Denali Therapeutics Inc.
DNLI- Exchange
- Nasdaq
- Industry
- Biological Products, (No Diagnostic Substances)
- SEC CIK
- 0001714899
In the last 90 days, Denali Therapeutics Inc. insiders filed 0 open-market purchases and 4 sales; 294 institutions reported holding it in 13F filings for Q2 2026, worth $4.00B in total; no superinvestor holds it.
13F holders, Q4 2024
Institutional positions in Denali Therapeutics Inc. as of Dec 31, 2024. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 224
- +9 vs. Q3 2024
- Shares held
- 127.9M
- +1.24M (+1.0%) vs. Q3 2024
- Total value
- $2.61B
- −$1.08B (−29.3%) vs. Q3 2024
- New holders
- 41
- 87 more added
- Sold out
- 32
- 59 more reduced
2 institutions that held it in Q3 2024 haven't filed for Q4 2024 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2024: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting DNLI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 294 | $4.00B |
| Q1 2026 | 269 | $2.82B |
| Q4 2025 | 250 | $2.50B |
| Q3 2025 | 240 | $1.97B |
| Q2 2025 | 231 | $1.93B |
| Q1 2025 | 222 | $1.85B |
| Q4 2024 | 224 | $2.61B |
| Q3 2024 | 217 | $3.69B |
| Q2 2024 | 203 | $2.88B |
| Q1 2024 | 211 | $2.51B |
| Q4 2023 | 209 | $2.47B |
| Q3 2023 | 195 | $2.24B |
| Q2 2023 | 203 | $3.18B |
| Q1 2023 | 202 | $2.49B |
| Q4 2022 | 199 | $2.94B |
| Q3 2022 | 200 | $2.84B |
| Q2 2022 | 188 | $2.73B |
| Q1 2022 | 190 | $2.79B |
| Q4 2021 | 213 | $3.80B |
| Q3 2021 | 214 | $4.28B |
| Q2 2021 | 210 | $6.32B |
| Q1 2021 | 218 | $4.60B |
Institutions, Q4 2024
Shares, value and share of portfolio for each institution holding Denali Therapeutics Inc.; share changes are against Q3 2024.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| BlackRock, Inc. | 13,920,245 | $283.7M | 0.01% | +131,728+1.0% | Added |
| Baillie Gifford & Co | 12,313,931 | $251.0M | 0.19% | −1,031,956−7.7% | Reduced |
| Vanguard Group Inc | 12,021,230 | $245.0M | 0.00% | +843,996+7.6% | Added |
| Wellington Management Group LLP | 9,847,951 | $200.7M | 0.04% | −879,499−8.2% | Reduced |
| FMR LLC | 8,019,746 | $163.4M | 0.01% | +188,368+2.4% | Added |
| Capital Research Global Investors | 5,477,211 | $111.6M | 0.02% | −2,431,903−30.7% | Reduced |
| Temasek Holdings (Private) Ltd | 5,355,832 | $109.2M | 0.43% | 00.0% | Unchanged |
| State Street Corp | 4,544,973 | $92.6M | 0.00% | +292,962+6.9% | Added |
| Crestline Management, LP | 4,310,732 | $87.9M | 3.06% | −150,000−3.4% | Reduced |
| Baker Bros. Advisors LP | 3,731,695 | $76.1M | 0.81% | 00.0% | Unchanged |
| UBS Asset Management Americas Inc | 3,582,874 | $73.0M | 0.02% | −166,612−4.4% | Reduced |
| Alliancebernstein L.P. | 3,315,642 | $67.6M | 0.02% | +268,378+8.8% | Added |
| Price T Rowe Associates Inc | 3,058,615 | $62.3M | 0.01% | +188,820+6.6% | Added |
| Geode Capital Management, LLC | 2,935,283 | $59.8M | 0.00% | −20,194−0.7% | Reduced |
| Camber Capital Management LP | 2,250,000 | $45.9M | 1.79% | +250,000+12.5% | Added |
| Dimensional Fund Advisors LP | 1,855,036 | $37.8M | 0.01% | +295,594+19.0% | Added |
| Marshall Wace, LLP | 1,788,737 | $36.5M | 0.05% | −178,404−9.1% | Reduced |
| Bank of New York Mellon Corp | 1,242,987 | $25.3M | 0.00% | −87,364−6.6% | Reduced |
| Morgan Stanley | 1,229,140 | $25.0M | 0.00% | −515,615−29.6% | Reduced |
| Northern Trust Corp | 1,201,518 | $24.5M | 0.00% | +115,876+10.7% | Added |
| Principal Financial Group Inc | 1,130,963 | $23.0M | 0.01% | −107,513−8.7% | Reduced |
| Norges Bank | 1,065,608 | $21.7M | 0.00% | +668,069+168.1% | Added |
| Goldman Sachs Group Inc | 1,057,523 | $21.6M | 0.00% | −310,298−22.7% | Reduced |
| Artisan Partners Limited Partnership | 1,054,523 | $21.5M | 0.03% | −36,495−3.3% | Reduced |
| Charles Schwab Investment Management Inc | 1,028,462 | $21.0M | 0.00% | +12,652+1.2% | Added |
| Casdin Capital, LLC | 990,000 | $20.2M | 1.35% | 00.0% | Unchanged |
| UBS Group AG | 852,861 | $17.4M | 0.00% | +711,458+503.1% | Added |
| Siren, L.L.C. | 834,028 | $17.0M | 0.75% | 00.0% | Unchanged |
| Candriam Luxembourg S.C.A. | 832,977 | $17.0M | 0.10% | −109,181−11.6% | Reduced |
| Citadel Advisors LLC | 829,911 | $16.9M | 0.02% | +52,631+6.8% | Added |
| Fisher Asset Management, LLC | 792,499 | $16.2M | 0.01% | +245,168+44.8% | Added |
| Yiheng Capital Management, L.P. | 700,098 | $14.3M | 3.16% | +100,000+16.7% | Added |
| Cercano Management LLC | 625,000 | $12.7M | 0.32% | 00.0% | Unchanged |
| StemPoint Capital LP | 584,328 | $11.9M | 2.99% | +302,278+107.2% | Added |
| Polar Asset Management Partners Inc. | 551,092 | $11.2M | 0.17% | +509,992+1,240.9% | Added |
| Point72 Asset Management, L.P. | 548,739 | $11.2M | 0.03% | +215,209+64.5% | Added |
| American Century Companies Inc | 480,529 | $9.79M | 0.01% | +29,155+6.5% | Added |
| Balyasny Asset Management LLC | 416,074 | $8.48M | 0.02% | +370,966+822.4% | Added |
| Clarius Group, LLC | 409,995 | $8.36M | 0.57% | 00.0% | Unchanged |
| Millennium Management LLC | 404,224 | $8.24M | 0.01% | +344,056+571.8% | Added |
| Standard Life Aberdeen plc | 402,282 | $8.20M | 0.02% | +38,603+10.6% | Added |
| Nuveen Asset Management, LLC | 355,057 | $7.24M | 0.00% | −360,243−50.4% | Reduced |
| Ensign Peak Advisors, Inc | 346,304 | $7.06M | 0.01% | 00.0% | Unchanged |
| Pier Capital, LLC | 332,319 | $6.77M | 0.97% | +164,237+97.7% | Added |
| Qube Research & Technologies Ltd | 311,507 | $6.35M | 0.01% | +311,507 | New |
| AXA S.A. | 293,755 | $5.99M | 0.02% | −51,128−14.8% | Reduced |
| Segall Bryant & Hamill, LLC | 289,075 | $5.89M | 0.08% | +289,075 | New |
| Barclays PLC | 278,067 | $5.67M | 0.00% | +22,184+8.7% | Added |
| Deutsche Bank AG | 277,853 | $5.66M | 0.00% | +37,907+15.8% | Added |
| Bank of America Corp | 270,333 | $5.51M | 0.00% | −77,831−22.4% | Reduced |
| TD Asset Management Inc | 265,752 | $5.42M | 0.00% | +21,200+8.7% | Added |
| Twinbeech Capital LP | 254,586 | $5.19M | 0.09% | +254,586 | New |
| Swiss National Bank | 253,500 | $5.17M | 0.00% | +2,800+1.1% | Added |
| Schroder Investment Management Group | 247,800 | $5.02M | 0.00% | +120,494+94.6% | Added |
| Jane Street Group, LLC | 229,165 | $4.67M | 0.01% | −140,506−38.0% | Reduced |
| JPMorgan Chase & Co | 222,983 | $4.54M | 0.00% | −12,403−5.3% | Reduced |
| Manufacturers Life Insurance Company, The | 208,521 | $4.25M | 0.00% | +1,702+0.8% | Added |
| Teachers Retirement System of the State of Kentucky | 207,124 | $4.22M | 0.04% | 00.0% | Unchanged |
| Edmond de Rothschild Holding S.A. | 205,680 | $4.19M | 0.07% | 00.0% | Unchanged |
| Holocene Advisors, LP | 199,072 | $4.06M | 0.01% | +101,625+104.3% | Added |
| Susquehanna Fundamental Investments, LLC | 192,563 | $3.92M | 0.07% | +192,563 | New |
| Rhumbline Advisers | 190,390 | $3.88M | 0.00% | +497+0.3% | Added |
| Two Sigma Investments, LP | 179,884 | $3.67M | 0.01% | +80,417+80.8% | Added |
| Citigroup Inc | 166,706 | $3.40M | 0.00% | +71,992+76.0% | Added |
| Legal & General Group Plc | 149,513 | $3.05M | 0.00% | +8,108+5.7% | Added |
| New York State Common Retirement Fund | 144,724 | $2.95M | 0.00% | −5,184−3.5% | Reduced |
| Rafferty Asset Management, LLC | 141,310 | $2.88M | 0.01% | +23,629+20.1% | Added |
| Cinctive Capital Management LP | 130,445 | $2.66M | 0.14% | −18,649−12.5% | Reduced |
| Invesco Ltd. | 121,478 | $2.48M | 0.00% | −84,885−41.1% | Reduced |
| California State Teachers Retirement System | 120,174 | $2.45M | 0.00% | −938−0.8% | Reduced |
| Alps Advisors Inc | 116,377 | $2.37M | 0.01% | +10,130+9.5% | Added |
| Prudential Financial Inc | 110,593 | $2.25M | 0.00% | −6,800−5.8% | Reduced |
| Groupama Asset Managment | 110,207 | $2.23M | 0.05% | +32,162+41.2% | Added |
| Woodline Partners LP | 100,000 | $2.04M | 0.01% | +100,000 | New |
| State of Wisconsin Investment Board | 93,094 | $1.90M | 0.00% | +11,643+14.3% | Added |
| Thrivent Financial for Lutherans | 92,972 | $1.90M | 0.00% | −45,890−33.0% | Reduced |
| Hudson Bay Capital Management LP | 92,500 | $1.89M | 0.01% | +58,000+168.1% | Added |
| Fred Alger Management, LLC | 91,807 | $1.87M | 0.01% | −29,509−24.3% | Reduced |
| Wells Fargo & Company | 88,933 | $1.81M | 0.00% | −4,764−5.1% | Reduced |
| State of New Jersey Common Pension Fund D | 86,243 | $1.76M | 0.01% | +8,760+11.3% | Added |
| Mirae Asset Global ETFs Holdings Ltd. | 85,075 | $1.73M | 0.00% | +3,411+4.2% | Added |
| MetLife Investment Management | 76,050 | $1.55M | 0.01% | +4,240+5.9% | Added |
| Franklin Resources Inc | 74,862 | $1.53M | 0.00% | −5,179−6.5% | Reduced |
| Susquehanna International Group, LLP | 71,240 | $1.45M | 0.00% | +21,070+42.0% | Added |
| Nisa Investment Advisors, LLC | 66,621 | $1.36M | 0.01% | +139+0.2% | Added |
| First Trust Advisors LP | 65,442 | $1.33M | 0.00% | +47,308+260.9% | Added |
| Corebridge Financial, Inc. | 61,800 | $1.26M | 0.01% | −4,665−7.0% | Reduced |
| Trexquant Investment LP | 60,656 | $1.24M | 0.01% | +36,122+147.2% | Added |
| Janus Henderson Group PLC | 60,028 | $1.22M | 0.00% | +7,900+15.2% | Added |
| Diadema Partners LP | 60,000 | $1.22M | 1.38% | +60,000 | New |
| DekaBank Deutsche Girozentrale | 59,800 | $1.22M | 0.00% | 00.0% | Unchanged |
| Voya Investment Management LLC | 54,813 | $1.12M | 0.00% | −2,991−5.2% | Reduced |
| Engineers Gate Manager LP | 53,358 | $1.09M | 0.02% | +53,358 | New |
| Squarepoint Ops LLC | 48,619 | $990.9K | 0.00% | +14,896+44.2% | Added |
| Guggenheim Capital LLC | 48,131 | $980.9K | 0.01% | +27,518+133.5% | Added |
| Creative Planning | 47,950 | $977.2K | 0.00% | −12,304−20.4% | Reduced |
| Intech Investment Management LLC | 47,401 | $966.0K | 0.01% | +17,858+60.4% | Added |
| MAI Capital Management | 46,526 | $948.2K | 0.01% | +46,526 | New |
| Pier 88 Investment Partners LLC | 45,410 | $925.5K | 0.18% | −13,760−23.3% | Reduced |
| ADAR1 Capital Management, LLC | 44,826 | $913.6K | 0.19% | −57,000−56.0% | Reduced |