Xenon Pharmaceuticals Inc.
XENE- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001582313
In the last 90 days, Xenon Pharmaceuticals Inc. insiders filed 0 open-market purchases and 2 sales; 315 institutions reported holding it in 13F filings for Q2 2026, worth $6.10B in total; Duquesne Family Office is the only superinvestor holding it.
13F holders, Q4 2025
Institutional positions in Xenon Pharmaceuticals Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 245
- +28 vs. Q3 2025
- Shares held
- 84.4M
- +294.5K (+0.4%) vs. Q3 2025
- Total value
- $3.78B
- +$405.9M (+12.0%) vs. Q3 2025
- New holders
- 50
- 81 more added
- Sold out
- 22
- 74 more reduced
2 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting XENE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 315 | $6.10B |
| Q1 2026 | 290 | $5.80B |
| Q4 2025 | 245 | $3.78B |
| Q3 2025 | 219 | $3.39B |
| Q2 2025 | 206 | $2.60B |
| Q1 2025 | 206 | $2.58B |
| Q4 2024 | 209 | $2.99B |
| Q3 2024 | 203 | $2.95B |
| Q2 2024 | 213 | $2.89B |
| Q1 2024 | 220 | $3.16B |
| Q4 2023 | 204 | $3.32B |
| Q3 2023 | 181 | $2.10B |
| Q2 2023 | 175 | $2.36B |
| Q1 2023 | 163 | $2.19B |
| Q4 2022 | 159 | $2.38B |
| Q3 2022 | 154 | $2.09B |
| Q2 2022 | 151 | $1.73B |
| Q1 2022 | 132 | $1.50B |
| Q4 2021 | 130 | $1.49B |
| Q3 2021 | 118 | $521.7M |
| Q2 2021 | 103 | $620.0M |
| Q1 2021 | 91 | $590.0M |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Xenon Pharmaceuticals Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Arizona State Retirement System | 16,179 | $725.1K | 0.00% | −3,111−16.1% | Reduced |
| Entropy Technologies, LP | 17,025 | $763.1K | 0.04% | +17,025 | New |
| ProShare Advisors LLC | 17,279 | $774.4K | 0.00% | +1,539+9.8% | Added |
| Stifel Financial Corp | 17,548 | $786.5K | 0.00% | −1,167−6.2% | Reduced |
| Creative Planning | 19,200 | $860.5K | 0.00% | +5,990+45.3% | Added |
| Walleye Capital LLC | 19,587 | $877.9K | 0.01% | +19,587 | New |
| State of New Jersey Common Pension Fund D | 19,738 | $884.7K | 0.00% | −35,973−64.6% | Reduced |
| Police & Firemen's Retirement System of New Jersey | 20,128 | $902.1K | 0.01% | −904−4.3% | Reduced |
| Birchview Capital, LP | 21,000 | $941.2K | 0.55% | 00.0% | Unchanged |
| Assetmark, Inc | 21,269 | $953.3K | 0.00% | −1,297−5.7% | Reduced |
| XTX Topco Ltd | 21,498 | $963.5K | 0.03% | +21,498 | New |
| Vestmark Advisory Solutions, Inc. | 21,884 | $980.8K | 0.01% | +21,884 | New |
| HighMark Wealth Management LLC | 23,000 | $1.03M | 0.42% | −3,100−11.9% | Reduced |
| Cinctive Capital Management LP | 23,317 | $1.05M | 0.06% | +263+1.1% | Added |
| Rathbone Brothers plc | 23,666 | $1.06M | 0.00% | 00.0% | Unchanged |
| Quantinno Capital Management LP | 24,628 | $1.10M | 0.00% | +11,257+84.2% | Added |
| Lighthouse Investment Partners, LLC | 25,000 | $1.12M | 0.04% | +25,000 | New |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 25,589 | $1.15M | 0.00% | 00.0% | Unchanged |
| Intech Investment Management LLC | 25,840 | $1.16M | 0.01% | +2,754+11.9% | Added |
| Handelsbanken Fonder AB | 29,800 | $1.34M | 0.00% | +7,100+31.3% | Added |
| Bamco Inc | 30,000 | $1.34M | 0.00% | 00.0% | Unchanged |
| D. E. Shaw & Co., Inc. | 30,851 | $1.38M | 0.00% | −17,604−36.3% | Reduced |
| Jump Financial, LLC | 30,987 | $1.39M | 0.02% | +24,487+376.7% | Added |
| Manufacturers Life Insurance Company, The | 32,622 | $1.45M | 0.00% | +8,690+36.3% | Added |
| Dark Forest Capital Management LP | 33,459 | $1.50M | 0.07% | +33,459 | New |
| Mirae Asset Global ETFs Holdings Ltd. | 35,310 | $1.58M | 0.00% | +90.0% | Added |
| Boothbay Fund Management, LLC | 35,681 | $1.60M | 0.04% | +6,822+23.6% | Added |
| Envestnet Asset Management Inc | 35,801 | $1.60M | 0.00% | −1,647−4.4% | Reduced |
| Legato Capital Management LLC | 37,038 | $1.66M | 0.14% | +22,829+160.7% | Added |
| TD Asset Management Inc | 38,148 | $1.71M | 0.00% | +21,918+135.0% | Added |
| Artia Global Partners LP | 40,000 | $1.79M | 0.29% | 00.0% | Unchanged |
| DekaBank Deutsche Girozentrale | 39,000 | $1.82M | 0.00% | 00.0% | Unchanged |
| MetLife Investment Management | 42,025 | $1.88M | 0.01% | −2,196−5.0% | Reduced |
| SEI Investments Co | 43,858 | $1.97M | 0.00% | +21,435+95.6% | Added |
| Nomura Asset Management International Inc. | 47,957 | $2.15M | 0.00% | +47,957 | New |
| Erste Asset Management GmbH | 50,000 | $2.22M | 0.02% | 00.0% | Unchanged |
| Invesco Ltd. | 50,947 | $2.28M | 0.00% | −5,117−9.1% | Reduced |
| UBS Group AG | 52,539 | $2.35M | 0.00% | −54,205−50.8% | Reduced |
| California State Teachers Retirement System | 56,564 | $2.54M | 0.00% | −3,673−6.1% | Reduced |
| Sofinnova Investments, Inc. | 59,900 | $2.68M | 0.12% | +59,900 | New |
| Voya Investment Management LLC | 60,858 | $2.73M | 0.00% | 00.0% | Unchanged |
| Alps Advisors Inc | 63,302 | $2.84M | 0.02% | +26,002+69.7% | Added |
| Legal & General Group Plc | 70,265 | $3.15M | 0.00% | −9,583−12.0% | Reduced |
| Y-Intercept (Hong Kong) Ltd | 72,957 | $3.27M | 0.07% | +72,957 | New |
| Lazard Asset Management LLC | 78,663 | $3.53M | 0.01% | +78,663 | New |
| Schroder Investment Management Group | 81,156 | $3.58M | 0.00% | 00.0% | Unchanged |
| Raymond James Financial Inc | 83,255 | $3.73M | 0.00% | +13,333+19.1% | Added |
| Balyasny Asset Management LLC | 84,360 | $3.78M | 0.01% | −238,096−73.8% | Reduced |
| Russell Investments Group, Ltd. | 86,220 | $3.86M | 0.00% | +16,328+23.4% | Added |
| Royal Bank of Canada | 89,757 | $4.02M | 0.00% | −30,788−25.5% | Reduced |
| Rhumbline Advisers | 90,143 | $4.04M | 0.00% | −16,648−15.6% | Reduced |
| Atika Capital Management LLC | 92,506 | $4.15M | 0.58% | +54,506+143.4% | Added |
| Granahan Investment Management Inc | 92,778 | $4.16M | 0.18% | +5,308+6.1% | Added |
| BNP Paribas Arbitrage, SA | 93,462 | $4.19M | 0.00% | −65,776−41.3% | Reduced |
| Verition Fund Management LLC | 93,756 | $4.20M | 0.02% | +36,639+64.1% | Added |
| Palo Alto Investors LP | 96,519 | $4.33M | 0.60% | +96,519 | New |
| Squadron Capital Management LLC | 105,551 | $4.73M | 2.11% | +105,551 | New |
| Ameriprise Financial Inc | 109,544 | $4.91M | 0.00% | +11,977+12.3% | Added |
| Swiss National Bank | 114,000 | $5.11M | 0.00% | −12,400−9.8% | Reduced |
| Man Group plc | 114,826 | $5.15M | 0.01% | +91,707+396.7% | Added |
| Mutual of America Capital Management LLC | 116,088 | $5.20M | 0.05% | +21,153+22.3% | Added |
| Assenagon Asset Management S.A. | 119,186 | $5.34M | 0.01% | +119,186 | New |
| Algert Global LLC | 123,189 | $5.52M | 0.09% | +68,934+127.1% | Added |
| Redmile Group, LLC | 133,882 | $6.00M | 0.44% | +133,882 | New |
| Patient Square Capital LP | 136,500 | $6.12M | 1.31% | +136,500 | New |
| Rhenman & Partners Asset Management AB | 139,000 | $6.23M | 0.58% | +58,000+71.6% | Added |
| Moore Capital Management, LP | 140,000 | $6.27M | 0.13% | 00.0% | Unchanged |
| Wells Fargo & Company | 152,297 | $6.83M | 0.00% | +37,076+32.2% | Added |
| Parkman Healthcare Partners LLC | 154,184 | $6.91M | 0.66% | −21,953−12.5% | Reduced |
| Foresite Capital Management IV, LLC | 160,000 | $7.17M | 3.12% | 00.0% | Unchanged |
| Marshall Wace, LLP | 162,551 | $7.29M | 0.01% | −449,431−73.4% | Reduced |
| Jain Global LLC | 173,882 | $7.79M | 0.08% | −78,497−31.1% | Reduced |
| Peregrine Capital Management LLC | 174,851 | $7.84M | 0.24% | +174,851 | New |
| Neuberger Berman Group LLC | 178,747 | $8.01M | 0.01% | +6,393+3.7% | Added |
| NEXTBio Capital Management LP | 183,704 | $8.23M | 4.83% | +183,704 | New |
| New York State Common Retirement Fund | 186,705 | $8.37M | 0.01% | +14,997+8.7% | Added |
| Charles Schwab Investment Management Inc | 189,059 | $8.47M | 0.00% | +312+0.2% | Added |
| Deutsche Bank AG | 190,233 | $8.53M | 0.00% | +77,282+68.4% | Added |
| Perceptive Advisors LLC | 200,791 | $9.00M | 0.16% | 00.0% | Unchanged |
| ADAR1 Capital Management, LLC | 203,969 | $9.14M | 0.68% | +14,871+7.9% | Added |
| State of Wisconsin Investment Board | 205,569 | $9.21M | 0.02% | −2,803−1.3% | Reduced |
| Nuveen, LLC | 216,238 | $9.69M | 0.00% | −8,051−3.6% | Reduced |
| Bank of America Corp | 221,368 | $9.92M | 0.00% | +22,262+11.2% | Added |
| Nan Fung Trinity (HK) Ltd | 226,965 | $10.2M | 0.81% | +68,360+43.1% | Added |
| Eversept Partners, LP | 231,380 | $10.4M | 0.58% | +231,380 | New |
| Iron Triangle Partners LP | 233,688 | $10.5M | 1.20% | +233,688 | New |
| Nicholas Investment Partners, LP | 242,989 | $10.9M | 0.79% | +123,891+104.0% | Added |
| Tudor Investment Corp Et Al | 254,002 | $11.4M | 0.06% | +177,178+230.6% | Added |
| Two Sigma Advisers, LP | 259,320 | $11.6M | 0.02% | +241,220+1,332.7% | Added |
| DnB Asset Management AS | 272,831 | $12.2M | 0.04% | +23,750+9.5% | Added |
| DAFNA Capital Management LLC | 287,939 | $12.9M | 3.00% | 00.0% | Unchanged |
| Morgan Stanley | 294,332 | $13.2M | 0.00% | −72,240−19.7% | Reduced |
| StemPoint Capital LP | 348,605 | $15.6M | 2.68% | +156,310+81.3% | Added |
| Deep Track Capital, LP | 366,435 | $16.4M | 0.37% | −833,565−69.5% | Reduced |
| Baker Bros. Advisors LP | 370,208 | $16.6M | 0.10% | 00.0% | Unchanged |
| Bank of New York Mellon Corp | 387,158 | $17.4M | 0.00% | −31,258−7.5% | Reduced |
| Candriam Luxembourg S.C.A. | 417,402 | $18.7M | 0.09% | +20,766+5.2% | Added |
| Two Sigma Investments, LP | 436,743 | $19.6M | 0.03% | +436,743 | New |
| Northern Trust Corp | 438,714 | $19.7M | 0.00% | −59,433−11.9% | Reduced |
| OrbiMed Advisors LLC | 447,200 | $20.0M | 0.41% | +27,600+6.6% | Added |