Spyre Therapeutics, Inc.
SYRE- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001636282
In the last 90 days, Spyre Therapeutics, Inc. insiders filed 0 open-market purchases and 6 sales; 265 institutions reported holding it in 13F filings for Q2 2026, worth $8.52B in total; no superinvestor holds it.
13F holders, Q2 2025
Institutional positions in Spyre Therapeutics, Inc. as of Jun 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 129
- +1 vs. Q1 2025
- Shares held
- 63.6M
- +1.52M (+2.4%) vs. Q1 2025
- Total value
- $952.6M
- −$51.6M (−5.1%) vs. Q1 2025
- New holders
- 18
- 64 more added
- Sold out
- 17
- 25 more reduced
1 institution that held it in Q1 2025 haven't filed for Q2 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q1 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SYRE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 265 | $8.52B |
| Q1 2026 | 198 | $4.16B |
| Q4 2025 | 153 | $2.65B |
| Q3 2025 | 137 | $1.08B |
| Q2 2025 | 129 | $952.6M |
| Q1 2025 | 129 | $1.00B |
| Q4 2024 | 131 | $1.39B |
| Q3 2024 | 119 | $1.51B |
| Q2 2024 | 107 | $1.18B |
| Q1 2024 | 103 | $1.21B |
| Q4 2023 | 54 | $601.0M |
| Q3 2023 | 29 | $43.9M |
| Q2 2023 | 44 | $31.9M |
| Q1 2023 | 45 | $12.0M |
| Q4 2022 | 51 | $19.2M |
| Q3 2022 | 55 | $23.5M |
| Q2 2022 | 67 | $24.8M |
| Q1 2022 | 84 | $95.4M |
| Q4 2021 | 86 | $189.4M |
| Q3 2021 | 77 | $322.5M |
| Q2 2021 | 78 | $285.8M |
| Q1 2021 | 84 | $328.7M |
Institutions, Q2 2025
Shares, value and share of portfolio for each institution holding Spyre Therapeutics, Inc.; share changes are against Q1 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Quest Partners LLC | 4,174 | $62.5K | 0.01% | +983+30.8% | Added |
| Mirae Asset Global Investments Co., Ltd. | 2,331 | $34.9K | 0.00% | +315+15.6% | Added |
| CWM, LLC | 1,712 | $26.0K | 0.00% | +1,338+357.8% | Added |
| Public Employees Retirement Association of Colorado | 1,589 | $24.0K | 0.00% | 00.0% | Unchanged |
| GF Fund Management Co. Ltd. | 1,502 | $22.5K | 0.00% | 00.0% | Unchanged |
| Huntington National Bank | 1,470 | $22.0K | 0.00% | 00.0% | Unchanged |
| Amalgamated Bank | 1,379 | $21.0K | 0.00% | 00.0% | Unchanged |
| Nisa Investment Advisors, LLC | 546 | $8.17K | 0.00% | +362+196.7% | Added |
| Sterling Capital Management LLC | 524 | $7.84K | 0.00% | −105−16.7% | Reduced |
| Skopos Labs, Inc. | 520 | $7.79K | 0.00% | +520 | New |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 377 | $6.00K | 0.00% | +377 | New |
| Advisor Group Holdings, Inc. | 300 | $4.49K | 0.00% | +62+26.1% | Added |
| Daiwa Securities Group Inc. | 206 | $3.00K | 0.00% | 00.0% | Unchanged |
| GAMMA Investing LLC | 174 | $2.60K | 0.00% | −96−35.6% | Reduced |
| Meeder Asset Management Inc | 170 | $2.54K | 0.00% | +170 | New |
| Signaturefd, LLC | 165 | $2.47K | 0.00% | +165 | New |
| Russell Investments Group, Ltd. | 142 | $2.13K | 0.00% | +142 | New |
| Rothschild Investment LLC | 140 | $2.10K | 0.00% | +90+180.0% | Added |
| Simplex Trading, LLC | 145 | $2.00K | 0.00% | +145 | New |
| Caitong International Asset Management Co., Ltd | 102 | $1.53K | 0.00% | +74+264.3% | Added |
| EverSource Wealth Advisors, LLC | 65 | $973 | 0.00% | +41+170.8% | Added |
| Parkside Financial Bank & Trust | 35 | $524 | 0.00% | +35 | New |
| Allworth Financial LP | 30 | $450 | 0.00% | +17+130.8% | Added |
| IFP Advisors, Inc | 23 | $374 | 0.00% | −86−78.9% | Reduced |
| Raymond James Financial Inc | 16 | $240 | 0.00% | +16 | New |
| SBI Securities Co., Ltd. | 11 | $165 | 0.00% | +6+120.0% | Added |
| US Bancorp | 10 | $150 | 0.00% | +1+11.1% | Added |
| Larson Financial Group LLC | 6 | $90 | 0.00% | −38−86.4% | Reduced |
| Covestor Ltd | 6 | $0 | 0.00% | +2+50.0% | Added |
| StemPoint Capital LP | 0 | $0 | 0.00% | −136,139−100.0% | Sold out |
| Citadel Advisors LLC | 0 | $0 | 0.00% | −130,884−100.0% | Sold out |
| Soros Fund Management LLCSuperinvestorSoros Fund Management | 0 | $0 | 0.00% | −125,000−100.0% | Sold out |
| EFG Asset Management (North America) Corp. | 0 | $0 | 0.00% | −82,472−100.0% | Sold out |
| Prosight Management, LP | 0 | $0 | 0.00% | −74,921−100.0% | Sold out |
| Wexford Capital LP | 0 | $0 | 0.00% | −38,292−100.0% | Sold out |
| XTX Topco Ltd | 0 | $0 | 0.00% | −28,499−100.0% | Sold out |
| Corebridge Financial, Inc. | 0 | $0 | 0.00% | −19,595−100.0% | Sold out |
| Natixis Advisors, L.P. | 0 | $0 | 0.00% | −16,401−100.0% | Sold out |
| Aquatic Capital Management LLC | 0 | $0 | 0.00% | −12,903−100.0% | Sold out |
| SG Americas Securities, LLC | 0 | $0 | 0.00% | −7,122−100.0% | Sold out |
| Aster Capital Management (DIFC) Ltd | 0 | $0 | 0.00% | −126−100.0% | Sold out |
| Clear Street Markets LLC | 0 | $0 | 0.00% | −133−100.0% | Sold out |
| CoreCap Advisors, LLC | 0 | $0 | 0.00% | −41−100.0% | Sold out |
| Stephens Consulting, LLC | 0 | $0 | 0.00% | −20−100.0% | Sold out |
| Parallel Advisors, LLC | 0 | $0 | 0.00% | −14−100.0% | Sold out |
| Amundi | 0 | $0 | 0.00% | −5−100.0% | Sold out |
| Lindbrook Capital, LLC | – | – | – | – | Not filed |