Spyre Therapeutics, Inc.
SYRE- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001636282
In the last 90 days, Spyre Therapeutics, Inc. insiders filed 0 open-market purchases and 9 sales; 265 institutions reported holding it in 13F filings for Q2 2026, worth $8.52B in total; no superinvestor holds it.
13F holders, Q2 2026
Institutional positions in Spyre Therapeutics, Inc. as of Jun 30, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 265
- +69 vs. Q1 2026
- Shares held
- 95.8M
- +14.8M (+18.3%) vs. Q1 2026
- Total value
- $8.52B
- +$4.44B (+108.8%) vs. Q1 2026
- New holders
- 91
- 105 more added
- Sold out
- 22
- 55 more reduced
2 institutions that held it in Q1 2026 haven't filed for Q2 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q1 2026: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SYRE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 265 | $8.52B |
| Q1 2026 | 198 | $4.16B |
| Q4 2025 | 153 | $2.65B |
| Q3 2025 | 137 | $1.08B |
| Q2 2025 | 129 | $952.6M |
| Q1 2025 | 129 | $1.00B |
| Q4 2024 | 131 | $1.39B |
| Q3 2024 | 119 | $1.51B |
| Q2 2024 | 107 | $1.18B |
| Q1 2024 | 103 | $1.21B |
| Q4 2023 | 54 | $601.0M |
| Q3 2023 | 29 | $43.9M |
| Q2 2023 | 44 | $31.9M |
| Q1 2023 | 45 | $12.0M |
| Q4 2022 | 51 | $19.2M |
| Q3 2022 | 55 | $23.5M |
| Q2 2022 | 67 | $24.8M |
| Q1 2022 | 84 | $95.4M |
| Q4 2021 | 86 | $189.4M |
| Q3 2021 | 77 | $322.5M |
| Q2 2021 | 78 | $285.8M |
| Q1 2021 | 84 | $328.7M |
Institutions, Q2 2026
Shares, value and share of portfolio for each institution holding Spyre Therapeutics, Inc.; share changes are against Q1 2026.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Two Sigma Securities, LLC | 3,003 | $266.6K | 0.02% | −3,848−56.2% | Reduced |
| Tower Research Capital LLC (TRC) | 3,001 | $266.4K | 0.01% | −5,789−65.9% | Reduced |
| Jane Street Group, LLC | 2,909 | $258.3K | 0.00% | +2,909 | New |
| VARCOV Co. | 2,895 | $257.0K | 0.10% | +2,895 | New |
| Aster Capital Management (DIFC) Ltd | 2,865 | $254.4K | 0.05% | +2,865 | New |
| Amundi | 2,793 | $248.0K | 0.00% | +2,793 | New |
| Empowered Funds, LLC | 2,731 | $242.5K | 0.00% | +2,731 | New |
| DnB Asset Management AS | 2,661 | $236.2K | 0.00% | +2,661 | New |
| Tudor Investment Corp Et Al | 2,645 | $234.8K | 0.00% | −5,719−68.4% | Reduced |
| Brinker Capital Investments, LLC | 2,577 | $228.8K | 0.00% | +2,577 | New |
| CIBC Asset Management Inc | 2,429 | $215.6K | 0.00% | +2,429 | New |
| Nisa Investment Advisors, LLC | 2,347 | $208.4K | 0.00% | +431+22.5% | Added |
| Royal Bank of Canada | 2,338 | $208.0K | 0.00% | −912−28.1% | Reduced |
| Los Angeles Capital Management LLC | 2,310 | $205.1K | 0.00% | −3,548−60.6% | Reduced |
| Bayforest Capital Ltd | 2,305 | $204.6K | 0.19% | +2,305 | New |
| Acadian Asset Management LLC | 2,296 | $203.0K | 0.00% | +2,296 | New |
| CFC Planning Co LLC | 2,277 | $202.2K | 0.12% | +2,277 | New |
| Fulcrum Asset Management LLP | 2,114 | $190.6K | 0.02% | +2,114 | New |
| Nykredit A/S | 1,953 | $173.4K | 0.00% | +1,953 | New |
| Mitsubishi UFJ Trust & Banking Corp | 1,844 | $163.7K | 0.00% | +1,844 | New |
| KBC Group NV | 1,796 | $159.0K | 0.00% | +424+30.9% | Added |
| GF Fund Management Co. Ltd. | 1,664 | $147.7K | 0.00% | −79−4.5% | Reduced |
| Public Employees Retirement Association of Colorado | 1,589 | $141.0K | 0.00% | 00.0% | Unchanged |
| US Bancorp | 1,507 | $133.8K | 0.00% | +1,410+1,453.6% | Added |
| Farther Finance Advisors, LLC | 1,129 | $100.2K | 0.00% | +1,055+1,425.7% | Added |
| The PNC Financial Services Group, Inc. | 914 | $81.1K | 0.00% | +791+643.1% | Added |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 897 | $79.6K | 0.00% | +9+1.0% | Added |
| Union Bancaire Privee, UBP SA | 880 | $79.3K | 0.00% | −3,000−77.3% | Reduced |
| Kemnay Advisory Services Inc. | 741 | $65.8K | 0.01% | +167+29.1% | Added |
| Parallel Advisors, LLC | 720 | $63.9K | 0.00% | +688+2,150.0% | Added |
| GAMMA Investing LLC | 663 | $58.9K | 0.00% | +140+26.8% | Added |
| Pacer Advisors, Inc. | 614 | $55.0K | 0.00% | +614 | New |
| Optiver Holding B.V. | 400 | $35.5K | 0.00% | +112+38.9% | Added |
| EverSource Wealth Advisors, LLC | 345 | $30.6K | 0.00% | +266+336.7% | Added |
| Simplex Trading, LLC | 278 | $24.7K | 0.00% | +278 | New |
| Toronto Dominion Bank | 270 | $24.0K | 0.00% | +270 | New |
| Sterling Capital Management LLC | 262 | $23.3K | 0.00% | −789−75.1% | Reduced |
| Allworth Financial LP | 226 | $20.1K | 0.00% | +109+93.2% | Added |
| Axiom Investment Management LLC | 200 | $17.8K | 0.01% | +200 | New |
| SRS Capital Advisors, Inc. | 169 | $15.0K | 0.00% | +151+838.9% | Added |
| J.Safra Asset Management Corp | 167 | $14.8K | 0.00% | +167 | New |
| IFG Advisory, LLC | 161 | $14.3K | 0.00% | +161 | New |
| Smartleaf Asset Management LLC | 157 | $14.2K | 0.00% | 00.0% | Unchanged |
| National Bank of Canada | 124 | $11.0K | 0.00% | +124 | New |
| Jones Financial Companies LLLP | 103 | $9.05K | 0.00% | +103 | New |
| Rothschild Investment LLC | 99 | $8.79K | 0.00% | 00.0% | Unchanged |
| Larson Financial Group LLC | 63 | $5.59K | 0.00% | +27+75.0% | Added |
| Signaturefd, LLC | 59 | $5.24K | 0.00% | −11−15.7% | Reduced |
| Parkside Financial Bank & Trust | 45 | $4.00K | 0.00% | +10+28.6% | Added |
| Meeder Asset Management Inc | 30 | $2.66K | 0.00% | +30 | New |
| IFP Advisors, Inc | 24 | $2.13K | 0.00% | 00.0% | Unchanged |
| Bare Financial Services, Inc | 16 | $1.42K | 0.00% | 00.0% | Unchanged |
| Covestor Ltd | 13 | $1.00K | 0.00% | +9+225.0% | Added |
| Ares Financial Consulting, LLC | 11 | $977 | 0.00% | +11 | New |
| SBI Securities Co., Ltd. | 5 | $444 | 0.00% | 00.0% | Unchanged |
| UMA Financial Services, Inc. | 5 | $444 | 0.00% | +5 | New |
| Keating Financial Advisory Services, Inc. | 4 | $355 | 0.00% | 00.0% | Unchanged |
| Stone House Investment Management, LLC | 4 | $355 | 0.00% | +4 | New |
| Hughes Financial Services, LLC | 4 | $355 | 0.00% | +4 | New |
| Silver Grove Financial Group, Inc. | 3 | $266 | 0.00% | +3 | New |
| Caitong International Asset Management Co., Ltd | 2 | $178 | 0.00% | −284−99.3% | Reduced |
| Essential Partners LLC | 2 | $178 | 0.00% | 00.0% | Unchanged |
| Quarry LP | 2 | $178 | 0.00% | +2 | New |
| Zions Bancorporation, National Association | 1 | $89 | 0.00% | +1 | New |
| ABS Investment Management LLC | 89 | – | – | +89 | New |
| Massmutual Trust Co FSB | 0 | $0 | 0.00% | −3−100.0% | Sold out |
| Fairmount Funds Management LLC | 0 | $0 | 0.00% | −4,018,101−100.0% | Sold out |
| Ra Capital Management, L.P. | 0 | $0 | 0.00% | −1,621,620−100.0% | Sold out |
| Baker Bros. Advisors LP | 0 | $0 | 0.00% | −1,000,000−100.0% | Sold out |
| Caligan Partners LP | 0 | $0 | 0.00% | −878,127−100.0% | Sold out |
| ExodusPoint Capital Management, LP | 0 | $0 | 0.00% | −87,065−100.0% | Sold out |
| Alps Advisors Inc | 0 | $0 | 0.00% | −63,939−100.0% | Sold out |
| Assenagon Asset Management S.A. | 0 | $0 | 0.00% | −18,647−100.0% | Sold out |
| Carlyle Group Inc. | 0 | $0 | 0.00% | −9,620−100.0% | Sold out |
| RWC Asset Management LLP | 0 | $0 | 0.00% | −8,166−100.0% | Sold out |
| Capstone Investment Advisors, LLC | 0 | $0 | 0.00% | −7,537−100.0% | Sold out |
| Scientech Research LLC | 0 | $0 | 0.00% | −7,088−100.0% | Sold out |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | 0 | $0 | 0.00% | −6,140−100.0% | Sold out |
| DeepCurrents Investment Group LLC | 0 | $0 | 0.00% | −4,740−100.0% | Sold out |
| ABS Direct Equity Fund LLC | 0 | $0 | 0.00% | −2,800−100.0% | Sold out |
| Patient Square Capital LP | 0 | $0 | 0.00% | −1,000−100.0% | Sold out |
| Group One Trading, L.P. | 0 | $0 | 0.00% | −901−100.0% | Sold out |
| Clear Street Markets LLC | 0 | $0 | 0.00% | −562−100.0% | Sold out |
| Delos Wealth Advisors, LLC | 0 | $0 | 0.00% | −250−100.0% | Sold out |
| Quadrant Capital Group LLC | 0 | $0 | 0.00% | −146−100.0% | Sold out |
| MAI Capital Management | 0 | $0 | 0.00% | −13−100.0% | Sold out |
| Twin Peaks Wealth Advisors, LLC | 0 | $0 | 0.00% | −3−100.0% | Sold out |
| Janus Henderson Group PLC | – | – | – | – | Not filed |
| CWM, LLC | – | – | – | – | Not filed |