Spyre Therapeutics, Inc.
SYRE- 交易所
- Nasdaq
- 產業
- Pharmaceutical Preparations
- SEC CIK
- 0001636282
近 90 天，Spyre Therapeutics, Inc. 內部人申報 0 筆公開市場買進、9 筆賣出；2026 年第 2 季末有 265 家機構在 13F 申報持有，市值合計 $85.2 億；沒有大師持有。
2025 年第 2 季 13F 持有人
Spyre Therapeutics, Inc. 在 2025/6/30 季末的機構持股。管理 1 億美元以上美股的機構，每季結束後 45 天內要用 13F 申報多頭部位。13F 是什麼
- 持有機構
- 129
- 較 2025 年第 1 季 +1 家
- 持有股數
- 6,362 萬
- 較 2025 年第 1 季 +151.7 萬 (+2.4%)
- 總市值
- $9.53 億
- 較 2025 年第 1 季 −$5,165 萬 (−5.1%)
- 新進機構
- 18
- 另有 64 家加碼
- 清倉機構
- 17
- 另有 25 家減碼
另有 1 家機構在 2025 年第 1 季持有、還沒有申報 2025 年第 2 季 13F：沒申報不算清倉，也不計入上面的變化。
歷季持有家數與市值
2021 年第 1 季起，每季在 13F 申報持有 SYRE 的機構家數與合計市值。市值是各季季末的申報市值，也會跟著股價漲跌。
| 季度 | 家數 | 市值 |
|---|---|---|
| 2026 年第 2 季 | 265 | $85.2 億 |
| 2026 年第 1 季 | 198 | $41.6 億 |
| 2025 年第 4 季 | 153 | $26.5 億 |
| 2025 年第 3 季 | 137 | $10.8 億 |
| 2025 年第 2 季 | 129 | $9.53 億 |
| 2025 年第 1 季 | 129 | $10.0 億 |
| 2024 年第 4 季 | 131 | $13.9 億 |
| 2024 年第 3 季 | 119 | $15.1 億 |
| 2024 年第 2 季 | 107 | $11.8 億 |
| 2024 年第 1 季 | 103 | $12.1 億 |
| 2023 年第 4 季 | 54 | $6.01 億 |
| 2023 年第 3 季 | 29 | $4,387 萬 |
| 2023 年第 2 季 | 44 | $3,194 萬 |
| 2023 年第 1 季 | 45 | $1,198 萬 |
| 2022 年第 4 季 | 51 | $1,919 萬 |
| 2022 年第 3 季 | 55 | $2,352 萬 |
| 2022 年第 2 季 | 67 | $2,481 萬 |
| 2022 年第 1 季 | 84 | $9,538 萬 |
| 2021 年第 4 季 | 86 | $1.89 億 |
| 2021 年第 3 季 | 77 | $3.22 億 |
| 2021 年第 2 季 | 78 | $2.86 億 |
| 2021 年第 1 季 | 84 | $3.29 億 |
2025 年第 2 季持有機構
每家機構持有 Spyre Therapeutics, Inc. 的股數、市值與佔組合比重；股數變化跟 2025 年第 1 季比。
| 機構 | 股數 | 市值 | 佔組合 % | 股數變化 | 動作 |
|---|---|---|---|---|---|
| FMR LLC | 9,053,034 | $1.36 億 | 0.01% | +14,481+0.2% | 加碼 |
| Fairmount Funds Management LLC | 4,018,101 | $6,015 萬 | 7.79% | 00.0% | 不變 |
| BlackRock, Inc. | 4,007,296 | $5,999 萬 | 0.00% | +434,622+12.2% | 加碼 |
| RTW Investments, LP | 3,621,996 | $5,422 萬 | 0.77% | 00.0% | 不變 |
| Tang Capital Management LLC | 3,200,000 | $4,790 萬 | 2.42% | +1,150,000+56.1% | 加碼 |
| Vanguard Group Inc | 3,066,586 | $4,591 萬 | 0.00% | +168,319+5.8% | 加碼 |
| VR Adviser, LLC | 2,685,448 | $4,020 萬 | 3.01% | 00.0% | 不變 |
| Braidwell LP | 2,578,404 | $3,860 萬 | 1.32% | 00.0% | 不變 |
| Capital International Investors | 2,392,541 | $3,582 萬 | 0.01% | 00.0% | 不變 |
| Driehaus Capital Management LLC | 2,085,590 | $3,122 萬 | 0.25% | −631,722−23.2% | 減碼 |
| Commodore Capital LP | 1,988,084 | $2,976 萬 | 2.10% | 00.0% | 不變 |
| Paradigm Biocapital Advisors LP | 1,870,445 | $2,800 萬 | 1.20% | −256,760−12.1% | 減碼 |
| State Street Corp | 1,595,291 | $2,388 萬 | 0.00% | −101,824−6.0% | 減碼 |
| Perceptive Advisors LLC | 1,529,445 | $2,290 萬 | 0.86% | −783,827−33.9% | 減碼 |
| Wellington Management Group LLP | 1,513,478 | $2,266 萬 | 0.00% | −80,200−5.0% | 減碼 |
| Jefferies Financial Group Inc. | 1,388,854 | $2,079 萬 | 0.34% | +140,000+11.2% | 加碼 |
| Geode Capital Management, LLC | 1,227,232 | $1,837 萬 | 0.00% | +167,669+15.8% | 加碼 |
| Pictet Asset Management Holding SA | 1,079,443 | $1,616 萬 | 0.02% | +10,551+1.0% | 加碼 |
| Price T Rowe Associates Inc | 930,481 | $1,393 萬 | 0.00% | +681,939+274.4% | 加碼 |
| Franklin Resources Inc | 795,275 | $1,191 萬 | 0.00% | +34,647+4.6% | 加碼 |
| Polar Capital Holdings Plc | 745,000 | $1,115 萬 | 0.06% | −80,000−9.7% | 減碼 |
| Morgan Stanley | 671,044 | $1,005 萬 | 0.00% | +335,577+100.0% | 加碼 |
| Baker Bros. Advisors LP | 626,703 | $938.2 萬 | 0.09% | +626,703 | 新進 |
| Deerfield Management Company, L.P. (Series C) | 613,665 | $918.7 萬 | 0.17% | +163,665+36.4% | 加碼 |
| Adage Capital Partners GP, L.L.C. | 610,200 | $913.5 萬 | 0.02% | −193,000−24.0% | 減碼 |
| Affinity Asset Advisors, LLC | 606,678 | $908.2 萬 | 1.34% | +125,000+26.0% | 加碼 |
| Emerald Advisers, LLC | 565,863 | $847.1 萬 | 0.31% | +18,036+3.3% | 加碼 |
| Goldman Sachs Group Inc | 523,416 | $783.6 萬 | 0.00% | +326,348+165.6% | 加碼 |
| Blackstone Group Inc. | 489,248 | $732.4 萬 | 0.03% | 00.0% | 不變 |
| Woodline Partners LP | 465,152 | $696.3 萬 | 0.04% | +344+0.1% | 加碼 |
| UBS Group AG | 462,863 | $692.9 萬 | 0.00% | −89,380−16.2% | 減碼 |
| Northern Trust Corp | 436,947 | $654.1 萬 | 0.00% | +57,072+15.0% | 加碼 |
| Charles Schwab Investment Management Inc | 418,503 | $626.5 萬 | 0.00% | +35,867+9.4% | 加碼 |
| Bank of America Corp | 396,351 | $593.3 萬 | 0.00% | −30,724−7.2% | 減碼 |
| Siren, L.L.C. | 368,598 | $551.8 萬 | 0.29% | 00.0% | 不變 |
| Victory Capital Management Inc | 354,116 | $530.1 萬 | 0.00% | +102,270+40.6% | 加碼 |
| Capital World Investors | 350,774 | $525.1 萬 | 0.00% | 00.0% | 不變 |
| Emerald Mutual Fund Advisers Trust | 329,430 | $493.2 萬 | 0.30% | −59,992−15.4% | 減碼 |
| Voloridge Investment Management, LLC | 278,920 | $417.5 萬 | 0.02% | +21,488+8.3% | 加碼 |
| Candriam Luxembourg S.C.A. | 246,030 | $368.3 萬 | 0.02% | 00.0% | 不變 |
| BNP Paribas Arbitrage, SA | 223,320 | $334.3 萬 | 0.00% | +167,487+300.0% | 加碼 |
| Deep Track Capital, LP | 219,015 | $327.9 萬 | 0.11% | 00.0% | 不變 |
| Barclays PLC | 216,646 | $324.3 萬 | 0.00% | +2,040+1.0% | 加碼 |
| Capitolis Liquid Global Markets LLC | 183,000 | $274.0 萬 | 0.02% | +183,000 | 新進 |
| Armistice Capital, LLC | 172,000 | $257.5 萬 | 0.10% | −28,000−14.0% | 減碼 |
| Nuveen, LLC | 135,068 | $202.2 萬 | 0.00% | −5,061−3.6% | 減碼 |
| Bank of New York Mellon Corp | 132,150 | $197.8 萬 | 0.00% | +17,910+15.7% | 加碼 |
| Schroder Investment Management Group | 129,558 | $197.2 萬 | 0.00% | +21,054+19.4% | 加碼 |
| TD Asset Management Inc | 113,968 | $170.6 萬 | 0.00% | +91,600+409.5% | 加碼 |
| HighVista Strategies LLC | 112,805 | $168.9 萬 | 0.62% | +17,646+18.5% | 加碼 |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 109,284 | $163.6 萬 | 0.00% | −11,037−9.2% | 減碼 |
| Mercer Global Advisors Inc | 106,142 | $158.9 萬 | 0.00% | +106,142 | 新進 |
| UBS Asset Management Americas Inc | 85,702 | $128.3 萬 | 0.00% | +33,564+64.4% | 加碼 |
| ExodusPoint Capital Management, LP | 82,977 | $124.2 萬 | 0.02% | +67,922+451.2% | 加碼 |
| B Group, Inc. | 80,000 | $119.8 萬 | 1.03% | +10,000+14.3% | 加碼 |
| Manufacturers Life Insurance Company, The | 79,896 | $119.6 萬 | 0.00% | +25,995+48.2% | 加碼 |
| Rhumbline Advisers | 73,168 | $109.5 萬 | 0.00% | +17,145+30.6% | 加碼 |
| Foresite Capital Management VI LLC | 70,000 | $104.8 萬 | 0.59% | +70,000 | 新進 |
| Swiss National Bank | 68,600 | $102.7 萬 | 0.00% | 00.0% | 不變 |
| Verition Fund Management LLC | 65,042 | $97.4 萬 | 0.01% | +65,042 | 新進 |
| Susquehanna International Group, LLP | 59,816 | $89.5 萬 | 0.00% | +1,120+1.9% | 加碼 |
| F/M Investments LLC | 52,546 | $78.7 萬 | 0.03% | +702+1.4% | 加碼 |
| Rafferty Asset Management, LLC | 50,957 | $76.3 萬 | 0.00% | −19,366−27.5% | 減碼 |
| JPMorgan Chase & Co | 47,279 | $70.8 萬 | 0.00% | +5,723+13.8% | 加碼 |
| Alliancebernstein L.P. | 36,230 | $54.2 萬 | 0.00% | 00.0% | 不變 |
| State of Wisconsin Investment Board | 35,046 | $52.5 萬 | 0.00% | +145+0.4% | 加碼 |
| Legal & General Group Plc | 34,969 | $52.3 萬 | 0.00% | −2,875−7.6% | 減碼 |
| Invesco Ltd. | 34,680 | $51.9 萬 | 0.00% | +9,473+37.6% | 加碼 |
| Wells Fargo & Company | 34,409 | $51.5 萬 | 0.00% | +4,374+14.6% | 加碼 |
| ADAR1 Capital Management, LLC | 34,051 | $51.0 萬 | 0.08% | +19,018+126.5% | 加碼 |
| Deutsche Bank AG | 33,938 | $50.8 萬 | 0.00% | +5,455+19.2% | 加碼 |
| California State Teachers Retirement System | 33,201 | $49.7 萬 | 0.00% | +603+1.8% | 加碼 |
| Renaissance Technologies LLC | 30,936 | $46.3 萬 | 0.00% | +30,936 | 新進 |
| Squarepoint Ops LLC | 30,046 | $45.0 萬 | 0.00% | −41,965−58.3% | 減碼 |
| MetLife Investment Management | 29,918 | $44.8 萬 | 0.00% | +6,185+26.1% | 加碼 |
| Mirae Asset Global ETFs Holdings Ltd. | 29,812 | $44.7 萬 | 0.00% | +2,794+10.3% | 加碼 |
| Citigroup Inc | 29,261 | $43.8 萬 | 0.00% | −54,203−64.9% | 減碼 |
| Teachers Retirement System of the State of Kentucky | 25,799 | $38.6 萬 | 0.00% | 00.0% | 不變 |
| Intech Investment Management LLC | 24,945 | $37.3 萬 | 0.00% | +4,517+22.1% | 加碼 |
| Natixis | 20,040 | $35.5 萬 | 0.00% | +20,040 | 新進 |
| Assenagon Asset Management S.A. | 22,136 | $33.1 萬 | 0.00% | −590−2.6% | 減碼 |
| Warren Averett Asset Management, LLC | 19,453 | $29.1 萬 | 0.00% | +23+0.1% | 加碼 |
| NBW Capital LLC | 19,430 | $29.1 萬 | 0.06% | 00.0% | 不變 |
| Global Endowment Management, LP | 18,184 | $27.2 萬 | 0.04% | 00.0% | 不變 |
| AQR Capital Management LLC | 17,973 | $26.9 萬 | 0.00% | +17,973 | 新進 |
| New York State Common Retirement Fund | 16,565 | $24.8 萬 | 0.00% | +6,300+61.4% | 加碼 |
| Voya Investment Management LLC | 13,589 | $20.3 萬 | 0.00% | +3,241+31.3% | 加碼 |
| Janus Henderson Group PLC | 13,000 | $19.4 萬 | 0.00% | −1,028,410−98.8% | 減碼 |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 12,873 | $19.3 萬 | 0.00% | +12,873 | 新進 |
| ProShare Advisors LLC | 12,479 | $18.7 萬 | 0.00% | +1,101+9.7% | 加碼 |
| China Universal Asset Management Co., Ltd. | 12,122 | $18.1 萬 | 0.02% | +35+0.3% | 加碼 |
| Police & Firemen's Retirement System of New Jersey | 11,525 | $17.3 萬 | 0.00% | +2,758+31.5% | 加碼 |
| Profund Advisors LLC | 11,043 | $16.5 萬 | 0.01% | −3,619−24.7% | 減碼 |
| Man Group plc | 10,843 | $16.2 萬 | 0.00% | +10,843 | 新進 |
| Arizona State Retirement System | 10,512 | $15.7 萬 | 0.00% | +495+4.9% | 加碼 |
| Royal Bank of Canada | 8,474 | $12.6 萬 | 0.00% | +6,302+290.1% | 加碼 |
| KLP Kapitalforvaltning AS | 7,800 | $11.7 萬 | 0.00% | 00.0% | 不變 |
| Tower Research Capital LLC (TRC) | 5,769 | $8.64 萬 | 0.00% | +3,725+182.2% | 加碼 |
| Virtus Investment Advisers, Inc. | 5,310 | $7.95 萬 | 0.03% | −1,551−22.6% | 減碼 |
| Ameritas Investment Partners, Inc. | 5,091 | $7.62 萬 | 0.00% | +1,045+25.8% | 加碼 |