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Denali Therapeutics Inc.

DNLI
Exchange
Nasdaq
Industry
Biological Products, (No Diagnostic Substances)
SEC CIK
0001714899

In the last 90 days, Denali Therapeutics Inc. insiders filed 0 open-market purchases and 4 sales; 294 institutions reported holding it in 13F filings for Q2 2026, worth $4.00B in total; no superinvestor holds it.

13F holders, Q2 2025

Institutional positions in Denali Therapeutics Inc. as of Jun 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
231
+10 vs. Q1 2025
Shares held
137.6M
+1.67M (+1.2%) vs. Q1 2025
Total value
$1.93B
+$76.1M (+4.1%) vs. Q1 2025
New holders
46
84 more added
Sold out
36
64 more reduced

1 institution that held it in Q1 2025 haven't filed for Q2 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.

Compare with Q1 2025: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting DNLI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ2 2025: 231 institutions
Q1 2021: 218 institutionsQ2 2021: 210 institutionsQ3 2021: 214 institutionsQ4 2021: 213 institutionsQ1 2022: 190 institutionsQ2 2022: 188 institutionsQ3 2022: 200 institutionsQ4 2022: 199 institutionsQ1 2023: 202 institutionsQ2 2023: 203 institutionsQ3 2023: 195 institutionsQ4 2023: 209 institutionsQ1 2024: 211 institutionsQ2 2024: 203 institutionsQ3 2024: 217 institutionsQ4 2024: 224 institutionsQ1 2025: 222 institutionsQ2 2025: 231 institutionsQ3 2025: 240 institutionsQ4 2025: 250 institutionsQ1 2026: 269 institutionsQ2 2026: 294 institutions
Value heldQ2 2025: $1.93B
Q1 2021: $4.60BQ2 2021: $6.32BQ3 2021: $4.28BQ4 2021: $3.80BQ1 2022: $2.79BQ2 2022: $2.73BQ3 2022: $2.84BQ4 2022: $2.94BQ1 2023: $2.49BQ2 2023: $3.18BQ3 2023: $2.24BQ4 2023: $2.47BQ1 2024: $2.51BQ2 2024: $2.88BQ3 2024: $3.69BQ4 2024: $2.61BQ1 2025: $1.85BQ2 2025: $1.93BQ3 2025: $1.97BQ4 2025: $2.50BQ1 2026: $2.82BQ2 2026: $4.00B
Institutions holding DNLI and their total value by quarter
QuarterHoldersValue
Q2 2026294$4.00B
Q1 2026269$2.82B
Q4 2025250$2.50B
Q3 2025240$1.97B
Q2 2025231$1.93B
Q1 2025222$1.85B
Q4 2024224$2.61B
Q3 2024217$3.69B
Q2 2024203$2.88B
Q1 2024211$2.51B
Q4 2023209$2.47B
Q3 2023195$2.24B
Q2 2023203$3.18B
Q1 2023202$2.49B
Q4 2022199$2.94B
Q3 2022200$2.84B
Q2 2022188$2.73B
Q1 2022190$2.79B
Q4 2021213$3.80B
Q3 2021214$4.28B
Q2 2021210$6.32B
Q1 2021218$4.60B

Institutions, Q2 2025

Shares, value and share of portfolio for each institution holding Denali Therapeutics Inc.; share changes are against Q1 2025.

Institutions holding DNLI in Q2 2025
InstitutionSharesValue% of portfolioChange in sharesAction
City State Bank250$3.50K0.00%00.0%Unchanged
Mount Yale Investment Advisors, LLC201$2.81K0.00%+201New
Caitong International Asset Management Co., Ltd200$2.80K0.00%−1,911−90.5%Reduced
National Bank of Canada172$2.40K0.00%+102+145.7%Added
Parkside Financial Bank & Trust150$2.10K0.00%+150New
UMA Financial Services, Inc.140$1.96K0.00%+140New
Massmutual Trust Co FSB123$1.72K0.00%−25−16.9%Reduced
Bell Investment Advisors, Inc123$1.72K0.00%+71+136.5%Added
EverSource Wealth Advisors, LLC115$1.61K0.00%−316−73.3%Reduced
Farther Finance Advisors, LLC107$1.50K0.00%+100+1,428.6%Added
Harbour Investments, Inc.100$1.40K0.00%00.0%Unchanged
Your Advocates Ltd., LLP100$1.40K0.00%00.0%Unchanged
Rise Advisors, LLC74$1.03K0.00%+74New
True Wealth Design, LLC56$7840.00%+56New
SRS Capital Advisors, Inc.52$7280.00%+52New
Fortitude Family Office, LLC41$5740.00%+41New
Ronald Blue Trust, Inc.40$5600.00%+40New
Bare Financial Services, Inc36$5040.00%+36New
CIBC Private Wealth Group, LLC35$4900.00%+35New
Skopos Labs, Inc.31$4340.00%+31New
WealthTrak Capital Management LLC10$1400.00%+10New
Private Wealth Asset Management, LLC8$1120.00%−30−78.9%Reduced
SBI Securities Co., Ltd.5$700.00%00.0%Unchanged
SJS Investment Consulting Inc.4$560.00%+1+33.3%Added
Global Retirement Partners, LLC3$420.00%+3New
HFM Investment Advisors, LLC3$420.00%+3New
Rialto Wealth Management, LLC2$280.00%+2New
Truvestments Capital LLC1$180.00%+1New
Bay Harbor Wealth Management, LLC1$130.00%00.0%Unchanged
Avion Wealth40$00.00%+15+60.0%Added
Hemington Wealth Management34$00.00%+18+112.5%Added
Squarepoint Ops LLC0$00.00%−687,151−100.0%Sold out
Artisan Partners Limited Partnership0$00.00%−612,438−100.0%Sold out
Qube Research & Technologies Ltd0$00.00%−288,221−100.0%Sold out
Boxer Capital Management, LLC0$00.00%−250,000−100.0%Sold out
D. E. Shaw & Co., Inc.0$00.00%−78,218−100.0%Sold out
Corebridge Financial, Inc.0$00.00%−60,898−100.0%Sold out
Y-Intercept (Hong Kong) Ltd0$00.00%−54,813−100.0%Sold out
SG Americas Securities, LLC0$00.00%−48,365−100.0%Sold out
Walleye Capital LLC0$00.00%−44,138−100.0%Sold out
VELA Investment Management, LLC0$00.00%−27,771−100.0%Sold out
Cetera Investment Advisers0$00.00%−19,993−100.0%Sold out
SEI Investments Co0$00.00%−17,276−100.0%Sold out
Balyasny Asset Management LLC0$00.00%−16,595−100.0%Sold out
Oxford Asset Management LLP0$00.00%−14,249−100.0%Sold out
XTX Topco Ltd0$00.00%−13,485−100.0%Sold out
Bridgefront Capital, LLC0$00.00%−13,084−100.0%Sold out
Pitcairn Co0$00.00%−12,423−100.0%Sold out
Entropy Technologies, LP0$00.00%−11,215−100.0%Sold out
Bayesian Capital Management, LP0$00.00%−10,130−100.0%Sold out
BI Asset Management Fondsmaeglerselskab A/S0$00.00%−2,988−100.0%Sold out
Riverview Trust Co0$00.00%−1,171−100.0%Sold out
Quadrant Capital Group LLC0$00.00%−515−100.0%Sold out
Umb Bank N A0$00.00%−416−100.0%Sold out
Coldstream Capital Management Inc0$00.00%−145−100.0%Sold out
Sherman Asset Management, Inc.0$00.00%−94−100.0%Sold out
Amundi0$00.00%−88−100.0%Sold out
Sierra Ocean, LLC0$00.00%−66−100.0%Sold out
South State Corp.0$00.00%−30−100.0%Sold out
Stephens Consulting, LLC0$00.00%−30−100.0%Sold out
Steward Partners Investment Advisory, LLC0$00.00%−25−100.0%Sold out
First Horizon Advisors, Inc.0$00.00%−25−100.0%Sold out
Principal Securities, Inc.0$00.00%−14−100.0%Sold out
Hexagon Capital Partners LLC0$00.00%−15−100.0%Sold out
Boston Private Wealth LLC0$00.00%−11−100.0%Sold out
Global Financial Private Client, LLC0$00.00%−5−100.0%Sold out
DiNuzzo Private Wealth, Inc.0$00.00%−2−100.0%Sold out
Lindbrook Capital, LLC––––Not filed