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Denali Therapeutics Inc.

DNLI
Exchange
Nasdaq
Industry
Biological Products, (No Diagnostic Substances)
SEC CIK
0001714899

In the last 90 days, Denali Therapeutics Inc. insiders filed 0 open-market purchases and 4 sales; 294 institutions reported holding it in 13F filings for Q2 2026, worth $4.00B in total; no superinvestor holds it.

Q4 2025 vs. Q3 2025

How the institutions holding Denali Therapeutics Inc. changed between Q3 2025 and Q4 2025.

All holders in Q4 2025All holders in Q3 2025

13F holders of DNLI: Q3 2025 compared with Q4 2025
MeasureQ3 2025Of which not filed for Q4 2025Q4 2025Change
Holders2407250+17
Shares135.5M541.4K151.1M+16.2M (+12.0%)
Value$1.97B$7.86M$2.50B+$536.1M (+27.4%)

7 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so the changes leave them out.

New holders (51)

Institutions that held Denali Therapeutics Inc. at the end of Q4 2025 but not at the end of Q3 2025.

Institutions new to DNLI in Q4 2025
InstitutionSharesValue% of portfolio
Norges Bank5,119,622$84.5M0.01%
ExodusPoint Capital Management, LP1,023,253$16.9M0.19%
Alyeska Investment Group, L.P.859,108$14.2M0.04%
Defilade Capital Management, L.P.656,713$10.8M1.47%
Vestal Point Capital, LP465,000$7.68M0.28%
Burkehill Global Management, LP200,000$3.30M0.22%
Susquehanna Portfolio Strategies, LLC167,713$2.77M0.04%
B. Metzler seel. Sohn & Co. AG112,300$1.84M0.02%
Nomura Asset Management International Inc.107,493$1.77M0.00%
D.A. Davidson & Co.106,933$1.77M0.01%
Ghisallo Capital Management LLC100,000$1.65M0.07%
Y-Intercept (Hong Kong) Ltd93,587$1.55M0.03%
Monashee Investment Management LLC91,620$1.51M0.85%
HRT Financial LP78,352$1.29M0.00%
Ishara Investments LP70,000$1.16M1.35%
1492 Capital Management LLC67,487$1.11M0.43%
Capricorn Fund Managers Ltd62,197$1.03M0.25%
Clough Capital Partners L P51,830$855.7K0.08%
Man Group plc48,994$808.9K0.00%
Headlands Technologies LLC46,383$765.8K0.06%
Capstone Investment Advisors, LLC38,812$640.8K0.01%
PSP Research LLC31,762$524.4K0.46%
Polen Capital Management LLC26,900$444.1K0.00%
Bayforest Capital Ltd20,433$337.3K0.25%
Martingale Asset Management L P18,535$306.0K0.01%
SBI Okasan Asset Management Co.Ltd.18,000$298.4K0.02%
Winton Group Ltd12,700$209.7K0.01%
Walleye Capital LLC12,652$208.9K0.00%
Perbak Capital Partners LLP12,611$208.2K0.06%
Bellevue Group AG7,138$117.8K0.00%
Persistent Asset Partners Ltd5,670$93.6K0.05%
Eurizon Capital SGR S.p.A.5,045$82.7K0.00%
Aster Capital Management (DIFC) Ltd3,451$57.0K0.02%
Pinnacle Wealth Planning Services, Inc.2,957$48.8K0.01%
Los Angeles Capital Management LLC627$10.3K0.00%
Eastern Bank282$4.66K0.00%
Umb Bank N A262$4.33K0.00%
Comprehensive Financial Planning, Inc.200$3.30K0.00%
SRS Capital Advisors, Inc.198$3.27K0.00%
ORG Partners LLC130$2.15K0.00%
Hantz Financial Services, Inc.57$1.00K0.00%
Larson Financial Group LLC38$6270.00%
Manchester Capital Management LLC36$5950.00%
Cornerstone Financial Management LLC34$5610.00%
Westside Investment Management, Inc.33$5450.00%
Basecamp Wealth Advisors LLC31$5120.00%
SageView Advisory Group, LLC25$4130.00%
Keating Financial Advisory Services, Inc.20$3300.00%
Atlantic Private Wealth, LLC10$1650.00%
JFS Wealth Advisors, LLC8$1330.00%
Dunhill Financial, LLC2$350.00%

Sold out (34)

Institutions that held Denali Therapeutics Inc. at the end of Q3 2025 and filed for Q4 2025 without it.

Not filed for Q4 2025 yet (7)

Institutions that held Denali Therapeutics Inc. at the end of Q3 2025 and haven't filed a 13F for Q4 2025. Not filing isn't selling, so they aren't counted as sold out.

Institutions holding DNLI in Q3 2025 that haven't filed for Q4 2025
InstitutionShares, Q3 2025Value, Q3 2025
AXA Investment Managers S.A.294,732$4.28M
Cubist Systematic Strategies, LLC230,968$3.35M
CIBC Bancorp USA Inc.14,118$205.0K
Shell Asset Management Co1,492$22.0K
Guerra Advisors Inc50$726
Point72 (DIFC) Ltd43$622
Hemington Wealth Management34$0