Spyre Therapeutics, Inc.
SYRE- 交易所
- Nasdaq
- 產業
- Pharmaceutical Preparations
- SEC CIK
- 0001636282
近 90 天，Spyre Therapeutics, Inc. 內部人申報 0 筆公開市場買進、9 筆賣出；2026 年第 2 季末有 265 家機構在 13F 申報持有，市值合計 $85.2 億；沒有大師持有。
2021 年第 4 季 13F 持有人
Spyre Therapeutics, Inc. 在 2021/12/31 季末的機構持股。管理 1 億美元以上美股的機構，每季結束後 45 天內要用 13F 申報多頭部位。13F 是什麼
- 持有機構
- 86
- 較 2021 年第 3 季 +10 家
- 持有股數
- 3,992 萬
- 較 2021 年第 3 季 −66.1 萬 (−1.6%)
- 總市值
- $1.89 億
- 較 2021 年第 3 季 −$1.33 億 (−41.3%)
- 新進機構
- 19
- 另有 26 家加碼
- 清倉機構
- 9
- 另有 22 家減碼
另有 1 家機構在 2021 年第 3 季持有、還沒有申報 2021 年第 4 季 13F：沒申報不算清倉，也不計入上面的變化。
歷季持有家數與市值
2021 年第 1 季起，每季在 13F 申報持有 SYRE 的機構家數與合計市值。市值是各季季末的申報市值，也會跟著股價漲跌。
| 季度 | 家數 | 市值 |
|---|---|---|
| 2026 年第 2 季 | 265 | $85.2 億 |
| 2026 年第 1 季 | 198 | $41.6 億 |
| 2025 年第 4 季 | 153 | $26.5 億 |
| 2025 年第 3 季 | 137 | $10.8 億 |
| 2025 年第 2 季 | 129 | $9.53 億 |
| 2025 年第 1 季 | 129 | $10.0 億 |
| 2024 年第 4 季 | 131 | $13.9 億 |
| 2024 年第 3 季 | 119 | $15.1 億 |
| 2024 年第 2 季 | 107 | $11.8 億 |
| 2024 年第 1 季 | 103 | $12.1 億 |
| 2023 年第 4 季 | 54 | $6.01 億 |
| 2023 年第 3 季 | 29 | $4,387 萬 |
| 2023 年第 2 季 | 44 | $3,194 萬 |
| 2023 年第 1 季 | 45 | $1,198 萬 |
| 2022 年第 4 季 | 51 | $1,919 萬 |
| 2022 年第 3 季 | 55 | $2,352 萬 |
| 2022 年第 2 季 | 67 | $2,481 萬 |
| 2022 年第 1 季 | 84 | $9,538 萬 |
| 2021 年第 4 季 | 86 | $1.89 億 |
| 2021 年第 3 季 | 77 | $3.22 億 |
| 2021 年第 2 季 | 78 | $2.86 億 |
| 2021 年第 1 季 | 84 | $3.29 億 |
2021 年第 4 季持有機構
每家機構持有 Spyre Therapeutics, Inc. 的股數、市值與佔組合比重；股數變化跟 2021 年第 3 季比。
| 機構 | 股數 | 市值 | 佔組合 % | 股數變化 | 動作 |
|---|---|---|---|---|---|
| Baker Bros. Advisors LP | 3,410,106 | $1,620 萬 | 0.08% | 00.0% | 不變 |
| BlackRock Inc. | 2,998,479 | $1,424 萬 | 0.00% | +14,584+0.5% | 加碼 |
| OrbiMed Advisors LLC | 2,956,124 | $1,404 萬 | 0.18% | −1,059,400−26.4% | 減碼 |
| Bain Capital Life Sciences Investors, LLC | 2,847,689 | $1,353 萬 | 1.07% | 00.0% | 不變 |
| Nantahala Capital Management, LLC | 2,813,560 | $1,336 萬 | 0.83% | +1,296,605+85.5% | 加碼 |
| Suvretta Capital Management, LLC | 2,571,000 | $1,221 萬 | 0.24% | +413,273+19.2% | 加碼 |
| Pictet Asset Management SA | 2,468,129 | $1,172 萬 | 0.01% | −64,670−2.6% | 減碼 |
| Vanguard Group Inc | 2,120,625 | $1,007 萬 | 0.00% | +11,865+0.6% | 加碼 |
| Aisling Capital Management LP | 1,691,151 | $803.3 萬 | 2.83% | 00.0% | 不變 |
| Rock Springs Capital Management LP | 1,577,296 | $749.2 萬 | 0.17% | 00.0% | 不變 |
| Laurion Capital Management LP | 1,450,638 | $689.1 萬 | 0.12% | +844,000+139.1% | 加碼 |
| Goldman Sachs Group Inc | 1,134,351 | $538.8 萬 | 0.00% | −1,699−0.1% | 減碼 |
| Artal Group S.A. | 1,045,000 | $496.4 萬 | 0.15% | 00.0% | 不變 |
| Adage Capital Partners GP, L.L.C. | 1,000,000 | $475.0 萬 | 0.01% | −2,500,000−71.4% | 減碼 |
| Great Point Partners LLC | 910,251 | $432.4 萬 | 0.97% | +10,251+1.1% | 加碼 |
| Samsara BioCapital, LLC | 883,720 | $419.8 萬 | 0.84% | 00.0% | 不變 |
| State Street Corp | 758,041 | $360.1 萬 | 0.00% | −8,900−1.2% | 減碼 |
| Dimensional Fund Advisors LP | 690,573 | $327.9 萬 | 0.00% | +57,740+9.1% | 加碼 |
| Geode Capital Management, LLC | 685,745 | $325.7 萬 | 0.00% | −4,252−0.6% | 減碼 |
| Sio Capital Management, LLC | 498,500 | $236.8 萬 | 0.72% | +52,500+11.8% | 加碼 |
| AXA S.A. | 444,931 | $211.3 萬 | 0.01% | +5,264+1.2% | 加碼 |
| Assenagon Asset Management S.A. | 416,174 | $197.7 萬 | 0.01% | +149,108+55.8% | 加碼 |
| Northern Trust Corp | 349,688 | $166.1 萬 | 0.00% | −16,015−4.4% | 減碼 |
| Lion Point Capital, LP | 300,000 | $142.5 萬 | 0.47% | 00.0% | 不變 |
| Altium Capital Management LP | 293,764 | $139.5 萬 | 0.39% | −315,925−51.8% | 減碼 |
| Renaissance Technologies LLC | 248,200 | $117.9 萬 | 0.00% | +147,900+147.5% | 加碼 |
| University of Texas/Texas Am Investment Managment Co | 245,678 | $116.7 萬 | 0.53% | 00.0% | 不變 |
| Abingworth LLP | 240,500 | $114.2 萬 | 0.28% | 00.0% | 不變 |
| D. E. Shaw & Co., Inc. | 227,508 | $108.1 萬 | 0.00% | +199,005+698.2% | 加碼 |
| Morgan Stanley | 196,218 | $93.2 萬 | 0.00% | +1,993+1.0% | 加碼 |
| Millennium Management LLC | 190,482 | $90.5 萬 | 0.00% | −344,740−64.4% | 減碼 |
| ClariVest Asset Management LLC | 174,919 | $83.2 萬 | 0.03% | +174,919 | 新進 |
| Bank of New York Mellon Corp | 159,274 | $75.7 萬 | 0.00% | −214−0.1% | 減碼 |
| Jacobs Levy Equity Management, Inc | 144,093 | $68.4 萬 | 0.00% | +144,093 | 新進 |
| Nuveen Asset Management, LLC | 168,822 | $65.3 萬 | 0.00% | −10,820−6.0% | 減碼 |
| UBS Group AG | 136,636 | $64.9 萬 | 0.00% | +82,416+152.0% | 加碼 |
| Acadian Asset Management LLC | 130,835 | $62.0 萬 | 0.00% | +130,835 | 新進 |
| Fan Yu | 112,044 | $53.2 萬 | 6.17% | 00.0% | 不變 |
| Franklin Street Advisors Inc | 105,800 | $50.3 萬 | 0.04% | +2,200+2.1% | 加碼 |
| Charles Schwab Investment Management Inc | 99,477 | $47.3 萬 | 0.00% | 00.0% | 不變 |
| Blair William & Co | 76,594 | $36.4 萬 | 0.00% | +24,390+46.7% | 加碼 |
| Ritholtz Wealth Management | 76,490 | $36.3 萬 | 0.02% | 00.0% | 不變 |
| Two Sigma Investments, LP | 64,511 | $30.6 萬 | 0.00% | +64,511 | 新進 |
| Alps Advisors Inc | 57,080 | $27.1 萬 | 0.00% | +57,080 | 新進 |
| Cubist Systematic Strategies, LLC | 55,945 | $26.6 萬 | 0.00% | +55,945 | 新進 |
| Rhumbline Advisers | 53,918 | $25.6 萬 | 0.00% | −225−0.4% | 減碼 |
| Barclays PLC | 49,153 | $23.3 萬 | 0.00% | +32,629+197.5% | 加碼 |
| Parametric Portfolio Associates LLC | 41,983 | $19.9 萬 | 0.00% | −3,123−6.9% | 減碼 |
| Marshall Wace, LLP | 41,624 | $19.7 萬 | 0.00% | −274,199−86.8% | 減碼 |
| Two Sigma Advisers, LP | 38,200 | $18.1 萬 | 0.00% | +38,200 | 新進 |
| Aristides Capital LLC | 35,763 | $17.0 萬 | 0.10% | +35,763 | 新進 |
| Algert Global LLC | 32,424 | $15.4 萬 | 0.02% | −4,380−11.9% | 減碼 |
| Bank of America Corp | 31,067 | $14.7 萬 | 0.00% | +5,428+21.2% | 加碼 |
| Alliancebernstein L.P. | 25,600 | $12.2 萬 | 0.00% | 00.0% | 不變 |
| BIT Capital GmbH | 25,000 | $11.9 萬 | 0.01% | +25,000 | 新進 |
| Deutsche Bank AG | 24,535 | $11.7 萬 | 0.00% | +1,292+5.6% | 加碼 |
| American International Group, Inc. | 21,476 | $10.2 萬 | 0.00% | −644−2.9% | 減碼 |
| California State Teachers Retirement System | 21,314 | $10.1 萬 | 0.00% | −384−1.8% | 減碼 |
| Wells Fargo & Company | 21,332 | $10.1 萬 | 0.00% | +19,120+864.4% | 加碼 |
| JPMorgan Chase & Co | 20,878 | $9.90 萬 | 0.00% | +1,691+8.8% | 加碼 |
| Manufacturers Life Insurance Company, The | 20,139 | $9.60 萬 | 0.00% | −5,184−20.5% | 減碼 |
| New York State Common Retirement Fund | 17,041 | $8.10 萬 | 0.00% | −38−0.2% | 減碼 |
| ProShare Advisors LLC | 15,771 | $7.50 萬 | 0.00% | +113+0.7% | 加碼 |
| Voya Investment Management LLC | 15,466 | $7.30 萬 | 0.00% | −4,412−22.2% | 減碼 |
| Engineers Gate Manager LP | 15,000 | $7.10 萬 | 0.00% | +15,000 | 新進 |
| Delphia (USA) Inc. | 12,944 | $6.10 萬 | 0.06% | +12,944 | 新進 |
| Invesco Ltd. | 12,212 | $5.80 萬 | 0.00% | −2,514−17.1% | 減碼 |
| Nisa Investment Advisors, LLC | 13,192 | $5.70 萬 | 0.00% | +13,192 | 新進 |
| Citigroup Inc | 11,894 | $5.60 萬 | 0.00% | +4,761+66.7% | 加碼 |
| BNP Paribas Arbitrage, SA | 11,159 | $5.30 萬 | 0.00% | +403+3.7% | 加碼 |
| SG Americas Securities, LLC | 11,033 | $5.20 萬 | 0.00% | −17,545−61.4% | 減碼 |
| Pinnacle Wealth Planning Services, Inc. | 10,130 | $4.80 萬 | 0.01% | +10,130 | 新進 |
| Royal Bank of Canada | 8,160 | $3.90 萬 | 0.00% | +2,692+49.2% | 加碼 |
| Group One Trading, L.P. | 5,300 | $2.50 萬 | 0.00% | +5,300 | 新進 |
| Tower Research Capital LLC (TRC) | 4,952 | $2.40 萬 | 0.00% | +1,702+52.4% | 加碼 |
| Ameritas Investment Partners, Inc. | 3,710 | $1.80 萬 | 0.00% | 00.0% | 不變 |
| Public Employees Retirement System of Ohio | 3,893 | $1.80 萬 | 0.00% | +3,893 | 新進 |
| Legal & General Group Plc | 3,264 | $1.60 萬 | 0.00% | 00.0% | 不變 |
| IFP Advisors, Inc | 2,980 | $1.40 萬 | 0.00% | 00.0% | 不變 |
| Russell Investments Group, Ltd. | 3,008 | $1.40 萬 | 0.00% | 00.0% | 不變 |
| Allspring Global Investments Holdings, LLC | 1,334 | $6,000 | 0.00% | +1,334 | 新進 |
| Quadrant Capital Group LLC | 1,137 | $5,000 | 0.00% | 00.0% | 不變 |
| Captrust Financial Advisors | 171 | $1,000 | 0.00% | +171 | 新進 |
| Point72 Hong Kong Ltd | 153 | $1,000 | 0.00% | +153 | 新進 |
| Daiwa Securities Group Inc. | 98 | $0 | 0.00% | 00.0% | 不變 |
| Toronto Dominion Bank | 5 | $0 | 0.00% | +5 | 新進 |
| AlphaCentric Advisors LLC | 0 | $0 | 0.00% | −110,000−100.0% | 清倉 |
| MetLife Investment Management | 0 | $0 | 0.00% | −15,353−100.0% | 清倉 |
| HighVista Strategies LLC | 0 | $0 | 0.00% | −13,137−100.0% | 清倉 |
| Metropolitan Life Insurance Co | 0 | $0 | 0.00% | −11,616−100.0% | 清倉 |
| Gsa Capital Partners LLP | 0 | $0 | 0.00% | −11,242−100.0% | 清倉 |
| Susquehanna International Group, LLP | 0 | $0 | 0.00% | −11,192−100.0% | 清倉 |
| Personal Cfo Solutions, LLC | 0 | $0 | 0.00% | −10,888−100.0% | 清倉 |
| Lazard Asset Management LLC | 0 | $0 | 0.00% | −8,801−100.0% | 清倉 |
| Penserra Capital Management LLC | 0 | $0 | 0.00% | −1,120−100.0% | 清倉 |
| Berman Capital Advisors, LLC | – | – | – | – | 本季未申報 |