Denali Therapeutics Inc.
DNLI- Exchange
- Nasdaq
- Industry
- Biological Products, (No Diagnostic Substances)
- SEC CIK
- 0001714899
In the last 90 days, Denali Therapeutics Inc. insiders filed 0 open-market purchases and 4 sales; 294 institutions reported holding it in 13F filings for Q2 2026, worth $4.00B in total; no superinvestor holds it.
13F holders, Q3 2025
Institutional positions in Denali Therapeutics Inc. as of Sep 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 240
- +13 vs. Q2 2025
- Shares held
- 135.5M
- +2.28M (+1.7%) vs. Q2 2025
- Total value
- $1.97B
- +$103.6M (+5.6%) vs. Q2 2025
- New holders
- 35
- 91 more added
- Sold out
- 22
- 67 more reduced
4 institutions that held it in Q2 2025 haven't filed for Q3 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q2 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting DNLI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 294 | $4.00B |
| Q1 2026 | 269 | $2.82B |
| Q4 2025 | 250 | $2.50B |
| Q3 2025 | 240 | $1.97B |
| Q2 2025 | 231 | $1.93B |
| Q1 2025 | 222 | $1.85B |
| Q4 2024 | 224 | $2.61B |
| Q3 2024 | 217 | $3.69B |
| Q2 2024 | 203 | $2.88B |
| Q1 2024 | 211 | $2.51B |
| Q4 2023 | 209 | $2.47B |
| Q3 2023 | 195 | $2.24B |
| Q2 2023 | 203 | $3.18B |
| Q1 2023 | 202 | $2.49B |
| Q4 2022 | 199 | $2.94B |
| Q3 2022 | 200 | $2.84B |
| Q2 2022 | 188 | $2.73B |
| Q1 2022 | 190 | $2.79B |
| Q4 2021 | 213 | $3.80B |
| Q3 2021 | 214 | $4.28B |
| Q2 2021 | 210 | $6.32B |
| Q1 2021 | 218 | $4.60B |
Institutions, Q3 2025
Shares, value and share of portfolio for each institution holding Denali Therapeutics Inc.; share changes are against Q2 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Janus Henderson Group PLC | 60,028 | $871.9K | 0.00% | 00.0% | Unchanged |
| Renaissance Technologies LLC | 59,800 | $868.3K | 0.00% | −135,900−69.4% | Reduced |
| DekaBank Deutsche Girozentrale | 59,800 | $864.0K | 0.00% | 00.0% | Unchanged |
| Wellington Management Group LLP | 59,234 | $860.1K | 0.00% | −5,605,499−99.0% | Reduced |
| Tudor Investment Corp Et Al | 56,368 | $818.5K | 0.01% | +920+1.7% | Added |
| Aquatic Capital Management LLC | 56,237 | $816.6K | 0.02% | +56,237 | New |
| Creative Planning | 54,834 | $796.2K | 0.00% | −2,844−4.9% | Reduced |
| Ironwood Investment Management LLC | 52,786 | $766.5K | 0.33% | −426−0.8% | Reduced |
| ADAR1 Capital Management, LLC | 51,516 | $748.0K | 0.07% | +15,800+44.2% | Added |
| Dana Investment Advisors, Inc. | 50,716 | $736.4K | 0.02% | +15,155+42.6% | Added |
| Knights of Columbus Asset Advisors LLC | 50,190 | $728.8K | 0.04% | +11,711+30.4% | Added |
| Guggenheim Capital LLC | 49,525 | $719.1K | 0.01% | −2,335−4.5% | Reduced |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 47,459 | $689.1K | 0.00% | +3,872+8.9% | Added |
| Intech Investment Management LLC | 46,797 | $679.5K | 0.01% | −25,069−34.9% | Reduced |
| MAI Capital Management | 46,526 | $675.6K | 0.00% | 00.0% | Unchanged |
| Jacobs Levy Equity Management, Inc | 45,969 | $667.5K | 0.00% | +45,969 | New |
| Pathstone Holdings, LLC | 45,830 | $665.4K | 0.00% | +790+1.8% | Added |
| Jennison Associates LLC | 45,445 | $659.9K | 0.00% | +45,445 | New |
| Cantor Fitzgerald, L. P. | 45,000 | $653.4K | 0.01% | +45,000 | New |
| Employees Retirement System of Texas | 43,769 | $636.0K | 0.01% | 00.0% | Unchanged |
| Susquehanna International Group, LLP | 40,986 | $595.1K | 0.00% | −120,150−74.6% | Reduced |
| Arizona State Retirement System | 40,813 | $592.6K | 0.00% | +2,699+7.1% | Added |
| Profund Advisors LLC | 40,156 | $583.1K | 0.02% | +13,433+50.3% | Added |
| Graham Capital Management, L.P. | 39,319 | $570.9K | 0.02% | −25,480−39.3% | Reduced |
| New York State Common Retirement Fund | 38,478 | $558.7K | 0.00% | 00.0% | Unchanged |
| Handelsbanken Fonder AB | 38,300 | $556.0K | 0.00% | 00.0% | Unchanged |
| SG Americas Securities, LLC | 38,201 | $555.0K | 0.00% | +38,201 | New |
| Police & Firemen's Retirement System of New Jersey | 36,663 | $532.3K | 0.00% | +6,269+20.6% | Added |
| Thrivent Financial for Lutherans | 35,619 | $517.0K | 0.00% | −32,298−47.6% | Reduced |
| State Board of Administration of Florida Retirement System | 34,168 | $496.1K | 0.00% | 00.0% | Unchanged |
| Teacher Retirement System of Texas | 33,827 | $491.2K | 0.00% | −1,394−4.0% | Reduced |
| Envestnet Asset Management Inc | 32,415 | $470.7K | 0.00% | −1,123−3.3% | Reduced |
| KLP Kapitalforvaltning AS | 29,900 | $434.1K | 0.00% | +3,800+14.6% | Added |
| ProShare Advisors LLC | 27,855 | $404.5K | 0.00% | −4,727−14.5% | Reduced |
| Cinctive Capital Management LP | 27,792 | $403.5K | 0.02% | +3,482+14.3% | Added |
| Erste Asset Management GmbH | 26,900 | $390.6K | 0.00% | 00.0% | Unchanged |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 26,223 | $380.8K | 0.00% | +4,739+22.1% | Added |
| China Universal Asset Management Co., Ltd. | 25,629 | $372.1K | 0.03% | −3,549−12.2% | Reduced |
| Raymond James Financial Inc | 25,326 | $367.7K | 0.00% | −1,270−4.8% | Reduced |
| Quantinno Capital Management LP | 24,707 | $358.7K | 0.00% | +24,707 | New |
| AQR Capital Management LLC | 24,139 | $350.5K | 0.00% | +2,922+13.8% | Added |
| EntryPoint Capital, LLC | 24,058 | $349.3K | 0.14% | +24,058 | New |
| Voya Investment Management LLC | 23,805 | $345.6K | 0.00% | −12,103−33.7% | Reduced |
| Oxford Asset Management LLP | 22,231 | $322.8K | 0.11% | +22,231 | New |
| HighTower Advisors, LLC | 21,322 | $309.6K | 0.00% | −1,211−5.4% | Reduced |
| Verition Fund Management LLC | 17,629 | $256.0K | 0.00% | −33,180−65.3% | Reduced |
| Jain Global LLC | 17,414 | $252.9K | 0.00% | +2,928+20.2% | Added |
| Prudential Financial Inc | 16,938 | $245.9K | 0.00% | +60+0.4% | Added |
| Breakwater Capital Group | 15,866 | $230.4K | 0.03% | −1,230−7.2% | Reduced |
| Victory Capital Management Inc | 15,064 | $218.7K | 0.00% | −30,552−67.0% | Reduced |
| Citigroup Inc | 14,936 | $216.9K | 0.00% | −61,379−80.4% | Reduced |
| CIBC Bancorp USA Inc. | 14,118 | $205.0K | 0.00% | +14,118 | New |
| HSBC Holdings PLC | 14,004 | $200.8K | 0.00% | +3,956+39.4% | Added |
| Russell Investments Group, Ltd. | 13,799 | $200.4K | 0.00% | +11,241+439.4% | Added |
| Great West Life Assurance Co | 13,434 | $195.0K | 0.00% | 00.0% | Unchanged |
| JustInvest LLC | 12,526 | $181.9K | 0.00% | −2,803−18.3% | Reduced |
| MONECO Advisors, LLC | 12,478 | $181.2K | 0.02% | +2,000+19.1% | Added |
| Public Employees Retirement Association of Colorado | 12,238 | $178.0K | 0.00% | 00.0% | Unchanged |
| Aigen Investment Management, LP | 12,075 | $175.3K | 0.03% | +1,413+13.3% | Added |
| Ameritas Investment Partners, Inc. | 11,065 | $160.7K | 0.00% | −2,457−18.2% | Reduced |
| Empowered Funds, LLC | 11,037 | $160.3K | 0.00% | −3,783−25.5% | Reduced |
| LPL Financial LLC | 10,648 | $154.6K | 0.00% | +10,648 | New |
| Intrust Bank NA | 10,575 | $153.5K | 0.01% | +10,575 | New |
| Xponance, Inc. | 10,400 | $151.0K | 0.00% | +48+0.5% | Added |
| Sterling Capital Management LLC | 8,654 | $125.7K | 0.00% | +5,268+155.6% | Added |
| The PNC Financial Services Group, Inc. | 8,290 | $120.4K | 0.00% | +54+0.7% | Added |
| Virtus Investment Advisers, Inc. | 7,624 | $110.7K | 0.03% | +1,324+21.0% | Added |
| Tower Research Capital LLC (TRC) | 7,376 | $107.1K | 0.00% | −6,293−46.0% | Reduced |
| Caption Management, LLC | 7,366 | $107.0K | 0.01% | +7,366 | New |
| Mirae Asset Global Investments Co., Ltd. | 5,653 | $82.1K | 0.00% | +41+0.7% | Added |
| KBC Group NV | 4,495 | $65.0K | 0.00% | 00.0% | Unchanged |
| Quarry LP | 4,375 | $63.5K | 0.02% | +4,375 | New |
| Amalgamated Bank | 4,305 | $63.0K | 0.00% | 00.0% | Unchanged |
| Assetmark, Inc | 3,937 | $57.2K | 0.00% | +317+8.8% | Added |
| GF Fund Management Co. Ltd. | 3,146 | $45.7K | 0.00% | −539−14.6% | Reduced |
| CWM, LLC | 2,397 | $35.0K | 0.00% | +122+5.4% | Added |
| State of Wyoming | 2,154 | $31.3K | 0.00% | +55+2.6% | Added |
| Johnson Financial Group, Inc. | 1,975 | $28.7K | 0.00% | +1,975 | New |
| Caitong International Asset Management Co., Ltd | 1,528 | $22.2K | 0.02% | +1,328+664.0% | Added |
| Shell Asset Management Co | 1,492 | $22.0K | 0.00% | −2,517−62.8% | Reduced |
| Bartlett & Co. Wealth Management LLC | 1,500 | $21.8K | 0.00% | 00.0% | Unchanged |
| Nisa Investment Advisors, LLC | 1,483 | $21.5K | 0.00% | +266+21.9% | Added |
| Versant Capital Management, Inc | 1,476 | $21.4K | 0.00% | +190+14.8% | Added |
| Advisor Group Holdings, Inc. | 1,388 | $20.9K | 0.00% | −207−13.0% | Reduced |
| Comerica Bank | 1,284 | $18.6K | 0.00% | 00.0% | Unchanged |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 1,271 | $18.0K | 0.00% | +132+11.6% | Added |
| Rockefeller Capital Management L.P. | 1,083 | $15.7K | 0.00% | +1,083 | New |
| Mitsubishi UFJ Kokusai Asset Management Co., Ltd. | 1,001 | $14.5K | 0.00% | 00.0% | Unchanged |
| Smartleaf Asset Management LLC | 954 | $13.9K | 0.00% | +500+110.1% | Added |
| Optiver Holding B.V. | 896 | $13.0K | 0.00% | +3+0.3% | Added |
| Quadrant Capital Group LLC | 782 | $11.4K | 0.00% | +782 | New |
| GAMMA Investing LLC | 729 | $10.6K | 0.00% | −20−2.7% | Reduced |
| Nemes Rush Group LLC | 700 | $10.2K | 0.00% | 00.0% | Unchanged |
| US Bancorp | 696 | $10.1K | 0.00% | +255+57.8% | Added |
| Covestor Ltd | 579 | $8.00K | 0.00% | −1−0.2% | Reduced |
| NBC Securities, Inc. | 532 | $7.72K | 0.00% | 00.0% | Unchanged |
| Groupe la Francaise | 620 | $7.67K | 0.00% | +620 | New |
| Daiwa Securities Group Inc. | 475 | $7.00K | 0.00% | 00.0% | Unchanged |
| Parallel Advisors, LLC | 434 | $6.30K | 0.00% | −111−20.4% | Reduced |
| GWM Advisors LLC | 400 | $5.81K | 0.00% | 00.0% | Unchanged |