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Xenon Pharmaceuticals Inc.

XENE
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001582313

In the last 90 days, Xenon Pharmaceuticals Inc. insiders filed 0 open-market purchases and 2 sales; 315 institutions reported holding it in 13F filings for Q2 2026, worth $6.10B in total; Duquesne Family Office is the only superinvestor holding it.

13F holders, Q4 2022

Institutional positions in Xenon Pharmaceuticals Inc. as of Dec 31, 2022. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
159
+5 vs. Q3 2022
Shares held
60.4M
+2.51M (+4.3%) vs. Q3 2022
Total value
$2.38B
+$291.8M (+14.0%) vs. Q3 2022
New holders
22
60 more added
Sold out
17
46 more reduced

Compare with Q3 2022: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting XENE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ4 2022: 159 institutions
Q1 2021: 91 institutionsQ2 2021: 103 institutionsQ3 2021: 118 institutionsQ4 2021: 130 institutionsQ1 2022: 132 institutionsQ2 2022: 151 institutionsQ3 2022: 154 institutionsQ4 2022: 159 institutionsQ1 2023: 163 institutionsQ2 2023: 175 institutionsQ3 2023: 181 institutionsQ4 2023: 204 institutionsQ1 2024: 220 institutionsQ2 2024: 213 institutionsQ3 2024: 203 institutionsQ4 2024: 209 institutionsQ1 2025: 206 institutionsQ2 2025: 206 institutionsQ3 2025: 219 institutionsQ4 2025: 245 institutionsQ1 2026: 290 institutionsQ2 2026: 315 institutions
Value heldQ4 2022: $2.38B
Q1 2021: $590.0MQ2 2021: $620.0MQ3 2021: $521.7MQ4 2021: $1.49BQ1 2022: $1.50BQ2 2022: $1.73BQ3 2022: $2.09BQ4 2022: $2.38BQ1 2023: $2.19BQ2 2023: $2.36BQ3 2023: $2.10BQ4 2023: $3.32BQ1 2024: $3.16BQ2 2024: $2.89BQ3 2024: $2.95BQ4 2024: $2.99BQ1 2025: $2.58BQ2 2025: $2.60BQ3 2025: $3.39BQ4 2025: $3.78BQ1 2026: $5.80BQ2 2026: $6.10B
Institutions holding XENE and their total value by quarter
QuarterHoldersValue
Q2 2026315$6.10B
Q1 2026290$5.80B
Q4 2025245$3.78B
Q3 2025219$3.39B
Q2 2025206$2.60B
Q1 2025206$2.58B
Q4 2024209$2.99B
Q3 2024203$2.95B
Q2 2024213$2.89B
Q1 2024220$3.16B
Q4 2023204$3.32B
Q3 2023181$2.10B
Q2 2023175$2.36B
Q1 2023163$2.19B
Q4 2022159$2.38B
Q3 2022154$2.09B
Q2 2022151$1.73B
Q1 2022132$1.50B
Q4 2021130$1.49B
Q3 2021118$521.7M
Q2 2021103$620.0M
Q1 202191$590.0M

Institutions, Q4 2022

Shares, value and share of portfolio for each institution holding Xenon Pharmaceuticals Inc.; share changes are against Q3 2022.

Institutions holding XENE in Q4 2022
InstitutionSharesValue% of portfolioChange in sharesAction
Allianz Asset Management GmbH20,000$788.6K0.00%00.0%Unchanged
Velan Capital Investment Management LP20,000$788.6K0.84%00.0%Unchanged
DekaBank Deutsche Girozentrale20,000$781.0K0.00%00.0%Unchanged
Jefferies Financial Group Inc.19,500$768.9K0.01%+19,500New
Guggenheim Capital LLC19,093$752.8K0.01%+4,155+27.8%Added
PFM Health Sciences, LP17,488$689.6K0.03%+17,488New
New York State Common Retirement Fund16,650$656.5K0.00%+650+4.1%Added
Royal Bank of Canada16,130$636.0K0.00%+16,129+1,612,900.0%Added
Employees Retirement System of Texas16,001$631.0K0.01%00.0%Unchanged
Legal & General Group Plc15,528$612.3K0.00%+3,950+34.1%Added
Jane Street Group, LLC15,290$602.9K0.00%−26,622−63.5%Reduced
Elmwood Wealth Management, Inc.14,994$591.2K0.30%00.0%Unchanged
Shell Asset Management Co14,649$578.0K0.03%−2,751−15.8%Reduced
Engineers Gate Manager LP14,383$567.1K0.03%+4,666+48.0%Added
Teacher Retirement System of Texas14,119$557.0K0.00%−835−5.6%Reduced
Handelsbanken Fonder AB14,100$556.0K0.00%+3,500+33.0%Added
Gsa Capital Partners LLP13,763$543.0K0.07%+13,763New
Ergoteles LLC13,516$532.9K0.02%+13,516New
Arizona State Retirement System13,177$519.6K0.01%+750+6.0%Added
Fox Run Management, L.L.C.12,975$511.6K0.21%+3,244+33.3%Added
Prelude Capital Management, LLC12,769$503.5K0.03%+12,769New
Virginia Retirement Systems Et Al12,500$492.9K0.01%−500−3.8%Reduced
Boothbay Fund Management, LLC11,825$466.3K0.02%00.0%Unchanged
American Century Companies Inc11,005$433.9K0.00%+4,335+65.0%Added
Supplemental Annuity Collective Trust of NJ11,000$433.7K0.18%00.0%Unchanged
Public Employees Retirement Association of Colorado10,633$419.0K0.00%00.0%Unchanged
Main Street Research LLC10,000$394.3K0.10%00.0%Unchanged
Birchview Capital, LP10,000$394.0K0.28%00.0%Unchanged
Stifel Financial Corp9,944$392.1K0.00%−100−1.0%Reduced
Zurcher Kantonalbank (Zurich Cantonalbank)9,439$372.2K0.00%+2,772+41.6%Added
Advisors Asset Management, Inc.7,846$309.4K0.01%+3,725+90.4%Added
Jump Financial, LLC7,725$304.6K0.02%−45,575−85.5%Reduced
Group One Trading, L.P.6,552$258.3K0.01%−5,021−43.4%Reduced
Connor, Clark & Lunn Investment Management Ltd.5,799$228.7K0.00%+5,799New
Virtu Financial LLC5,604$221.0K0.03%+5,604New
ProShare Advisors LLC5,172$203.9K0.00%+5,172New
Northwestern Mutual Wealth Management Co5,000$197.2K0.00%+5,000New
UBS Group AG4,662$183.8K0.00%+1,236+36.1%Added
Virtus ETF Advisers LLC3,616$142.6K0.07%−57−1.6%Reduced
Tower Research Capital LLC (TRC)2,552$101.0K0.00%−1,648−39.2%Reduced
Deutsche Bank AG2,495$98.4K0.00%+2,495New
Great West Life Assurance Co2,392$95.0K0.00%00.0%Unchanged
JPMorgan Chase & Co2,087$82.0K0.00%−2,184−51.1%Reduced
Proequities, Inc.2,000$78.9K0.01%00.0%Unchanged
High Net Worth Advisory Group LLC2,000$78.9K0.03%+1,000+100.0%Added
Citigroup Inc1,809$71.3K0.00%+92+5.4%Added
BNP Paribas Arbitrage, SA1,526$60.2K0.00%−3,430−69.2%Reduced
Wells Fargo & Company1,123$44.3K0.00%+623+124.6%Added
Advisor Group Holdings, Inc.676$27.0K0.00%+85+14.4%Added
China Universal Asset Management Co., Ltd.635$25.0K0.01%+52+8.9%Added
Leonteq Securities AG530$20.9K0.00%00.0%Unchanged
Householder Group Estate & Retirement Specialist, LLC275$10.0K0.01%00.0%Unchanged
Daiwa Securities Group Inc.252$10.0K0.00%+54+27.3%Added
Cubist Systematic Strategies, LLC177$6.98K0.00%−20,034−99.1%Reduced
IFP Advisors, Inc1,000$6.00K0.00%00.0%Unchanged
Hexagon Capital Partners LLC109$4.30K0.00%−88−44.7%Reduced
Cutler Group LP100$3.00K0.00%00.0%Unchanged
Belpointe Asset Management LLC70$2.76K0.00%+70New
Ronald Blue Trust, Inc.29$1.00K0.00%+29New
Acuta Capital Partners, LLC0$00.00%−272,500−100.0%Sold out
Two Sigma Investments, LP0$00.00%−55,974−100.0%Sold out
UBS Oconnor LLC0$00.00%−54,208−100.0%Sold out
Bridger Management, LLC0$00.00%−45,235−100.0%Sold out
Fred Alger Management, LLC0$00.00%−45,143−100.0%Sold out
Difesa Capital Management, LP0$00.00%−24,500−100.0%Sold out
HRT Financial LP0$00.00%−15,927−100.0%Sold out
Victory Capital Management Inc0$00.00%−12,228−100.0%Sold out
Oppenheimer & Co Inc0$00.00%−11,113−100.0%Sold out
Squarepoint Ops LLC0$00.00%−10,605−100.0%Sold out
Dynamic Technology Lab Private Ltd0$00.00%−9,990−100.0%Sold out
Occudo Quantitative Strategies LP0$00.00%−7,263−100.0%Sold out
Walleye Trading LLC0$00.00%−5,603−100.0%Sold out
Amundi0$00.00%−3,581−100.0%Sold out
Quantbot Technologies LP0$00.00%−1,300−100.0%Sold out
Macquarie Group Ltd0$00.00%−132−100.0%Sold out
Simplex Trading, LLC0$00.00%−432−100.0%Sold out