Spyre Therapeutics, Inc.
SYRE- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001636282
In the last 90 days, Spyre Therapeutics, Inc. insiders filed 0 open-market purchases and 9 sales; 265 institutions reported holding it in 13F filings for Q2 2026, worth $8.52B in total; no superinvestor holds it.
13F holders, Q1 2022
Institutional positions in Spyre Therapeutics, Inc. as of Mar 31, 2022. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 84
- −2 vs. Q4 2021
- Shares held
- 41.5M
- +1.54M (+3.9%) vs. Q4 2021
- Total value
- $95.4M
- −$94.1M (−49.7%) vs. Q4 2021
- New holders
- 10
- 29 more added
- Sold out
- 12
- 25 more reduced
Compare with Q4 2021: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SYRE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 265 | $8.52B |
| Q1 2026 | 198 | $4.16B |
| Q4 2025 | 153 | $2.65B |
| Q3 2025 | 137 | $1.08B |
| Q2 2025 | 129 | $952.6M |
| Q1 2025 | 129 | $1.00B |
| Q4 2024 | 131 | $1.39B |
| Q3 2024 | 119 | $1.51B |
| Q2 2024 | 107 | $1.18B |
| Q1 2024 | 103 | $1.21B |
| Q4 2023 | 54 | $601.0M |
| Q3 2023 | 29 | $43.9M |
| Q2 2023 | 44 | $31.9M |
| Q1 2023 | 45 | $12.0M |
| Q4 2022 | 51 | $19.2M |
| Q3 2022 | 55 | $23.5M |
| Q2 2022 | 67 | $24.8M |
| Q1 2022 | 84 | $95.4M |
| Q4 2021 | 86 | $189.4M |
| Q3 2021 | 77 | $322.5M |
| Q2 2021 | 78 | $285.8M |
| Q1 2021 | 84 | $328.7M |
Institutions, Q1 2022
Shares, value and share of portfolio for each institution holding Spyre Therapeutics, Inc.; share changes are against Q4 2021.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Suvretta Capital Management, LLC | 4,059,894 | $9.34M | 0.29% | +1,488,894+57.9% | Added |
| Baker Bros. Advisors LP | 3,410,106 | $7.84M | 0.05% | 00.0% | Unchanged |
| Nantahala Capital Management, LLC | 3,200,593 | $7.36M | 0.51% | +387,033+13.8% | Added |
| OrbiMed Advisors LLC | 2,956,124 | $6.80M | 0.11% | 00.0% | Unchanged |
| BlackRock Inc. | 2,921,810 | $6.72M | 0.00% | −76,669−2.6% | Reduced |
| Bain Capital Life Sciences Investors, LLC | 2,847,689 | $6.55M | 0.64% | 00.0% | Unchanged |
| Pictet Asset Management SA | 2,552,434 | $5.87M | 0.01% | +84,305+3.4% | Added |
| Vanguard Group Inc | 2,117,323 | $4.87M | 0.00% | −3,302−0.2% | Reduced |
| Rock Springs Capital Management LP | 1,811,425 | $4.17M | 0.10% | +234,129+14.8% | Added |
| Aisling Capital Management LP | 1,691,151 | $3.89M | 2.10% | 00.0% | Unchanged |
| Laurion Capital Management LP | 1,575,638 | $3.62M | 0.09% | +125,000+8.6% | Added |
| Goldman Sachs Group Inc | 1,124,789 | $2.59M | 0.00% | −9,562−0.8% | Reduced |
| Samsara BioCapital, LLC | 883,720 | $2.03M | 0.51% | 00.0% | Unchanged |
| Sio Capital Management, LLC | 871,101 | $2.00M | 0.81% | +372,601+74.7% | Added |
| State Street Corp | 787,048 | $1.81M | 0.00% | +29,007+3.8% | Added |
| Geode Capital Management, LLC | 692,221 | $1.59M | 0.00% | +6,476+0.9% | Added |
| Ghost Tree Capital, LLC | 686,599 | $1.58M | 0.78% | +686,599 | New |
| Dimensional Fund Advisors LP | 680,964 | $1.57M | 0.00% | −9,609−1.4% | Reduced |
| Assenagon Asset Management S.A. | 523,142 | $1.20M | 0.00% | +106,968+25.7% | Added |
| Deutsche Bank AG | 515,133 | $1.19M | 0.00% | +490,598+1,999.6% | Added |
| D. E. Shaw & Co., Inc. | 454,093 | $1.04M | 0.00% | +226,585+99.6% | Added |
| Jacobs Levy Equity Management, Inc | 436,183 | $1.00M | 0.01% | +292,090+202.7% | Added |
| Millennium Management LLC | 423,914 | $975.0K | 0.00% | +233,432+122.5% | Added |
| Northern Trust Corp | 333,741 | $768.0K | 0.00% | −15,947−4.6% | Reduced |
| Lion Point Capital, LP | 300,000 | $690.0K | 0.23% | 00.0% | Unchanged |
| University of Texas/Texas Am Investment Managment Co | 245,678 | $565.0K | 0.29% | 00.0% | Unchanged |
| Abingworth LLP | 240,500 | $553.0K | 0.16% | 00.0% | Unchanged |
| Two Sigma Investments, LP | 216,601 | $498.0K | 0.00% | +152,090+235.8% | Added |
| Nuveen Asset Management, LLC | 169,120 | $425.0K | 0.00% | +298+0.2% | Added |
| ClariVest Asset Management LLC | 184,119 | $424.0K | 0.02% | +9,200+5.3% | Added |
| Morgan Stanley | 181,701 | $418.0K | 0.00% | −14,517−7.4% | Reduced |
| Parametric Portfolio Associates LLC | 178,016 | $409.0K | 0.00% | +136,033+324.0% | Added |
| Two Sigma Advisers, LP | 161,300 | $371.0K | 0.00% | +123,100+322.3% | Added |
| Bank of New York Mellon Corp | 157,657 | $362.0K | 0.00% | −1,617−1.0% | Reduced |
| Marshall Wace, LLP | 154,175 | $355.0K | 0.00% | +112,551+270.4% | Added |
| Renaissance Technologies LLC | 151,868 | $349.0K | 0.00% | −96,332−38.8% | Reduced |
| Acadian Asset Management LLC | 149,399 | $342.0K | 0.00% | +18,564+14.2% | Added |
| Walleye Capital LLC | 135,611 | $312.0K | 0.01% | +135,611 | New |
| Bridgeway Capital Management, LLC | 123,000 | $283.0K | 0.01% | +123,000 | New |
| Fan Yu | 112,044 | $258.0K | 3.49% | 00.0% | Unchanged |
| Charles Schwab Investment Management Inc | 106,810 | $246.0K | 0.00% | +7,333+7.4% | Added |
| Franklin Street Advisors Inc | 105,800 | $243.0K | 0.02% | 00.0% | Unchanged |
| Blair William & Co | 76,594 | $176.0K | 0.00% | 00.0% | Unchanged |
| Ritholtz Wealth Management | 76,490 | $176.0K | 0.01% | 00.0% | Unchanged |
| Citadel Advisors LLC | 73,414 | $169.0K | 0.00% | +73,414 | New |
| UBS Group AG | 65,276 | $150.0K | 0.00% | −71,360−52.2% | Reduced |
| Algert Global LLC | 56,944 | $131.0K | 0.01% | +24,520+75.6% | Added |
| Alps Advisors Inc | 50,735 | $117.0K | 0.00% | −6,345−11.1% | Reduced |
| Rhumbline Advisers | 48,918 | $113.0K | 0.00% | −5,000−9.3% | Reduced |
| Franklin Resources Inc | 46,300 | $106.0K | 0.00% | +46,300 | New |
| AQR Capital Management LLC | 36,787 | $85.0K | 0.00% | +36,787 | New |
| JPMorgan Chase & Co | 24,923 | $58.0K | 0.00% | +4,045+19.4% | Added |
| BIT Capital GmbH | 25,000 | $57.5K | 0.01% | 00.0% | Unchanged |
| Tower Research Capital LLC (TRC) | 22,079 | $51.0K | 0.00% | +17,127+345.9% | Added |
| Alliancebernstein L.P. | 21,600 | $50.0K | 0.00% | −4,000−15.6% | Reduced |
| American International Group, Inc. | 20,064 | $46.0K | 0.00% | −1,412−6.6% | Reduced |
| Bank of America Corp | 18,005 | $41.0K | 0.00% | −13,062−42.0% | Reduced |
| California State Teachers Retirement System | 17,202 | $40.0K | 0.00% | −4,112−19.3% | Reduced |
| New York State Common Retirement Fund | 17,041 | $39.0K | 0.00% | 00.0% | Unchanged |
| Voya Investment Management LLC | 15,466 | $36.0K | 0.00% | 00.0% | Unchanged |
| ProShare Advisors LLC | 12,680 | $29.0K | 0.00% | −3,091−19.6% | Reduced |
| Invesco Ltd. | 12,350 | $29.0K | 0.00% | +138+1.1% | Added |
| Cubist Systematic Strategies, LLC | 12,096 | $28.0K | 0.00% | −43,849−78.4% | Reduced |
| Manufacturers Life Insurance Company, The | 11,679 | $26.9K | 0.00% | −8,460−42.0% | Reduced |
| Public Employees Retirement System of Ohio | 8,189 | $19.0K | 0.00% | +4,296+110.4% | Added |
| Barclays PLC | 6,660 | $16.0K | 0.00% | −42,493−86.5% | Reduced |
| Wells Fargo & Company | 7,025 | $16.0K | 0.00% | −14,307−67.1% | Reduced |
| Amalgamated Bank | 4,887 | $11.0K | 0.00% | +4,887 | New |
| Amalgamated Financial Corp. | 4,887 | $11.0K | 0.00% | +4,887 | New |
| Citigroup Inc | 4,319 | $10.0K | 0.00% | −7,575−63.7% | Reduced |
| Ameritas Investment Partners, Inc. | 3,710 | $9.00K | 0.00% | 00.0% | Unchanged |
| Point72 Hong Kong Ltd | 3,921 | $9.00K | 0.00% | +3,768+2,462.7% | Added |
| BNP Paribas Arbitrage, SA | 3,580 | $8.23K | 0.00% | −7,579−67.9% | Reduced |
| Legal & General Group Plc | 3,264 | $8.00K | 0.00% | 00.0% | Unchanged |
| Group One Trading, L.P. | 3,000 | $7.00K | 0.00% | −2,300−43.4% | Reduced |
| Royal Bank of Canada | 2,483 | $6.00K | 0.00% | −5,677−69.6% | Reduced |
| Russell Investments Group, Ltd. | 3,008 | $6.00K | 0.00% | 00.0% | Unchanged |
| Allspring Global Investments Holdings, LLC | 1,151 | $2.00K | 0.00% | −183−13.7% | Reduced |
| Captrust Financial Advisors | 1,084 | $2.00K | 0.00% | +913+533.9% | Added |
| Toronto Dominion Bank | 5 | $0 | 0.00% | 00.0% | Unchanged |
| Daiwa Securities Group Inc. | 98 | $0 | 0.00% | 00.0% | Unchanged |
| FMR LLC | 121 | $0 | 0.00% | +121 | New |
| Glassman Wealth Services | 88 | $0 | 0.00% | +88 | New |
| IFP Advisors, Inc | 5,840 | – | – | +2,860+96.0% | Added |
| Artal Group S.A. | 0 | $0 | 0.00% | −1,045,000−100.0% | Sold out |
| Adage Capital Partners GP, L.L.C. | 0 | $0 | 0.00% | −1,000,000−100.0% | Sold out |
| Great Point Partners LLC | 0 | $0 | 0.00% | −910,251−100.0% | Sold out |
| AXA S.A. | 0 | $0 | 0.00% | −444,931−100.0% | Sold out |
| Altium Capital Management LP | 0 | $0 | 0.00% | −293,764−100.0% | Sold out |
| Aristides Capital LLC | 0 | $0 | 0.00% | −35,763−100.0% | Sold out |
| Engineers Gate Manager LP | 0 | $0 | 0.00% | −15,000−100.0% | Sold out |
| Delphia (USA) Inc. | 0 | $0 | 0.00% | −12,944−100.0% | Sold out |
| Nisa Investment Advisors, LLC | 0 | $0 | 0.00% | −13,192−100.0% | Sold out |
| SG Americas Securities, LLC | 0 | $0 | 0.00% | −11,033−100.0% | Sold out |
| Pinnacle Wealth Planning Services, Inc. | 0 | $0 | 0.00% | −10,130−100.0% | Sold out |
| Quadrant Capital Group LLC | 0 | $0 | 0.00% | −1,137−100.0% | Sold out |