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Spyre Therapeutics, Inc.

SYRE
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001636282

In the last 90 days, Spyre Therapeutics, Inc. insiders filed 0 open-market purchases and 9 sales; 265 institutions reported holding it in 13F filings for Q2 2026, worth $8.52B in total; no superinvestor holds it.

13F holders, Q2 2023

Institutional positions in Spyre Therapeutics, Inc. as of Jun 30, 2023. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
44
−1 vs. Q1 2023
Shares held
70.9M
+29.6M (+71.6%) vs. Q1 2023
Total value
$31.9M
+$20.0M (+166.5%) vs. Q1 2023
New holders
14
5 more added
Sold out
15
9 more reduced

Compare with Q1 2023: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting SYRE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ2 2023: 44 institutions
Q1 2021: 84 institutionsQ2 2021: 78 institutionsQ3 2021: 77 institutionsQ4 2021: 86 institutionsQ1 2022: 84 institutionsQ2 2022: 67 institutionsQ3 2022: 55 institutionsQ4 2022: 51 institutionsQ1 2023: 45 institutionsQ2 2023: 44 institutionsQ3 2023: 29 institutionsQ4 2023: 54 institutionsQ1 2024: 103 institutionsQ2 2024: 107 institutionsQ3 2024: 119 institutionsQ4 2024: 131 institutionsQ1 2025: 129 institutionsQ2 2025: 129 institutionsQ3 2025: 137 institutionsQ4 2025: 153 institutionsQ1 2026: 198 institutionsQ2 2026: 265 institutions
Value heldQ2 2023: $31.9M
Q1 2021: $328.7MQ2 2021: $285.8MQ3 2021: $322.5MQ4 2021: $189.4MQ1 2022: $95.4MQ2 2022: $24.8MQ3 2022: $23.5MQ4 2022: $19.2MQ1 2023: $12.0MQ2 2023: $31.9MQ3 2023: $43.9MQ4 2023: $601.0MQ1 2024: $1.21BQ2 2024: $1.18BQ3 2024: $1.51BQ4 2024: $1.39BQ1 2025: $1.00BQ2 2025: $952.6MQ3 2025: $1.08BQ4 2025: $2.65BQ1 2026: $4.16BQ2 2026: $8.52B
Institutions holding SYRE and their total value by quarter
QuarterHoldersValue
Q2 2026265$8.52B
Q1 2026198$4.16B
Q4 2025153$2.65B
Q3 2025137$1.08B
Q2 2025129$952.6M
Q1 2025129$1.00B
Q4 2024131$1.39B
Q3 2024119$1.51B
Q2 2024107$1.18B
Q1 2024103$1.21B
Q4 202354$601.0M
Q3 202329$43.9M
Q2 202344$31.9M
Q1 202345$12.0M
Q4 202251$19.2M
Q3 202255$23.5M
Q2 202267$24.8M
Q1 202284$95.4M
Q4 202186$189.4M
Q3 202177$322.5M
Q2 202178$285.8M
Q1 202184$328.7M

Institutions, Q2 2023

Shares, value and share of portfolio for each institution holding Spyre Therapeutics, Inc.; share changes are against Q1 2023.

Institutions holding SYRE in Q2 2023
InstitutionSharesValue% of portfolioChange in sharesAction
Fairmount Funds Management LLC9,460,540$4.26M0.60%+9,460,540New
Wellington Management Group LLP8,819,168$3.97M0.00%+8,819,168New
VR Adviser, LLC6,343,221$2.86M0.46%+6,343,221New
EcoR1 Capital, LLC5,000,000$2.25M0.06%+5,000,000New
Affinity Asset Advisors, LLC4,900,000$2.21M0.87%+4,900,000New
Driehaus Capital Management LLC4,643,357$2.09M0.03%+4,643,357New
Nantahala Capital Management, LLC4,101,193$1.85M0.22%−456,819−10.0%Reduced
Suvretta Capital Management, LLC4,059,894$1.83M0.10%00.0%Unchanged
Rock Springs Capital Management LP3,413,906$1.54M0.04%00.0%Unchanged
Baker Bros. Advisors LP3,410,106$1.54M0.01%00.0%Unchanged
Logos Global Management LP3,142,880$1.42M0.20%+3,142,880New
Commodore Capital LP2,908,100$1.31M0.15%+2,908,100New
Millennium Management LLC2,453,221$1.11M0.00%−1,283,262−34.3%Reduced
Aisling Capital Management LP1,691,151$761.9K0.37%00.0%Unchanged
Acadian Asset Management LLC1,391,381$625.0K0.00%00.0%Unchanged
Samsara BioCapital, LLC883,720$398.1K0.07%00.0%Unchanged
Vanguard Group Inc648,053$291.9K0.00%−1,349,544−67.6%Reduced
Geode Capital Management, LLC600,455$270.5K0.00%00.0%Unchanged
Goldman Sachs Group Inc558,650$251.7K0.00%+558,650New
BlackRock Inc.528,897$238.3K0.00%−119,751−18.5%Reduced
Renaissance Technologies LLC393,000$177.0K0.00%+211,900+117.0%Added
Avoro Capital Advisors LLC286,459$129.1K0.00%+286,459New
University of Texas/Texas Am Investment Managment Co245,678$111.0K0.04%00.0%Unchanged
Carlyle Group Inc.240,500$108.2K0.00%00.0%Unchanged
State Street Corp195,089$87.9K0.00%−19,900−9.3%Reduced
HRT Financial LP164,528$74.0K0.00%+164,528New
Fan Yu112,044$50.5K3.96%00.0%Unchanged
Northern Trust Corp97,927$44.1K0.00%00.0%Unchanged
Jane Street Group, LLC54,278$24.5K0.00%+11,515+26.9%Added
Susquehanna International Group, LLP36,179$16.3K0.00%+36,179New
Franklin Resources Inc31,364$14.1K0.00%00.0%Unchanged
Bank of New York Mellon Corp23,233$10.5K0.00%00.0%Unchanged
Tower Research Capital LLC (TRC)22,749$10.3K0.00%−14,632−39.1%Reduced
Wells Fargo & Company8,746$3.94K0.00%+522+6.3%Added
UBS Group AG8,091$3.65K0.00%+8,084+115,485.7%Added
Advisor Group Holdings, Inc.5,000$2.25K0.00%+5,000New
Morgan Stanley3,306$1.49K0.00%−10,350−75.8%Reduced
Simplex Trading, LLC2,800$1.00K0.00%+2,744+4,900.0%Added
Royal Bank of Canada1,317$1.00K0.00%+1,317New
JPMorgan Chase & Co1,068$4810.00%00.0%Unchanged
Group One Trading, L.P.572$2580.00%−2,310−80.2%Reduced
Barclays PLC99$450.00%00.0%Unchanged
BNP Paribas Arbitrage, SA1$00.00%−395−99.7%Reduced
IFP Advisors, Inc2,860––00.0%Unchanged
Bain Capital Life Sciences Investors, LLC0$00.00%−5,347,689−100.0%Sold out
Sio Capital Management, LLC0$00.00%−3,004,959−100.0%Sold out
OrbiMed Advisors LLC0$00.00%−1,797,221−100.0%Sold out
Adage Capital Partners GP, L.L.C.0$00.00%−1,500,000−100.0%Sold out
Sphera Funds Management Ltd.0$00.00%−646,478−100.0%Sold out
Two Sigma Investments, LP0$00.00%−320,498−100.0%Sold out
Assenagon Asset Management S.A.0$00.00%−318,451−100.0%Sold out
Two Sigma Advisers, LP0$00.00%−210,800−100.0%Sold out
Bridgeway Capital Management, LLC0$00.00%−150,000−100.0%Sold out
ExodusPoint Capital Management, LP0$00.00%−117,479−100.0%Sold out
Franklin Street Advisors Inc0$00.00%−105,800−100.0%Sold out
Blair William & Co0$00.00%−60,302−100.0%Sold out
Ritholtz Wealth Management0$00.00%−41,774−100.0%Sold out
Bank of America Corp0$00.00%−35,230−100.0%Sold out
Virtu Financial LLC0$00.00%−19,295−100.0%Sold out