Spyre Therapeutics, Inc.
SYRE- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001636282
In the last 90 days, Spyre Therapeutics, Inc. insiders filed 0 open-market purchases and 9 sales; 265 institutions reported holding it in 13F filings for Q2 2026, worth $8.52B in total; no superinvestor holds it.
13F holders, Q1 2024
Institutional positions in Spyre Therapeutics, Inc. as of Mar 31, 2024. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 103
- +49 vs. Q4 2023
- Shares held
- 32.4M
- +4.37M (+15.6%) vs. Q4 2023
- Total value
- $1.21B
- +$612.4M (+101.9%) vs. Q4 2023
- New holders
- 55
- 20 more added
- Sold out
- 6
- 15 more reduced
Compare with Q4 2023: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SYRE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 265 | $8.52B |
| Q1 2026 | 198 | $4.16B |
| Q4 2025 | 153 | $2.65B |
| Q3 2025 | 137 | $1.08B |
| Q2 2025 | 129 | $952.6M |
| Q1 2025 | 129 | $1.00B |
| Q4 2024 | 131 | $1.39B |
| Q3 2024 | 119 | $1.51B |
| Q2 2024 | 107 | $1.18B |
| Q1 2024 | 103 | $1.21B |
| Q4 2023 | 54 | $601.0M |
| Q3 2023 | 29 | $43.9M |
| Q2 2023 | 44 | $31.9M |
| Q1 2023 | 45 | $12.0M |
| Q4 2022 | 51 | $19.2M |
| Q3 2022 | 55 | $23.5M |
| Q2 2022 | 67 | $24.8M |
| Q1 2022 | 84 | $95.4M |
| Q4 2021 | 86 | $189.4M |
| Q3 2021 | 77 | $322.5M |
| Q2 2021 | 78 | $285.8M |
| Q1 2021 | 84 | $328.7M |
Institutions, Q1 2024
Shares, value and share of portfolio for each institution holding Spyre Therapeutics, Inc.; share changes are against Q4 2023.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| FMR LLC | 6,583,755 | $246.6M | 0.02% | +2,797,878+73.9% | Added |
| Perceptive Advisors LLC | 2,556,679 | $97.0M | 1.71% | −50,000−1.9% | Reduced |
| RTW Investments, LP | 2,232,760 | $84.7M | 1.25% | 00.0% | Unchanged |
| VR Adviser, LLC | 2,171,782 | $82.4M | 3.92% | −200,932−8.5% | Reduced |
| Commodore Capital LP | 1,884,084 | $71.5M | 4.78% | 00.0% | Unchanged |
| Avoro Capital Advisors LLC | 1,839,138 | $69.8M | 0.81% | 00.0% | Unchanged |
| Deep Track Capital, LP | 1,213,420 | $46.0M | 1.32% | −739,340−37.9% | Reduced |
| Adage Capital Partners GP, L.L.C. | 1,105,200 | $41.9M | 0.08% | +105,200+10.5% | Added |
| Wellington Management Group LLP | 812,860 | $30.8M | 0.01% | +177,405+27.9% | Added |
| Franklin Resources Inc | 741,904 | $28.1M | 0.01% | +54,814+8.0% | Added |
| Citadel Advisors LLC | 707,590 | $26.8M | 0.03% | +130,879+22.7% | Added |
| Driehaus Capital Management LLC | 687,080 | $26.1M | 0.26% | −84,822−11.0% | Reduced |
| BlackRock Inc. | 556,691 | $21.1M | 0.00% | +536,929+2,717.0% | Added |
| Braidwell LP | 515,000 | $19.5M | 0.63% | 00.0% | Unchanged |
| Polar Capital Holdings Plc | 500,000 | $19.0M | 0.11% | 00.0% | Unchanged |
| Vanguard Group Inc | 497,181 | $18.9M | 0.00% | +457,735+1,160.4% | Added |
| Darwin Global Management, Ltd. | 473,200 | $17.9M | 2.39% | +473,200 | New |
| Farallon Capital Management, L.L.C. | 466,000 | $17.7M | 0.10% | +466,000 | New |
| First Turn Management, LLC | 464,435 | $17.6M | 2.64% | +464,435 | New |
| Fan Yu | 737,000 | $16.4M | 22.68% | +737,000 | New |
| Affinity Asset Advisors, LLC | 410,000 | $15.6M | 2.53% | −107,554−20.8% | Reduced |
| Fairmount Funds Management LLC | 378,421 | $14.4M | 1.56% | 00.0% | Unchanged |
| Geode Capital Management, LLC | 330,225 | $12.5M | 0.00% | +299,899+988.9% | Added |
| Millennium Management LLC | 319,563 | $12.1M | 0.01% | +211,077+194.6% | Added |
| Cormorant Asset Management, LP | 250,000 | $9.48M | 0.42% | −687,080−73.3% | Reduced |
| Boxer Capital, LLC | 250,000 | $9.48M | 0.47% | 00.0% | Unchanged |
| Logos Global Management LP | 250,000 | $9.48M | 1.00% | +100,000+66.7% | Added |
| Goldman Sachs Group Inc | 239,915 | $9.10M | 0.00% | +239,915 | New |
| Voloridge Investment Management, LLC | 188,053 | $7.13M | 0.03% | +188,053 | New |
| Suvretta Capital Management, LLC | 162,395 | $6.16M | 0.26% | 00.0% | Unchanged |
| Marshall Wace, LLP | 161,921 | $6.14M | 0.01% | +141,669+699.5% | Added |
| HighVista Strategies LLC | 154,381 | $5.86M | 2.09% | −423,235−73.3% | Reduced |
| Invesco Ltd. | 152,578 | $5.79M | 0.00% | +152,578 | New |
| State Street Corp | 134,426 | $5.10M | 0.00% | +134,426 | New |
| Great Point Partners LLC | 125,000 | $4.74M | 0.74% | 00.0% | Unchanged |
| Walleye Capital LLC | 111,478 | $4.23M | 0.05% | +111,478 | New |
| Candriam Luxembourg S.C.A. | 105,000 | $3.98M | 0.03% | +105,000 | New |
| Susquehanna International Group, LLP | 101,503 | $3.85M | 0.01% | +101,503 | New |
| Woodline Partners LP | 100,527 | $3.81M | 0.04% | +100,527 | New |
| Ghost Tree Capital, LLC | 100,000 | $3.79M | 1.22% | +100,000 | New |
| Integral Health Asset Management, LLC | 100,000 | $3.79M | 0.37% | +100,000 | New |
| Nicholas Investment Partners, LP | 89,962 | $3.41M | 0.35% | +89,962 | New |
| HRT Financial LP | 78,996 | $3.00M | 0.02% | +78,996 | New |
| Price T Rowe Associates Inc | 78,529 | $2.98M | 0.00% | +78,529 | New |
| Northern Trust Corp | 66,340 | $2.52M | 0.00% | +66,340 | New |
| Assenagon Asset Management S.A. | 64,400 | $2.44M | 0.01% | +64,400 | New |
| StemPoint Capital LP | 62,253 | $2.36M | 0.63% | −316,513−83.6% | Reduced |
| TD Asset Management Inc | 60,968 | $2.31M | 0.00% | +60,968 | New |
| Qube Research & Technologies Ltd | 57,678 | $2.19M | 0.00% | +57,678 | New |
| Morgan Stanley | 51,188 | $1.94M | 0.00% | +51,148+127,870.0% | Added |
| ADAR1 Capital Management, LLC | 49,500 | $1.88M | 0.51% | +43,060+668.6% | Added |
| Renaissance Technologies LLC | 49,468 | $1.88M | 0.00% | +932+1.9% | Added |
| Cubist Systematic Strategies, LLC | 49,303 | $1.87M | 0.02% | +23,153+88.5% | Added |
| Barclays PLC | 45,962 | $1.74M | 0.00% | +464+1.0% | Added |
| Swiss National Bank | 39,100 | $1.48M | 0.00% | +39,100 | New |
| Bank of America Corp | 36,332 | $1.38M | 0.00% | +36,332 | New |
| Schonfeld Strategic Advisors LLC | 35,500 | $1.35M | 0.01% | +35,500 | New |
| NBW Capital LLC | 34,360 | $1.30M | 0.27% | +34,360 | New |
| Balyasny Asset Management LLC | 32,397 | $1.23M | 0.00% | +32,397 | New |
| Allianz Asset Management GmbH | 31,800 | $1.21M | 0.00% | +31,800 | New |
| Citigroup Inc | 31,757 | $1.20M | 0.00% | +21,460+208.4% | Added |
| Soros Fund Management LLCSuperinvestorSoros Fund Management | 30,038 | $1.14M | 0.03% | +30,038 | New |
| Manufacturers Life Insurance Company, The | 24,657 | $935.2K | 0.00% | +24,657 | New |
| ExodusPoint Capital Management, LP | 24,472 | $928.0K | 0.01% | −1,738−6.6% | Reduced |
| Jump Financial, LLC | 22,800 | $864.8K | 0.02% | +22,800 | New |
| Credit Suisse AG | 22,056 | $836.6K | 0.00% | +22,056 | New |
| Blackstone Group Inc. | 19,991 | $758.3K | 0.00% | 00.0% | Unchanged |
| Global Endowment Management, LP | 18,184 | $689.7K | 0.07% | −495,252−96.5% | Reduced |
| Fred Alger Management, LLC | 18,158 | $688.7K | 0.00% | +18,158 | New |
| EAM Investors, LLC | 17,938 | $680.4K | 0.11% | +17,938 | New |
| California State Teachers Retirement System | 17,803 | $675.3K | 0.00% | +17,803 | New |
| Legal & General Group Plc | 17,032 | $646.0K | 0.00% | +17,032 | New |
| Virtu Financial LLC | 16,213 | $615.0K | 0.05% | +16,213 | New |
| Engineers Gate Manager LP | 15,653 | $593.7K | 0.02% | +15,653 | New |
| Charles Schwab Investment Management Inc | 15,000 | $569.0K | 0.00% | +15,000 | New |
| New York State Common Retirement Fund | 14,670 | $556.4K | 0.00% | +14,305+3,919.2% | Added |
| State of Wisconsin Investment Board | 14,632 | $555.0K | 0.00% | +14,632 | New |
| Janus Henderson Group PLC | 13,977 | $530.5K | 0.00% | +13,977 | New |
| Two Sigma Investments, LP | 13,355 | $506.6K | 0.00% | −14,740−52.5% | Reduced |
| Scientech Research LLC | 13,143 | $498.5K | 0.26% | +13,143 | New |
| Legato Capital Management LLC | 11,458 | $434.6K | 0.05% | +11,458 | New |
| EFG Asset Management (North America) Corp. | 11,151 | $423.2K | 0.07% | +11,151 | New |
| LMR Partners LLP | 11,093 | $420.8K | 0.01% | +11,093 | New |
| Polymer Capital Management (HK) LTD | 10,520 | $399.0K | 0.10% | +10,520 | New |
| Carlyle Group Inc. | 9,620 | $364.8K | 0.02% | 00.0% | Unchanged |
| Squarepoint Ops LLC | 8,161 | $309.5K | 0.00% | +8,161 | New |
| Susquehanna Fundamental Investments, LLC | 8,075 | $306.3K | 0.01% | +8,075 | New |
| Jane Street Group, LLC | 7,210 | $273.5K | 0.00% | +7,210 | New |
| Chartwell Investment Partners, LLC | 6,835 | $259.0K | 0.01% | +6,835 | New |
| Bank of New York Mellon Corp | 6,050 | $229.5K | 0.00% | +6,050 | New |
| Virtus ETF Advisers LLC | 5,838 | $221.4K | 0.12% | −401−6.4% | Reduced |
| Arizona State Retirement System | 5,445 | $206.5K | 0.00% | +5,445 | New |
| Tower Research Capital LLC (TRC) | 3,828 | $145.2K | 0.00% | +1,248+48.4% | Added |
| UBS Group AG | 2,601 | $98.7K | 0.00% | −1,125−30.2% | Reduced |
| Wells Fargo & Company | 2,242 | $85.0K | 0.00% | +2,219+9,647.8% | Added |
| Deutsche Bank AG | 298 | $11.3K | 0.00% | +298 | New |
| IFP Advisors, Inc | 114 | $4.32K | 0.00% | 00.0% | Unchanged |
| Advisor Group Holdings, Inc. | 83 | $3.15K | 0.00% | −200−70.7% | Reduced |
| Royal Bank of Canada | 56 | $2.00K | 0.00% | +56 | New |
| Point72 (DIFC) Ltd | 22 | $847 | 0.00% | +22 | New |