Denali Therapeutics Inc.
DNLI- Exchange
- Nasdaq
- Industry
- Biological Products, (No Diagnostic Substances)
- SEC CIK
- 0001714899
In the last 90 days, Denali Therapeutics Inc. insiders filed 0 open-market purchases and 4 sales; 294 institutions reported holding it in 13F filings for Q2 2026, worth $4.00B in total; no superinvestor holds it.
13F holders, Q1 2026
Institutional positions in Denali Therapeutics Inc. as of Mar 31, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 269
- +25 vs. Q4 2025
- Shares held
- 147.4M
- +14.8M (+11.2%) vs. Q4 2025
- Total value
- $2.82B
- +$631.6M (+28.8%) vs. Q4 2025
- New holders
- 55
- 104 more added
- Sold out
- 30
- 58 more reduced
6 institutions that held it in Q4 2025 haven't filed for Q1 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting DNLI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 294 | $4.00B |
| Q1 2026 | 269 | $2.82B |
| Q4 2025 | 250 | $2.50B |
| Q3 2025 | 240 | $1.97B |
| Q2 2025 | 231 | $1.93B |
| Q1 2025 | 222 | $1.85B |
| Q4 2024 | 224 | $2.61B |
| Q3 2024 | 217 | $3.69B |
| Q2 2024 | 203 | $2.88B |
| Q1 2024 | 211 | $2.51B |
| Q4 2023 | 209 | $2.47B |
| Q3 2023 | 195 | $2.24B |
| Q2 2023 | 203 | $3.18B |
| Q1 2023 | 202 | $2.49B |
| Q4 2022 | 199 | $2.94B |
| Q3 2022 | 200 | $2.84B |
| Q2 2022 | 188 | $2.73B |
| Q1 2022 | 190 | $2.79B |
| Q4 2021 | 213 | $3.80B |
| Q3 2021 | 214 | $4.28B |
| Q2 2021 | 210 | $6.32B |
| Q1 2021 | 218 | $4.60B |
Institutions, Q1 2026
Shares, value and share of portfolio for each institution holding Denali Therapeutics Inc.; share changes are against Q4 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Mitsubishi UFJ Kokusai Asset Management Co., Ltd. | 1,001 | $19.2K | 0.00% | 00.0% | Unchanged |
| Los Angeles Capital Management LLC | 927 | $17.8K | 0.00% | +300+47.8% | Added |
| US Bancorp | 902 | $17.3K | 0.00% | +68+8.2% | Added |
| Optiver Holding B.V. | 866 | $16.6K | 0.00% | +457+111.7% | Added |
| Advisory Services Network, LLC | 848 | $16.3K | 0.00% | +848 | New |
| Quadrant Capital Group LLC | 758 | $14.6K | 0.00% | 00.0% | Unchanged |
| Nemes Rush Group LLC | 700 | $13.4K | 0.00% | 00.0% | Unchanged |
| Umb Bank N A | 624 | $12.0K | 0.00% | +362+138.2% | Added |
| Quantbot Technologies LP | 512 | $9.83K | 0.00% | +512 | New |
| Mowery & Schoenfeld Wealth Management, LLC | 500 | $9.60K | 0.01% | +500 | New |
| Owl Creek Wealth Partners LLC | 450 | $8.64K | 0.00% | +450 | New |
| Huntington National Bank | 420 | $8.06K | 0.00% | −71−14.5% | Reduced |
| GWM Advisors LLC | 400 | $7.68K | 0.00% | 00.0% | Unchanged |
| SBI Securities Co., Ltd. | 368 | $7.07K | 0.00% | −854−69.9% | Reduced |
| Parallel Advisors, LLC | 358 | $6.87K | 0.00% | 00.0% | Unchanged |
| Covestor Ltd | 322 | $6.00K | 0.00% | −257−44.4% | Reduced |
| SRS Capital Advisors, Inc. | 301 | $5.80K | 0.00% | +103+52.0% | Added |
| Private Wealth Management Group, LLC | 296 | $5.68K | 0.00% | 00.0% | Unchanged |
| Rothschild Investment LLC | 288 | $5.53K | 0.00% | +93+47.7% | Added |
| Eastern Bank | 282 | $5.41K | 0.00% | 00.0% | Unchanged |
| Allworth Financial LP | 280 | $5.38K | 0.00% | +190+211.1% | Added |
| Farther Finance Advisors, LLC | 255 | $5.02K | 0.00% | +53+26.2% | Added |
| EverSource Wealth Advisors, LLC | 256 | $4.91K | 0.00% | +49+23.7% | Added |
| City State Bank | 250 | $4.80K | 0.00% | 00.0% | Unchanged |
| Signaturefd, LLC | 241 | $4.63K | 0.00% | +11+4.8% | Added |
| Comprehensive Financial Planning, Inc. | 200 | $3.84K | 0.00% | 00.0% | Unchanged |
| Parkside Financial Bank & Trust | 189 | $3.63K | 0.00% | 00.0% | Unchanged |
| Root Financial Partners, LLC | 188 | $3.61K | 0.00% | +88+88.0% | Added |
| Aster Capital Management (DIFC) Ltd | 246 | $3.34K | 0.00% | −3,205−92.9% | Reduced |
| Massmutual Trust Co FSB | 143 | $2.75K | 0.00% | 00.0% | Unchanged |
| Steward Partners Investment Advisory, LLC | 136 | $2.61K | 0.00% | +136 | New |
| Golden State Equity Partners | 130 | $2.50K | 0.00% | +130 | New |
| Your Advocates Ltd., LLP | 100 | $1.92K | 0.00% | 00.0% | Unchanged |
| Johnson Financial Group, Inc. | 81 | $1.56K | 0.00% | 00.0% | Unchanged |
| UMA Financial Services, Inc. | 76 | $1.46K | 0.00% | 00.0% | Unchanged |
| TD Private Client Wealth LLC | 71 | $1.36K | 0.00% | 00.0% | Unchanged |
| Bayforest Capital Ltd | 67 | $1.29K | 0.00% | −20,366−99.7% | Reduced |
| Rossby Financial, LCC | 65 | $1.28K | 0.00% | +65 | New |
| WPG Advisers, LLC | 66 | $1.27K | 0.00% | +66 | New |
| CVA Family Office, LLC | 63 | $1.21K | 0.00% | +63 | New |
| Larson Financial Group LLC | 62 | $1.19K | 0.00% | +24+63.2% | Added |
| True Wealth Design, LLC | 57 | $1.09K | 0.00% | +1+1.8% | Added |
| Hantz Financial Services, Inc. | 57 | $1.00K | 0.00% | 00.0% | Unchanged |
| Essential Partners LLC | 45 | $864 | 0.00% | +45 | New |
| Wealth Preservation Advisors, LLC | 43 | $826 | 0.00% | +43 | New |
| Ronald Blue Trust, Inc. | 40 | $768 | 0.00% | 00.0% | Unchanged |
| Transamerica Financial Advisors, Inc. | 40 | $768 | 0.00% | +40 | New |
| Bell Investment Advisors, Inc | 38 | $730 | 0.00% | 00.0% | Unchanged |
| Jones Financial Companies LLLP | 39 | $708 | 0.00% | +39 | New |
| Manchester Capital Management LLC | 36 | $692 | 0.00% | 00.0% | Unchanged |
| Fortitude Family Office, LLC | 35 | $672 | 0.00% | +28+400.0% | Added |
| Cornerstone Financial Management LLC | 34 | $653 | 0.00% | 00.0% | Unchanged |
| Keating Financial Advisory Services, Inc. | 33 | $634 | 0.00% | +13+65.0% | Added |
| Sunbelt Securities, Inc. | 22 | $422 | 0.00% | 00.0% | Unchanged |
| Basecamp Wealth Advisors LLC | 17 | $326 | 0.00% | −14−45.2% | Reduced |
| SJS Investment Consulting Inc. | 16 | $308 | 0.00% | +12+300.0% | Added |
| Atlantic Private Wealth, LLC | 10 | $192 | 0.00% | 00.0% | Unchanged |
| Cullen/Frost Bankers, Inc. | 10 | $192 | 0.00% | +10 | New |
| IFP Advisors, Inc | 9 | $173 | 0.00% | 00.0% | Unchanged |
| JFS Wealth Advisors, LLC | 8 | $154 | 0.00% | 00.0% | Unchanged |
| Bay Harbor Wealth Management, LLC | 6 | $115 | 0.00% | +3+100.0% | Added |
| HFM Investment Advisors, LLC | 5 | $96 | 0.00% | −4−44.4% | Reduced |
| Rialto Wealth Management, LLC | 5 | $96 | 0.00% | −3−37.5% | Reduced |
| Dunhill Financial, LLC | 2 | $40 | 0.00% | 00.0% | Unchanged |
| DiNuzzo Private Wealth, Inc. | 2 | $39 | 0.00% | +2 | New |
| Raffa Wealth Management, LLC | 1 | $19 | 0.00% | +1 | New |
| Vermillion Wealth Management, Inc. | 1 | $19 | 0.00% | +1 | New |
| Curio Wealth, LLC | 1 | $19 | 0.00% | +1 | New |
| Avion Wealth | 40 | $0 | 0.00% | 00.0% | Unchanged |
| Point72 Asset Management, L.P. | 0 | $0 | 0.00% | −1,700,000−100.0% | Sold out |
| ExodusPoint Capital Management, LP | 0 | $0 | 0.00% | −1,023,253−100.0% | Sold out |
| Voloridge Investment Management, LLC | 0 | $0 | 0.00% | −591,461−100.0% | Sold out |
| Qube Research & Technologies Ltd | 0 | $0 | 0.00% | −590,314−100.0% | Sold out |
| Two Sigma Investments, LP | 0 | $0 | 0.00% | −430,177−100.0% | Sold out |
| Trexquant Investment LP | 0 | $0 | 0.00% | −209,609−100.0% | Sold out |
| Two Sigma Advisers, LP | 0 | $0 | 0.00% | −154,800−100.0% | Sold out |
| Algert Global LLC | 0 | $0 | 0.00% | −127,030−100.0% | Sold out |
| Monashee Investment Management LLC | 0 | $0 | 0.00% | −91,620−100.0% | Sold out |
| HRT Financial LP | 0 | $0 | 0.00% | −78,352−100.0% | Sold out |
| Ishara Investments LP | 0 | $0 | 0.00% | −70,000−100.0% | Sold out |
| Capricorn Fund Managers Ltd | 0 | $0 | 0.00% | −62,197−100.0% | Sold out |
| Tudor Investment Corp Et Al | 0 | $0 | 0.00% | −53,683−100.0% | Sold out |
| Clough Capital Partners L P | 0 | $0 | 0.00% | −51,830−100.0% | Sold out |
| Quest Partners LLC | 0 | $0 | 0.00% | −42,909−100.0% | Sold out |
| Jump Financial, LLC | 0 | $0 | 0.00% | −40,608−100.0% | Sold out |
| Savvy Advisors, Inc. | 0 | $0 | 0.00% | −39,030−100.0% | Sold out |
| PSP Research LLC | 0 | $0 | 0.00% | −31,762−100.0% | Sold out |
| TT International Asset Management LTD | 0 | $0 | 0.00% | −27,000−100.0% | Sold out |
| Graham Capital Management, L.P. | 0 | $0 | 0.00% | −18,121−100.0% | Sold out |
| Walleye Capital LLC | 0 | $0 | 0.00% | −12,652−100.0% | Sold out |
| Renaissance Technologies LLC | 0 | $0 | 0.00% | −10,700−100.0% | Sold out |
| Quarry LP | 0 | $0 | 0.00% | −7,000−100.0% | Sold out |
| Persistent Asset Partners Ltd | 0 | $0 | 0.00% | −5,670−100.0% | Sold out |
| Amalgamated Bank | 0 | $0 | 0.00% | −4,161−100.0% | Sold out |
| State of Wyoming | 0 | $0 | 0.00% | −2,686−100.0% | Sold out |
| Daiwa Securities Group Inc. | 0 | $0 | 0.00% | −475−100.0% | Sold out |
| Westside Investment Management, Inc. | 0 | $0 | 0.00% | −33−100.0% | Sold out |
| SageView Advisory Group, LLC | 0 | $0 | 0.00% | −25−100.0% | Sold out |
| Private Wealth Asset Management, LLC | 0 | $0 | 0.00% | −8−100.0% | Sold out |
| Vanguard Group Inc | – | – | – | – | Not filed |