Spyre Therapeutics, Inc.
SYRE- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001636282
In the last 90 days, Spyre Therapeutics, Inc. insiders filed 0 open-market purchases and 9 sales; 265 institutions reported holding it in 13F filings for Q2 2026, worth $8.52B in total; no superinvestor holds it.
13F holders, Q2 2025
Institutional positions in Spyre Therapeutics, Inc. as of Jun 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 129
- +1 vs. Q1 2025
- Shares held
- 63.6M
- +1.52M (+2.4%) vs. Q1 2025
- Total value
- $952.6M
- −$51.6M (−5.1%) vs. Q1 2025
- New holders
- 18
- 64 more added
- Sold out
- 17
- 25 more reduced
1 institution that held it in Q1 2025 haven't filed for Q2 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q1 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SYRE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 265 | $8.52B |
| Q1 2026 | 198 | $4.16B |
| Q4 2025 | 153 | $2.65B |
| Q3 2025 | 137 | $1.08B |
| Q2 2025 | 129 | $952.6M |
| Q1 2025 | 129 | $1.00B |
| Q4 2024 | 131 | $1.39B |
| Q3 2024 | 119 | $1.51B |
| Q2 2024 | 107 | $1.18B |
| Q1 2024 | 103 | $1.21B |
| Q4 2023 | 54 | $601.0M |
| Q3 2023 | 29 | $43.9M |
| Q2 2023 | 44 | $31.9M |
| Q1 2023 | 45 | $12.0M |
| Q4 2022 | 51 | $19.2M |
| Q3 2022 | 55 | $23.5M |
| Q2 2022 | 67 | $24.8M |
| Q1 2022 | 84 | $95.4M |
| Q4 2021 | 86 | $189.4M |
| Q3 2021 | 77 | $322.5M |
| Q2 2021 | 78 | $285.8M |
| Q1 2021 | 84 | $328.7M |
Institutions, Q2 2025
Shares, value and share of portfolio for each institution holding Spyre Therapeutics, Inc.; share changes are against Q1 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| FMR LLC | 9,053,034 | $135.5M | 0.01% | +14,481+0.2% | Added |
| Fairmount Funds Management LLC | 4,018,101 | $60.2M | 7.79% | 00.0% | Unchanged |
| BlackRock, Inc. | 4,007,296 | $60.0M | 0.00% | +434,622+12.2% | Added |
| RTW Investments, LP | 3,621,996 | $54.2M | 0.77% | 00.0% | Unchanged |
| Tang Capital Management LLC | 3,200,000 | $47.9M | 2.42% | +1,150,000+56.1% | Added |
| Vanguard Group Inc | 3,066,586 | $45.9M | 0.00% | +168,319+5.8% | Added |
| VR Adviser, LLC | 2,685,448 | $40.2M | 3.01% | 00.0% | Unchanged |
| Braidwell LP | 2,578,404 | $38.6M | 1.32% | 00.0% | Unchanged |
| Capital International Investors | 2,392,541 | $35.8M | 0.01% | 00.0% | Unchanged |
| Driehaus Capital Management LLC | 2,085,590 | $31.2M | 0.25% | −631,722−23.2% | Reduced |
| Commodore Capital LP | 1,988,084 | $29.8M | 2.10% | 00.0% | Unchanged |
| Paradigm Biocapital Advisors LP | 1,870,445 | $28.0M | 1.20% | −256,760−12.1% | Reduced |
| State Street Corp | 1,595,291 | $23.9M | 0.00% | −101,824−6.0% | Reduced |
| Perceptive Advisors LLC | 1,529,445 | $22.9M | 0.86% | −783,827−33.9% | Reduced |
| Wellington Management Group LLP | 1,513,478 | $22.7M | 0.00% | −80,200−5.0% | Reduced |
| Jefferies Financial Group Inc. | 1,388,854 | $20.8M | 0.34% | +140,000+11.2% | Added |
| Geode Capital Management, LLC | 1,227,232 | $18.4M | 0.00% | +167,669+15.8% | Added |
| Pictet Asset Management Holding SA | 1,079,443 | $16.2M | 0.02% | +10,551+1.0% | Added |
| Price T Rowe Associates Inc | 930,481 | $13.9M | 0.00% | +681,939+274.4% | Added |
| Franklin Resources Inc | 795,275 | $11.9M | 0.00% | +34,647+4.6% | Added |
| Polar Capital Holdings Plc | 745,000 | $11.2M | 0.06% | −80,000−9.7% | Reduced |
| Morgan Stanley | 671,044 | $10.0M | 0.00% | +335,577+100.0% | Added |
| Baker Bros. Advisors LP | 626,703 | $9.38M | 0.09% | +626,703 | New |
| Deerfield Management Company, L.P. (Series C) | 613,665 | $9.19M | 0.17% | +163,665+36.4% | Added |
| Adage Capital Partners GP, L.L.C. | 610,200 | $9.13M | 0.02% | −193,000−24.0% | Reduced |
| Affinity Asset Advisors, LLC | 606,678 | $9.08M | 1.34% | +125,000+26.0% | Added |
| Emerald Advisers, LLC | 565,863 | $8.47M | 0.31% | +18,036+3.3% | Added |
| Goldman Sachs Group Inc | 523,416 | $7.84M | 0.00% | +326,348+165.6% | Added |
| Blackstone Group Inc. | 489,248 | $7.32M | 0.03% | 00.0% | Unchanged |
| Woodline Partners LP | 465,152 | $6.96M | 0.04% | +344+0.1% | Added |
| UBS Group AG | 462,863 | $6.93M | 0.00% | −89,380−16.2% | Reduced |
| Northern Trust Corp | 436,947 | $6.54M | 0.00% | +57,072+15.0% | Added |
| Charles Schwab Investment Management Inc | 418,503 | $6.26M | 0.00% | +35,867+9.4% | Added |
| Bank of America Corp | 396,351 | $5.93M | 0.00% | −30,724−7.2% | Reduced |
| Siren, L.L.C. | 368,598 | $5.52M | 0.29% | 00.0% | Unchanged |
| Victory Capital Management Inc | 354,116 | $5.30M | 0.00% | +102,270+40.6% | Added |
| Capital World Investors | 350,774 | $5.25M | 0.00% | 00.0% | Unchanged |
| Emerald Mutual Fund Advisers Trust | 329,430 | $4.93M | 0.30% | −59,992−15.4% | Reduced |
| Voloridge Investment Management, LLC | 278,920 | $4.18M | 0.02% | +21,488+8.3% | Added |
| Candriam Luxembourg S.C.A. | 246,030 | $3.68M | 0.02% | 00.0% | Unchanged |
| BNP Paribas Arbitrage, SA | 223,320 | $3.34M | 0.00% | +167,487+300.0% | Added |
| Deep Track Capital, LP | 219,015 | $3.28M | 0.11% | 00.0% | Unchanged |
| Barclays PLC | 216,646 | $3.24M | 0.00% | +2,040+1.0% | Added |
| Capitolis Liquid Global Markets LLC | 183,000 | $2.74M | 0.02% | +183,000 | New |
| Armistice Capital, LLC | 172,000 | $2.57M | 0.10% | −28,000−14.0% | Reduced |
| Nuveen, LLC | 135,068 | $2.02M | 0.00% | −5,061−3.6% | Reduced |
| Bank of New York Mellon Corp | 132,150 | $1.98M | 0.00% | +17,910+15.7% | Added |
| Schroder Investment Management Group | 129,558 | $1.97M | 0.00% | +21,054+19.4% | Added |
| TD Asset Management Inc | 113,968 | $1.71M | 0.00% | +91,600+409.5% | Added |
| HighVista Strategies LLC | 112,805 | $1.69M | 0.62% | +17,646+18.5% | Added |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 109,284 | $1.64M | 0.00% | −11,037−9.2% | Reduced |
| Mercer Global Advisors Inc | 106,142 | $1.59M | 0.00% | +106,142 | New |
| UBS Asset Management Americas Inc | 85,702 | $1.28M | 0.00% | +33,564+64.4% | Added |
| ExodusPoint Capital Management, LP | 82,977 | $1.24M | 0.02% | +67,922+451.2% | Added |
| B Group, Inc. | 80,000 | $1.20M | 1.03% | +10,000+14.3% | Added |
| Manufacturers Life Insurance Company, The | 79,896 | $1.20M | 0.00% | +25,995+48.2% | Added |
| Rhumbline Advisers | 73,168 | $1.10M | 0.00% | +17,145+30.6% | Added |
| Foresite Capital Management VI LLC | 70,000 | $1.05M | 0.59% | +70,000 | New |
| Swiss National Bank | 68,600 | $1.03M | 0.00% | 00.0% | Unchanged |
| Verition Fund Management LLC | 65,042 | $973.7K | 0.01% | +65,042 | New |
| Susquehanna International Group, LLP | 59,816 | $895.4K | 0.00% | +1,120+1.9% | Added |
| F/M Investments LLC | 52,546 | $786.6K | 0.03% | +702+1.4% | Added |
| Rafferty Asset Management, LLC | 50,957 | $762.8K | 0.00% | −19,366−27.5% | Reduced |
| JPMorgan Chase & Co | 47,279 | $707.8K | 0.00% | +5,723+13.8% | Added |
| Alliancebernstein L.P. | 36,230 | $542.4K | 0.00% | 00.0% | Unchanged |
| State of Wisconsin Investment Board | 35,046 | $524.6K | 0.00% | +145+0.4% | Added |
| Legal & General Group Plc | 34,969 | $523.5K | 0.00% | −2,875−7.6% | Reduced |
| Invesco Ltd. | 34,680 | $519.2K | 0.00% | +9,473+37.6% | Added |
| Wells Fargo & Company | 34,409 | $515.1K | 0.00% | +4,374+14.6% | Added |
| ADAR1 Capital Management, LLC | 34,051 | $509.7K | 0.08% | +19,018+126.5% | Added |
| Deutsche Bank AG | 33,938 | $508.1K | 0.00% | +5,455+19.2% | Added |
| California State Teachers Retirement System | 33,201 | $497.0K | 0.00% | +603+1.8% | Added |
| Renaissance Technologies LLC | 30,936 | $463.1K | 0.00% | +30,936 | New |
| Squarepoint Ops LLC | 30,046 | $449.8K | 0.00% | −41,965−58.3% | Reduced |
| MetLife Investment Management | 29,918 | $447.9K | 0.00% | +6,185+26.1% | Added |
| Mirae Asset Global ETFs Holdings Ltd. | 29,812 | $446.9K | 0.00% | +2,794+10.3% | Added |
| Citigroup Inc | 29,261 | $438.0K | 0.00% | −54,203−64.9% | Reduced |
| Teachers Retirement System of the State of Kentucky | 25,799 | $386.0K | 0.00% | 00.0% | Unchanged |
| Intech Investment Management LLC | 24,945 | $373.4K | 0.00% | +4,517+22.1% | Added |
| Natixis | 20,040 | $354.9K | 0.00% | +20,040 | New |
| Assenagon Asset Management S.A. | 22,136 | $331.4K | 0.00% | −590−2.6% | Reduced |
| Warren Averett Asset Management, LLC | 19,453 | $291.2K | 0.00% | +23+0.1% | Added |
| NBW Capital LLC | 19,430 | $290.9K | 0.06% | 00.0% | Unchanged |
| Global Endowment Management, LP | 18,184 | $272.2K | 0.04% | 00.0% | Unchanged |
| AQR Capital Management LLC | 17,973 | $269.1K | 0.00% | +17,973 | New |
| New York State Common Retirement Fund | 16,565 | $248.0K | 0.00% | +6,300+61.4% | Added |
| Voya Investment Management LLC | 13,589 | $203.4K | 0.00% | +3,241+31.3% | Added |
| Janus Henderson Group PLC | 13,000 | $194.5K | 0.00% | −1,028,410−98.8% | Reduced |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 12,873 | $192.7K | 0.00% | +12,873 | New |
| ProShare Advisors LLC | 12,479 | $186.8K | 0.00% | +1,101+9.7% | Added |
| China Universal Asset Management Co., Ltd. | 12,122 | $181.5K | 0.02% | +35+0.3% | Added |
| Police & Firemen's Retirement System of New Jersey | 11,525 | $172.5K | 0.00% | +2,758+31.5% | Added |
| Profund Advisors LLC | 11,043 | $165.3K | 0.01% | −3,619−24.7% | Reduced |
| Man Group plc | 10,843 | $162.3K | 0.00% | +10,843 | New |
| Arizona State Retirement System | 10,512 | $157.4K | 0.00% | +495+4.9% | Added |
| Royal Bank of Canada | 8,474 | $126.0K | 0.00% | +6,302+290.1% | Added |
| KLP Kapitalforvaltning AS | 7,800 | $116.8K | 0.00% | 00.0% | Unchanged |
| Tower Research Capital LLC (TRC) | 5,769 | $86.4K | 0.00% | +3,725+182.2% | Added |
| Virtus Investment Advisers, Inc. | 5,310 | $79.5K | 0.03% | −1,551−22.6% | Reduced |
| Ameritas Investment Partners, Inc. | 5,091 | $76.2K | 0.00% | +1,045+25.8% | Added |