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Xenon Pharmaceuticals Inc.

XENE
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001582313

In the last 90 days, Xenon Pharmaceuticals Inc. insiders filed 2 open-market purchases and 2 sales; 315 institutions reported holding it in 13F filings for Q2 2026, worth $6.10B in total; Duquesne Family Office is the only superinvestor holding it.

13F holders, Q1 2025

Institutional positions in Xenon Pharmaceuticals Inc. as of Mar 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
206
−3 vs. Q4 2024
Shares held
76.7M
+410.6K (+0.5%) vs. Q4 2024
Total value
$2.58B
−$414.7M (−13.9%) vs. Q4 2024
New holders
20
69 more added
Sold out
23
73 more reduced

Compare with Q4 2024: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting XENE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ1 2025: 206 institutions
Q1 2021: 91 institutionsQ2 2021: 103 institutionsQ3 2021: 118 institutionsQ4 2021: 130 institutionsQ1 2022: 132 institutionsQ2 2022: 151 institutionsQ3 2022: 154 institutionsQ4 2022: 159 institutionsQ1 2023: 163 institutionsQ2 2023: 175 institutionsQ3 2023: 181 institutionsQ4 2023: 204 institutionsQ1 2024: 220 institutionsQ2 2024: 213 institutionsQ3 2024: 203 institutionsQ4 2024: 209 institutionsQ1 2025: 206 institutionsQ2 2025: 206 institutionsQ3 2025: 219 institutionsQ4 2025: 245 institutionsQ1 2026: 290 institutionsQ2 2026: 315 institutions
Value heldQ1 2025: $2.58B
Q1 2021: $590.0MQ2 2021: $620.0MQ3 2021: $521.7MQ4 2021: $1.49BQ1 2022: $1.50BQ2 2022: $1.73BQ3 2022: $2.09BQ4 2022: $2.38BQ1 2023: $2.19BQ2 2023: $2.36BQ3 2023: $2.10BQ4 2023: $3.32BQ1 2024: $3.16BQ2 2024: $2.89BQ3 2024: $2.95BQ4 2024: $2.99BQ1 2025: $2.58BQ2 2025: $2.60BQ3 2025: $3.39BQ4 2025: $3.78BQ1 2026: $5.80BQ2 2026: $6.10B
Institutions holding XENE and their total value by quarter
QuarterHoldersValue
Q2 2026315$6.10B
Q1 2026290$5.80B
Q4 2025245$3.78B
Q3 2025219$3.39B
Q2 2025206$2.60B
Q1 2025206$2.58B
Q4 2024209$2.99B
Q3 2024203$2.95B
Q2 2024213$2.89B
Q1 2024220$3.16B
Q4 2023204$3.32B
Q3 2023181$2.10B
Q2 2023175$2.36B
Q1 2023163$2.19B
Q4 2022159$2.38B
Q3 2022154$2.09B
Q2 2022151$1.73B
Q1 2022132$1.50B
Q4 2021130$1.49B
Q3 2021118$521.7M
Q2 2021103$620.0M
Q1 202191$590.0M

Institutions, Q1 2025

Shares, value and share of portfolio for each institution holding Xenon Pharmaceuticals Inc.; share changes are against Q4 2024.

Institutions holding XENE in Q1 2025
InstitutionSharesValue% of portfolioChange in sharesAction
Mutual of America Capital Management LLC48,763$1.64M0.02%+48,763New
Voya Investment Management LLC48,065$1.61M0.00%−14,350−23.0%Reduced
Skandinaviska Enskilda Banken AB (publ)47,457$1.59M0.01%+7,081+17.5%Added
Nebula Research & Development LLC46,561$1.56M0.14%+26,201+128.7%Added
Neuberger Berman Group LLC44,852$1.50M0.00%−48,109−51.8%Reduced
Envestnet Asset Management Inc42,850$1.44M0.00%−4,447−9.4%Reduced
ExodusPoint Capital Management, LP42,000$1.41M0.02%−26,884−39.0%Reduced
Artia Global Partners LP40,000$1.34M0.39%00.0%Unchanged
DekaBank Deutsche Girozentrale39,000$1.31M0.00%00.0%Unchanged
Prudential Financial Inc39,000$1.31M0.00%00.0%Unchanged
Rhenman & Partners Asset Management AB35,000$1.17M0.13%00.0%Unchanged
TLS Advisors LLC32,956$1.11M2.50%00.0%Unchanged
J. Safra Sarasin Holding AG30,573$1.03M0.02%+12,787+71.9%Added
Allostery Investments LP30,000$1.01M1.45%00.0%Unchanged
Sphera Funds Management Ltd.26,097$875.6K0.22%−26,000−49.9%Reduced
Ensign Peak Advisors, Inc26,094$875.5K0.00%00.0%Unchanged
NJ State Employees Deferred Compensation Plan25,000$838.8K0.11%00.0%Unchanged
Natixis Advisors, L.P.24,010$806.0K0.00%+456+1.9%Added
Atika Capital Management LLC24,000$805.2K0.12%−48,600−66.9%Reduced
Rathbone Brothers plc23,666$794.0K0.00%00.0%Unchanged
Schonfeld Strategic Advisors LLC22,954$770.1K0.01%+7,804+51.5%Added
Handelsbanken Fonder AB22,700$762.0K0.00%00.0%Unchanged
CenterBook Partners LP22,211$745.2K0.05%+22,211New
Birchview Capital, LP21,000$704.5K0.61%+11,000+110.0%Added
Stifel Financial Corp20,527$688.7K0.00%−161−0.8%Reduced
Assetmark, Inc19,934$668.8K0.00%−1,651−7.6%Reduced
Sanders Morris Harris LLC21,500$658.8K0.10%00.0%Unchanged
Barclays PLC19,270$646.5K0.00%+1,143+6.3%Added
Zurcher Kantonalbank (Zurich Cantonalbank)18,956$636.0K0.00%−318−1.6%Reduced
Arizona State Retirement System18,579$623.3K0.00%−87−0.5%Reduced
Prelude Capital Management, LLC18,266$612.8K0.06%00.0%Unchanged
Teacher Retirement System of Texas17,439$585.1K0.00%−1,644−8.6%Reduced
BIT Capital GmbH17,352$582.2K0.07%−36,576−67.8%Reduced
Occudo Quantitative Strategies LP16,975$581.6K0.08%+5,534+48.4%Added
CIBC World Markets Inc.16,335$548.0K0.00%−3,500−17.6%Reduced
Knott David M Jr15,866$532.3K0.25%−5,000−24.0%Reduced
Brinker Capital Investments, LLC15,531$521.1K0.01%+2,095+15.6%Added
Orion Portfolio Solutions, LLC15,531$521.1K0.01%+2,095+15.6%Added
China Universal Asset Management Co., Ltd.15,353$515.1K0.05%−813−5.0%Reduced
Advisors Asset Management, Inc.14,281$479.1K0.01%+1,233+9.4%Added
KLP Kapitalforvaltning AS12,800$429.4K0.00%00.0%Unchanged
Verition Fund Management LLC12,508$419.6K0.00%+4,211+50.8%Added
Y-Intercept (Hong Kong) Ltd11,949$400.9K0.03%+11,949New
Fox Run Management, L.L.C.11,372$381.5K0.06%+2,751+31.9%Added
Elmwood Wealth Management, Inc.11,007$369.3K0.15%00.0%Unchanged
Supplemental Annuity Collective Trust of NJ11,000$369.1K0.12%00.0%Unchanged
Public Employees Retirement Association of Colorado10,633$357.0K0.00%00.0%Unchanged
Aquatic Capital Management LLC10,511$352.6K0.01%+2,251+27.3%Added
Silverarc Capital Management, LLC10,121$339.6K0.07%+10,121New
Legato Capital Management LLC9,622$322.8K0.04%+9,622New
SEI Investments Co9,404$315.5K0.00%+9,404New
Allianz Asset Management GmbH9,400$315.4K0.00%−3,000−24.2%Reduced
EntryPoint Capital, LLC8,872$297.7K0.14%+8,872New
SG Americas Securities, LLC8,655$290.0K0.00%−4,638−34.9%Reduced
Great West Life Assurance Co7,024$236.0K0.00%−8,887−55.9%Reduced
Citigroup Inc7,029$235.8K0.00%+581+9.0%Added
Vident Advisory, LLC6,574$220.6K0.00%+1,161+21.4%Added
Twinbeech Capital LP6,445$216.2K0.00%+6,445New
Oxford Asset Management LLP6,174$207.1K0.09%+6,174New
NEOS Investment Management LLC6,111$205.0K0.00%00.0%Unchanged
Tema ETFs LLC6,111$205.0K0.06%00.0%Unchanged
HighMark Wealth Management LLC6,100$204.7K0.12%00.0%Unchanged
Guggenheim Capital LLC6,019$201.9K0.00%−158−2.6%Reduced
The PNC Financial Services Group, Inc.5,220$175.1K0.00%+80+1.6%Added
Northwestern Mutual Wealth Management Co5,000$167.8K0.00%−19−0.4%Reduced
Virtus Investment Advisers, Inc.4,161$139.6K0.04%+4,161New
BNP Paribas Arbitrage, SA3,210$107.7K0.00%−122−3.7%Reduced
KBC Group NV2,761$93.0K0.00%+19+0.7%Added
Mirae Asset Global Investments Co., Ltd.2,561$87.7K0.00%+20+0.8%Added
Quarry LP2,000$67.1K0.02%00.0%Unchanged
GF Fund Management Co. Ltd.1,952$65.5K0.00%+351+21.9%Added
IFP Advisors, Inc1,921$64.6K0.00%−37−1.9%Reduced
Caitong International Asset Management Co., Ltd905$30.4K0.02%+905New
Parallel Advisors, LLC688$23.1K0.00%+222+47.6%Added
Coldstream Capital Management Inc648$21.7K0.00%+648New
State of Wyoming574$19.3K0.00%+30+5.5%Added
First Horizon Advisors, Inc.370$12.4K0.00%00.0%Unchanged
Point72 Hong Kong Ltd329$11.0K0.00%+329New
Mitsubishi UFJ Kokusai Asset Management Co., Ltd.276$9.26K0.00%00.0%Unchanged
US Bancorp275$9.23K0.00%−311−53.1%Reduced
Ronald Blue Trust, Inc.270$9.06K0.00%+22+8.9%Added
Daiwa Securities Group Inc.252$8.00K0.00%00.0%Unchanged
CWM, LLC239$8.00K0.00%+181+312.1%Added
National Bank of Canada235$7.88K0.00%00.0%Unchanged
Clearstead Advisors, LLC218$7.31K0.00%00.0%Unchanged
Spire Wealth Management200$6.71K0.00%00.0%Unchanged
Lindbrook Capital, LLC198$6.64K0.00%−27−12.0%Reduced
Advisor Group Holdings, Inc.191$6.41K0.00%−272−58.7%Reduced
Signaturefd, LLC185$6.21K0.00%−386−67.6%Reduced
Amundi114$3.50K0.00%+25+28.1%Added
J.Safra Asset Management Corp84$2.82K0.00%+73+663.6%Added
Principal Securities, Inc.58$2.27K0.00%00.0%Unchanged
Point72 (DIFC) Ltd66$2.21K0.00%+66New
EverSource Wealth Advisors, LLC58$1.95K0.00%+28+93.3%Added
Tower Research Capital LLC (TRC)50$1.68K0.00%−597−92.3%Reduced
Massmutual Trust Co FSB39$1.31K0.00%+39New
Whittier Trust Co of Nevada Inc36$1.21K0.00%−1−2.7%Reduced
CVA Family Office, LLC33$1.11K0.00%00.0%Unchanged
CIBC Private Wealth Group, LLC39$1.10K0.00%+39New
Rhumbline Advisers29$9720.00%00.0%Unchanged