Spyre Therapeutics, Inc.
SYRE- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001636282
In the last 90 days, Spyre Therapeutics, Inc. insiders filed 0 open-market purchases and 9 sales; 265 institutions reported holding it in 13F filings for Q2 2026, worth $8.52B in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in Spyre Therapeutics, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 153
- +16 vs. Q3 2025
- Shares held
- 81.0M
- +16.7M (+25.9%) vs. Q3 2025
- Total value
- $2.65B
- +$1.57B (+146.2%) vs. Q3 2025
- New holders
- 30
- 76 more added
- Sold out
- 14
- 27 more reduced
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SYRE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 265 | $8.52B |
| Q1 2026 | 198 | $4.16B |
| Q4 2025 | 153 | $2.65B |
| Q3 2025 | 137 | $1.08B |
| Q2 2025 | 129 | $952.6M |
| Q1 2025 | 129 | $1.00B |
| Q4 2024 | 131 | $1.39B |
| Q3 2024 | 119 | $1.51B |
| Q2 2024 | 107 | $1.18B |
| Q1 2024 | 103 | $1.21B |
| Q4 2023 | 54 | $601.0M |
| Q3 2023 | 29 | $43.9M |
| Q2 2023 | 44 | $31.9M |
| Q1 2023 | 45 | $12.0M |
| Q4 2022 | 51 | $19.2M |
| Q3 2022 | 55 | $23.5M |
| Q2 2022 | 67 | $24.8M |
| Q1 2022 | 84 | $95.4M |
| Q4 2021 | 86 | $189.4M |
| Q3 2021 | 77 | $322.5M |
| Q2 2021 | 78 | $285.8M |
| Q1 2021 | 84 | $328.7M |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Spyre Therapeutics, Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| FMR LLC | 11,638,819 | $381.3M | 0.02% | +2,578,675+28.5% | Added |
| BlackRock, Inc. | 5,522,101 | $180.9M | 0.00% | +1,539,357+38.7% | Added |
| RTW Investments, LP | 4,171,996 | $136.7M | 1.37% | +550,000+15.2% | Added |
| Vanguard Group Inc | 4,035,074 | $132.2M | 0.00% | +984,344+32.3% | Added |
| Fairmount Funds Management LLC | 4,018,101 | $131.6M | 10.02% | 00.0% | Unchanged |
| VR Adviser, LLC | 3,685,448 | $120.7M | 5.96% | +1,000,000+37.2% | Added |
| Capital International Investors | 3,492,541 | $114.4M | 0.02% | +1,100,000+46.0% | Added |
| Perceptive Advisors LLC | 3,069,225 | $100.5M | 1.84% | +1,839,780+149.6% | Added |
| Driehaus Capital Management LLC | 2,882,420 | $94.4M | 0.64% | +822,045+39.9% | Added |
| Commodore Capital LP | 2,388,245 | $78.2M | 5.21% | +400,161+20.1% | Added |
| State Street Corp | 2,262,839 | $74.1M | 0.00% | +477,633+26.8% | Added |
| TCG Crossover Management, LLC | 1,900,582 | $62.3M | 2.06% | +800,000+72.7% | Added |
| Tang Capital Management LLC | 1,892,200 | $62.0M | 3.06% | −1,307,800−40.9% | Reduced |
| Janus Henderson Group PLC | 1,829,009 | $59.9M | 0.03% | +1,816,009+13,969.3% | Added |
| Geode Capital Management, LLC | 1,659,140 | $54.4M | 0.00% | +433,987+35.4% | Added |
| Braidwell LP | 1,634,615 | $53.5M | 1.71% | −943,789−36.6% | Reduced |
| Ra Capital Management, L.P. | 1,621,620 | $53.1M | 0.54% | +1,621,620 | New |
| Price T Rowe Associates Inc | 1,601,882 | $52.5M | 0.01% | +981,262+158.1% | Added |
| Wellington Management Group LLP | 1,549,284 | $50.8M | 0.01% | −91,028−5.5% | Reduced |
| Paradigm Biocapital Advisors LP | 1,467,266 | $48.1M | 1.29% | 00.0% | Unchanged |
| Remedium Capital Partners, LLC | 1,456,231 | $47.7M | 28.03% | +1,456,231 | New |
| Affinity Asset Advisors, LLC | 1,432,591 | $46.9M | 3.37% | +13,292+0.9% | Added |
| Franklin Resources Inc | 1,109,274 | $36.3M | 0.01% | +313,999+39.5% | Added |
| Baker Bros. Advisors LP | 1,000,000 | $32.8M | 0.19% | 00.0% | Unchanged |
| Pictet Asset Management Holding SA | 913,960 | $29.9M | 0.03% | −122,258−11.8% | Reduced |
| Siren, L.L.C. | 818,598 | $26.8M | 0.80% | +450,000+122.1% | Added |
| Polar Capital Holdings Plc | 740,326 | $24.3M | 0.11% | −48,462−6.1% | Reduced |
| Deerfield Management Company, L.P. (Series C) | 710,626 | $23.3M | 0.30% | +96,961+15.8% | Added |
| UBS Group AG | 680,566 | $22.3M | 0.00% | +294,977+76.5% | Added |
| Point72 Asset Management, L.P. | 662,351 | $21.7M | 0.03% | +662,351 | New |
| Emerald Advisers, LLC | 636,109 | $20.8M | 0.64% | +87,397+15.9% | Added |
| Charles Schwab Investment Management Inc | 574,622 | $18.8M | 0.00% | +149,277+35.1% | Added |
| Northern Trust Corp | 561,023 | $18.4M | 0.00% | +118,987+26.9% | Added |
| Blackstone Group Inc. | 500,998 | $16.4M | 0.07% | 00.0% | Unchanged |
| Candriam Luxembourg S.C.A. | 425,534 | $13.9M | 0.07% | +21,172+5.2% | Added |
| Bank of America Corp | 419,727 | $13.8M | 0.00% | +74,924+21.7% | Added |
| Emerald Mutual Fund Advisers Trust | 412,371 | $13.5M | 0.66% | +104,159+33.8% | Added |
| Goldman Sachs Group Inc | 275,065 | $9.01M | 0.00% | −54,468−16.5% | Reduced |
| Woodline Partners LP | 265,892 | $8.71M | 0.03% | +134,016+101.6% | Added |
| Capital World Investors | 200,172 | $6.56M | 0.00% | 00.0% | Unchanged |
| Armistice Capital, LLC | 196,426 | $6.43M | 0.16% | +40,426+25.9% | Added |
| Bank of New York Mellon Corp | 192,830 | $6.32M | 0.00% | +56,870+41.8% | Added |
| HighVista Strategies LLC | 188,206 | $6.17M | 1.59% | −27,540−12.8% | Reduced |
| Silverarc Capital Management, LLC | 187,737 | $6.15M | 0.89% | +187,737 | New |
| Morgan Stanley | 182,734 | $5.99M | 0.00% | −151,988−45.4% | Reduced |
| Barclays PLC | 182,524 | $5.98M | 0.00% | +14,194+8.4% | Added |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 171,211 | $5.61M | 0.01% | +60,755+55.0% | Added |
| Nuveen, LLC | 150,980 | $4.95M | 0.00% | +54,808+57.0% | Added |
| Invesco Ltd. | 150,934 | $4.94M | 0.00% | +100,232+197.7% | Added |
| Patient Square Capital LP | 150,000 | $4.91M | 1.05% | +150,000 | New |
| TD Asset Management Inc | 149,822 | $4.91M | 0.00% | +77,454+107.0% | Added |
| Victory Capital Management Inc | 146,079 | $4.79M | 0.00% | −180,002−55.2% | Reduced |
| Manufacturers Life Insurance Company, The | 129,013 | $4.14M | 0.00% | +57,065+79.3% | Added |
| Parkman Healthcare Partners LLC | 124,485 | $4.08M | 0.39% | −76,268−38.0% | Reduced |
| Deutsche Bank AG | 121,941 | $3.99M | 0.00% | +83,398+216.4% | Added |
| Mercer Global Advisors Inc | 106,316 | $3.48M | 0.01% | −348−0.3% | Reduced |
| F/M Investments LLC | 103,718 | $3.40M | 0.13% | +48,825+88.9% | Added |
| Citigroup Inc | 100,058 | $3.28M | 0.00% | +67,162+204.2% | Added |
| B Group, Inc. | 100,000 | $3.28M | 2.43% | 00.0% | Unchanged |
| Seven Grand Managers, LLC | 100,000 | $3.28M | 0.25% | +100,000 | New |
| Swiss National Bank | 96,500 | $3.16M | 0.00% | +26,300+37.5% | Added |
| Rhumbline Advisers | 82,956 | $2.72M | 0.00% | +12,042+17.0% | Added |
| Wells Fargo & Company | 82,416 | $2.70M | 0.00% | +43,097+109.6% | Added |
| Dimensional Fund Advisors LP | 77,290 | $2.53M | 0.00% | −6,926−8.2% | Reduced |
| Millennium Management LLC | 76,194 | $2.50M | 0.00% | −332,005−81.3% | Reduced |
| Balyasny Asset Management LLC | 73,465 | $2.41M | 0.00% | +73,465 | New |
| Alliancebernstein L.P. | 67,500 | $2.21M | 0.00% | +31,270+86.3% | Added |
| Citadel Advisors LLC | 63,904 | $2.09M | 0.00% | +63,904 | New |
| Alps Advisors Inc | 63,708 | $2.09M | 0.01% | +63,708 | New |
| JPMorgan Chase & Co | 62,951 | $2.06M | 0.00% | −213,033−77.2% | Reduced |
| UBS Asset Management Americas Inc | 62,216 | $2.04M | 0.00% | +22,718+57.5% | Added |
| Schroder Investment Management Group | 61,574 | $1.96M | 0.00% | −46,164−42.8% | Reduced |
| Legal & General Group Plc | 56,448 | $1.85M | 0.00% | +9,607+20.5% | Added |
| Rafferty Asset Management, LLC | 53,410 | $1.75M | 0.01% | −6,257−10.5% | Reduced |
| Susquehanna Portfolio Strategies, LLC | 53,101 | $1.74M | 0.03% | +31,362+144.3% | Added |
| California State Teachers Retirement System | 48,038 | $1.57M | 0.00% | +14,835+44.7% | Added |
| Ameriprise Financial Inc | 38,256 | $1.25M | 0.00% | +38,256 | New |
| MetLife Investment Management | 38,011 | $1.25M | 0.01% | +8,093+27.1% | Added |
| ExodusPoint Capital Management, LP | 37,871 | $1.24M | 0.01% | −30,692−44.8% | Reduced |
| Cinctive Capital Management LP | 35,935 | $1.18M | 0.07% | +35,935 | New |
| Mirae Asset Global ETFs Holdings Ltd. | 35,144 | $1.15M | 0.00% | +8,696+32.9% | Added |
| ADAR1 Capital Management, LLC | 34,051 | $1.12M | 0.08% | 00.0% | Unchanged |
| StemPoint Capital LP | 32,377 | $1.06M | 0.18% | +32,377 | New |
| Voya Investment Management LLC | 27,277 | $893.6K | 0.00% | +27,277 | New |
| State of Wisconsin Investment Board | 27,252 | $892.8K | 0.00% | −6,294−18.8% | Reduced |
| Warren Averett Asset Management, LLC | 25,954 | $850.3K | 0.01% | +10.0% | Added |
| Teachers Retirement System of the State of Kentucky | 25,799 | $845.0K | 0.01% | 00.0% | Unchanged |
| Optimize Financial Inc | 25,331 | $829.8K | 0.42% | +364+1.5% | Added |
| Virginia Retirement Systems Et Al | 24,950 | $817.4K | 0.00% | +6,450+34.9% | Added |
| SG Americas Securities, LLC | 23,343 | $765.0K | 0.00% | +23,343 | New |
| Assenagon Asset Management S.A. | 22,136 | $725.2K | 0.00% | 00.0% | Unchanged |
| Profund Advisors LLC | 20,593 | $674.6K | 0.02% | +7,370+55.7% | Added |
| New York State Common Retirement Fund | 19,165 | $627.8K | 0.00% | +2,600+15.7% | Added |
| Police & Firemen's Retirement System of New Jersey | 18,360 | $601.5K | 0.01% | +4,551+33.0% | Added |
| Intech Investment Management LLC | 18,274 | $598.7K | 0.01% | −2,086−10.2% | Reduced |
| Neo Ivy Capital Management | 18,261 | $598.2K | 0.09% | +18,261 | New |
| Global Endowment Management, LP | 18,184 | $596.0K | 0.07% | 00.0% | Unchanged |
| AQR Capital Management LLC | 17,820 | $583.8K | 0.00% | +773+4.5% | Added |
| State of New Jersey Common Pension Fund D | 16,698 | $547.0K | 0.00% | +16,698 | New |
| ProShare Advisors LLC | 15,989 | $523.8K | 0.00% | +5,311+49.7% | Added |