Unchanged |
| Knights of Columbus Asset Advisors LLC | 38,479 | $538.3K | 0.03% | −1,796−4.5% | Reduced |
| New York State Common Retirement Fund | 38,478 | $538.3K | 0.00% | −31,762−45.2% | Reduced |
| Handelsbanken Fonder AB | 38,300 | $536.0K | 0.00% | 00.0% | Unchanged |
| Arizona State Retirement System | 38,114 | $533.2K | 0.00% | +1,002+2.7% | Added |
| Voya Investment Management LLC | 35,908 | $502.4K | 0.00% | −15,103−29.6% | Reduced |
| ADAR1 Capital Management, LLC | 35,716 | $499.7K | 0.08% | +21,843+157.4% | Added |
| Dana Investment Advisors, Inc. | 35,561 | $497.5K | 0.02% | +3,406+10.6% | Added |
| Teacher Retirement System of Texas | 35,221 | $492.7K | 0.00% | +364+1.0% | Added |
| State Board of Administration of Florida Retirement System | 34,168 | $478.0K | 0.00% | 00.0% | Unchanged |
| Envestnet Asset Management Inc | 33,538 | $469.2K | 0.00% | +2,108+6.7% | Added |
| ProShare Advisors LLC | 32,582 | $455.8K | 0.00% | −879−2.6% | Reduced |
| Police & Firemen's Retirement System of New Jersey | 30,394 | $425.2K | 0.00% | +3,915+14.8% | Added |
| China Universal Asset Management Co., Ltd. | 29,178 | $408.2K | 0.04% | +50+0.2% | Added |
| Dark Forest Capital Management LP | 28,433 | $397.8K | 0.02% | −52,387−64.8% | Reduced |
| Two Sigma Advisers, LP | 27,600 | $386.1K | 0.00% | −7,700−21.8% | Reduced |
| Erste Asset Management GmbH | 26,900 | $379.3K | 0.00% | 00.0% | Unchanged |
| Profund Advisors LLC | 26,723 | $373.9K | 0.01% | −1,146−4.1% | Reduced |
| Raymond James Financial Inc | 26,596 | $372.1K | 0.00% | +662+2.6% | Added |
| KLP Kapitalforvaltning AS | 26,100 | $365.1K | 0.00% | 00.0% | Unchanged |
| Cinctive Capital Management LP | 24,310 | $340.1K | 0.02% | +24,310 | New |
| Quest Partners LLC | 22,964 | $321.3K | 0.03% | −2,096−8.4% | Reduced |
| HighTower Advisors, LLC | 22,533 | $315.2K | 0.00% | −1,070−4.5% | Reduced |
| Capital Fund Management S.A. | 21,871 | $306.0K | 0.00% | +21,871 | New |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 21,484 | $300.6K | 0.00% | +2,785+14.9% | Added |
| AQR Capital Management LLC | 21,217 | $296.8K | 0.00% | +21,217 | New |
| Two Sigma Investments, LP | 19,300 | $270.0K | 0.00% | −83,103−81.2% | Reduced |
| BNP Paribas Arbitrage, SA | 19,082 | $267.0K | 0.00% | +10,367+119.0% | Added |
| Virtu Financial LLC | 18,438 | $258.0K | 0.01% | +18,438 | New |
| Breakwater Capital Group | 17,096 | $239.2K | 0.04% | +2,081+13.9% | Added |
| Prudential Financial Inc | 16,878 | $236.1K | 0.00% | −21,765−56.3% | Reduced |
| CIBC World Markets Corp | 16,318 | $228.3K | 0.00% | −11,264−40.8% | Reduced |
| Prelude Capital Management, LLC | 15,940 | $223.0K | 0.02% | +15,940 | New |
| JustInvest LLC | 15,329 | $214.5K | 0.00% | +15,329 | New |
| NEOS Investment Management LLC | 15,174 | $212.3K | 0.00% | 00.0% | Unchanged |
| Tema ETFs LLC | 15,174 | $212.3K | 0.06% | 00.0% | Unchanged |
| Empowered Funds, LLC | 14,820 | $207.3K | 0.00% | −5,819−28.2% | Reduced |
| Jain Global LLC | 14,486 | $202.7K | 0.00% | +14,486 | New |
| STRS Ohio | 14,300 | $200.1K | 0.00% | −9,500−39.9% | Reduced |
| Caxton Associates LLP | 14,229 | $199.1K | 0.01% | +14,229 | New |
| Tower Research Capital LLC (TRC) | 13,669 | $191.2K | 0.01% | +10,457+325.6% | Added |
| E Fund Management Co., Ltd. | 13,612 | $190.4K | 0.01% | +1,543+12.8% | Added |
| Ameritas Investment Partners, Inc. | 13,522 | $189.2K | 0.01% | +930+7.4% | Added |
| Great West Life Assurance Co | 13,434 | $188.0K | 0.00% | 00.0% | Unchanged |
| Public Employees Retirement Association of Colorado | 12,238 | $171.0K | 0.00% | 00.0% | Unchanged |
| Aigen Investment Management, LP | 10,662 | $149.2K | 0.02% | +10,662 | New |
| MONECO Advisors, LLC | 10,478 | $146.6K | 0.01% | −122−1.2% | Reduced |
| Xponance, Inc. | 10,352 | $144.8K | 0.00% | +10,352 | New |
| HSBC Holdings PLC | 10,048 | $141.2K | 0.00% | −47,955−82.7% | Reduced |
| The PNC Financial Services Group, Inc. | 8,236 | $115.2K | 0.00% | +4,494+120.1% | Added |
| Virtus Investment Advisers, Inc. | 6,300 | $88.1K | 0.03% | −691−9.9% | Reduced |
| Mirae Asset Global Investments Co., Ltd. | 5,612 | $78.5K | 0.00% | +753+15.5% | Added |
| KBC Group NV | 4,495 | $63.0K | 0.00% | −1,955−30.3% | Reduced |
| Amalgamated Bank | 4,305 | $60.0K | 0.00% | 00.0% | Unchanged |
| Shell Asset Management Co | 4,009 | $56.0K | 0.00% | −447−10.0% | Reduced |
| GF Fund Management Co. Ltd. | 3,685 | $51.6K | 0.00% | 00.0% | Unchanged |
| Assetmark, Inc | 3,620 | $50.6K | 0.00% | +435+13.7% | Added |
| Sterling Capital Management LLC | 3,386 | $47.4K | 0.00% | +2,397+242.4% | Added |
| Russell Investments Group, Ltd. | 2,558 | $35.8K | 0.00% | −83−3.1% | Reduced |
| Simplex Trading, LLC | 2,502 | $35.0K | 0.00% | +2,502 | New |
| CWM, LLC | 2,275 | $32.0K | 0.00% | +251+12.4% | Added |
| State of Wyoming | 2,099 | $29.4K | 0.00% | +2,099 | New |
| Headlands Technologies LLC | 1,847 | $25.8K | 0.00% | +1,847 | New |
| Advisor Group Holdings, Inc. | 1,595 | $22.2K | 0.00% | +547+52.2% | Added |
| Bartlett & Co. Wealth Management LLC | 1,500 | $21.0K | 0.00% | 00.0% | Unchanged |
| Point72 Asia (Singapore) Pte. Ltd. | 1,369 | $19.2K | 0.00% | +1,369 | New |
| Versant Capital Management, Inc | 1,286 | $18.0K | 0.00% | +570+79.6% | Added |
| Comerica Bank | 1,284 | $18.0K | 0.00% | +100+8.4% | Added |
| Nisa Investment Advisors, LLC | 1,217 | $17.0K | 0.00% | −199−14.1% | Reduced |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 1,139 | $16.0K | 0.00% | +1,139 | New |
| Mitsubishi UFJ Kokusai Asset Management Co., Ltd. | 1,001 | $14.0K | 0.00% | 00.0% | Unchanged |
| IFP Advisors, Inc | 0 | $13.5K | 0.00% | 0 | New |
| Optiver Holding B.V. | 893 | $12.5K | 0.00% | +862+2,780.6% | Added |
| GAMMA Investing LLC | 749 | $10.5K | 0.00% | +164+28.0% | Added |
| Nemes Rush Group LLC | 700 | $9.79K | 0.00% | 00.0% | Unchanged |
| Covestor Ltd | 580 | $8.00K | 0.00% | −1−0.2% | Reduced |
| Parallel Advisors, LLC | 545 | $7.63K | 0.00% | +383+236.4% | Added |
| NBC Securities, Inc. | 532 | $7.00K | 0.00% | 00.0% | Unchanged |
| Daiwa Securities Group Inc. | 475 | $7.00K | 0.00% | 00.0% | Unchanged |
| Smartleaf Asset Management LLC | 454 | $6.40K | 0.00% | −19−4.0% | Reduced |
| US Bancorp | 441 | $6.17K | 0.00% | −93−17.4% | Reduced |
| GWM Advisors LLC | 400 | $5.60K | 0.00% | 00.0% | Unchanged |
| Signaturefd, LLC | 329 | $4.60K | 0.00% | −196−37.3% | Reduced |
| Rothschild Investment LLC | 325 | $4.55K | 0.00% | +260+400.0% | Added |
| Private Wealth Management Group, LLC | 296 | $4.14K | 0.00% | +296 | New |
| Allworth Financial LP | 275 | $3.85K | 0.00% | −28−9.2% | Reduced |
| Huntington National Bank | 270 | $3.78K | 0.00% | −423−61.0% | Reduced |