Spyre Therapeutics, Inc.
SYRE- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001636282
In the last 90 days, Spyre Therapeutics, Inc. insiders filed 0 open-market purchases and 9 sales; 265 institutions reported holding it in 13F filings for Q2 2026, worth $8.52B in total; no superinvestor holds it.
13F holders, Q2 2025
Institutional positions in Spyre Therapeutics, Inc. as of Jun 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 129
- +1 vs. Q1 2025
- Shares held
- 63.6M
- +1.52M (+2.4%) vs. Q1 2025
- Total value
- $952.6M
- −$51.6M (−5.1%) vs. Q1 2025
- New holders
- 18
- 64 more added
- Sold out
- 17
- 25 more reduced
1 institution that held it in Q1 2025 haven't filed for Q2 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q1 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SYRE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 265 | $8.52B |
| Q1 2026 | 198 | $4.16B |
| Q4 2025 | 153 | $2.65B |
| Q3 2025 | 137 | $1.08B |
| Q2 2025 | 129 | $952.6M |
| Q1 2025 | 129 | $1.00B |
| Q4 2024 | 131 | $1.39B |
| Q3 2024 | 119 | $1.51B |
| Q2 2024 | 107 | $1.18B |
| Q1 2024 | 103 | $1.21B |
| Q4 2023 | 54 | $601.0M |
| Q3 2023 | 29 | $43.9M |
| Q2 2023 | 44 | $31.9M |
| Q1 2023 | 45 | $12.0M |
| Q4 2022 | 51 | $19.2M |
| Q3 2022 | 55 | $23.5M |
| Q2 2022 | 67 | $24.8M |
| Q1 2022 | 84 | $95.4M |
| Q4 2021 | 86 | $189.4M |
| Q3 2021 | 77 | $322.5M |
| Q2 2021 | 78 | $285.8M |
| Q1 2021 | 84 | $328.7M |
Institutions, Q2 2025
Shares, value and share of portfolio for each institution holding Spyre Therapeutics, Inc.; share changes are against Q1 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Covestor Ltd | 6 | $0 | 0.00% | +2+50.0% | Added |
| Larson Financial Group LLC | 6 | $90 | 0.00% | −38−86.4% | Reduced |
| US Bancorp | 10 | $150 | 0.00% | +1+11.1% | Added |
| SBI Securities Co., Ltd. | 11 | $165 | 0.00% | +6+120.0% | Added |
| Raymond James Financial Inc | 16 | $240 | 0.00% | +16 | New |
| IFP Advisors, Inc | 23 | $374 | 0.00% | −86−78.9% | Reduced |
| Allworth Financial LP | 30 | $450 | 0.00% | +17+130.8% | Added |
| Parkside Financial Bank & Trust | 35 | $524 | 0.00% | +35 | New |
| EverSource Wealth Advisors, LLC | 65 | $973 | 0.00% | +41+170.8% | Added |
| Caitong International Asset Management Co., Ltd | 102 | $1.53K | 0.00% | +74+264.3% | Added |
| Simplex Trading, LLC | 145 | $2.00K | 0.00% | +145 | New |
| Rothschild Investment LLC | 140 | $2.10K | 0.00% | +90+180.0% | Added |
| Russell Investments Group, Ltd. | 142 | $2.13K | 0.00% | +142 | New |
| Signaturefd, LLC | 165 | $2.47K | 0.00% | +165 | New |
| Meeder Asset Management Inc | 170 | $2.54K | 0.00% | +170 | New |
| GAMMA Investing LLC | 174 | $2.60K | 0.00% | −96−35.6% | Reduced |
| Daiwa Securities Group Inc. | 206 | $3.00K | 0.00% | 00.0% | Unchanged |
| Advisor Group Holdings, Inc. | 300 | $4.49K | 0.00% | +62+26.1% | Added |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 377 | $6.00K | 0.00% | +377 | New |
| Skopos Labs, Inc. | 520 | $7.79K | 0.00% | +520 | New |
| Sterling Capital Management LLC | 524 | $7.84K | 0.00% | −105−16.7% | Reduced |
| Nisa Investment Advisors, LLC | 546 | $8.17K | 0.00% | +362+196.7% | Added |
| Amalgamated Bank | 1,379 | $21.0K | 0.00% | 00.0% | Unchanged |
| Huntington National Bank | 1,470 | $22.0K | 0.00% | 00.0% | Unchanged |
| GF Fund Management Co. Ltd. | 1,502 | $22.5K | 0.00% | 00.0% | Unchanged |
| Public Employees Retirement Association of Colorado | 1,589 | $24.0K | 0.00% | 00.0% | Unchanged |
| CWM, LLC | 1,712 | $26.0K | 0.00% | +1,338+357.8% | Added |
| Mirae Asset Global Investments Co., Ltd. | 2,331 | $34.9K | 0.00% | +315+15.6% | Added |
| Quest Partners LLC | 4,174 | $62.5K | 0.01% | +983+30.8% | Added |
| Ameritas Investment Partners, Inc. | 5,091 | $76.2K | 0.00% | +1,045+25.8% | Added |
| Virtus Investment Advisers, Inc. | 5,310 | $79.5K | 0.03% | −1,551−22.6% | Reduced |
| Tower Research Capital LLC (TRC) | 5,769 | $86.4K | 0.00% | +3,725+182.2% | Added |
| KLP Kapitalforvaltning AS | 7,800 | $116.8K | 0.00% | 00.0% | Unchanged |
| Royal Bank of Canada | 8,474 | $126.0K | 0.00% | +6,302+290.1% | Added |
| Arizona State Retirement System | 10,512 | $157.4K | 0.00% | +495+4.9% | Added |
| Man Group plc | 10,843 | $162.3K | 0.00% | +10,843 | New |
| Profund Advisors LLC | 11,043 | $165.3K | 0.01% | −3,619−24.7% | Reduced |
| Police & Firemen's Retirement System of New Jersey | 11,525 | $172.5K | 0.00% | +2,758+31.5% | Added |
| China Universal Asset Management Co., Ltd. | 12,122 | $181.5K | 0.02% | +35+0.3% | Added |
| ProShare Advisors LLC | 12,479 | $186.8K | 0.00% | +1,101+9.7% | Added |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 12,873 | $192.7K | 0.00% | +12,873 | New |
| Janus Henderson Group PLC | 13,000 | $194.5K | 0.00% | −1,028,410−98.8% | Reduced |
| Voya Investment Management LLC | 13,589 | $203.4K | 0.00% | +3,241+31.3% | Added |
| New York State Common Retirement Fund | 16,565 | $248.0K | 0.00% | +6,300+61.4% | Added |
| AQR Capital Management LLC | 17,973 | $269.1K | 0.00% | +17,973 | New |
| Global Endowment Management, LP | 18,184 | $272.2K | 0.04% | 00.0% | Unchanged |
| NBW Capital LLC | 19,430 | $290.9K | 0.06% | 00.0% | Unchanged |
| Warren Averett Asset Management, LLC | 19,453 | $291.2K | 0.00% | +23+0.1% | Added |
| Assenagon Asset Management S.A. | 22,136 | $331.4K | 0.00% | −590−2.6% | Reduced |
| Natixis | 20,040 | $354.9K | 0.00% | +20,040 | New |
| Intech Investment Management LLC | 24,945 | $373.4K | 0.00% | +4,517+22.1% | Added |
| Teachers Retirement System of the State of Kentucky | 25,799 | $386.0K | 0.00% | 00.0% | Unchanged |
| Citigroup Inc | 29,261 | $438.0K | 0.00% | −54,203−64.9% | Reduced |
| Mirae Asset Global ETFs Holdings Ltd. | 29,812 | $446.9K | 0.00% | +2,794+10.3% | Added |
| MetLife Investment Management | 29,918 | $447.9K | 0.00% | +6,185+26.1% | Added |
| Squarepoint Ops LLC | 30,046 | $449.8K | 0.00% | −41,965−58.3% | Reduced |
| Renaissance Technologies LLC | 30,936 | $463.1K | 0.00% | +30,936 | New |
| California State Teachers Retirement System | 33,201 | $497.0K | 0.00% | +603+1.8% | Added |
| Deutsche Bank AG | 33,938 | $508.1K | 0.00% | +5,455+19.2% | Added |
| ADAR1 Capital Management, LLC | 34,051 | $509.7K | 0.08% | +19,018+126.5% | Added |
| Wells Fargo & Company | 34,409 | $515.1K | 0.00% | +4,374+14.6% | Added |
| Invesco Ltd. | 34,680 | $519.2K | 0.00% | +9,473+37.6% | Added |
| Legal & General Group Plc | 34,969 | $523.5K | 0.00% | −2,875−7.6% | Reduced |
| State of Wisconsin Investment Board | 35,046 | $524.6K | 0.00% | +145+0.4% | Added |
| Alliancebernstein L.P. | 36,230 | $542.4K | 0.00% | 00.0% | Unchanged |
| JPMorgan Chase & Co | 47,279 | $707.8K | 0.00% | +5,723+13.8% | Added |
| Rafferty Asset Management, LLC | 50,957 | $762.8K | 0.00% | −19,366−27.5% | Reduced |
| F/M Investments LLC | 52,546 | $786.6K | 0.03% | +702+1.4% | Added |
| Susquehanna International Group, LLP | 59,816 | $895.4K | 0.00% | +1,120+1.9% | Added |
| Verition Fund Management LLC | 65,042 | $973.7K | 0.01% | +65,042 | New |
| Swiss National Bank | 68,600 | $1.03M | 0.00% | 00.0% | Unchanged |
| Foresite Capital Management VI LLC | 70,000 | $1.05M | 0.59% | +70,000 | New |
| Rhumbline Advisers | 73,168 | $1.10M | 0.00% | +17,145+30.6% | Added |
| Manufacturers Life Insurance Company, The | 79,896 | $1.20M | 0.00% | +25,995+48.2% | Added |
| B Group, Inc. | 80,000 | $1.20M | 1.03% | +10,000+14.3% | Added |
| ExodusPoint Capital Management, LP | 82,977 | $1.24M | 0.02% | +67,922+451.2% | Added |
| UBS Asset Management Americas Inc | 85,702 | $1.28M | 0.00% | +33,564+64.4% | Added |
| Mercer Global Advisors Inc | 106,142 | $1.59M | 0.00% | +106,142 | New |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 109,284 | $1.64M | 0.00% | −11,037−9.2% | Reduced |
| HighVista Strategies LLC | 112,805 | $1.69M | 0.62% | +17,646+18.5% | Added |
| TD Asset Management Inc | 113,968 | $1.71M | 0.00% | +91,600+409.5% | Added |
| Schroder Investment Management Group | 129,558 | $1.97M | 0.00% | +21,054+19.4% | Added |
| Bank of New York Mellon Corp | 132,150 | $1.98M | 0.00% | +17,910+15.7% | Added |
| Nuveen, LLC | 135,068 | $2.02M | 0.00% | −5,061−3.6% | Reduced |
| Armistice Capital, LLC | 172,000 | $2.57M | 0.10% | −28,000−14.0% | Reduced |
| Capitolis Liquid Global Markets LLC | 183,000 | $2.74M | 0.02% | +183,000 | New |
| Barclays PLC | 216,646 | $3.24M | 0.00% | +2,040+1.0% | Added |
| Deep Track Capital, LP | 219,015 | $3.28M | 0.11% | 00.0% | Unchanged |
| BNP Paribas Arbitrage, SA | 223,320 | $3.34M | 0.00% | +167,487+300.0% | Added |
| Candriam Luxembourg S.C.A. | 246,030 | $3.68M | 0.02% | 00.0% | Unchanged |
| Voloridge Investment Management, LLC | 278,920 | $4.18M | 0.02% | +21,488+8.3% | Added |
| Emerald Mutual Fund Advisers Trust | 329,430 | $4.93M | 0.30% | −59,992−15.4% | Reduced |
| Capital World Investors | 350,774 | $5.25M | 0.00% | 00.0% | Unchanged |
| Victory Capital Management Inc | 354,116 | $5.30M | 0.00% | +102,270+40.6% | Added |
| Siren, L.L.C. | 368,598 | $5.52M | 0.29% | 00.0% | Unchanged |
| Bank of America Corp | 396,351 | $5.93M | 0.00% | −30,724−7.2% | Reduced |
| Charles Schwab Investment Management Inc | 418,503 | $6.26M | 0.00% | +35,867+9.4% | Added |
| Northern Trust Corp | 436,947 | $6.54M | 0.00% | +57,072+15.0% | Added |
| UBS Group AG | 462,863 | $6.93M | 0.00% | −89,380−16.2% | Reduced |
| Woodline Partners LP | 465,152 | $6.96M | 0.04% | +344+0.1% | Added |