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Xenon Pharmaceuticals Inc.

XENE
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001582313

In the last 90 days, Xenon Pharmaceuticals Inc. insiders filed 0 open-market purchases and 2 sales; 315 institutions reported holding it in 13F filings for Q2 2026, worth $6.10B in total; Duquesne Family Office is the only superinvestor holding it.

13F holders, Q1 2025

Institutional positions in Xenon Pharmaceuticals Inc. as of Mar 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
206
−3 vs. Q4 2024
Shares held
76.7M
+410.6K (+0.5%) vs. Q4 2024
Total value
$2.58B
−$414.7M (−13.9%) vs. Q4 2024
New holders
20
69 more added
Sold out
23
73 more reduced

Compare with Q4 2024: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting XENE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ1 2025: 206 institutions
Q1 2021: 91 institutionsQ2 2021: 103 institutionsQ3 2021: 118 institutionsQ4 2021: 130 institutionsQ1 2022: 132 institutionsQ2 2022: 151 institutionsQ3 2022: 154 institutionsQ4 2022: 159 institutionsQ1 2023: 163 institutionsQ2 2023: 175 institutionsQ3 2023: 181 institutionsQ4 2023: 204 institutionsQ1 2024: 220 institutionsQ2 2024: 213 institutionsQ3 2024: 203 institutionsQ4 2024: 209 institutionsQ1 2025: 206 institutionsQ2 2025: 206 institutionsQ3 2025: 219 institutionsQ4 2025: 245 institutionsQ1 2026: 290 institutionsQ2 2026: 315 institutions
Value heldQ1 2025: $2.58B
Q1 2021: $590.0MQ2 2021: $620.0MQ3 2021: $521.7MQ4 2021: $1.49BQ1 2022: $1.50BQ2 2022: $1.73BQ3 2022: $2.09BQ4 2022: $2.38BQ1 2023: $2.19BQ2 2023: $2.36BQ3 2023: $2.10BQ4 2023: $3.32BQ1 2024: $3.16BQ2 2024: $2.89BQ3 2024: $2.95BQ4 2024: $2.99BQ1 2025: $2.58BQ2 2025: $2.60BQ3 2025: $3.39BQ4 2025: $3.78BQ1 2026: $5.80BQ2 2026: $6.10B
Institutions holding XENE and their total value by quarter
QuarterHoldersValue
Q2 2026315$6.10B
Q1 2026290$5.80B
Q4 2025245$3.78B
Q3 2025219$3.39B
Q2 2025206$2.60B
Q1 2025206$2.58B
Q4 2024209$2.99B
Q3 2024203$2.95B
Q2 2024213$2.89B
Q1 2024220$3.16B
Q4 2023204$3.32B
Q3 2023181$2.10B
Q2 2023175$2.36B
Q1 2023163$2.19B
Q4 2022159$2.38B
Q3 2022154$2.09B
Q2 2022151$1.73B
Q1 2022132$1.50B
Q4 2021130$1.49B
Q3 2021118$521.7M
Q2 2021103$620.0M
Q1 202191$590.0M

Institutions, Q1 2025

Shares, value and share of portfolio for each institution holding Xenon Pharmaceuticals Inc.; share changes are against Q4 2024.

Institutions holding XENE in Q1 2025
InstitutionSharesValue% of portfolioChange in sharesAction
GAMMA Investing LLC8$2680.00%−43−84.3%Reduced
True Wealth Design, LLC9$3020.00%+9New
Bell Investment Advisors, Inc11$3700.00%−88−88.9%Reduced
Allworth Financial LP12$4590.00%00.0%Unchanged
Park Place Capital Corp16$5370.00%+16New
Continuum Advisory, LLC27$9060.00%00.0%Unchanged
Rhumbline Advisers29$9720.00%00.0%Unchanged
CIBC Private Wealth Group, LLC39$1.10K0.00%+39New
CVA Family Office, LLC33$1.11K0.00%00.0%Unchanged
Whittier Trust Co of Nevada Inc36$1.21K0.00%−1−2.7%Reduced
Massmutual Trust Co FSB39$1.31K0.00%+39New
Tower Research Capital LLC (TRC)50$1.68K0.00%−597−92.3%Reduced
EverSource Wealth Advisors, LLC58$1.95K0.00%+28+93.3%Added
Point72 (DIFC) Ltd66$2.21K0.00%+66New
Principal Securities, Inc.58$2.27K0.00%00.0%Unchanged
J.Safra Asset Management Corp84$2.82K0.00%+73+663.6%Added
Amundi114$3.50K0.00%+25+28.1%Added
Signaturefd, LLC185$6.21K0.00%−386−67.6%Reduced
Advisor Group Holdings, Inc.191$6.41K0.00%−272−58.7%Reduced
Lindbrook Capital, LLC198$6.64K0.00%−27−12.0%Reduced
Spire Wealth Management200$6.71K0.00%00.0%Unchanged
Clearstead Advisors, LLC218$7.31K0.00%00.0%Unchanged
National Bank of Canada235$7.88K0.00%00.0%Unchanged
Daiwa Securities Group Inc.252$8.00K0.00%00.0%Unchanged
CWM, LLC239$8.00K0.00%+181+312.1%Added
Ronald Blue Trust, Inc.270$9.06K0.00%+22+8.9%Added
US Bancorp275$9.23K0.00%−311−53.1%Reduced
Mitsubishi UFJ Kokusai Asset Management Co., Ltd.276$9.26K0.00%00.0%Unchanged
Point72 Hong Kong Ltd329$11.0K0.00%+329New
First Horizon Advisors, Inc.370$12.4K0.00%00.0%Unchanged
State of Wyoming574$19.3K0.00%+30+5.5%Added
Coldstream Capital Management Inc648$21.7K0.00%+648New
Parallel Advisors, LLC688$23.1K0.00%+222+47.6%Added
Caitong International Asset Management Co., Ltd905$30.4K0.02%+905New
IFP Advisors, Inc1,921$64.6K0.00%−37−1.9%Reduced
GF Fund Management Co. Ltd.1,952$65.5K0.00%+351+21.9%Added
Quarry LP2,000$67.1K0.02%00.0%Unchanged
Mirae Asset Global Investments Co., Ltd.2,561$87.7K0.00%+20+0.8%Added
KBC Group NV2,761$93.0K0.00%+19+0.7%Added
BNP Paribas Arbitrage, SA3,210$107.7K0.00%−122−3.7%Reduced
Virtus Investment Advisers, Inc.4,161$139.6K0.04%+4,161New
Northwestern Mutual Wealth Management Co5,000$167.8K0.00%−19−0.4%Reduced
The PNC Financial Services Group, Inc.5,220$175.1K0.00%+80+1.6%Added
Guggenheim Capital LLC6,019$201.9K0.00%−158−2.6%Reduced
HighMark Wealth Management LLC6,100$204.7K0.12%00.0%Unchanged
NEOS Investment Management LLC6,111$205.0K0.00%00.0%Unchanged
Tema ETFs LLC6,111$205.0K0.06%00.0%Unchanged
Oxford Asset Management LLP6,174$207.1K0.09%+6,174New
Twinbeech Capital LP6,445$216.2K0.00%+6,445New
Vident Advisory, LLC6,574$220.6K0.00%+1,161+21.4%Added
Citigroup Inc7,029$235.8K0.00%+581+9.0%Added
Great West Life Assurance Co7,024$236.0K0.00%−8,887−55.9%Reduced
SG Americas Securities, LLC8,655$290.0K0.00%−4,638−34.9%Reduced
EntryPoint Capital, LLC8,872$297.7K0.14%+8,872New
Allianz Asset Management GmbH9,400$315.4K0.00%−3,000−24.2%Reduced
SEI Investments Co9,404$315.5K0.00%+9,404New
Legato Capital Management LLC9,622$322.8K0.04%+9,622New
Silverarc Capital Management, LLC10,121$339.6K0.07%+10,121New
Aquatic Capital Management LLC10,511$352.6K0.01%+2,251+27.3%Added
Public Employees Retirement Association of Colorado10,633$357.0K0.00%00.0%Unchanged
Supplemental Annuity Collective Trust of NJ11,000$369.1K0.12%00.0%Unchanged
Elmwood Wealth Management, Inc.11,007$369.3K0.15%00.0%Unchanged
Fox Run Management, L.L.C.11,372$381.5K0.06%+2,751+31.9%Added
Y-Intercept (Hong Kong) Ltd11,949$400.9K0.03%+11,949New
Verition Fund Management LLC12,508$419.6K0.00%+4,211+50.8%Added
KLP Kapitalforvaltning AS12,800$429.4K0.00%00.0%Unchanged
Advisors Asset Management, Inc.14,281$479.1K0.01%+1,233+9.4%Added
China Universal Asset Management Co., Ltd.15,353$515.1K0.05%−813−5.0%Reduced
Brinker Capital Investments, LLC15,531$521.1K0.01%+2,095+15.6%Added
Orion Portfolio Solutions, LLC15,531$521.1K0.01%+2,095+15.6%Added
Knott David M Jr15,866$532.3K0.25%−5,000−24.0%Reduced
CIBC World Markets Inc.16,335$548.0K0.00%−3,500−17.6%Reduced
Occudo Quantitative Strategies LP16,975$581.6K0.08%+5,534+48.4%Added
BIT Capital GmbH17,352$582.2K0.07%−36,576−67.8%Reduced
Teacher Retirement System of Texas17,439$585.1K0.00%−1,644−8.6%Reduced
Prelude Capital Management, LLC18,266$612.8K0.06%00.0%Unchanged
Arizona State Retirement System18,579$623.3K0.00%−87−0.5%Reduced
Zurcher Kantonalbank (Zurich Cantonalbank)18,956$636.0K0.00%−318−1.6%Reduced
Barclays PLC19,270$646.5K0.00%+1,143+6.3%Added
Sanders Morris Harris LLC21,500$658.8K0.10%00.0%Unchanged
Assetmark, Inc19,934$668.8K0.00%−1,651−7.6%Reduced
Stifel Financial Corp20,527$688.7K0.00%−161−0.8%Reduced
Birchview Capital, LP21,000$704.5K0.61%+11,000+110.0%Added
CenterBook Partners LP22,211$745.2K0.05%+22,211New
Handelsbanken Fonder AB22,700$762.0K0.00%00.0%Unchanged
Schonfeld Strategic Advisors LLC22,954$770.1K0.01%+7,804+51.5%Added
Rathbone Brothers plc23,666$794.0K0.00%00.0%Unchanged
Atika Capital Management LLC24,000$805.2K0.12%−48,600−66.9%Reduced
Natixis Advisors, L.P.24,010$806.0K0.00%+456+1.9%Added
NJ State Employees Deferred Compensation Plan25,000$838.8K0.11%00.0%Unchanged
Ensign Peak Advisors, Inc26,094$875.5K0.00%00.0%Unchanged
Sphera Funds Management Ltd.26,097$875.6K0.22%−26,000−49.9%Reduced
Allostery Investments LP30,000$1.01M1.45%00.0%Unchanged
J. Safra Sarasin Holding AG30,573$1.03M0.02%+12,787+71.9%Added
TLS Advisors LLC32,956$1.11M2.50%00.0%Unchanged
Rhenman & Partners Asset Management AB35,000$1.17M0.13%00.0%Unchanged
Prudential Financial Inc39,000$1.31M0.00%00.0%Unchanged
DekaBank Deutsche Girozentrale39,000$1.31M0.00%00.0%Unchanged
Artia Global Partners LP40,000$1.34M0.39%00.0%Unchanged
ExodusPoint Capital Management, LP42,000$1.41M0.02%−26,884−39.0%Reduced