Spyre Therapeutics, Inc.
SYRE- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001636282
In the last 90 days, Spyre Therapeutics, Inc. insiders filed 0 open-market purchases and 9 sales; 265 institutions reported holding it in 13F filings for Q2 2026, worth $8.52B in total; no superinvestor holds it.
13F holders, Q3 2024
Institutional positions in Spyre Therapeutics, Inc. as of Sep 30, 2024. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 119
- +13 vs. Q2 2024
- Shares held
- 51.4M
- +3.40M (+7.1%) vs. Q2 2024
- Total value
- $1.51B
- +$384.1M (+34.1%) vs. Q2 2024
- New holders
- 31
- 42 more added
- Sold out
- 18
- 24 more reduced
1 institution that held it in Q2 2024 haven't filed for Q3 2024 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q2 2024: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SYRE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 265 | $8.52B |
| Q1 2026 | 198 | $4.16B |
| Q4 2025 | 153 | $2.65B |
| Q3 2025 | 137 | $1.08B |
| Q2 2025 | 129 | $952.6M |
| Q1 2025 | 129 | $1.00B |
| Q4 2024 | 131 | $1.39B |
| Q3 2024 | 119 | $1.51B |
| Q2 2024 | 107 | $1.18B |
| Q1 2024 | 103 | $1.21B |
| Q4 2023 | 54 | $601.0M |
| Q3 2023 | 29 | $43.9M |
| Q2 2023 | 44 | $31.9M |
| Q1 2023 | 45 | $12.0M |
| Q4 2022 | 51 | $19.2M |
| Q3 2022 | 55 | $23.5M |
| Q2 2022 | 67 | $24.8M |
| Q1 2022 | 84 | $95.4M |
| Q4 2021 | 86 | $189.4M |
| Q3 2021 | 77 | $322.5M |
| Q2 2021 | 78 | $285.8M |
| Q1 2021 | 84 | $328.7M |
Institutions, Q3 2024
Shares, value and share of portfolio for each institution holding Spyre Therapeutics, Inc.; share changes are against Q2 2024.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| FMR LLC | 7,623,881 | $224.2M | 0.01% | +115,898+1.5% | Added |
| Fairmount Funds Management LLC | 4,018,101 | $118.2M | 9.58% | 00.0% | Unchanged |
| RTW Investments, LP | 3,258,360 | $95.8M | 1.39% | 00.0% | Unchanged |
| Perceptive Advisors LLC | 2,872,547 | $84.5M | 1.81% | −158,471−5.2% | Reduced |
| VR Adviser, LLC | 2,685,448 | $79.0M | 4.14% | 00.0% | Unchanged |
| BlackRock, Inc. | 2,663,147 | $78.3M | 0.00% | +2,663,147 | New |
| Vanguard Group Inc | 2,515,920 | $74.0M | 0.00% | +604,354+31.6% | Added |
| Braidwell LP | 2,189,836 | $64.4M | 1.83% | −324,702−12.9% | Reduced |
| Commodore Capital LP | 1,988,084 | $58.5M | 3.65% | 00.0% | Unchanged |
| State Street Corp | 1,541,555 | $45.3M | 0.00% | +131,896+9.4% | Added |
| Wellington Management Group LLP | 1,507,200 | $44.3M | 0.01% | +711,254+89.4% | Added |
| Paradigm Biocapital Advisors LP | 1,267,581 | $37.3M | 1.30% | +1,267,581 | New |
| Assenagon Asset Management S.A. | 1,142,768 | $33.6M | 0.07% | +1,142,768 | New |
| Janus Henderson Group PLC | 1,120,531 | $32.9M | 0.02% | +446,664+66.3% | Added |
| Adage Capital Partners GP, L.L.C. | 1,055,000 | $31.0M | 0.05% | −97,411−8.5% | Reduced |
| Deep Track Capital, LP | 1,000,000 | $29.4M | 0.94% | −756,667−43.1% | Reduced |
| Geode Capital Management, LLC | 891,048 | $26.2M | 0.00% | +125,214+16.4% | Added |
| Pictet Asset Management Holding SA | 825,706 | $24.3M | 0.03% | +439,089+113.6% | Added |
| Franklin Resources Inc | 760,666 | $23.3M | 0.01% | +18,762+2.5% | Added |
| Citadel Advisors LLC | 707,586 | $20.8M | 0.02% | 00.0% | Unchanged |
| Boxer Capital, LLC | 696,480 | $20.5M | 1.01% | 00.0% | Unchanged |
| Driehaus Capital Management LLC | 687,080 | $20.2M | 0.17% | 00.0% | Unchanged |
| Avoro Capital Advisors LLC | 598,600 | $17.6M | 0.26% | −1,240,538−67.5% | Reduced |
| Polar Capital Holdings Plc | 500,000 | $14.7M | 0.09% | 00.0% | Unchanged |
| Affinity Asset Advisors, LLC | 498,420 | $14.7M | 2.27% | −15,000−2.9% | Reduced |
| Jefferies Financial Group Inc. | 454,807 | $13.4M | 0.22% | +357,234+366.1% | Added |
| Price T Rowe Associates Inc | 429,127 | $12.6M | 0.00% | +121,151+39.3% | Added |
| Charles Schwab Investment Management Inc | 333,275 | $9.80M | 0.00% | +235,094+239.4% | Added |
| Northern Trust Corp | 314,290 | $9.24M | 0.00% | +228,702+267.2% | Added |
| Ikarian Capital, LLC | 302,247 | $8.89M | 2.76% | +302,247 | New |
| Blackstone Group Inc. | 292,995 | $8.62M | 0.04% | 00.0% | Unchanged |
| Emerald Advisers, LLC | 292,569 | $8.60M | 0.33% | +292,569 | New |
| Woodline Partners LP | 264,256 | $7.77M | 0.07% | +1,640+0.6% | Added |
| Bank of America Corp | 257,797 | $7.58M | 0.00% | +66,628+34.9% | Added |
| Emerald Mutual Fund Advisers Trust | 253,550 | $7.46M | 0.39% | +253,550 | New |
| Morgan Stanley | 243,742 | $7.17M | 0.00% | −165,111−40.4% | Reduced |
| Walleye Capital LLC | 243,372 | $7.16M | 0.08% | +92,552+61.4% | Added |
| Balyasny Asset Management LLC | 227,950 | $6.70M | 0.02% | −44,686−16.4% | Reduced |
| Logos Global Management LP | 200,000 | $5.88M | 0.66% | −375,000−65.2% | Reduced |
| Goldman Sachs Group Inc | 169,314 | $4.98M | 0.00% | −723,769−81.0% | Reduced |
| Voloridge Investment Management, LLC | 156,481 | $4.60M | 0.02% | −118,745−43.1% | Reduced |
| Soros Fund Management LLCSuperinvestorSoros Fund Management | 145,000 | $4.26M | 0.09% | 00.0% | Unchanged |
| Invesco Ltd. | 137,858 | $4.05M | 0.00% | +121,494+742.4% | Added |
| Armistice Capital, LLC | 136,000 | $4.00M | 0.10% | 00.0% | Unchanged |
| Nuveen Asset Management, LLC | 125,290 | $3.68M | 0.00% | +8,150+7.0% | Added |
| Barclays PLC | 105,467 | $3.10M | 0.00% | +41,424+64.7% | Added |
| HighVista Strategies LLC | 105,351 | $3.10M | 1.07% | −8,199−7.2% | Reduced |
| Candriam Luxembourg S.C.A. | 105,000 | $3.09M | 0.02% | 00.0% | Unchanged |
| Bank of New York Mellon Corp | 104,806 | $3.08M | 0.00% | −12,880−10.9% | Reduced |
| Boothbay Fund Management, LLC | 91,775 | $2.70M | 0.09% | +91,775 | New |
| Ensign Peak Advisors, Inc | 82,475 | $2.43M | 0.00% | 00.0% | Unchanged |
| Rafferty Asset Management, LLC | 70,586 | $2.08M | 0.01% | +3,477+5.2% | Added |
| Cinctive Capital Management LP | 61,256 | $1.80M | 0.10% | +61,256 | New |
| Ghost Tree Capital, LLC | 60,000 | $1.76M | 0.60% | −190,237−76.0% | Reduced |
| UBS Group AG | 57,838 | $1.70M | 0.00% | +13,334+30.0% | Added |
| Rhumbline Advisers | 53,935 | $1.59M | 0.00% | +2,039+3.9% | Added |
| EFG Asset Management (North America) Corp. | 52,210 | $1.53M | 0.26% | +15,429+41.9% | Added |
| TD Asset Management Inc | 52,768 | $1.50M | 0.00% | +17,600+50.0% | Added |
| Swiss National Bank | 49,600 | $1.46M | 0.00% | +13,500+37.4% | Added |
| Schonfeld Strategic Advisors LLC | 46,072 | $1.35M | 0.01% | −32,428−41.3% | Reduced |
| Manufacturers Life Insurance Company, The | 43,460 | $1.28M | 0.00% | +5,678+15.0% | Added |
| Superstring Capital Management LP | 37,287 | $1.10M | 0.98% | −8,284−18.2% | Reduced |
| Alliancebernstein L.P. | 36,230 | $1.07M | 0.00% | 00.0% | Unchanged |
| AQR Capital Management LLC | 35,003 | $1.03M | 0.00% | +35,003 | New |
| Tudor Investment Corp Et Al | 31,138 | $915.8K | 0.01% | +31,138 | New |
| JPMorgan Chase & Co | 29,473 | $866.8K | 0.00% | +6,701+29.4% | Added |
| Legal & General Group Plc | 29,155 | $857.5K | 0.00% | +5,892+25.3% | Added |
| NBW Capital LLC | 26,930 | $792.0K | 0.15% | −7,430−21.6% | Reduced |
| UBS Asset Management Americas Inc | 26,441 | $777.6K | 0.00% | −3,680−12.2% | Reduced |
| Citigroup Inc | 25,191 | $740.9K | 0.00% | +5,871+30.4% | Added |
| California State Teachers Retirement System | 24,675 | $725.7K | 0.00% | +5,570+29.2% | Added |
| Mirae Asset Global ETFs Holdings Ltd. | 21,825 | $639.3K | 0.00% | +19,299+764.0% | Added |
| Deutsche Bank AG | 21,508 | $632.5K | 0.00% | +5,263+32.4% | Added |
| Teachers Retirement System of the State of Kentucky | 21,154 | $622.0K | 0.01% | +21,154 | New |
| Jane Street Group, LLC | 20,641 | $607.1K | 0.00% | +9,090+78.7% | Added |
| MetLife Investment Management | 20,132 | $592.1K | 0.00% | +11,344+129.1% | Added |
| Corebridge Financial, Inc. | 18,512 | $544.4K | 0.00% | −113−0.6% | Reduced |
| State of Wisconsin Investment Board | 18,315 | $538.6K | 0.00% | +4,383+31.5% | Added |
| Global Endowment Management, LP | 18,184 | $534.8K | 0.05% | 00.0% | Unchanged |
| Wells Fargo & Company | 17,810 | $523.8K | 0.00% | +635+3.7% | Added |
| Profund Advisors LLC | 14,075 | $413.9K | 0.02% | +1,469+11.7% | Added |
| Susquehanna International Group, LLP | 13,198 | $388.2K | 0.00% | +13,198 | New |
| SG Americas Securities, LLC | 12,589 | $370.0K | 0.00% | +7,044+127.0% | Added |
| ADAR1 Capital Management, LLC | 12,560 | $369.4K | 0.06% | −22,620−64.3% | Reduced |
| Voya Investment Management LLC | 11,351 | $333.8K | 0.00% | −256−2.2% | Reduced |
| New York State Common Retirement Fund | 10,265 | $301.9K | 0.00% | −4,100−28.5% | Reduced |
| Two Sigma Investments, LP | 9,803 | $288.3K | 0.00% | −39−0.4% | Reduced |
| ExodusPoint Capital Management, LP | 9,733 | $286.0K | 0.00% | +9,733 | New |
| Carlyle Group Inc. | 9,620 | $282.4K | 0.03% | 00.0% | Unchanged |
| State Board of Administration of Florida Retirement System | 9,030 | $265.6K | 0.00% | 00.0% | Unchanged |
| Squarepoint Ops LLC | 8,477 | $249.3K | 0.00% | +8,477 | New |
| Intech Investment Management LLC | 8,371 | $246.2K | 0.00% | +8,371 | New |
| Arizona State Retirement System | 7,310 | $215.0K | 0.00% | +7,310 | New |
| Quest Partners LLC | 5,654 | $166.3K | 0.01% | +4,131+271.2% | Added |
| Royal Bank of Canada | 3,786 | $111.0K | 0.00% | +530+16.3% | Added |
| Ameritas Investment Partners, Inc. | 3,392 | $99.8K | 0.00% | 00.0% | Unchanged |
| Virtus ETF Advisers LLC | 2,848 | $83.8K | 0.04% | +51+1.8% | Added |
| Public Employees Retirement Association of Colorado | 1,589 | $47.0K | 0.00% | +1,589 | New |
| Amalgamated Bank | 1,198 | $35.0K | 0.00% | 00.0% | Unchanged |
| Acadian Asset Management LLC | 814 | $23.0K | 0.00% | +814 | New |