Spyre Therapeutics, Inc.
SYRE- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001636282
In the last 90 days, Spyre Therapeutics, Inc. insiders filed 0 open-market purchases and 9 sales; 265 institutions reported holding it in 13F filings for Q2 2026, worth $8.52B in total; no superinvestor holds it.
13F holders, Q3 2021
Institutional positions in Spyre Therapeutics, Inc. as of Sep 30, 2021. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 77
- 0 vs. Q2 2021
- Shares held
- 40.6M
- +2.04M (+5.3%) vs. Q2 2021
- Total value
- $322.5M
- +$54.3M (+20.2%) vs. Q2 2021
- New holders
- 10
- 24 more added
- Sold out
- 10
- 23 more reduced
1 institution that held it in Q2 2021 haven't filed for Q3 2021 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q2 2021: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SYRE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 265 | $8.52B |
| Q1 2026 | 198 | $4.16B |
| Q4 2025 | 153 | $2.65B |
| Q3 2025 | 137 | $1.08B |
| Q2 2025 | 129 | $952.6M |
| Q1 2025 | 129 | $1.00B |
| Q4 2024 | 131 | $1.39B |
| Q3 2024 | 119 | $1.51B |
| Q2 2024 | 107 | $1.18B |
| Q1 2024 | 103 | $1.21B |
| Q4 2023 | 54 | $601.0M |
| Q3 2023 | 29 | $43.9M |
| Q2 2023 | 44 | $31.9M |
| Q1 2023 | 45 | $12.0M |
| Q4 2022 | 51 | $19.2M |
| Q3 2022 | 55 | $23.5M |
| Q2 2022 | 67 | $24.8M |
| Q1 2022 | 84 | $95.4M |
| Q4 2021 | 86 | $189.4M |
| Q3 2021 | 77 | $322.5M |
| Q2 2021 | 78 | $285.8M |
| Q1 2021 | 84 | $328.7M |
Institutions, Q3 2021
Shares, value and share of portfolio for each institution holding Spyre Therapeutics, Inc.; share changes are against Q2 2021.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| OrbiMed Advisors LLC | 4,015,524 | $31.9M | 0.35% | 00.0% | Unchanged |
| Adage Capital Partners GP, L.L.C. | 3,500,000 | $27.8M | 0.05% | +450,419+14.8% | Added |
| Baker Bros. Advisors LP | 3,410,106 | $27.1M | 0.12% | 00.0% | Unchanged |
| BlackRock Inc. | 2,983,895 | $23.7M | 0.00% | −119,984−3.9% | Reduced |
| Bain Capital Life Sciences Investors, LLC | 2,847,689 | $22.6M | 1.40% | +147,689+5.5% | Added |
| Pictet Asset Management SA | 2,532,799 | $20.1M | 0.02% | +2,532,799 | New |
| Suvretta Capital Management, LLC | 2,157,727 | $17.2M | 0.29% | +63,627+3.0% | Added |
| Vanguard Group Inc | 2,108,760 | $16.8M | 0.00% | +11,594+0.6% | Added |
| Aisling Capital Management LP | 1,691,151 | $13.4M | 2.68% | 00.0% | Unchanged |
| Rock Springs Capital Management LP | 1,577,296 | $12.5M | 0.26% | 00.0% | Unchanged |
| Nantahala Capital Management, LLC | 1,516,955 | $12.1M | 0.71% | −160,081−9.5% | Reduced |
| Goldman Sachs Group Inc | 1,136,050 | $9.03M | 0.00% | +4,991+0.4% | Added |
| Artal Group S.A. | 1,045,000 | $8.31M | 0.20% | 00.0% | Unchanged |
| Great Point Partners LLC | 900,000 | $7.16M | 1.69% | 00.0% | Unchanged |
| Samsara BioCapital, LLC | 883,720 | $7.03M | 1.17% | 00.0% | Unchanged |
| State Street Corp | 766,941 | $6.10M | 0.00% | +9,441+1.2% | Added |
| Geode Capital Management, LLC | 689,997 | $5.49M | 0.00% | +12,271+1.8% | Added |
| Dimensional Fund Advisors LP | 632,833 | $5.03M | 0.00% | +28,721+4.8% | Added |
| Altium Capital Management LP | 609,689 | $4.85M | 1.29% | 00.0% | Unchanged |
| Laurion Capital Management LP | 606,638 | $4.82M | 0.07% | +606,638 | New |
| Millennium Management LLC | 535,222 | $4.25M | 0.01% | −7,963−1.5% | Reduced |
| Sio Capital Management, LLC | 446,000 | $3.55M | 1.14% | +43,347+10.8% | Added |
| AXA S.A. | 439,667 | $3.50M | 0.01% | +15,315+3.6% | Added |
| Northern Trust Corp | 365,703 | $2.91M | 0.00% | −2,637−0.7% | Reduced |
| Marshall Wace, LLP | 315,823 | $2.51M | 0.01% | −335,580−51.5% | Reduced |
| Lion Point Capital, LP | 300,000 | $2.38M | 0.63% | 00.0% | Unchanged |
| Assenagon Asset Management S.A. | 267,066 | $2.12M | 0.01% | −15,002−5.3% | Reduced |
| University of Texas/Texas Am Investment Managment Co | 245,678 | $1.95M | 1.12% | −23,900−8.9% | Reduced |
| Abingworth LLP | 240,500 | $1.91M | 0.43% | 00.0% | Unchanged |
| Morgan Stanley | 194,225 | $1.54M | 0.00% | −1,310−0.7% | Reduced |
| Nuveen Asset Management, LLC | 179,642 | $1.34M | 0.00% | −4,629−2.5% | Reduced |
| Bank of New York Mellon Corp | 159,488 | $1.27M | 0.00% | +12,087+8.2% | Added |
| Fan Yu | 112,044 | $891.0K | 15.31% | 00.0% | Unchanged |
| AlphaCentric Advisors LLC | 110,000 | $875.0K | 0.22% | +17,500+18.9% | Added |
| Franklin Street Advisors Inc | 103,600 | $824.0K | 0.07% | 00.0% | Unchanged |
| Renaissance Technologies LLC | 100,300 | $797.0K | 0.00% | +49,513+97.5% | Added |
| Charles Schwab Investment Management Inc | 99,477 | $791.0K | 0.00% | −6,302−6.0% | Reduced |
| Ritholtz Wealth Management | 76,490 | $608.0K | 0.04% | −98,156−56.2% | Reduced |
| UBS Group AG | 54,220 | $431.0K | 0.00% | +2,143+4.1% | Added |
| Rhumbline Advisers | 54,143 | $430.0K | 0.00% | +1,476+2.8% | Added |
| Blair William & Co | 52,204 | $415.0K | 0.00% | 00.0% | Unchanged |
| Parametric Portfolio Associates LLC | 45,106 | $359.0K | 0.00% | +11,958+36.1% | Added |
| Algert Global LLC | 36,804 | $293.0K | 0.04% | −4,696−11.3% | Reduced |
| D. E. Shaw & Co., Inc. | 28,503 | $227.0K | 0.00% | −17,478−38.0% | Reduced |
| SG Americas Securities, LLC | 28,578 | $227.0K | 0.00% | +28,578 | New |
| Alliancebernstein L.P. | 25,600 | $204.0K | 0.00% | 00.0% | Unchanged |
| Bank of America Corp | 25,639 | $204.0K | 0.00% | +5,423+26.8% | Added |
| Manufacturers Life Insurance Company, The | 25,323 | $201.0K | 0.00% | −1,200−4.5% | Reduced |
| Deutsche Bank AG | 23,243 | $185.0K | 0.00% | −750−3.1% | Reduced |
| American International Group, Inc. | 22,120 | $176.0K | 0.00% | −525−2.3% | Reduced |
| California State Teachers Retirement System | 21,698 | $172.0K | 0.00% | −34,163−61.2% | Reduced |
| Voya Investment Management LLC | 19,878 | $158.0K | 0.00% | 00.0% | Unchanged |
| JPMorgan Chase & Co | 19,187 | $152.0K | 0.00% | −68,446−78.1% | Reduced |
| New York State Common Retirement Fund | 17,079 | $136.0K | 0.00% | −14,405−45.8% | Reduced |
| Barclays PLC | 16,524 | $131.0K | 0.00% | +10,856+191.5% | Added |
| ProShare Advisors LLC | 15,658 | $124.0K | 0.00% | −3,635−18.8% | Reduced |
| MetLife Investment Management | 15,353 | $122.1K | 0.00% | +15,353 | New |
| Invesco Ltd. | 14,726 | $117.0K | 0.00% | +1,681+12.9% | Added |
| HighVista Strategies LLC | 13,137 | $105.0K | 0.07% | +13,137 | New |
| Metropolitan Life Insurance Co | 11,616 | $92.3K | 0.00% | +11,616 | New |
| Gsa Capital Partners LLP | 11,242 | $89.0K | 0.01% | +11,242 | New |
| Susquehanna International Group, LLP | 11,192 | $89.0K | 0.00% | +11,192 | New |
| Personal Cfo Solutions, LLC | 10,888 | $87.0K | 0.02% | −500−4.4% | Reduced |
| BNP Paribas Arbitrage, SA | 10,756 | $85.5K | 0.00% | +6,051+128.6% | Added |
| Lazard Asset Management LLC | 8,801 | $69.0K | 0.00% | +8,801 | New |
| Citigroup Inc | 7,133 | $57.0K | 0.00% | +2,150+43.1% | Added |
| Royal Bank of Canada | 5,468 | $44.0K | 0.00% | +2,502+84.4% | Added |
| Ameritas Investment Partners, Inc. | 3,710 | $29.0K | 0.00% | 00.0% | Unchanged |
| Legal & General Group Plc | 3,264 | $26.0K | 0.00% | 00.0% | Unchanged |
| Tower Research Capital LLC (TRC) | 3,250 | $26.0K | 0.00% | +229+7.6% | Added |
| IFP Advisors, Inc | 2,980 | $24.0K | 0.00% | −1,000−25.1% | Reduced |
| Russell Investments Group, Ltd. | 3,008 | $23.0K | 0.00% | −21,027−87.5% | Reduced |
| Wells Fargo & Company | 2,212 | $18.0K | 0.00% | 00.0% | Unchanged |
| Quadrant Capital Group LLC | 1,137 | $9.00K | 0.00% | 00.0% | Unchanged |
| Penserra Capital Management LLC | 1,120 | $8.00K | 0.00% | +5+0.4% | Added |
| Daiwa Securities Group Inc. | 98 | $1.00K | 0.00% | 00.0% | Unchanged |
| Berman Capital Advisors, LLC | 56 | $0 | 0.00% | +56 | New |
| Boxer Capital, LLC | 0 | $0 | 0.00% | −550,000−100.0% | Sold out |
| Point72 Asset Management, L.P. | 0 | $0 | 0.00% | −469,765−100.0% | Sold out |
| Jacobs Levy Equity Management, Inc | 0 | $0 | 0.00% | −59,294−100.0% | Sold out |
| Ergoteles LLC | 0 | $0 | 0.00% | −34,100−100.0% | Sold out |
| California Public Employees Retirement System | 0 | $0 | 0.00% | −20,841−100.0% | Sold out |
| Cerity Partners LLC | 0 | $0 | 0.00% | −18,000−100.0% | Sold out |
| Cubist Systematic Strategies, LLC | 0 | $0 | 0.00% | −11,722−100.0% | Sold out |
| O'Shaughnessy Asset Management, LLC | 0 | $0 | 0.00% | −1,654−100.0% | Sold out |
| Group One Trading, L.P. | 0 | $0 | 0.00% | −300−100.0% | Sold out |
| Ellevest, Inc. | 0 | $0 | 0.00% | −150−100.0% | Sold out |
| Pictet Asset Management Ltd | – | – | – | – | Not filed |