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Xenon Pharmaceuticals Inc.

XENE
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001582313

In the last 90 days, Xenon Pharmaceuticals Inc. insiders filed 0 open-market purchases and 2 sales; 315 institutions reported holding it in 13F filings for Q2 2026, worth $6.10B in total; Duquesne Family Office is the only superinvestor holding it.

13F holders, Q4 2022

Institutional positions in Xenon Pharmaceuticals Inc. as of Dec 31, 2022. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
159
+5 vs. Q3 2022
Shares held
60.4M
+2.51M (+4.3%) vs. Q3 2022
Total value
$2.38B
+$291.8M (+14.0%) vs. Q3 2022
New holders
22
60 more added
Sold out
17
46 more reduced

Compare with Q3 2022: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting XENE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ4 2022: 159 institutions
Q1 2021: 91 institutionsQ2 2021: 103 institutionsQ3 2021: 118 institutionsQ4 2021: 130 institutionsQ1 2022: 132 institutionsQ2 2022: 151 institutionsQ3 2022: 154 institutionsQ4 2022: 159 institutionsQ1 2023: 163 institutionsQ2 2023: 175 institutionsQ3 2023: 181 institutionsQ4 2023: 204 institutionsQ1 2024: 220 institutionsQ2 2024: 213 institutionsQ3 2024: 203 institutionsQ4 2024: 209 institutionsQ1 2025: 206 institutionsQ2 2025: 206 institutionsQ3 2025: 219 institutionsQ4 2025: 245 institutionsQ1 2026: 290 institutionsQ2 2026: 315 institutions
Value heldQ4 2022: $2.38B
Q1 2021: $590.0MQ2 2021: $620.0MQ3 2021: $521.7MQ4 2021: $1.49BQ1 2022: $1.50BQ2 2022: $1.73BQ3 2022: $2.09BQ4 2022: $2.38BQ1 2023: $2.19BQ2 2023: $2.36BQ3 2023: $2.10BQ4 2023: $3.32BQ1 2024: $3.16BQ2 2024: $2.89BQ3 2024: $2.95BQ4 2024: $2.99BQ1 2025: $2.58BQ2 2025: $2.60BQ3 2025: $3.39BQ4 2025: $3.78BQ1 2026: $5.80BQ2 2026: $6.10B
Institutions holding XENE and their total value by quarter
QuarterHoldersValue
Q2 2026315$6.10B
Q1 2026290$5.80B
Q4 2025245$3.78B
Q3 2025219$3.39B
Q2 2025206$2.60B
Q1 2025206$2.58B
Q4 2024209$2.99B
Q3 2024203$2.95B
Q2 2024213$2.89B
Q1 2024220$3.16B
Q4 2023204$3.32B
Q3 2023181$2.10B
Q2 2023175$2.36B
Q1 2023163$2.19B
Q4 2022159$2.38B
Q3 2022154$2.09B
Q2 2022151$1.73B
Q1 2022132$1.50B
Q4 2021130$1.49B
Q3 2021118$521.7M
Q2 2021103$620.0M
Q1 202191$590.0M

Institutions, Q4 2022

Shares, value and share of portfolio for each institution holding Xenon Pharmaceuticals Inc.; share changes are against Q3 2022.

Institutions holding XENE in Q4 2022
InstitutionSharesValue% of portfolioChange in sharesAction
Ronald Blue Trust, Inc.29$1.00K0.00%+29New
Belpointe Asset Management LLC70$2.76K0.00%+70New
Cutler Group LP100$3.00K0.00%00.0%Unchanged
Hexagon Capital Partners LLC109$4.30K0.00%−88−44.7%Reduced
IFP Advisors, Inc1,000$6.00K0.00%00.0%Unchanged
Cubist Systematic Strategies, LLC177$6.98K0.00%−20,034−99.1%Reduced
Householder Group Estate & Retirement Specialist, LLC275$10.0K0.01%00.0%Unchanged
Daiwa Securities Group Inc.252$10.0K0.00%+54+27.3%Added
Leonteq Securities AG530$20.9K0.00%00.0%Unchanged
China Universal Asset Management Co., Ltd.635$25.0K0.01%+52+8.9%Added
Advisor Group Holdings, Inc.676$27.0K0.00%+85+14.4%Added
Wells Fargo & Company1,123$44.3K0.00%+623+124.6%Added
BNP Paribas Arbitrage, SA1,526$60.2K0.00%−3,430−69.2%Reduced
Citigroup Inc1,809$71.3K0.00%+92+5.4%Added
Proequities, Inc.2,000$78.9K0.01%00.0%Unchanged
High Net Worth Advisory Group LLC2,000$78.9K0.03%+1,000+100.0%Added
JPMorgan Chase & Co2,087$82.0K0.00%−2,184−51.1%Reduced
Great West Life Assurance Co2,392$95.0K0.00%00.0%Unchanged
Deutsche Bank AG2,495$98.4K0.00%+2,495New
Tower Research Capital LLC (TRC)2,552$101.0K0.00%−1,648−39.2%Reduced
Virtus ETF Advisers LLC3,616$142.6K0.07%−57−1.6%Reduced
UBS Group AG4,662$183.8K0.00%+1,236+36.1%Added
Northwestern Mutual Wealth Management Co5,000$197.2K0.00%+5,000New
ProShare Advisors LLC5,172$203.9K0.00%+5,172New
Virtu Financial LLC5,604$221.0K0.03%+5,604New
Connor, Clark & Lunn Investment Management Ltd.5,799$228.7K0.00%+5,799New
Group One Trading, L.P.6,552$258.3K0.01%−5,021−43.4%Reduced
Jump Financial, LLC7,725$304.6K0.02%−45,575−85.5%Reduced
Advisors Asset Management, Inc.7,846$309.4K0.01%+3,725+90.4%Added
Zurcher Kantonalbank (Zurich Cantonalbank)9,439$372.2K0.00%+2,772+41.6%Added
Stifel Financial Corp9,944$392.1K0.00%−100−1.0%Reduced
Birchview Capital, LP10,000$394.0K0.28%00.0%Unchanged
Main Street Research LLC10,000$394.3K0.10%00.0%Unchanged
Public Employees Retirement Association of Colorado10,633$419.0K0.00%00.0%Unchanged
Supplemental Annuity Collective Trust of NJ11,000$433.7K0.18%00.0%Unchanged
American Century Companies Inc11,005$433.9K0.00%+4,335+65.0%Added
Boothbay Fund Management, LLC11,825$466.3K0.02%00.0%Unchanged
Virginia Retirement Systems Et Al12,500$492.9K0.01%−500−3.8%Reduced
Prelude Capital Management, LLC12,769$503.5K0.03%+12,769New
Fox Run Management, L.L.C.12,975$511.6K0.21%+3,244+33.3%Added
Arizona State Retirement System13,177$519.6K0.01%+750+6.0%Added
Ergoteles LLC13,516$532.9K0.02%+13,516New
Gsa Capital Partners LLP13,763$543.0K0.07%+13,763New
Handelsbanken Fonder AB14,100$556.0K0.00%+3,500+33.0%Added
Teacher Retirement System of Texas14,119$557.0K0.00%−835−5.6%Reduced
Engineers Gate Manager LP14,383$567.1K0.03%+4,666+48.0%Added
Shell Asset Management Co14,649$578.0K0.03%−2,751−15.8%Reduced
Elmwood Wealth Management, Inc.14,994$591.2K0.30%00.0%Unchanged
Jane Street Group, LLC15,290$602.9K0.00%−26,622−63.5%Reduced
Legal & General Group Plc15,528$612.3K0.00%+3,950+34.1%Added
Employees Retirement System of Texas16,001$631.0K0.01%00.0%Unchanged
Royal Bank of Canada16,130$636.0K0.00%+16,129+1,612,900.0%Added
New York State Common Retirement Fund16,650$656.5K0.00%+650+4.1%Added
PFM Health Sciences, LP17,488$689.6K0.03%+17,488New
Guggenheim Capital LLC19,093$752.8K0.01%+4,155+27.8%Added
Jefferies Financial Group Inc.19,500$768.9K0.01%+19,500New
DekaBank Deutsche Girozentrale20,000$781.0K0.00%00.0%Unchanged
Allianz Asset Management GmbH20,000$788.6K0.00%00.0%Unchanged
Velan Capital Investment Management LP20,000$788.6K0.84%00.0%Unchanged
Natixis Advisors, L.P.21,492$847.0K0.00%−111−0.5%Reduced
Sanders Morris Harris LLC21,500$847.7K0.32%00.0%Unchanged
CIBC World Markets Inc.22,550$889.0K0.00%−750−3.2%Reduced
Ameriprise Financial Inc22,626$891.0K0.00%−18,518−45.0%Reduced
Two Sigma Advisers, LP22,700$895.1K0.00%−68,300−75.1%Reduced
Chartwell Investment Partners, LLC23,630$932.0K0.04%+1,341+6.0%Added
NJ State Employees Deferred Compensation Plan25,000$985.8K0.16%00.0%Unchanged
HighVista Strategies LLC25,340$999.2K0.59%+2,768+12.3%Added
International Biotechnology Trust PLC25,500$1.00M0.31%00.0%Unchanged
Scotia Capital Inc.26,859$1.06M0.01%−7,392−21.6%Reduced
Susquehanna Fundamental Investments, LLC28,663$1.13M0.02%−4,518−13.6%Reduced
Kynam Capital Management, LP28,887$1.14M0.17%+95+0.3%Added
Mirabella Financial Services LLP31,459$1.24M0.11%+31,459New
Advisory Research Inc32,731$1.29M0.12%−3,707−10.2%Reduced
TLS Advisors LLC33,756$1.33M6.56%+33,756New
Erste Asset Management GmbH35,000$1.37M0.03%00.0%Unchanged
SG Americas Securities, LLC35,465$1.40M0.02%+13,633+62.4%Added
Algert Global LLC36,416$1.44M0.08%−8,830−19.5%Reduced
Soleus Capital Management, L.P.38,000$1.50M0.21%−58,800−60.7%Reduced
UBS Asset Management Americas Inc38,938$1.54M0.00%+534+1.4%Added
California State Teachers Retirement System40,635$1.60M0.00%+1,288+3.3%Added
Alps Advisors Inc42,371$1.67M0.01%+8,412+24.8%Added
Cheyne Capital Management (UK) LLP42,500$1.68M2.96%+42,500New
Bamco Inc47,400$1.87M0.01%+19,900+72.4%Added
LMR Partners LLP50,000$1.97M0.05%−15,698−23.9%Reduced
Affinity Asset Advisors, LLC50,000$1.97M0.90%+50,000New
Nuveen Asset Management, LLC51,280$2.02M0.00%+920+1.8%Added
Credit Suisse AG54,789$2.16M0.00%+11,136+25.5%Added
Geode Capital Management, LLC55,285$2.18M0.00%−6,538−10.6%Reduced
Alliancebernstein L.P.56,835$2.24M0.00%−85,891−60.2%Reduced
Knott David M Jr59,500$2.35M1.01%00.0%Unchanged
Northern Trust Corp60,217$2.37M0.00%+9,326+18.3%Added
State of New Jersey Common Pension Fund D64,454$2.54M0.01%00.0%Unchanged
Voya Investment Management LLC67,140$2.65M0.00%00.0%Unchanged
Qube Research & Technologies Ltd75,759$2.99M0.02%+41,276+119.7%Added
Castleark Management LLC77,740$3.07M0.16%+77,740New
Tekla Capital Management LLC83,714$3.30M0.12%+21,981+35.6%Added
Russell Investments Group, Ltd.84,330$3.33M0.01%−14,744−14.9%Reduced
Walleye Capital LLC86,517$3.41M0.07%−1,454−1.7%Reduced
Morgan Stanley88,134$3.48M0.00%−70,318−44.4%Reduced
Bank of America Corp88,748$3.50M0.00%+61,753+228.8%Added