Spyre Therapeutics, Inc.
SYRE- 交易所
- Nasdaq
- 產業
- Pharmaceutical Preparations
- SEC CIK
- 0001636282
近 90 天，Spyre Therapeutics, Inc. 內部人申報 0 筆公開市場買進、9 筆賣出；2026 年第 2 季末有 265 家機構在 13F 申報持有，市值合計 $85.2 億；沒有大師持有。
2024 年第 3 季 13F 持有人
Spyre Therapeutics, Inc. 在 2024/9/30 季末的機構持股。管理 1 億美元以上美股的機構，每季結束後 45 天內要用 13F 申報多頭部位。13F 是什麼
- 持有機構
- 119
- 較 2024 年第 2 季 +13 家
- 持有股數
- 5,138 萬
- 較 2024 年第 2 季 +339.6 萬 (+7.1%)
- 總市值
- $15.1 億
- 較 2024 年第 2 季 +$3.84 億 (+34.1%)
- 新進機構
- 31
- 另有 42 家加碼
- 清倉機構
- 18
- 另有 24 家減碼
另有 1 家機構在 2024 年第 2 季持有、還沒有申報 2024 年第 3 季 13F：沒申報不算清倉，也不計入上面的變化。
歷季持有家數與市值
2021 年第 1 季起，每季在 13F 申報持有 SYRE 的機構家數與合計市值。市值是各季季末的申報市值，也會跟著股價漲跌。
| 季度 | 家數 | 市值 |
|---|---|---|
| 2026 年第 2 季 | 265 | $85.2 億 |
| 2026 年第 1 季 | 198 | $41.6 億 |
| 2025 年第 4 季 | 153 | $26.5 億 |
| 2025 年第 3 季 | 137 | $10.8 億 |
| 2025 年第 2 季 | 129 | $9.53 億 |
| 2025 年第 1 季 | 129 | $10.0 億 |
| 2024 年第 4 季 | 131 | $13.9 億 |
| 2024 年第 3 季 | 119 | $15.1 億 |
| 2024 年第 2 季 | 107 | $11.8 億 |
| 2024 年第 1 季 | 103 | $12.1 億 |
| 2023 年第 4 季 | 54 | $6.01 億 |
| 2023 年第 3 季 | 29 | $4,387 萬 |
| 2023 年第 2 季 | 44 | $3,194 萬 |
| 2023 年第 1 季 | 45 | $1,198 萬 |
| 2022 年第 4 季 | 51 | $1,919 萬 |
| 2022 年第 3 季 | 55 | $2,352 萬 |
| 2022 年第 2 季 | 67 | $2,481 萬 |
| 2022 年第 1 季 | 84 | $9,538 萬 |
| 2021 年第 4 季 | 86 | $1.89 億 |
| 2021 年第 3 季 | 77 | $3.22 億 |
| 2021 年第 2 季 | 78 | $2.86 億 |
| 2021 年第 1 季 | 84 | $3.29 億 |
2024 年第 3 季持有機構
每家機構持有 Spyre Therapeutics, Inc. 的股數、市值與佔組合比重；股數變化跟 2024 年第 2 季比。
| 機構 | 股數 | 市值 | 佔組合 % | 股數變化 | 動作 |
|---|---|---|---|---|---|
| FMR LLC | 7,623,881 | $2.24 億 | 0.01% | +115,898+1.5% | 加碼 |
| Fairmount Funds Management LLC | 4,018,101 | $1.18 億 | 9.58% | 00.0% | 不變 |
| RTW Investments, LP | 3,258,360 | $9,583 萬 | 1.39% | 00.0% | 不變 |
| Perceptive Advisors LLC | 2,872,547 | $8,448 萬 | 1.81% | −158,471−5.2% | 減碼 |
| VR Adviser, LLC | 2,685,448 | $7,898 萬 | 4.14% | 00.0% | 不變 |
| BlackRock, Inc. | 2,663,147 | $7,832 萬 | 0.00% | +2,663,147 | 新進 |
| Vanguard Group Inc | 2,515,920 | $7,399 萬 | 0.00% | +604,354+31.6% | 加碼 |
| Braidwell LP | 2,189,836 | $6,440 萬 | 1.83% | −324,702−12.9% | 減碼 |
| Commodore Capital LP | 1,988,084 | $5,847 萬 | 3.65% | 00.0% | 不變 |
| State Street Corp | 1,541,555 | $4,534 萬 | 0.00% | +131,896+9.4% | 加碼 |
| Wellington Management Group LLP | 1,507,200 | $4,433 萬 | 0.01% | +711,254+89.4% | 加碼 |
| Paradigm Biocapital Advisors LP | 1,267,581 | $3,728 萬 | 1.30% | +1,267,581 | 新進 |
| Assenagon Asset Management S.A. | 1,142,768 | $3,361 萬 | 0.07% | +1,142,768 | 新進 |
| Janus Henderson Group PLC | 1,120,531 | $3,292 萬 | 0.02% | +446,664+66.3% | 加碼 |
| Adage Capital Partners GP, L.L.C. | 1,055,000 | $3,103 萬 | 0.05% | −97,411−8.5% | 減碼 |
| Deep Track Capital, LP | 1,000,000 | $2,941 萬 | 0.94% | −756,667−43.1% | 減碼 |
| Geode Capital Management, LLC | 891,048 | $2,621 萬 | 0.00% | +125,214+16.4% | 加碼 |
| Pictet Asset Management Holding SA | 825,706 | $2,428 萬 | 0.03% | +439,089+113.6% | 加碼 |
| Franklin Resources Inc | 760,666 | $2,332 萬 | 0.01% | +18,762+2.5% | 加碼 |
| Citadel Advisors LLC | 707,586 | $2,081 萬 | 0.02% | 00.0% | 不變 |
| Boxer Capital, LLC | 696,480 | $2,048 萬 | 1.01% | 00.0% | 不變 |
| Driehaus Capital Management LLC | 687,080 | $2,021 萬 | 0.17% | 00.0% | 不變 |
| Avoro Capital Advisors LLC | 598,600 | $1,760 萬 | 0.26% | −1,240,538−67.5% | 減碼 |
| Polar Capital Holdings Plc | 500,000 | $1,471 萬 | 0.09% | 00.0% | 不變 |
| Affinity Asset Advisors, LLC | 498,420 | $1,466 萬 | 2.27% | −15,000−2.9% | 減碼 |
| Jefferies Financial Group Inc. | 454,807 | $1,338 萬 | 0.22% | +357,234+366.1% | 加碼 |
| Price T Rowe Associates Inc | 429,127 | $1,262 萬 | 0.00% | +121,151+39.3% | 加碼 |
| Charles Schwab Investment Management Inc | 333,275 | $980.2 萬 | 0.00% | +235,094+239.4% | 加碼 |
| Northern Trust Corp | 314,290 | $924.3 萬 | 0.00% | +228,702+267.2% | 加碼 |
| Ikarian Capital, LLC | 302,247 | $888.9 萬 | 2.76% | +302,247 | 新進 |
| Blackstone Group Inc. | 292,995 | $861.7 萬 | 0.04% | 00.0% | 不變 |
| Emerald Advisers, LLC | 292,569 | $860.4 萬 | 0.33% | +292,569 | 新進 |
| Woodline Partners LP | 264,256 | $777.2 萬 | 0.07% | +1,640+0.6% | 加碼 |
| Bank of America Corp | 257,797 | $758.2 萬 | 0.00% | +66,628+34.9% | 加碼 |
| Emerald Mutual Fund Advisers Trust | 253,550 | $745.7 萬 | 0.39% | +253,550 | 新進 |
| Morgan Stanley | 243,742 | $716.8 萬 | 0.00% | −165,111−40.4% | 減碼 |
| Walleye Capital LLC | 243,372 | $715.8 萬 | 0.08% | +92,552+61.4% | 加碼 |
| Balyasny Asset Management LLC | 227,950 | $670.4 萬 | 0.02% | −44,686−16.4% | 減碼 |
| Logos Global Management LP | 200,000 | $588.2 萬 | 0.66% | −375,000−65.2% | 減碼 |
| Goldman Sachs Group Inc | 169,314 | $498.0 萬 | 0.00% | −723,769−81.0% | 減碼 |
| Voloridge Investment Management, LLC | 156,481 | $460.2 萬 | 0.02% | −118,745−43.1% | 減碼 |
| Soros Fund Management LLC大師索羅斯基金管理 | 145,000 | $426.4 萬 | 0.09% | 00.0% | 不變 |
| Invesco Ltd. | 137,858 | $405.4 萬 | 0.00% | +121,494+742.4% | 加碼 |
| Armistice Capital, LLC | 136,000 | $400.0 萬 | 0.10% | 00.0% | 不變 |
| Nuveen Asset Management, LLC | 125,290 | $368.5 萬 | 0.00% | +8,150+7.0% | 加碼 |
| Barclays PLC | 105,467 | $310.2 萬 | 0.00% | +41,424+64.7% | 加碼 |
| HighVista Strategies LLC | 105,351 | $309.8 萬 | 1.07% | −8,199−7.2% | 減碼 |
| Candriam Luxembourg S.C.A. | 105,000 | $308.8 萬 | 0.02% | 00.0% | 不變 |
| Bank of New York Mellon Corp | 104,806 | $308.2 萬 | 0.00% | −12,880−10.9% | 減碼 |
| Boothbay Fund Management, LLC | 91,775 | $269.9 萬 | 0.09% | +91,775 | 新進 |
| Ensign Peak Advisors, Inc | 82,475 | $242.6 萬 | 0.00% | 00.0% | 不變 |
| Rafferty Asset Management, LLC | 70,586 | $207.6 萬 | 0.01% | +3,477+5.2% | 加碼 |
| Cinctive Capital Management LP | 61,256 | $180.2 萬 | 0.10% | +61,256 | 新進 |
| Ghost Tree Capital, LLC | 60,000 | $176.5 萬 | 0.60% | −190,237−76.0% | 減碼 |
| UBS Group AG | 57,838 | $170.1 萬 | 0.00% | +13,334+30.0% | 加碼 |
| Rhumbline Advisers | 53,935 | $158.6 萬 | 0.00% | +2,039+3.9% | 加碼 |
| EFG Asset Management (North America) Corp. | 52,210 | $153.4 萬 | 0.26% | +15,429+41.9% | 加碼 |
| TD Asset Management Inc | 52,768 | $150.3 萬 | 0.00% | +17,600+50.0% | 加碼 |
| Swiss National Bank | 49,600 | $145.9 萬 | 0.00% | +13,500+37.4% | 加碼 |
| Schonfeld Strategic Advisors LLC | 46,072 | $135.5 萬 | 0.01% | −32,428−41.3% | 減碼 |
| Manufacturers Life Insurance Company, The | 43,460 | $127.8 萬 | 0.00% | +5,678+15.0% | 加碼 |
| Superstring Capital Management LP | 37,287 | $109.7 萬 | 0.98% | −8,284−18.2% | 減碼 |
| Alliancebernstein L.P. | 36,230 | $106.6 萬 | 0.00% | 00.0% | 不變 |
| AQR Capital Management LLC | 35,003 | $102.9 萬 | 0.00% | +35,003 | 新進 |
| Tudor Investment Corp Et Al | 31,138 | $91.6 萬 | 0.01% | +31,138 | 新進 |
| JPMorgan Chase & Co | 29,473 | $86.7 萬 | 0.00% | +6,701+29.4% | 加碼 |
| Legal & General Group Plc | 29,155 | $85.7 萬 | 0.00% | +5,892+25.3% | 加碼 |
| NBW Capital LLC | 26,930 | $79.2 萬 | 0.15% | −7,430−21.6% | 減碼 |
| UBS Asset Management Americas Inc | 26,441 | $77.8 萬 | 0.00% | −3,680−12.2% | 減碼 |
| Citigroup Inc | 25,191 | $74.1 萬 | 0.00% | +5,871+30.4% | 加碼 |
| California State Teachers Retirement System | 24,675 | $72.6 萬 | 0.00% | +5,570+29.2% | 加碼 |
| Mirae Asset Global ETFs Holdings Ltd. | 21,825 | $63.9 萬 | 0.00% | +19,299+764.0% | 加碼 |
| Deutsche Bank AG | 21,508 | $63.3 萬 | 0.00% | +5,263+32.4% | 加碼 |
| Teachers Retirement System of the State of Kentucky | 21,154 | $62.2 萬 | 0.01% | +21,154 | 新進 |
| Jane Street Group, LLC | 20,641 | $60.7 萬 | 0.00% | +9,090+78.7% | 加碼 |
| MetLife Investment Management | 20,132 | $59.2 萬 | 0.00% | +11,344+129.1% | 加碼 |
| Corebridge Financial, Inc. | 18,512 | $54.4 萬 | 0.00% | −113−0.6% | 減碼 |
| State of Wisconsin Investment Board | 18,315 | $53.9 萬 | 0.00% | +4,383+31.5% | 加碼 |
| Global Endowment Management, LP | 18,184 | $53.5 萬 | 0.05% | 00.0% | 不變 |
| Wells Fargo & Company | 17,810 | $52.4 萬 | 0.00% | +635+3.7% | 加碼 |
| Profund Advisors LLC | 14,075 | $41.4 萬 | 0.02% | +1,469+11.7% | 加碼 |
| Susquehanna International Group, LLP | 13,198 | $38.8 萬 | 0.00% | +13,198 | 新進 |
| SG Americas Securities, LLC | 12,589 | $37.0 萬 | 0.00% | +7,044+127.0% | 加碼 |
| ADAR1 Capital Management, LLC | 12,560 | $36.9 萬 | 0.06% | −22,620−64.3% | 減碼 |
| Voya Investment Management LLC | 11,351 | $33.4 萬 | 0.00% | −256−2.2% | 減碼 |
| New York State Common Retirement Fund | 10,265 | $30.2 萬 | 0.00% | −4,100−28.5% | 減碼 |
| Two Sigma Investments, LP | 9,803 | $28.8 萬 | 0.00% | −39−0.4% | 減碼 |
| ExodusPoint Capital Management, LP | 9,733 | $28.6 萬 | 0.00% | +9,733 | 新進 |
| Carlyle Group Inc. | 9,620 | $28.2 萬 | 0.03% | 00.0% | 不變 |
| State Board of Administration of Florida Retirement System | 9,030 | $26.6 萬 | 0.00% | 00.0% | 不變 |
| Squarepoint Ops LLC | 8,477 | $24.9 萬 | 0.00% | +8,477 | 新進 |
| Intech Investment Management LLC | 8,371 | $24.6 萬 | 0.00% | +8,371 | 新進 |
| Arizona State Retirement System | 7,310 | $21.5 萬 | 0.00% | +7,310 | 新進 |
| Quest Partners LLC | 5,654 | $16.6 萬 | 0.01% | +4,131+271.2% | 加碼 |
| Royal Bank of Canada | 3,786 | $11.1 萬 | 0.00% | +530+16.3% | 加碼 |
| Ameritas Investment Partners, Inc. | 3,392 | $9.98 萬 | 0.00% | 00.0% | 不變 |
| Virtus ETF Advisers LLC | 2,848 | $8.38 萬 | 0.04% | +51+1.8% | 加碼 |
| Public Employees Retirement Association of Colorado | 1,589 | $4.70 萬 | 0.00% | +1,589 | 新進 |
| Amalgamated Bank | 1,198 | $3.50 萬 | 0.00% | 00.0% | 不變 |
| Acadian Asset Management LLC | 814 | $2.30 萬 | 0.00% | +814 | 新進 |