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Xenon Pharmaceuticals Inc.

XENE
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001582313

In the last 90 days, Xenon Pharmaceuticals Inc. insiders filed 2 open-market purchases and 2 sales; 315 institutions reported holding it in 13F filings for Q2 2026, worth $6.10B in total; Duquesne Family Office is the only superinvestor holding it.

13F holders, Q1 2026

Institutional positions in Xenon Pharmaceuticals Inc. as of Mar 31, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
290
+49 vs. Q4 2025
Shares held
100.2M
+16.7M (+20.0%) vs. Q4 2025
Total value
$5.80B
+$2.06B (+55.0%) vs. Q4 2025
New holders
82
123 more added
Sold out
33
60 more reduced

4 institutions that held it in Q4 2025 haven't filed for Q1 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.

Compare with Q4 2025: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting XENE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ1 2026: 290 institutions
Q1 2021: 91 institutionsQ2 2021: 103 institutionsQ3 2021: 118 institutionsQ4 2021: 130 institutionsQ1 2022: 132 institutionsQ2 2022: 151 institutionsQ3 2022: 154 institutionsQ4 2022: 159 institutionsQ1 2023: 163 institutionsQ2 2023: 175 institutionsQ3 2023: 181 institutionsQ4 2023: 204 institutionsQ1 2024: 220 institutionsQ2 2024: 213 institutionsQ3 2024: 203 institutionsQ4 2024: 209 institutionsQ1 2025: 206 institutionsQ2 2025: 206 institutionsQ3 2025: 219 institutionsQ4 2025: 245 institutionsQ1 2026: 290 institutionsQ2 2026: 315 institutions
Value heldQ1 2026: $5.80B
Q1 2021: $590.0MQ2 2021: $620.0MQ3 2021: $521.7MQ4 2021: $1.49BQ1 2022: $1.50BQ2 2022: $1.73BQ3 2022: $2.09BQ4 2022: $2.38BQ1 2023: $2.19BQ2 2023: $2.36BQ3 2023: $2.10BQ4 2023: $3.32BQ1 2024: $3.16BQ2 2024: $2.89BQ3 2024: $2.95BQ4 2024: $2.99BQ1 2025: $2.58BQ2 2025: $2.60BQ3 2025: $3.39BQ4 2025: $3.78BQ1 2026: $5.80BQ2 2026: $6.10B
Institutions holding XENE and their total value by quarter
QuarterHoldersValue
Q2 2026315$6.10B
Q1 2026290$5.80B
Q4 2025245$3.78B
Q3 2025219$3.39B
Q2 2025206$2.60B
Q1 2025206$2.58B
Q4 2024209$2.99B
Q3 2024203$2.95B
Q2 2024213$2.89B
Q1 2024220$3.16B
Q4 2023204$3.32B
Q3 2023181$2.10B
Q2 2023175$2.36B
Q1 2023163$2.19B
Q4 2022159$2.38B
Q3 2022154$2.09B
Q2 2022151$1.73B
Q1 2022132$1.50B
Q4 2021130$1.49B
Q3 2021118$521.7M
Q2 2021103$620.0M
Q1 202191$590.0M

Institutions, Q1 2026

Shares, value and share of portfolio for each institution holding Xenon Pharmaceuticals Inc.; share changes are against Q4 2025.

Institutions holding XENE in Q1 2026
InstitutionSharesValue% of portfolioChange in sharesAction
Dark Forest Capital Management LP0$00.00%−33,459−100.0%Sold out
Lighthouse Investment Partners, LLC0$00.00%−25,000−100.0%Sold out
Cinctive Capital Management LP0$00.00%−23,317−100.0%Sold out
Walleye Capital LLC0$00.00%−19,587−100.0%Sold out
Entropy Technologies, LP0$00.00%−17,025−100.0%Sold out
Himension Fund0$00.00%−11,279−100.0%Sold out
Supplemental Annuity Collective Trust of NJ0$00.00%−11,000−100.0%Sold out
Knott David M Jr0$00.00%−10,962−100.0%Sold out
Marex Group plc0$00.00%−10,557−100.0%Sold out
Harbor Capital Advisors, Inc.0$00.00%−10,053−100.0%Sold out
Altfest L J & Co Inc0$00.00%−8,232−100.0%Sold out
Abel Hall, LLC0$00.00%−6,757−100.0%Sold out
Magnetar Financial LLC0$00.00%−5,153−100.0%Sold out
Mackenzie Financial Corp0$00.00%−4,772−100.0%Sold out
Whalen Wealth Management Inc.0$00.00%−4,641−100.0%Sold out
Amalgamated Bank0$00.00%−2,387−100.0%Sold out
Clearstead Advisors, LLC0$00.00%−1,215−100.0%Sold out
Kestra Advisory Services, LLC0$00.00%−740−100.0%Sold out
Daiwa Securities Group Inc.0$00.00%−229−100.0%Sold out
Cape Investment Advisory, Inc.0$00.00%−39−100.0%Sold out
Aster Capital Management (DIFC) Ltd0$00.00%−36−100.0%Sold out
SRS Capital Advisors, Inc.0$00.00%−27−100.0%Sold out
TD Private Client Wealth LLC0$00.00%−3−100.0%Sold out
Vanguard Group Inc––––Not filed
Iron Triangle Partners LP––––Not filed
CIBC World Markets Corp––––Not filed
Motiv8 Investments LLC––––Not filed