Spyre Therapeutics, Inc.
SYRE- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001636282
In the last 90 days, Spyre Therapeutics, Inc. insiders filed 0 open-market purchases and 9 sales; 265 institutions reported holding it in 13F filings for Q2 2026, worth $8.52B in total; no superinvestor holds it.
13F holders, Q4 2023
Institutional positions in Spyre Therapeutics, Inc. as of Dec 31, 2023. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 54
- +25 vs. Q3 2023
- Shares held
- 28.0M
- +24.4M (+683.2%) vs. Q3 2023
- Total value
- $601.0M
- +$557.1M (+1,269.8%) vs. Q3 2023
- New holders
- 29
- 15 more added
- Sold out
- 4
- 6 more reduced
Compare with Q3 2023: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SYRE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 265 | $8.52B |
| Q1 2026 | 198 | $4.16B |
| Q4 2025 | 153 | $2.65B |
| Q3 2025 | 137 | $1.08B |
| Q2 2025 | 129 | $952.6M |
| Q1 2025 | 129 | $1.00B |
| Q4 2024 | 131 | $1.39B |
| Q3 2024 | 119 | $1.51B |
| Q2 2024 | 107 | $1.18B |
| Q1 2024 | 103 | $1.21B |
| Q4 2023 | 54 | $601.0M |
| Q3 2023 | 29 | $43.9M |
| Q2 2023 | 44 | $31.9M |
| Q1 2023 | 45 | $12.0M |
| Q4 2022 | 51 | $19.2M |
| Q3 2022 | 55 | $23.5M |
| Q2 2022 | 67 | $24.8M |
| Q1 2022 | 84 | $95.4M |
| Q4 2021 | 86 | $189.4M |
| Q3 2021 | 77 | $322.5M |
| Q2 2021 | 78 | $285.8M |
| Q1 2021 | 84 | $328.7M |
Institutions, Q4 2023
Shares, value and share of portfolio for each institution holding Spyre Therapeutics, Inc.; share changes are against Q3 2023.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| FMR LLC | 3,785,877 | $79.7M | 0.01% | +3,785,877 | New |
| Perceptive Advisors LLC | 2,606,679 | $56.1M | 1.25% | +2,525,563+3,113.5% | Added |
| VR Adviser, LLC | 2,372,714 | $51.1M | 3.50% | +2,077,680+704.2% | Added |
| RTW Investments, LP | 2,232,760 | $48.0M | 0.75% | +2,232,760 | New |
| Deep Track Capital, LP | 1,952,760 | $42.0M | 1.47% | +1,952,760 | New |
| Commodore Capital LP | 1,884,084 | $40.5M | 3.54% | +1,767,760+1,519.7% | Added |
| Avoro Capital Advisors LLC | 1,839,138 | $39.6M | 0.55% | +1,827,680+15,951.1% | Added |
| Adage Capital Partners GP, L.L.C. | 1,000,000 | $21.5M | 0.04% | +1,000,000 | New |
| Cormorant Asset Management, LP | 937,080 | $20.2M | 0.97% | +937,080 | New |
| EcoR1 Capital, LLC | 887,076 | $19.1M | 0.50% | +687,080+343.5% | Added |
| Driehaus Capital Management LLC | 771,902 | $16.6M | 0.20% | −28,951−3.6% | Reduced |
| Franklin Resources Inc | 687,090 | $14.8M | 0.01% | +687,090 | New |
| BVF Inc | 687,080 | $14.8M | 0.37% | +687,080 | New |
| Wellington Management Group LLP | 635,455 | $13.7M | 0.00% | +335,526+111.9% | Added |
| University of Notre Dame du Lac | 577,616 | $12.4M | 12.73% | +577,616 | New |
| HighVista Strategies LLC | 577,616 | $12.4M | 4.51% | +577,616 | New |
| Citadel Advisors LLC | 576,711 | $12.4M | 0.01% | +479,658+494.2% | Added |
| Affinity Asset Advisors, LLC | 517,554 | $11.1M | 2.22% | +275,257+113.6% | Added |
| Braidwell LP | 515,000 | $11.1M | 0.41% | +515,000 | New |
| Global Endowment Management, LP | 513,436 | $11.0M | 1.23% | +513,436 | New |
| Polar Capital Holdings Plc | 500,000 | $10.8M | 0.07% | +200,000+66.7% | Added |
| StemPoint Capital LP | 378,766 | $8.15M | 2.20% | +378,766 | New |
| Fairmount Funds Management LLC | 378,421 | $8.14M | 0.86% | 00.0% | Unchanged |
| Boxer Capital, LLC | 250,000 | $5.38M | 0.27% | +250,000 | New |
| Suvretta Capital Management, LLC | 162,395 | $3.49M | 0.16% | 00.0% | Unchanged |
| Logos Global Management LP | 150,000 | $3.23M | 0.36% | −60,000−28.6% | Reduced |
| Great Point Partners LLC | 125,000 | $2.69M | 0.46% | +125,000 | New |
| Millennium Management LLC | 108,486 | $2.33M | 0.00% | +70,673+186.9% | Added |
| Prosight Management, LP | 55,000 | $1.18M | 0.48% | +55,000 | New |
| Renaissance Technologies LLC | 48,536 | $1.04M | 0.00% | +25,307+108.9% | Added |
| Barclays PLC | 45,498 | $979.1K | 0.00% | +45,498 | New |
| Vanguard Group Inc | 39,446 | $848.9K | 0.00% | +6,369+19.3% | Added |
| Geode Capital Management, LLC | 30,326 | $652.8K | 0.00% | +3,526+13.2% | Added |
| Two Sigma Investments, LP | 28,095 | $604.6K | 0.00% | +28,095 | New |
| ExodusPoint Capital Management, LP | 26,210 | $564.0K | 0.01% | +26,210 | New |
| Cubist Systematic Strategies, LLC | 26,150 | $562.7K | 0.01% | +26,150 | New |
| Marshall Wace, LLP | 20,252 | $435.8K | 0.00% | +20,252 | New |
| Blackstone Group Inc. | 19,991 | $430.2K | 0.00% | +19,991 | New |
| BlackRock Inc. | 19,762 | $425.3K | 0.00% | −60.0% | Reduced |
| Citigroup Inc | 10,297 | $221.6K | 0.00% | +10,297 | New |
| Carlyle Group Inc. | 9,620 | $203.9K | 0.01% | +9,620 | New |
| ADAR1 Capital Management, LLC | 6,440 | $138.6K | 0.06% | +6,440 | New |
| Virtus ETF Advisers LLC | 6,239 | $134.3K | 0.09% | +6,239 | New |
| UBS Group AG | 3,726 | $80.2K | 0.00% | +3,726 | New |
| Tower Research Capital LLC (TRC) | 2,580 | $55.5K | 0.00% | +2,158+511.4% | Added |
| Acadian Asset Management LLC | 1,169 | $25.0K | 0.00% | −10,719−90.2% | Reduced |
| New York State Common Retirement Fund | 365 | $7.86K | 0.00% | +365 | New |
| Advisor Group Holdings, Inc. | 283 | $6.09K | 0.00% | 00.0% | Unchanged |
| IFP Advisors, Inc | 114 | $2.45K | 0.00% | −2,860−96.2% | Reduced |
| JPMorgan Chase & Co | 41 | $882 | 0.00% | 00.0% | Unchanged |
| Morgan Stanley | 40 | $861 | 0.00% | −6−13.0% | Reduced |
| Wells Fargo & Company | 23 | $495 | 0.00% | +1+4.5% | Added |
| Pacific Capital Wealth Advisors, Inc | 8 | $172 | 0.00% | +8 | New |
| Parallel Advisors, LLC | 1 | $22 | 0.00% | +1 | New |
| Rock Springs Capital Management LP | 0 | $0 | 0.00% | −136,556−100.0% | Sold out |
| Aisling Capital Management LP | 0 | $0 | 0.00% | −67,645−100.0% | Sold out |
| Fan Yu | 0 | $0 | 0.00% | −20,592−100.0% | Sold out |
| Royal Bank of Canada | 0 | $0 | 0.00% | −437−100.0% | Sold out |