Denali Therapeutics Inc.
DNLI- Exchange
- Nasdaq
- Industry
- Biological Products, (No Diagnostic Substances)
- SEC CIK
- 0001714899
In the last 90 days, Denali Therapeutics Inc. insiders filed 0 open-market purchases and 4 sales; 294 institutions reported holding it in 13F filings for Q2 2026, worth $4.00B in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in Denali Therapeutics Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 250
- +17 vs. Q3 2025
- Shares held
- 151.1M
- +16.2M (+12.0%) vs. Q3 2025
- Total value
- $2.50B
- +$536.1M (+27.4%) vs. Q3 2025
- New holders
- 51
- 86 more added
- Sold out
- 34
- 71 more reduced
7 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting DNLI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 294 | $4.00B |
| Q1 2026 | 269 | $2.82B |
| Q4 2025 | 250 | $2.50B |
| Q3 2025 | 240 | $1.97B |
| Q2 2025 | 231 | $1.93B |
| Q1 2025 | 222 | $1.85B |
| Q4 2024 | 224 | $2.61B |
| Q3 2024 | 217 | $3.69B |
| Q2 2024 | 203 | $2.88B |
| Q1 2024 | 211 | $2.51B |
| Q4 2023 | 209 | $2.47B |
| Q3 2023 | 195 | $2.24B |
| Q2 2023 | 203 | $3.18B |
| Q1 2023 | 202 | $2.49B |
| Q4 2022 | 199 | $2.94B |
| Q3 2022 | 200 | $2.84B |
| Q2 2022 | 188 | $2.73B |
| Q1 2022 | 190 | $2.79B |
| Q4 2021 | 213 | $3.80B |
| Q3 2021 | 214 | $4.28B |
| Q2 2021 | 210 | $6.32B |
| Q1 2021 | 218 | $4.60B |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Denali Therapeutics Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Avion Wealth | 40 | $0 | 0.00% | 00.0% | Unchanged |
| Global Retirement Partners, LLC | 1 | $17 | 0.00% | 00.0% | Unchanged |
| Dunhill Financial, LLC | 2 | $35 | 0.00% | +2 | New |
| Bay Harbor Wealth Management, LLC | 3 | $49 | 0.00% | +2+200.0% | Added |
| SJS Investment Consulting Inc. | 4 | $67 | 0.00% | 00.0% | Unchanged |
| Fortitude Family Office, LLC | 7 | $116 | 0.00% | −2−22.2% | Reduced |
| Private Wealth Asset Management, LLC | 8 | $132 | 0.00% | 00.0% | Unchanged |
| Rialto Wealth Management, LLC | 8 | $133 | 0.00% | +6+300.0% | Added |
| JFS Wealth Advisors, LLC | 8 | $133 | 0.00% | +8 | New |
| IFP Advisors, Inc | 9 | $149 | 0.00% | 00.0% | Unchanged |
| HFM Investment Advisors, LLC | 9 | $149 | 0.00% | +7+350.0% | Added |
| Atlantic Private Wealth, LLC | 10 | $165 | 0.00% | +10 | New |
| Keating Financial Advisory Services, Inc. | 20 | $330 | 0.00% | +20 | New |
| Sunbelt Securities, Inc. | 22 | $363 | 0.00% | 00.0% | Unchanged |
| SageView Advisory Group, LLC | 25 | $413 | 0.00% | +25 | New |
| Basecamp Wealth Advisors LLC | 31 | $512 | 0.00% | +31 | New |
| Westside Investment Management, Inc. | 33 | $545 | 0.00% | +33 | New |
| Cornerstone Financial Management LLC | 34 | $561 | 0.00% | +34 | New |
| Manchester Capital Management LLC | 36 | $595 | 0.00% | +36 | New |
| Larson Financial Group LLC | 38 | $627 | 0.00% | +38 | New |
| Bell Investment Advisors, Inc | 38 | $628 | 0.00% | −21−35.6% | Reduced |
| Ronald Blue Trust, Inc. | 40 | $660 | 0.00% | 00.0% | Unchanged |
| True Wealth Design, LLC | 56 | $925 | 0.00% | 00.0% | Unchanged |
| Hantz Financial Services, Inc. | 57 | $1.00K | 0.00% | +57 | New |
| TD Private Client Wealth LLC | 71 | $1.17K | 0.00% | 00.0% | Unchanged |
| UMA Financial Services, Inc. | 76 | $1.25K | 0.00% | 00.0% | Unchanged |
| Johnson Financial Group, Inc. | 81 | $1.34K | 0.00% | −1,894−95.9% | Reduced |
| Allworth Financial LP | 90 | $1.49K | 0.00% | −9−9.1% | Reduced |
| Your Advocates Ltd., LLP | 100 | $1.65K | 0.00% | 00.0% | Unchanged |
| Root Financial Partners, LLC | 100 | $1.65K | 0.00% | +30+42.9% | Added |
| ORG Partners LLC | 130 | $2.15K | 0.00% | +130 | New |
| Massmutual Trust Co FSB | 143 | $2.36K | 0.00% | 00.0% | Unchanged |
| Parkside Financial Bank & Trust | 189 | $3.12K | 0.00% | 00.0% | Unchanged |
| Rothschild Investment LLC | 195 | $3.22K | 0.00% | −30−13.3% | Reduced |
| SRS Capital Advisors, Inc. | 198 | $3.27K | 0.00% | +198 | New |
| Comprehensive Financial Planning, Inc. | 200 | $3.30K | 0.00% | +200 | New |
| Farther Finance Advisors, LLC | 202 | $3.33K | 0.00% | +75+59.1% | Added |
| EverSource Wealth Advisors, LLC | 207 | $3.42K | 0.00% | +41+24.7% | Added |
| Signaturefd, LLC | 230 | $3.80K | 0.00% | 00.0% | Unchanged |
| City State Bank | 250 | $4.13K | 0.00% | 00.0% | Unchanged |
| Umb Bank N A | 262 | $4.33K | 0.00% | +262 | New |
| Eastern Bank | 282 | $4.66K | 0.00% | +282 | New |
| Private Wealth Management Group, LLC | 296 | $4.89K | 0.00% | 00.0% | Unchanged |
| Parallel Advisors, LLC | 358 | $5.91K | 0.00% | −76−17.5% | Reduced |
| GWM Advisors LLC | 400 | $6.60K | 0.00% | 00.0% | Unchanged |
| Optiver Holding B.V. | 409 | $6.75K | 0.00% | −487−54.4% | Reduced |
| Daiwa Securities Group Inc. | 475 | $8.00K | 0.00% | 00.0% | Unchanged |
| Huntington National Bank | 491 | $8.11K | 0.00% | +183+59.4% | Added |
| Covestor Ltd | 579 | $10.0K | 0.01% | 00.0% | Unchanged |
| Los Angeles Capital Management LLC | 627 | $10.3K | 0.00% | +627 | New |
| Nemes Rush Group LLC | 700 | $11.6K | 0.00% | 00.0% | Unchanged |
| Quadrant Capital Group LLC | 758 | $12.5K | 0.00% | −24−3.1% | Reduced |
| US Bancorp | 834 | $13.8K | 0.00% | +138+19.8% | Added |
| GAMMA Investing LLC | 962 | $15.9K | 0.00% | +233+32.0% | Added |
| Mitsubishi UFJ Kokusai Asset Management Co., Ltd. | 1,001 | $16.3K | 0.00% | 00.0% | Unchanged |
| Advisor Group Holdings, Inc. | 1,074 | $17.7K | 0.00% | −314−22.6% | Reduced |
| SBI Securities Co., Ltd. | 1,222 | $20.2K | 0.00% | +1,200+5,454.5% | Added |
| Rockefeller Capital Management L.P. | 1,265 | $20.9K | 0.00% | +182+16.8% | Added |
| Comerica Bank | 1,284 | $21.2K | 0.00% | 00.0% | Unchanged |
| Smartleaf Asset Management LLC | 1,313 | $21.5K | 0.00% | +359+37.6% | Added |
| Nisa Investment Advisors, LLC | 1,449 | $23.9K | 0.00% | −34−2.3% | Reduced |
| Versant Capital Management, Inc | 1,476 | $24.4K | 0.00% | 00.0% | Unchanged |
| Bartlett & Co. Wealth Management LLC | 1,500 | $24.8K | 0.00% | 00.0% | Unchanged |
| CWM, LLC | 2,606 | $43.0K | 0.00% | +209+8.7% | Added |
| State of Wyoming | 2,686 | $44.3K | 0.00% | +532+24.7% | Added |
| GF Fund Management Co. Ltd. | 2,881 | $47.6K | 0.00% | −265−8.4% | Reduced |
| Pinnacle Wealth Planning Services, Inc. | 2,957 | $48.8K | 0.01% | +2,957 | New |
| Aster Capital Management (DIFC) Ltd | 3,451 | $57.0K | 0.02% | +3,451 | New |
| Amalgamated Bank | 4,161 | $69.0K | 0.00% | −144−3.3% | Reduced |
| Eurizon Capital SGR S.p.A. | 5,045 | $82.7K | 0.00% | +5,045 | New |
| Assetmark, Inc | 5,187 | $85.6K | 0.00% | +1,250+31.8% | Added |
| Persistent Asset Partners Ltd | 5,670 | $93.6K | 0.05% | +5,670 | New |
| KBC Group NV | 6,268 | $103.0K | 0.00% | +1,773+39.4% | Added |
| NBC Securities, Inc. | 6,536 | $107.9K | 0.01% | +6,004+1,128.6% | Added |
| Quarry LP | 7,000 | $115.6K | 0.02% | +2,625+60.0% | Added |
| Mirae Asset Global Investments Co., Ltd. | 7,127 | $117.7K | 0.00% | +1,474+26.1% | Added |
| Bellevue Group AG | 7,138 | $117.8K | 0.00% | +7,138 | New |
| Sterling Capital Management LLC | 7,238 | $119.5K | 0.00% | −1,416−16.4% | Reduced |
| The PNC Financial Services Group, Inc. | 8,481 | $140.0K | 0.00% | +191+2.3% | Added |
| Xponance, Inc. | 10,497 | $173.3K | 0.00% | +97+0.9% | Added |
| LPL Financial LLC | 10,504 | $173.4K | 0.00% | −144−1.4% | Reduced |
| Renaissance Technologies LLC | 10,700 | $176.7K | 0.00% | −49,100−82.1% | Reduced |
| Ameritas Investment Partners, Inc. | 11,065 | $182.7K | 0.01% | 00.0% | Unchanged |
| Intrust Bank NA | 11,164 | $184.3K | 0.02% | +589+5.6% | Added |
| Empowered Funds, LLC | 11,325 | $187.0K | 0.00% | +288+2.6% | Added |
| Royal Bank of Canada | 11,335 | $187.0K | 0.00% | −360,841−97.0% | Reduced |
| JustInvest LLC | 11,736 | $193.8K | 0.00% | −790−6.3% | Reduced |
| HighTower Advisors, LLC | 11,757 | $194.1K | 0.00% | −9,565−44.9% | Reduced |
| Public Employees Retirement Association of Colorado | 12,238 | $202.0K | 0.00% | 00.0% | Unchanged |
| Guggenheim Capital LLC | 12,468 | $205.8K | 0.00% | −37,057−74.8% | Reduced |
| Perbak Capital Partners LLP | 12,611 | $208.2K | 0.06% | +12,611 | New |
| Walleye Capital LLC | 12,652 | $208.9K | 0.00% | +12,652 | New |
| Winton Group Ltd | 12,700 | $209.7K | 0.01% | +12,700 | New |
| Tower Research Capital LLC (TRC) | 12,941 | $213.7K | 0.01% | +5,565+75.4% | Added |
| Great West Life Assurance Co | 13,434 | $222.0K | 0.00% | 00.0% | Unchanged |
| Russell Investments Group, Ltd. | 13,467 | $222.3K | 0.00% | −332−2.4% | Reduced |
| Virtus Investment Advisers, Inc. | 14,795 | $244.3K | 0.07% | +7,171+94.1% | Added |
| Victory Capital Management Inc | 15,064 | $248.7K | 0.00% | 00.0% | Unchanged |
| BNP Paribas Arbitrage, SA | 15,497 | $255.9K | 0.00% | −248,564−94.1% | Reduced |
| Breakwater Capital Group | 16,366 | $270.2K | 0.04% | +500+3.2% | Added |